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표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results
김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.
후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출
최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.
패스트푸드 레스토랑의 제품과 매장특성이 매력에 미치는 영향 : 1인 가구와 다인 가구 비교를 중심으로
노용환(Roh Yong hwan),김은경(Kim Eun kyoung),조춘한(Cho Chun han) 韓國商品學會 2016 商品學硏究 Vol.34 No.1
최근 우리 사회에서 1인 가구가 차지하는 비중은 계속해서 증가하고 있다. 이런 배경 속에서 본 연구는 1인 가구의 외식 패턴 중의 하나인 패스트푸드 레스토랑에 대해 주목하였다. 장차 1인 가구가 우리나라의 대표적인 가구 형태가 될 수도 있다는 가정에 따라 패스트푸드 레스토랑에 방문한 1인 가구 소비자가 패스트푸드 제품특성과 매장특성 중 어떤 점에 매력을 느끼는지에 가설을 세워 연구를 진행하였다. 패스트푸드 레스토랑에 방문한 1인 가구 227명과 다인 가구 195명의 표본을 비교·분석한 결과는 다음과 같다. 첫째 매력과 관련하여 제품 특성과 매장특성은 지속가능한 매력에 영향을 미친다. 하지만 상황적 매력에 해당하는 제품의 특성에서 제품의 건강성과 매장 특성 중 매장운영성은 영향을 미치지 않는 것으로 나타났다. 둘 째, 1인 가구와 다인 가구의 차이에서 1인 가구의 경우, 제품특성이 지속가능한 매력을 느끼는 데 유의한 영향을 미치는 것으로 나타났다. 하지만 매장 특성 중에서는 매장 공간성만 상황적 매력에 영향을 미치는 것으로 나타났다. 다인 가구는 제품특성 중 패스트푸드 레스토랑의 제품 건강성에 매력을 느끼지 못하는 것으로 나타났다. 또한, 지속가능한 매력과 관련하여 매장 외향성이, 상황적 매력과 관련해서는 매장운영성이 영향을 미치지 못하는 것으로 나타났다. 하지만 종합적으로 제품특성과 매장특성은 전반적인 매력에 영향을 미치는 것으로 볼 수 있다. In relation to the increasing proportion of single-person-households, this study focused on the fast food restaurant, which is one of the eating out patterns of single-person-households. Considering the fact that single-person-households will become a typical type of household in Korea, we studied whether single-person-household consumers are attracted to the characteristics of the product sold at the fast food restaurants, or the characteristics of the restaurant itself. In order to test the hypothesis, we carried out a comparative analysis of 227 single-person household consumers and 195multi-person household consumers who visited fast food restaurants. The following is the result. First, characteristics of the product and the restaurant had an impact on sustainable attraction, but in regards to situational attraction, healthiness of the product (product characteristics) and restaurant management (restaurant characteristics) did not. Second, when comparing single-person and multi-person households, for single-person-households, product characteristics had a significant impact on sustainable attraction, but out of all restaurant characteristics, only the spacial character of the restaurant had an influence on situational attraction. As for multi-person households, consumers were not attracted to the healthiness of the product. In addition, extroversion of the restaurant and restaurant management did not have an effect on sustainable and situational attraction, respectively. Overall, product and restaurant characteristics had an influence on general attraction.
( Jae Yong Yoon ),( Dong Heon Yang ),( Hyun Jun Cho ),( Nam Kyun Kim ),( Chang-yeon Kim ),( Jihyun Son ),( Jae-hyung Roh ),( Se Yong Jang ),( Myung Hwan Bae ),( Jang Hoon Lee ),( Hun Sik Park ),( Yong 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.4
Background/Aims: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). Methods: This observational study included a total of 413 patients (64.1 ± 15.6 year-old, 214 men) with ADHF. All-cause mortality during the 2-year follow-up was investigated for the prognosis. Results: During the follow-up (mean follow-up, 591 ± 233 days), 109 deaths (26.0%) were recorded. In the multivariable analysis model, CA-125 was an independent factor associated with all-cause mortality (log CA-125: hazard ratio, 1.23; 95% confidence interval, 1.02 to 1.48; p = 0.030) together with age, sex, New York Heart Association class, β-blocker, and NT-proBNP. The Kaplan-Meier survival analysis demonstrated that the group with both low marker levels showed the best 2-year survival (87.9%) followed by the group with low NT-proBNP and high CA-125 (76.1%), high NT-proBNP and low CA-125 (64.7%) and high NT-proBNP and high CA-125 levels (54.3%) (p < 0.001). Addition of CA-125 in combination with NT-proBNP and established risk factors further increased the predictive power for mortality in patients with ADHF. Conclusions: CA-125 was an independent factor associated with all-cause mortality in patients with ADHF. Combination of CA-125 with NT-proBNP significantly improved the prediction of mortality in patients with ADHF.
A New Soybean Cultivar with Lodging Resistance and Adaptability for Mechanized Harvesting, "Shingi"
Jung Kyung Moon,Keum Yong Park,Hong Tae Yun,Yeong Ho Lee,Min Jung Seo,Sun Lim Kim,Yong Hwan Ryu,Suk Ha Lee,Ja Hwan Ku,Jae Hwan Roh,Jung Soo Park,Ik Jae Kim,Soo Kyeong KimMoon 한국육종학회 2005 한국육종학회지 Vol.37 No.2