心室中隔欠損을 兼有한 大動脈洞 動脈瘤破裂症의 手術治驗例

尹世玉(Sei Ok Yoon),金世煥(Sae Whan Kim),李世淳(Sae Soon Lee),洪弼勳(Pill Whoon Hong) 대한외과학회 1964 Annals of Surgical Treatment and Research(ASRT) Vol.6 No.6

Effect of Extraction and Fermentation on Antioxidant Activities of Hemerocallis fulva L.

Sae-Rom Lee,Sungryul Yu,Youngseung Lee,Yoonhwa Jeong,Misook Kim,Geun Pyo Choi,Soo Jeong Lee,Na-Young Kim,Namji Cho,Seongjun Yoon,Ok Hyun Yoon 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

유방 종괴 절제술을 받은 환자에서 수술후 오심 구토에 대한 Propofol 마취와 Ondansetron의 예방적 투여의 비교

최세진,김윤희,안미정,조정옥 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

Breast surgery is associated with a high incidence of postoperative nausea and vomiting. Propofol as an induction and maintenance agent has been associated with a lower incidence of postoperative nausea and vomiting. Ondansetron is a 5TH-3 antagonist and is an effective antiemetic. We conducted a randomized study to compare the efficacy of ondansetron and intraoperative propofol in the prevention of postoperative nausea and vomiting in the breast surgery. 90 ASA 1 or 2 patient between ages 18-55 scheduled for breast surgery were assigned randomly to one of three groups. In groups. In group I, anesthesia was induced with thiopental 5mg/kg, fentanyl 150mcg and maintained with enflurane 1-1.5vol%. In group P, anesthesia was induced with fentanyl 150mcg, propofol 2mg/kg and maintained with propofol infusion 0.05-0.5mg/kg/min. In group O, ondansetron 4mg was administered intransvenously before induction of anesthesia. In group O, anesthesia was induced with thiopental 5mg/kg, fentanyl 150mcg and maintained with enflurane 1-1.5vol%, In All groups, 50% o_2 and 50% N_2O was administered. All patient received vecuronium to facilitated intubation and subsequent muscle relaxation during surgery. Fentanyl i.v. was used as an analgesic during anesthesia. The incidence of nausea, vomiting and request for rescue antiemetics were recorded at PACU, 6hr, 12hr, and 24hr postoperatively. The incidence of postoperative nausea and request for rescue antiemetics in group P and group O were significantly lower group I (p<0.1). But the incidence of vomiting in groups was not significantly different(p>0.1). The Prophylatic ondansetron and popofol anesthesia reduces nausea and antiemetic requirements after breast surgery.

행정규제정책순응에 미치는 학습지능과 사회지능의 영향력 비교

하옥현(Ok-Hyun Ha),오세윤(Sae-Yoon Oh) 한국컴퓨터정보학회 2009 韓國컴퓨터情報學會論文誌 Vol.14 No.11

본 연구의 목적은 학습지능과 사회지능이 행정규제정책순응에 미치는 영향을 비교해보는 것이다. 분석결과 발견된 내용은 크게 두 가지이다. 하나는 학습지능과 사회지능 사이의 상관성이 극히 낮다는 것이다. 즉, 아무리 학습지능이 높다고 하더라도 사회지능이 이에 비례해서 높아지는 것은 아니라는 것이다. 다른 하나는 사회지능이 학습지능보다 정책순응에 미치는 영향력이 크다는 것이다. 정책의 효율적인 집행을 위해서 사회지능을 무시해서는 성공할 수 없는 시대가 되었다. 따라서 행정규제정책의 전반적인 순환과정에 사회지능적 요소가 적극적으로 관여되도록 정책 당국과 시민사회 모두의 노력이 있어야 할 것으로 사료된다. The purpose of this study is to compare the impact of intellectual quotient and social intelligence on compliance with the administrative regulatory policies. This study found two things. The first one is the correlation between intellectual quotient and social intelligence is not so high. No matter how high is his or her intellectual quotient may be, it cannot be said that his or her social intelligence will be high in proportion to IQ. The second one is the influence of social intelligence on administrative regulatory policies is bigger than that of intellectual quotient. So to execute a policy efficiently, we cannot succeed without consideration to the factors of social intelligence. The result of analysis implies that policy authorities and the concerned citizens should try to get the social intelligence factors involved in all processes of administrative regulatory policies such as agenda setting, decision, implementation, evaluation and feedback.

