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        • KCI등재SCOPUS

          Noise and vibration on the bogie of a mass rapid train

          Hsiu-Ying,Hwang,Jia-Shiun,Chen 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.10

          This paper investigated a noise and vibration concern on a metro train while the train made turns. The study was conducted to identify the root causes of the vibration and noise through hardware experimental testing as well as dynamic computer simulation. The initial investigation indicated the noise came from the bogie of the train. It was between the slewing ring bearing and the friction sets. A lab test was established to duplicate the reported problem and to root out the causes. One-factor-at-a-time method was used to screen the main key factors. Under certain contact conditions, unsmooth turning would occur and cause the noise and vibration. Dynamic simulation was proposed in the study to predict the potential issue. A multibody dynamic model was built with train body, underbody, slewing ring bearing and friction set to simulate the train turning motion. The results showed unsmooth/discontinuous dynamic motions and torque oscillation behaviors. The stop-and-go and stick-and-slip motion led to the vibration. The analysis confirmed the unsmooth friction forces and adhesion could cause the noise and vibration. The computer simulation showed good correlation with the hardware testing. It demonstrated the computer dynamic simulation could be used to predict the potential friction induced vibration issues. In the study, a different substitute material was also investigated through the computer simulation. The results showed the vibration could be effectively reduced if ceramic compound friction material was used.

        • KCI등재SCOPUS

          Bolted joint torque setting using numerical simulation and experiments

          Hsiu-Ying,Hwang 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.5

          In vehicle design process, the torque setting for a bolted joint is mainly determined based on hardware tests. For a newly designed joint of a vehicle, making prototypes and performing tests is expensive and time consuming. Numerical simulation can help predict joint behavior and detect potential failure modes prior to hardware testing. This study developed a numerical simulation using the finite element method to set the installation torque for a joint based on torque-angle signature curves. A three-dimensional detailed model of the joint was constructed. Then, finite element dynamic simulation was used to simulate the installation process of the bolt by gradually applying a torque until the bolt failed. Using these simulations, the torque-angle curves were generated and were used to determine the installation torque of the joint. This was different from the majority of earlier approaches which mainly used hardware tests, two-dimensional or three-dimensional simplified models, and static analyses instead of dynamic analyses. Material nonlinearity and contact were used in the study to capture the joint failure and contact conditions. For comparison, experiments were conducted. The study showed that the finite element analysis accurately predicted the bolt behavior. These results show that numerical simulation can be used to determine torque settings analytically, and can be developed as a standard practice for determining joint torque when designing vehicles.

        • The Excessive Structural Article in Mandarin-Study of dao(到)

          ( Hsiu Ying Liu ) 한국언어정보학회 2007 학술대회 논문집 Vol.2007 No.-

          The present paper targets on the excessive structural article dao in the "X1 + dao + si" phrases, aiming to see the possible generation of the excessive meaning. The generation of excessiveness will be analyzed from the aspect of cognition, including conceptual structure and metaphor. It will be concluded that the position indicated by si in concept plays a crucial, which then tells the importance of collocation. What is more, the comparison of dao and Southern Min kah will be made to see the degree of grammaticalization of dao.

        • HPV Vaccine Knowledge and Perceived Risk of Cervical Cancer among Female College Students in Taiwan

          Wang,,Hsiu-Ho,Wu,,Shiao-Ying Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

          Aims: The study targeted the HPV vaccine knowledge and perceived risk of cervical cancer among female college students in Taiwan as well as the relationship between knowledge of the HPV vaccine and perceived risk of cervical cancer. Materials and Method: The results of this study on female college students are described using descriptive and correlation designs. A convenience sampling approach was employed with a self-filling structured questionnaire. Results: A total of 150 students completed the questionnaire. Values were 7.49 for the mean HPV vaccine knowledge scale and 18.0 for their mean perceived risk of cervical cancer scale. HPV vaccine knowledge was positively correlated with perceived risk of cervical cancer. Conclusions: The findings of this study can serve as a reference for future HPV prevention in Taiwan.

