류마티스 질환자의 피로와 통증 비교연구 : 강직성척추염, 섬유조직염, 루프스환자를 중심으로

이여진,임난영,이은영 성인간호학회 2000 성인간호학회지 Vol.12 No.4

This study was designed to order descriptive data for nursing intervention for relief of fatigue and pain, and to distinguish by the characteristic difference and the symptoms such as fatigue and pain on Ankylosing Spondylitis(AS), Fibromyalgia(FM), and Systemic Lupus Erythematosus(SLE) patients. The sample consisted of 92 Patients(AS 29: FM 30; SLE 33) who visited H-University Rheumatism Hospital in Seoul The data were collected by a structured questionnaire from May 1. 1999 to April 30, 2000. The results were as follows: Patients of 95% experienced fatigue in the last week and a fatigue score of three disease groups were above average. The fatigue score of FM patients was highest in the other disease, but which was not a statistically significant difference(F= 1.417. p=.248). The mean score of AS and FM patients in pain was higher than the SLE patients, and there was the statistical significance among the three groups on pain (F=8.239. p=.001). There wasn't a statistical difference among three groups on coping wtih pain(F= 1.451, p=.240). There wasn't any correlation between fatigue and pain in each disease (AS. r=.008. p=.966; FM: r=.328, p=.077: SLE: r=.237,p=.185). Therefore, morning stillness and pain management during sleeping is needed through good body alignment in the AS patients. Adequate rest for fatigue and multiple coping strategies for pain maybe basic nursing intervention in FM and SLE. According to their fatigue rhythm. a regular exercise program is needed for rheumatic disease because they complained of fatigue above average and their fatigue was repeated bettor and worse only during the one week.

만성관절염과 루푸스의 피로, 통증, 및 통증효능감에 관한 연구

임난영,이은영,양용숙,정순애,차경옥,이여진 대한류마티스 건강전문학회 2000 근관절건강학회지 Vol.7 No.1

This study was designed to distinguish by the characteristic difference and the degree of symptoms such as fatigue, pain, coping to pain, and efficacy on pain, and to offer descriptive data for nursing intervention for improving coping ability to pain along each characteristics of disease in chronic arthritis and systemic lupus erythematosus. The subjects were 135 outpatients in the hospital for rheumatic disease in H-University, Seoul. The data were collected by structural questionnaire, from April 29 to June 29, 1999. The results were that the fatigue score was high in the OA patients while the RA patients and SLE patients experienced middle range of fatigue score, but which was not statistically different. Although the RA patients felt higher pain than other diseases, they have well coped with their pain than the others. In efficacy on pain the SLE patients had higher score than others but all of the disease showed lower score. No statistically significant difference among the three croup was recorded in efficacy on pain. Therefore, pain management in the RA patients was primary nursing intervention because they felt severe pain and have well coped with pain while they had lower pain efficacy score than the others. It is also important that fatigue management and coping strategies on pain for the OA patients and SLE patients are specially supportive in the nursing intervention.

Staurosporine Induced Apoptosis Rapidly Downregulates TDP-43 in Glioma Cells

Nan, Yi-Nan,Zhu, Jing-Yan,Tan, Yan,Zhang, Qi,Jia, William,Hua, Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

TDP-43 is a ubiquitously expressed DNA/RNA binding protein that has recently attracted attention for its involvement in neurodegenerative diseases. While TDP-43 has been found to participate in various important cellular activities including stress and apoptosis, little is known about its role in cancer cells. Here we report that staurosporine (STS) induced apoptosis in U87 glioma cells is associated with rapid downregulation of TDP-43 at both mRNA and protein levels. The latter is dependent on activation of caspase 3. More importantly, we have shown that knockdown of TDP-43 by specific siRNA dramatically enhanced cytotoxicity of STS. These results suggest that normal level of TDP-43 may be protective for cancer cells under apoptotic insult.