중앙정맥압측정 - 임상적 의의

윤세옥,Yoon Sae Ok 대한간호협회 1967 대한간호 Vol.6 No.2

지속적 흉부 척추옆블록에 의한 개흉술 후 통증관리

윤여옥 ( Yeo Ok Yun ),오세철 ( Sae Cheol Oh ),박종민 ( Jong Min Park ),윤건중 ( Keon Jung Yoon ) 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.2

L - Arginine Production by Fusant MWE 9031 of Coryneform bacteria

Park, Chung,Choi, Ok Yoon,Ok, Chi Young,Lee, Sae Bae,Lim, Bun Sam 한국농화학회 1990 Applied Biological Chemistry (Appl Biol Chem) Vol.33 No.2

In order to overproduce L-arginine, intergeneric protoplast fusion between Brevibacterium flavum and Corynebacterium glutamicum was performed. For the protoplast fusion, various amino acid analogs, sulfa drugs and/or purine base analogs resistant mutants were isolated from B. flavum ATCC 21493 and C. glutamicum ATCC 21831. The optimum conditions for protoplast fusion of these mutants were examined. Fusani MWE 9031 was found co accumulate a large amount of L-arginine in the culture medium. The concentration of accumulated L-arginine reached 32.5㎎/㎖ with a medium containing 10% glucose. Also the characteristics of culture condition in fusant MWE 9031 was investigated to compare with those of parental strains.

소아에서 조혈모세포이식 후 급성 신질환의 분석

김세윤,최정연,하정옥,박용훈,Kim, Sae-Yoon,Choi, Jung-Youn,Ha, Jeong-Ok,Park, Yong-Hoon 대한소아신장학회 2009 Childhood kidney diseases Vol.13 No.2

소아 악성종양환아들의 완치를 위한 조혈모세포이식술이 최근 널리 이루어지고 있다. 하지만 높은 치료율과 더불어 이의 부작용 또한 많이 보고되고 있다. 본 연구에서는 소아에서 조혈모세포이식술 이후의 급성 신질환의 임상적인 특성과 결과에 대해 알아보고자 하였다. 1995년 9월부터 2009년 4월까지 영남대학교 부속병원 소아청소년과에서 조혈모세포이식을 시행한 53명의 환자들을 대상으로 하였다. 조혈모세포이식 3개월 후의 사구체여과율을 계산하여 신장의 기능이 25% 이상 감소한 '조기 신기능 감소군'과 25% 미만 감소한 '조기 신기능 비감소군' 두 군으로 나누어 의무기록을 후향적으로 분석하였다. 환아의 원인 질환은 급성 백혈병과 신경모세포종이 각각 23명과 13명으로 가장 많았고, 그 외 뇌종양 및 기타 고형 종양이 6명, 재생불량성 빈혈이 4명, 악성 림프종이 4명, 골수이형성 증후군이 2명, 선천성 면역결핍질환이 1명이었다. 조혈모세포이식 3개월 후 25% 이상의 사구체여과율이 감소한 환아는 18명이었다. '조기 신기능 감소군'과 '조기 신기능 비감소군'은 각각 18명과 35명이었고, 이식세포 공급원은 제대혈(n=11)이 4명과 7명, 골수(n=16)는 8명과 8명, 자가 말초혈액(n=26)은 6명과 20명으로 차이는 없었다. 골수 및 제대혈 이식을 시행한 27명의 환아에서 급성 이식편대숙주반응은 신기능 감소군과 비감소군에서 차이를 보이지 않았다. 모든 환아는 전처치법 중 1가지 이상의 신독성 항암제를 투여받았으며 전신방사선조사 및 항흉선세포글로불린을 포함한 전처치법에 따른 두 군의 차이는 없었다. 사망한 환아는 '조기 신기능 감소군'과 '조기 신기능 비감소군'이 각각 12명과 10명이었고, '조기 신기능 감소군'에서 사망환아의 비율이 더 많았고, 사망의 원인으로는 감염, 급성 신부전, 재발 등이었고 '조기 신기능 비감소군'에 비해서 '조기 신기능 감소군'에서 급성 신부전이 많았다. 하지만 신장기능의 저하정도에 따라서는 사망한 환아는 차이를 보이지 않았다. 이번 연구에서는 소아에서 조혈모세포이식 3개월 후의 조기 신기능 저하는 18명이 있었으며 조혈모세포이식 후 발생하는 합병증 중 하나인 급성 이식편대숙주반응과 관련이 없었으며 이식세포 공급원과도 관련이 없었다. 조기 신기능 저하를 보인 환아에서 사망한 환아가 많았고, 신장기능 저하가 중요한 사망 원인이었다. 생존한 조기 신기능 저하군의 환아는 모두 신기능을 회복하였으며, 이식 12개월 후 후기 신기능 저하는 1명으로 이식의 합병증과는 관련이 없었으나 이후 이식 6년째에 재발로 사망하였다. Purpose : Stem cell transplantation (SCT) has gained worldwide acceptance as a treatment for hematologic disorders. This study was performed to evaluate the clinical characteristics and outcomes of the acute kidney injury after SCT in children. Methods : The records of 53 patients who were treated with SCT at the pediatric department of Yeungnam University Hospital between January, 1996 and April, 2009 were used as subjects. Their were divided into two groups ; 'Early renal insufficiency' (ERI, n=18) and 'Non-early renal insufficiency' (NERI, n=35). ERI had greater than 25% of drop in GFR after SCT. Results: Total 53 patients were analyzed. In cord blood SCT (n=11), ERI was 4 (36.4%) and NERI was 7 (63.6%). In bone marrow SCT (n=16), ERI was 8 (50.0%) and NERI was 8 (50.5%). In autologous peripheral blood SCT (n=26), ERI was 6 (23.1%) and NERI was 20 (76.9%). There is no difference in both groups according to kinds of SCT. GVHD was developed in 22 patients, and there is no difference in each group. Twenty two of 53 patients died. ERI was 12 (66.7%) and NERI was 10 (28.6%). Acute renal failure is most important cause of the deaths. Conclusion : Out of 53 pediatric patients who were treated with SCT, 18 patients had greater than 25% of drop in GFR. There is no difference in both groups according to kinds of SCT. GVHD was found in 22 patients and there is no relation between GVHD development and acute kideney injury.

