방광암 환자에서 염색체 이상이 예후에 미치는 영향에 대한 세포유전학적 연구

나용길,임재성,윤율로,설종구 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Bladder cancer is the most common type of urinary cancer in Korea. Usually it has an unpredictable natural history with respect to tumor invasion and recurrence. The cytogenetic results and genetic alterations of bladder cancer are thought to be closely related to cancer promotion and progression. To predict the possible relationship among them, we performed the cytogenetic analysis in the bladder cancer patients. The specimens of the 32 patients who underwent operations for the bladder cancer were obtained and cultured. Of them 15 cases were cytogenetically abnormal. There were wide variety of structural and numerical chromosomal aberrations. The most frequently affected chromosomes were 4, 8, 9 and 19 as determined by karyotyping. In our study, as in other studies the more the genes were hyperdiploidy and the more the genetic aberrations were complex, and the cancer was more invasive and the cancer grade was higher. There was frequent loss on chromosome 4, 9, 19 and the appearance of marker chromosomes. Although most amplifications and deletions have been previously described in the literature, our study showed some intriguing and uncommon regions, different from those found in past studies.

Parkinson's Disease 환자의 배뇨장애에 관한 연구

나용길 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Parkinson's disease is one of the most common neurologic conditions causing voiding dysfunction. It is supposed that 35% to 75% of patients with Parkinson's disease will have symptoms of neurogenic voiding dysfunction. Carefully performed urodynamic investigation is the key to understanding the pathophysiology of Parkinson's disease and forms the basis for reasonable treatment. We evaluated the 20 cases of Parkinson's disease who were admitted to Chungnam National University Hospital from Aug., 1995 to Nov., 1996. Symptoms of voiding dysfunction were presented in 70% of the patients. The presenting symptoms were urgency and frequency(64%), obstructive symptoms(21%), and mixed irritative and obstructive symptoms(15%). Detrusor hyperreflexia was the most common urodynamic finding(55%), and normal(20%), impaired detrusor contractility(15%), detrusor areflxia(10%) were in order. There was a poor correlation between the parkinsonian patient's urologic symptoms and the urodynamic findings.

Portable Diode Laser와 Fiberoptic Delivery System을 이용한 전립선비대증의 치료

나용길 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Interstitial laser coagulation (ILC) therapy which coagulates prostate tissue is a new and promissing method of treatment for symptomatic benign prostatic hyperplasia (BPH) patients. We studied the clinical efficacy and safety of ILC using a diode laser. A total of 15 patients with symptomatic BPH underwent interstitial laser coagulation by portable diode laser and a fiberoptic delivery system. Voiding outcomes, including international prostate symptom scores (IPSS), peak urinary flow rates, and prostate volume were measured by time, and immediate and short-term (3 months)complications were assessed. Epidural anesthesia was performed in all patients. At 3 months, there was as 64.9% improvement is IPSS (25.9 to 9.1, P<0.05) and a 48.2% decrease in prostate volume (46.2 to 23.9 gm, P<0.05). There were no intraoperative complications. Postoperatively, four patients had tansient hematuria and two had transient urinary retention. Our results show that interstitial laser coagulation by diode laser appears to be a single, safe and efficacious procedure for the treatment of symptomatic BPH. I n addition, it is hoped that this will reduce the postoperative dyuria that a significant proportion of men complan of following endoscopic laser coagulation or vaporization of the prostatic urethral lumen.

요도손상환자의 임상적 고찰

나용길,김영수 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

We studied 49 cases of urethral injury, patient who had been admitted to the department of urology, Chugnam National University Hospital from 1995 to 1997. The following results were obtained: 1. Among the 49 patients the age distribution ranged form 11 to 75 years of age with the average being 38.8 years. 2. In most of the cases the injury site was located in the anterior part of the urethra(85.7%) and the cause of injury was the straddle injury(62.3%). complete urethral rupture was common in the posterior urethral injuries while incomplete urethral injury was common in the anterior urethral injuries. 3. In the cases of anterior urethral injury, the group who were managed by initial suprapubic cystostomy developed urethral stricture in 92.3% of the patients. Among the 12 cases of urethral stricture, eight were shown to have a complete obstruction of the urethra by concomitant retrograde and voiding cystourethrography. Therefore more aggravative management i.e., primary realignment, is needed in cases of complete rupture in anterior urethral injuries.