Novel Deadlock Control for Smartphone Manufacturing Systems Using Petri Nets

Yi-Nan Lin,Sheng-Kuan Wang,Gwo-Jen Chiou,Cheng-Ying Yang,Victor R. L. Shen,Tony Tong-Ying Juang,Ting-Jui Huang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.3

Currently, the marketing strategy in the manufacturing industry is becoming more and more competitive. Thus, the production efficiency becomes the main developing trend, which many people are now pursuing. However, the automatic production might cause resource conflicts and system deadlocks. In this study, Petri net models and analysis were used to effectively avoid deadlocks and to achieve the goal of lean production. The iPhone XS device developed by Apple is now a popular product. Consequently, this paper aims to describe its manufacturing system by using Petri net models. Meanwhile, the siphon property of Petri nets can be used to detect the deadlock in the manufacturing processes and to avoid it from occurring. Two simulation software tools, WoPeD and PIPE, were applied to conduct the experiments. The experimental results have indicated that our proposed approach is more feasible and acceptable than other existing ones.

Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction

( Yi Li ),( Nan-young Jung ),( Jae Cheal Yoo ),( Yul Kim ),( Gwan-su Yi ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.

Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases

Yi-Xin Zou,Jia Qiao,Hua-Yuan Zhu,Rui-Nan Lu,Yi Xia,Lei Cao,Wei Wu,Hui Jin,Wen-Jie Liu,Jin-Hua Liang,Jia-Zhu Wu,Li Wang,Lei Fan,Wei Xu,Jian-Yong Li 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. Materials and Methods In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients. Results The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70. Conclusion These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.

Competing Narratives, Identity Politics, And Cross-Strait Reconciliation

( Yi Nan He ) 경남대학교 극동문제연구소 2010 ASIAN PERSPECTIVE Vol.34 No.4

After nearly sixty years of political confrontation, hopes for cross-Taiwan Strait reconciliation have run high since the traditionally pro-unification Nationalist Party (the Kuomintang, KMT) returned to power in Taiwan in May 2008. However, obstacles to reconciliation remain daunting, due to a fundamental disjuncture between the ideological beliefs of the two sides, in particular because China and Taiwan still lack a shared memory of Taiwanese history that can serve as the foundation for their reconciliation. This article examines a wide variety of sources from Taiwan and China over recent decades. It illustrates their conspicuous memory gap over the history of the island. Cross-Strait reconciliation needs to begin with recognizing rather than ignoring or covering up the memory gap. Dialogue and joint studies should be carried out to better understand each other`s political perspective and emotional appeal associated with historical memory.

MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression

Nan Zhang,Ling Qiu,Tao Li,Xiao Wang,Rui Deng,Hai Yi,Yi Su,Fang-yi Fan 생화학분자생물학회 2020 BMB Reports Vol.53 No.5

Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy- associated 4B (ATG4B) expression, which subsequently reduced the autophagy of T-cell lymphoma cells. Mechanistically, miR-449a decreased ATG4B protein level by binding to its mRNA 3’UTR, thus reducing the mRNA stability. In addition, studies with nude mice showed that miR-449a significantly inhibited lymphoma characteristics in vivo. In conclusion, our results demonstrated that the “miR-449a/ATG4B/autophagy” pathway played a vital role in the malignancy of T-cell lymphoma, suggesting a novel therapeutic target.

Research of Adaptive Fault-Tolerant Control based on T-S Fuzzy Model for EMB System

Yi-Nan Xi 호서대학교 공업기술연구소 2014 공업기술연구 논문집 Vol.33 No.1

In the electro mechanical brake (EMB) system, an improvement of the fault-tolerant control, like invalid protecticais of sensors and electric systems are the key problems to the development of electric vehicles. The adaptive fault-tolerant control in this paper is focus on the descriptor nonlinear system A^iich contains double time-delays and parameter uncertainties. In fault detection and estimatic»i, cxmstruct the controlled system model wliich contains multi-sensor, double time-delays and parameter uncertainties based on T-S fuzzy model, then design the observer to realize fault detection and estimation in real-time. In building the fault-tolerant control model, the first step is to choose an appropriate sliding surface, and combine the algorithm of sliding control with adaptive generic model control. Then apply the state observer to the designed sliding adaptive generic model, and build the decision model with dynamic fault reconfiguration. And the goal of this paper about the adaptive robust fault-tolerant control for the complex nonlinear controller system is achieved. Numerical SIMULINK simulation examples are given to illustrate the application and the effectiveness of the proposed design method.

Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction

Li, Yi,Jung, Nan-Young,Yoo, Jae Cheal,Kim, Yul,Yi, Gwan-Su The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.