임상연구 : 소구개신경차단이 소아 편도절제술 후 통증조절에 미치는 효과

김효정 ( Hyo Jung Kim ),송선옥 ( Sun Ok Song ),이창훈 ( Chang Hoon Lee ),손윤숙 ( Yoon Suk Son ),서일숙 ( Il Sook Seo ),김세연 ( Sae Yeon Kim ) 대한마취과학회 2003 Korean Journal of Anesthesiology Vol.44 No.6

Inhibition of platelet aggregation by 1-methyl-4-phenyl pyridinium ion (MPP+) through ATP depletion: Evidence for the reduced platelet activities in Parkinson's disease.

Lim, Kyung-Min,Kim, Hyun-Hee,Bae, Ok-Nam,Noh, Ji-Yoon,Kim, Keun-Young,Kim, Sae-Hwan,Chung, Seung-Min,Shin, Sue,Kim, Hyeon-Yeong,Chung, Jin-Ho Churchill Livingstone 2009 Platelets Vol.20 No.3

<P>Neuronal accumulation of 1-methyl-4-phenylpyridinium ion (MPP(+)), the metabolite of neural toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine (MPTP), induces a rapid depletion of cellular ATP level and loss of neuronal cell viability which simulates human Parkinson's disease (PD). Since ATP plays an important role in the physiology and function of platelets, which share many biochemical and physiological features with neuronal cells, we examined the effect of MPP(+) on platelet aggregation and viability using freshly isolated rat platelets. While the treatment of MPP(+) to platelets did not induce cytotoxicity, it significantly attenuated agonist-induced platelet aggregation in a concentration dependent manner. The inhibition of aggregation by MPP(+) was mediated by the depletion of the cytoplasmic ATP pool and resultant decreased ATP secretion. Different from the previous reports in neuronal cells, MPP(+) did not affect intracellular levels of glutathione and cytoplasmic Ca(2+) in platelets. The combined treatment with MPP(+) and 2-deoxyglucose, a glycolysis inhibitor, showed the additive effect in the decrease of ATP secretion and intracellular content. Consistent with these findings, inhibitory effects of MPP(+) on platelet aggregation was significantly enhanced by the treatment with 2-deoxyglucose. In conclusion, these results suggested that MPP(+) can induce ATP depletion in platelets and attenuate platelet aggregation providing a new theory on the reduced platelet activities in PD patients.</P>