        • The most ideal interval between blastocyst biopsy and vitrification applied in preimplantation genetic screening (PGS)

          ( Hui-ying Low ), ( Hsiu-hui Chen ), ( Chun-chia Huang ), ( Tsung-hsien Lee ), ( Chung-i Chen ), ( Lii-sheng Huang ), ( Maw-sheng Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

          Study Question: To evaluate the most ideal interval between blastocyst biopsy and vitrification in preimplantation genetic screening (PGS). Study Design, Size, Duration: This is a retrospective study and total 224 patients underwent the PGS from 2012 Dec. to 2015 Mar. All of patients underwent blastocyst vitrification after biopsy and 1~2 euploid blastocyst for transfer after warming. The primary outcome measures were the implantation and pregnancy rates per PGS-frozen embryo transfer cycle. Materials, Setting, Methods: The blastocyst grading including grade 4, 5 and 6 (according to Gardner grading system) on day 5 or day 6 were selected for trophectoderm biopsy. All blastocyst underwent vitrification immediately (interval: 0.5 hour) or 1 to 7 hours after biopsy. At the time of vitrification the grade of blastocyst expansion was also recorded. All patients were divided into two groups according to the grade of expanded (Group1: ≤1/2 expansion (n=41), Group2: ≥3/4 expansion (n=183)). Furthermore, combined two factors including the interval and morphology of blastocyst after biopsy, all patients were further divided into interval 1 (<3 hours and ≤1/2 expansion) and interval 2 (≥3 hours and ≥3/4 expansion). The morphologically best euploid blastocyst(s) (1~2 embryos) was/were selected first for transfer on the next cycle. Main Results: Assessment morphology of blastocyst after biopsy in different interval, at 0.5 hour after biopsy, 100% blastocyst was non-expansion; at 1 hour after biopsy, only 17% blastocyst was 3/4 expansion or all-expansion; at 3 hours after biopsy, 86% blastocyst was 3/4 expansion or all-expansion and after 5.5 hours, 100% blastocyst was all-expansion or hatching. All blastocysts were survival (100%, 359/359) after warming. The mean of embryo transfer number between all groups were no significantly difference. The implantation rate in Group2 (63.4%) was significantly higher than that in Group1 (46.9%, p=0.014). The pregnancy rates in Group4 (73.8%) was sig-nificantly higher than that in Group1 (51.2%, p=0.004). The implantation and pregnancy rates in the group of embryo ≥3/4 expansion combined with ≥3 hours after biopsy (63.6%, 178/280; 73.8%, 127/172) were significantly higher than that in the group of ≤1/2 expansion with <3 hour (45.6, 26/57; 50.0%, 18/36; p=0.0113 and p=0.0056, respectively). Conclusion: The most ideal interval between biopsy and vitrification was least 3 hours and ≥3/4 expansion of blastocyst after biopsy could improve the implantation and pregnancy rates for PGS.

        • KCI등재SSCISCOPUS

          7,8-Dihydroxyflavone, a Tropomyosin-Kinase Related Receptor B Agonist, Produces Fast-Onset Antidepressant-Like Effects in Rats Exposed to Chronic Mild Stress

          Hsin-An,Chang,Ying-Hsiu,Wang,Che-Se,Tung,Chin-Bin,Yeh,Yia-Ping,Liu 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.5

