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- 저자 : Yoo Jinie Kim (검색결과 5 건)
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Yoo Jinie Kim,Sung Hwan Choi,Sohee Oh,Jin A Sohn,Younghwa Jung,Seung Han Shin,Chang Won Choi,Ee Kyung Kim,Han Suk Kim,김병일,Jin A Lee 대한신생아학회 2018 Neonatal medicine Vol.25 No.4
Purpose: We assessed the influence of antenatal corticosteroid (ACS) on the inhospital outcomes of intrauterine growth restriction (IUGR) infants. Methods: A retrospective study was conducted with singletons born at 23+0 to 33+6 weeks of gestation at Seoul National University Hospital from 2007 to 2014. We compared clinical outcomes between infants who received ACS 2 to 7 days before birth (complete ACS), at <2 or >7 days (incomplete ACS), and those who did not receive ACS in IUGR and AGA infants. Multivariate logistic regression using Firth’s penalized likelihood was performed. Results: 304 neonates with 91 IUGR neonates were eligible. Among AGA neonates, mortality (adjusted odds ratio [aOR], 0.13; 95% confidence interval [CI], 0.02 to 0.78), hypotension within 7 postnatal days (aOR, 0.20; 95% CI, 0.06 to 0.64), and severe bronchopulmonary dysplasia (BPD) or death (aOR, 0.24; 95% CI, 0.07 to 0.77) were lower in complete ACS group after adjusting for pregnancy induced hypertension and uncontrolled preterm labor. Mortality (aOR, 0.18; 95% CI, 0.04 to 0.78), hypotension (aOR, 0.26; 95% CI, 0.09 to 0.70), and severe BPD or death (aOR, 0.33; 95% CI, 0.12 to 0.92) were also lower in the incomplete ACS group. Among IUGR infants, after adjusting for birth weight and 5-minute Apgar score, inhaled nitric oxide use within 14 postnatal days was lower in both complete ACS (aOR, 0.07; 95% CI, 0.01 to 0.67) and incomplete ACS (aOR, 0.04; 95% CI, 0.01 to 0.37) groups. Conclusion: ACS was not effective in reducing morbidities in IUGR preterm infants.
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Hearing and Neurodevelopmental Outcomes in Preterm Infants with Postnatal Cytomegalovirus Infection
( Yoo Jinie Kim ),( Seung Han Shin ),( Ee-kyung Kim ),( Han-suk Kim ) 대한주산의학회 2022 Perinatology Vol.33 No.2
Objective: We aimed to investigate whether preterm infants with postnatal cytomegalovirus (CMV) infection have unfavorable hearing and neurodevelopmental outcomes. We also tried to find the difference between symptomatic and asymptomatic group of preterm infants with CMV infection. Methods: Preterm infants born before 32 weeks’ gestation between January, 2014 and October, 2020 with urine CMV polymerase chain reaction-positive 2 weeks after birth were enrolled. Those who presented more than one of symptoms including thrombocytopenia, neutropenia, hepatitis, cholestasis, and pneumonitis were classified as a symptomatic group. Hearing status and neurodevelopmental outcomes were compared between symptomatic and asymptomatic groups by using results of auditory brainstem response threshold and Bayley Scales of Infant and Toddler Development, third edition (Bayley-III) performed at 8 to 12 and 18 to 24-months corrected age, respectively. Results: Among 553 live births, 32 patients (5.8%) were diagnosed as postnatal CMV infection. Of 32 patients, 20 (62.5%) were classified as a symptomatic group. The incidence of respiratory distress syndrome was significantly higher in symptomatic group (95.0 vs. 58.3%, P=0.018). Composite scores of cognitive, language, and motor domains of Bayley-III was comparable between 2 groups. Total of 2 patients showed mild hearing impairment and one of each was included in the group. Conclusion: No significant difference in short-term outcome was observed between symptomatic and asymptomatic groups. Postnatal CMV infection in preterm infants resulted in mild degree of auditory impairment and no unfavorable neurodevelopmental outcome. Further study with large study population is needed to confirm the consequences of postnatal CMV infection among preterm infants.
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Disseminated Postnatal Cytomegalovirus Infection in a Preterm Neonate: Autopsy Case Report
Kim, Ka-Young,Kim, Ee-Kyung,Park, Sung-Hye,Kim, Yoo Jinie,Shin, Seung-Han,Kim, Han-Suk The Korean Society of Neonatology 2021 Neonatal medicine Vol.28 No.2
Treatment guidelines for postnatal cytomegalovirus (pCMV) infection in preterm have not been established yet. Neutropenia, thrombocytopenia, hepatitis, colitis, and sepsis-like disease are among the clinical manifestations, which range from moderate to serious. We present a case of autopsy diagnosed as pCMV infection in a premature infant delivered at gestational age of 24 weeks and 5 days. On the 7th and 14th days of birth, urinary CMV polymerase chain reaction samples were negative, ruling out congenital CMV infection. However, autopsy examination revealed that the patient had disseminated pCMV infection. CMV inclusion bodies were found in the majority of tissues, including the lung, liver, pancreas, breast, kidney, and adrenal gland, but not the placenta. The thymus exhibited significant cortical atrophy and T-cell immunodeficiency, possibly induced by dexamethasone treatment for bronchopulmonary dysplasia or by pCMV infection itself. If dexamethasone treatment is extended or high doses are considered, it may be beneficial to test the CMV infection status to prevent aggravation of infection. This case demonstrates that, despite the low prevalence, pCMV infection should be considered a differential diagnosis in preterm if other conditions or etiology cannot justify clinical deterioration.
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Lim Gina,Kim Yoo Jinie,Chung Sochung,Park Yong Mean,Kim Kyo Sun,Park Hye Won 대한의학회 2022 Journal of Korean medical science Vol.37 No.16
Background: This meta-analysis was performed to examine the association between maternal hypertension during pregnancy (HDP) and neonatal bronchopulmonary dysplasia (BPD). Methods: We systematically searched PubMed, EMBASE, the Cochrane Library, and the KoreaMed database for relevant studies. We used the Newcastle-Ottawa Scale for quality assessment of all included studies. The meta-analysis was performed using Comprehensive Meta-Analysis software (version 3.3). Results: We included 35 studies that fulfilled the inclusion criteria; the total number of infants evaluated came to 97,399 through review process. Maternal HDP was not significantly associated with any definition of BPD, i.e., oxygen dependency at 36 weeks of gestation (odds ratio [OR], 1.162; 95% confidence interval [CI], 0.991–1.362; P = 0.064) in pooled analysis of 29 studies or oxygen dependency at 28 days of age (OR, 1.084; 95% CI, 0.660–1.780; P = 0.751) in pooled analysis of 8 studies. Maternal HDP was significantly associated only with severe BPD (OR, 2.341; 95% CI, 1.726–3.174; P < 0.001). BPD was not associated with HDP in the overall analysis (OR, 1.131; 95% CI, 0.977–1.309; P = 0.100) or subgroup analysis according to the definition of HDP. Conclusion: Maternal HDP was not associated with neonatal BPD defined by the duration of oxygen dependency (at either 36 weeks of gestation or 28 days of life) but was associated with severe BPD.
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