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

여성 복압성 요실금에서 전기자극을 이용한 골반저근운동의 효과

김윤종,김진겸,임재성,나용길,설종구 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Purpose: PFME(Pelvic floor muscle exercise) has been used in stress Incontinence patients as a primary treatment. The purpose of this study is to evaluate the efficacy of well structed PFME with functional electrical stimulation in these patients. Materials and methods: Ninety five women with stress incontinence were assigned to pelvic floor muscle training program. The mean age of the patients was 43.5 years and according to the Stamey grades, 50(52.6%) were grade 1, 42(44.2%) were grade II and 3(3.2%) were grade III. In principle, we performed electrical stimulation. of 2 times a day, each 30 minutes in length and continued for at least 3 months. Results: In our study, overall success ratee was 76% at lmonth, 96.3% at 2months, 94.4% at 3months and 92% at 6months after treatment, at respectively. The cure rate according to the symptom grade was 48% in grade I, 23.8% in grade II and 0% in grade III, so the degree of grade was significant parameter predictive of a good outcome (p<0.05). Intravaginal pressure increased by 10cmH2O. Increased vaginal pressure was found in 93% of the patients and at least 50% improvement was 61%. Conclusion: PFME using functional electrical stimulation is more effective for the patients who have good compliance, low degree stress incontinence. In order to attain and maintain good results, a well structed program that teaches specific muscle exercise should be used and the patients should be followed by a maintenance program and reinforcement.

Improvement of Gas Sensing Characteristics by Adding Pt Nanoparticles on ZnO-Branched SnO₂ Nanowires

Na, Han Gil,Kwon, Yong Jung,Cho, Hong Yeon,Kang, Sung Yong,Kim, Hyoun Woo American Scientific Publishers 2015 Journal of nanoscience and nanotechnology Vol.15 No.11

Reduced graphene oxide functionalized with Cu nanoparticles: Fabrication, structure, and sensing properties

Na, Han Gil,Cho, Hong Yeon,Kwon, Yong Jung,Kang, Sung Yong,Lee, Chongmu,Jung, Taek Kyun,Lee, Hyo-Soo,Kim, Hyoun Woo Elsevier 2015 THIN SOLID FILMS - Vol.588 No.-

<P><B>Abstract</B></P> <P>We have fabricated the NO<SUB>2</SUB> gas sensors by using reduced graphene oxide (RGO) functionalized with copper (Cu) nanoparticles, revealing that the sensitivity was significantly enhanced by the Cu functionalization. Transmission electron microscopy indicated that the nanoparticles with a cubic Cu phase were attached on the surface of RGO. Raman spectra revealed that the structural disorder of RGO was increased by the Cu-functionalization. We performed the NO<SUB>2</SUB> gas sensing test, revealing that the sensor response of RGOs was increased by 326% by means of the Cu-functionalization. We have discussed the associated mechanisms. In addition, we have ascribed the functionalization-induced changes of response and recovery times to the increase of low-energy binding sites.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We fabricated NO<SUB>2</SUB> gas sensors by using RGOs functionalized with Cu nanoparticles. </LI> <LI> The sensitivity was significantly enhanced by the Cu functionalization. </LI> <LI> We examined changes in response and recovery times by the Cu functionalization. </LI> </UL> </P>

Improved Sensing Behaviors in Reduced Graphene Oxide Functionalized with Ni(OH)₂ Nanoparticles

Na, Han Gil,Kwon, Yong Jung,Cho, Hong Yeon,Kang, Sung Yong,Jung, Taek Kyun,Lee, Hyo-Soo,Kim, Hyoun Woo American Scientific Publishers 2015 Journal of nanoscience and nanotechnology Vol.15 No.11

<P>In this paper, we detail improvements in the sensing properties of reduced graphene oxide (AGO), which were achieved through functionalization. The functionalization process utilizes graphene oxide suspensions, generating nanoparticles on the AGO surface mainly comprised of Ni(OH)(2) phase. Raman spectra indicate that functionalization increases the degree of disorder in RGOs. NO2 gas sensing tests reveal an approximate increase of 154% in the sensor response of the RGOs after functionalization. Possible mechanisms for improving sensing responses via functionalization are discussed. The enhancement is due to the spillover effect, to the increase of the sensor surface by the catalytic particles, to the reduction of AGO conduction volume through the generation of depletion region, and to the resistance modulation of the heterojunctions.</P>