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Objective Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), play important roles in treating depression. In this experiment, we examined whether 7,8-dihydroxyflavone, a novel potent TrkB agonist, could reverse the behavioral and biochemical abnormalities induced by the chronic mild stress (CMS) paradigm in rats. Methods SD rats were exposed to a battery of stressors for 56 days. 7,8-dihydroxyflavone (5 and 20 mg/kg) were administered intraperitoneally during the last 28 days of the CMS paradigm. Rats were tested in sucrose consumption test (SCT), forced-swimming test (FST) and elevated T-maze (ETM). Serum corticosterone levels and hippocampal BDNF levels of the rats were measured. Results Four-week CMS on the rats induced their depression-like behavior in SCT. The CMS-reduced sucrose consumption was reversed starting from 7 days after the 7,8-dihydroxyflavone (20 mg/kg) treatment and remained across the subsequent treatment regime. 7,8-dihydroxyflavone, when given at 5 mg/kg for 3 weeks, reduced the immobility time in the FST in the CMS-subjected rats. Additionally, the 4-week treatment with 7,8-dihydroxyflavone (20 mg/kg) attenuated the CMS-induced increase in anxiety-like behavior in the ETM. For the CMS-subjected rats, 7,8-dihydroxyflavone treatment dose-dependently reduced their serum corticosterone levels but increased their hippocampal BDNF levels only at 5 mg/kg. Conclusiona 7,8-dihydroxyflavone was beneficial for both depression and anxiety-like behaviors, and may exert fast-onset antidepressant effects. This provides a new insight into the pharmacological management of depression. ObjectiveaaBrain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), play important roles in treating depression. In this experiment, we examined whether 7,8-dihydroxyflavone, a novel potent TrkB agonist, could reverse the behavioral and biochemical abnormalities induced by the chronic mild stress (CMS) paradigm in rats. MethodsaaSD rats were exposed to a battery of stressors for 56 days. 7,8-dihydroxyflavone (5 and 20 mg/kg) were administered intraperitoneally during the last 28 days of the CMS paradigm. Rats were tested in sucrose consumption test (SCT), forced-swimming test (FST) and elevated T-maze (ETM). Serum corticosterone levels and hippocampal BDNF levels of the rats were measured. ResultsaaFour-week CMS on the rats induced their depression-like behavior in SCT. The CMS-reduced sucrose consumption was reversed starting from 7 days after the 7,8-dihydroxyflavone (20 mg/kg) treatment and remained across the subsequent treatment regime. 7,8-dihydroxyflavone, when given at 5 mg/kg for 3 weeks, reduced the immobility time in the FST in the CMS-subjected rats. Additionally, the 4-week treatment with 7,8-dihydroxyflavone (20 mg/kg) attenuated the CMS-induced increase in anxiety-like behavior in the ETM. For the CMS-subjected rats, 7,8-dihydroxyflavone treatment dose-dependently reduced their serum corticosterone levels but increased their hippocampal BDNF levels only at 5 mg/kg. Conclusion 7,8-dihydroxyflavone was beneficial for both depression and anxiety-like behaviors, and may exert fast-onset antidepressant effects. This provides a new insight into the pharmacological management of depression.

        • SCIESCOPUSKCI등재후보

          An integrate information technology model during earthquake dynamics

          Chen,,Chen-Yuan,Chen,,Ying-Hsiu,Yu,,Shang-En,Chen,,Yi-Wen,Li,,Chien-Chung Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.5

          Applying Information Technology (IT) in practical engineering has become one of the most important issues in the past few decades, especially on internal solitary wave, intelligent robot interaction, artificial intelligence, fuzzy Lyapunov, tension leg platform (TLP), consumer and service quality. Other than affecting the traditional teaching mode or increasing the inter-relation with users, IT can also be connected with the current society by collecting the latest information from the internet. It is apparently a fashion-catching-up technology. Therefore, the learning of how to use IT facilities is becoming one of engineers' skills nowadays. In addition to studying how well engineers learn to operate IT facilities and apply them into teaching, how engineers' general capacity of information effects the results of learning IT are also discussed. This research introduces the "Combined TAM and TPB mode," to understand the situation of engineers using IT facilities.

        • KCI등재SCOPUS

          An integrate information technology model during earthquake dynamics

          Chen-Yuan,Chen,Ying-Hsiu,Chen,Shang-En,Yu,Yi-Wen,Chen,Chien-Chung,Li 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.5

          Applying Information Technology (IT) in practical engineering has become one of the most important issues in the past few decades, especially on internal solitary wave, intelligent robot interaction, artificial intelligence, fuzzy Lyapunov, tension leg platform (TLP), consumer and service quality. Other than affecting the traditional teaching mode or increasing the inter-relation with users, IT can also be connected with the current society by collecting the latest information from the internet. It is apparently a fashion-catching-up technology. Therefore, the learning of how to use IT facilities is becoming one of engineers' skills nowadays. In addition to studying how well engineers learn to operate IT facilities and apply them into teaching, how engineers' general capacity of information effects the results of learning IT are also discussed. This research introduces the “Combined TAM and TPB mode,” to understand the situation of engineers using IT facilities.

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