Impact of Coronavirus Disease on Persons with Dementia and Their Caregivers: An Audit Study

Zi Ying Koh,Felicia Law,Justin Chew,Noorhazlina Ali,Wee Shiong Lim 대한노인병학회 2020 Annals of geriatric medicine and research Vol.24 No.4

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한글 반포 550 주년 기념 / 한글 문화 파리 국제 학술회의 발표 논문 ; 대회주제 " 한글과 한글 문화 " ( 1996 . 6 . 25 - 26 ) ; 중국에서의 조선어 이질화 현상

문영자(Ying Zi Wen) 국제한국어교육학회 1996 한국어 교육 Vol.7 No.-

한·중 인칭접미사 '-자(者), -가(家), -인(人), -사(師)'의 의미 기능 고찰

이영자(Ying Zi Li) 언어과학회 2008 언어과학연구 Vol.47 No.-

한국어 어휘의 의미와 그 사용실태

문영자 ( Ying Zi Wen ) 우리어문학회 2011 우리어문연구 Vol.39 No.-

본 연구는 한국의 신문, 방송, 텔레비전, 광고 등 주로 일상에서 쓰이는 언어를 논의의 대상으로 그의 어휘적 의미를 살펴보고 현재의 어휘 사용 실태를 몇 가지 유형으로 나누어 고찰 분석하였다. 이를 통해 아름다운 한국어를 보호하고, 한국어 사용을 진작해야 할 중요성을 호소하고, 그 책임감을 고양하고자 하였다. 이런 목적 아래, 언론매체 뿐만이 아니라 한국어 보호와 사용 및 홍보에 앞장서야 할 한국 정부의 기관이 오히려 외국어를 과도하게 사용하고 있다는 점을 지적하였다. 그리고 친족어의 확대 사용과 경어의 사용 실태를 고찰하면서 사회적으로 비록 널리 사용되고 있지만 우려할 만큼 비문법적인 경향으로 흘러가고 있으며, 빠른 속도로 일상용 언어로 자리 잡고 있는 문제점에 대해 심각한 우려를 표했다. 따라서 신조어의 남용과 어휘의 과다 생략 사용실태를 통해 외국어를 그대로 받아들이거나 차용하여 만들어낸 언어 그리고 한국어 어휘의 생성 규칙에 위배되거나 한국어 어휘의 특성을 지니지 않은 언어들을 무절제하게 만들어 내어 사용하는 현상에 대해서는 마땅한 주시와 관찰이 요구된다는 점을 지적하였다. 한국 정부가 한국어의 순화작업을 꾸준히 진행해 왔는데도 불구하고 최근에 와서 영어를 위주로 하는 외국어들이 한국 고유어의 자리를 빼앗고 있는 점에 대해 우려를 표했으며 한국의 것보다는 해외의 것들을 더 격식 높고 수준 높은 것으로 보고 한국어를 사용하는 것보다 외국어를 사용하는 것을 더 박식한 것으로 느끼는 사회 풍토를 비판하였다. 따라서 바야흐로 세계화의 길에 들어서는 현시대에 한국정부와 산하의 많은 관련기구들 그리고 한국국민 모두가 한국어를 사랑하고 지키고 홍보하는 선두에서 최선을 다해야 한다고 주장하였다. Korea has a long history as a nation have a beautiful language and culture. Korean in the world`s population are within the top 10 with a language and is the world`s most beautiful language. These excellent Korean and Korea`s own culture and tradition of the beautiful features need to be held well. In the agricultural and food, Koreans very much emphasize "local purchasing (身土不二)". But otherwise nothing seems to be in use Korean. The language of their country than the other countries prefer the language of everyday conversation, and more Korean Foreign Origin in the more fun to use. They use easy and clear Korean incorrectly sometimes. Accordingly, the original appearance of Korean is increasingly becoming. In this paper, we will analyze the Korean language which the meaning is becoming gradually or is misused. The purpose is to protect the Korean language, promote the importance of using Korean, and enhance the accountability.

