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Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.
This paper was the study on the change of the water quality an water quality management of reservior when Yong-dam dam constructed. The results obtained are as follows, water quality of river in surroundings area was BOD 1-2 ㎎/ℓ, TKN 1 ㎎/ℓ, T-P 0.03-0.013 ㎎/ℓ. Results from calculatin of the pollution loading of conteminations according to environmental factor, water quality was calculated to BOD 0.87 ㎎/ℓ, T-N 0.07 ㎎/ℓ. Because of increased of inlet nutrient, nutrient conditions in Yong-dam reservior will generated to eutrophication. Therefore, methods for control and management nutrition conditions are must be intercept and control to inflow of nutrient that included to water and wastewater.
We aimed at in this paper analyzing the content of homework in arithmetic and science education in elementary school, and finding out teacher’s guiding direction and student’s solving trend of it. The results are as follows: 1. Homework is given similarly by the ratio of the problem in textbook of the assigned school hours of the subject. 2. Teachers demand sincerity of the students in solving their problems, but they seem to negiect further direction. 3. Students are keen on solving the problems and think that it gives them great help for their learning. 4. It will be more effective for the teachers to make out the homework jointly rather than individually.
The negative weight often can be seen in Hopfield neural network, which is difficult to implement negative conductance in circuits. So we replaced the negative weight with the positive by using inverting neurons. And It has been shown that the input conductance affects the stability of the circuits greatly, and this paper offers the way to decide the appropriate value.
This paper shows that the capacitance of the input space of the neuron affects the point of convergence of the output of the neuron in Lapunove energy function for Hopfield neural network. And this paper also shows that the gain factor of sygmoid function affects the shape of energy map and the point of convergence of the output of the neuron.
Speech database is a indispensable part of speech research. This paper introduces the PBW(Phonetically Balanced Words) set for Korean speech database. To collect a speech database, all possible phonological phenomenon should be included. In addition, PBW set has the properties that it has minimal nember of words and even probability distribution between phonological events. In this paper, we investigate some considerations to construct word set for Korean speech database. We extract PBW set composed of 452 words from 5,000 high-frequency words and it's properties are presented.