Interleukin-18 Synergism with Interleukin-2 in Cytotoxicity and NKG2D Expression of Human Natural Killer Cells

Qi, Yuan-Ying,Lu, Chao,Ju, Ying,Wang, Zi-E,Li, Yuan-Tang,Shen, Ya-Juan,Lu, Zhi-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Natural killer (NK) cells play an important role in anti-tumor immunity. Interleukin (IL)-18 is an immunoregulatory cytokine that induces potent NK cell-dependent anti-tumor responses when administrated with other cytokines. In this study, we explored the effects of combining IL-18 and IL-2 on NK cytotoxicity as well as expression levels of the NK cell receptor NKG2D in vitro. Freshly isolated PBMCs were incubated for 48 h with IL-18 and IL-2, then CD107a expression on $CD3^-CD56^+$ NK cells was determined by three-colour flow cytometry to evaluate the cytotoxicity of NK cells against human erythroleukemia K562 cells and human colon carcinoma HT29 cells. Flow cytometric analysis was also employed to determine NKG2D expression on NK cells. The combined use of IL-18 and IL-2 significantly increased CD107a expression on NK cells compared with using IL-18 or IL-2 alone, suggesting that the combination of these two cytokines exerted synergistic enhancement of NK cytotoxicity. IL-18 also enhanced NKG2D expression on NK cells when administered with IL-2. In addition, blockade of NKG2D signaling with NKG2D-blocking antibody attenuated the up-regulatory effect of combining IL-18 and IL-2 on NK cytolysis. Our data revealed that IL-18 synergized with IL-2 to dramatically enhance the cytolytic activity of human NK cells in a NKG2D-dependent manner. The results appear encouraging for the use of combined IL-18 and IL-2 in tumor immunotherapy.

온라인 협업 도구 활용 한국어 수업 사례 : 상해 삼달대학교를 중심으로

배영련(Pei, Ying Lian),오선자(Wu, Shan Zi),최선진(Choi, Seon Jin),한나(Han, Na),오영화(Wu, Ying Hua) 글로벌교육연구학회 2021 글로벌교육연구 Vol.13 No.4

본 연구는 온라인 수업에서의 상호작용에 도움을 주며, 중국과 한국에서 동시에 사용할수 있는 다양한 온라인 협업 도구를 소개하고, 이 도구 네 가지(mentimeter, zoom, padlet, Quizizz)를 사용하여 중국인 대상 한국어 수업을 운영한 사례를 제시하였다. 그리고본 수업 운영에 대한 학습자 만족도를 살펴보기 위하여 2021학년도 3월 학기에 본 수업을수강한 상해 삼달대학교 한국어 학습자 75명을 대상으로 만족도 조사를 시행하였으며, 그결과 전체적인 수업 만족도는 평균 4.09였다. 또한, 온라인 수업에서의 상호작용 향상을위한 방법으로 활용한 온라인 협업 도구에 대한 전체적인 만족도는 4.24였으며, 각 도구의만족도는 mentimeter가 4.63, zoom이 4.15, padlet이 4.09, Quizizz 3.81 순이었다. 이 중에서 협업 도구에 대한 전체적인 만족도와 padlet 만족도가 수업 전체 만족도에 영향을미치는 것으로 분석되었다. 본 연구 결과에 따른 제언은 다음과 같다. 첫째, 온라인 협업도구 활용에 대한 학습자 만족도가 높기 때문에 한국어 수업에 활용할 수 있는 다양한 협업도구 연구를 바탕으로 수업 적용이 필요하며, 각 국 학습자용 교재 편찬이 필요하다고 할수 있다. 본 연구는 다양한 온라인 수업에서의 상호작용에 필요한 다양한 협업 도구를 소개하고 비대면 수업에서의 실제 활용방안을 제시했으며, 이에 대한 학습자들의 의견을 수렴했다는 점에서 의의가 있다. This study was to present a case of an Online Korean class using four online tools such as Mentimeter, Zoom, Padlet, Quizizz for helping the interaction of Korean and Chinese students. To investigate learner satisfaction, 75 Chinese students from Shanda University participated in a survey after the class. The results were as follows: First, the overall class satisfaction was 4.09, especially students were satisfied with using collaboration tools. Second, online tool satisfaction was 4.63 for Mentimeter, 4.15 for Zoom, 4.09 for Padlet, and 3.81 for Quizizz in the order of the program. Based on the results, it was suggested applications of various online tools into class and textbooks for learners. At last, it was significant that the case of online Korean class was presented with many online tools and learners satisfaction in this study.

Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): a systematic review

Ming Yang,Ya-xi Shang,Zi-yu Tian,Min Xiong,Chun-li Lu,Jiang Yue,Zhang Yao,Zhang Ying-ying,Jin Xin-yan,Jin Qiu-bai,Zhang Ying-ying,Willcox Merlin L.,Liu Jian-ping 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: The World Health Organization characterized the Coronavirus disease 2019 (COVID-19) as a pandemic on March 11th. Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. Methods: Studies on COVID-19 registered before March 3rd, 2020 on eight registry platforms worldwide were searched and the data of design, participants, interventions, and outcomes were extracted and analyzed. Results: Three hundred and ninety-three studies were identified and 380 (96.7%) were from mainland China, while 3 in Japan, 3 in France, 2 in the US, and 3 were international collaborative studies. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. Two hundred and two studies (51.4%) were randomized controlled trials. Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). Half of the studies (45.5%) had not started recruiting till March 3rd. Conclusion: Inappropriate outcome setting, delayed recruitment and insufficient numbers of new cases in China implied many studies may fail to complete. Strategies and protocols of the studies with robust and rapid data sharing are warranted for emergency public health events, helping the timely evidence-based decision-making.

A Study on the Influence of E-Commerce Live Characteristics on Consumers’ Impulsive Purchase Intention

Ying QIU(구영),Zi-Yang Liu(유자양) 한국컴퓨터정보학회 2022 한국컴퓨터정보학회 학술발표논문집 Vol.30 No.2

Effects of Growth Differentiation Factor 9 and Bone Morphogenic Protein 15 on the In Vitro Maturation of Porcine Oocytes

Zi-Li Lin,Ying-Hua Li,Yong-Nan Xu,Suk Namgoong,Xiang-Shun Cui,Nam-Hyung Kim 한국동물생명공학회(구 한국동물번식학회) 2013 Reproductive & Developmental Biology(Supplement) Vol.37 No.2s

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are members of the transforming growth factor β (TGF-β) family, and their roles in oocyte maturation and cumulus expansion are well known in the mouse and human, but not in the pig. We investigated GDF9 and BMP15 expression in porcine oocytes during in vitro maturation. A significant increase in the mRNA levels of GDF9 and BMP15 was observed at germinal vesicle breakdown, with expression levels peaking at metaphase I (MI) but decreasing at metaphase II (MII). GDF9 and BMP15 protein localized to the oocyte cytoplasm. While treatment with GDF9 and BMP15 increased cumulus expansion and the expression of genes involved in both oocyte maturation (c-mos, cyclinb1, and cdc2) and cumulus expansion (has2, ptgs2, ptx3, and tnfaip6). SB431542 (a TGFβ–GDF9 inhibitor) decreased meiotic maturation at MII. Following parthenogenetic activation, the percentage of blastocysts in SB431542 treatment was lower than in the control (74.4% and 41.3%, respectively). Treatment with GDF9 and BMP15 also increased the mRNA levels of maternal genes such as c-mos (a regulatory subunit of mitogen-activated protein kinase (MAPK)), and cyclinb1 and cdc2 (regulatory subunits of maturation/M phase promoting factor (MPF)); however, SB431-542 significantly decreased their mRNA levels. These data were supported by poly (A)-test PCR and protein activity analyses. Our results show that GDF9 and BMP15 function in cumulus expansion and that they stimulate MPF and MAPK activity in porcine oocytes during in vitro maturation.

Inhibition of the Arp2/3 complex impairs early embryo development of porcine parthenotes

Ying-Hua Li,Yong-Nan Xu,Zi Li Lin,권정우,최향순,김남형 한국통합생물학회 2016 Animal cells and systems Vol.20 No.5

The Arp2/3 complex, which nucleates actin filaments, comprises a stable assembly of seven-protein subunits including two actin-related proteins (Arp2 and Arp3). Previous work showed that Arp2/3 binds to the sides of actin filaments and is concentrated at the leading edges of motile cells. In the present study, we show that the Arp2/3 complex is critical for cytokinesis during early embryonic development in porcine parthenotes. The Arp2/3 complex is concentrated at the cortex of each cell at the 1-, 2-, and 4-cell stages, and at the periphery at the morula stage. The amount of Arp2/3 significantly decreased at the blastocyst stage in parthenogenetically activated porcine embryos. Inhibition of the Arp2/3 complex in the pig embryos by the Arp2/3-specific inhibitor CK666 resulted in abnormal cell division, a decrease in developmental rate and total cell numbers, and an increase in the ratio of trophectoderm cell number to inner cell mass number in blastocyst-stage embryos. In addition, 4-cell stage embryos subjected to CK666 treatment exhibited significantly decreased expression of ZGA genes (Pou5f1, Sox2, and Nanog), suggesting that the Arp2/3 complex plays an important role in early porcine embryo development. Thus, our data demonstrate that the Arp2/3 complex is required for early embryonic development in pigs and appears to regulate the expression of pluripotency genes.