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김규현,이송이 경희대학교 디자인연구원 2005 예술· 디자인학연구 Vol.7 No.2
After the invention of a direct circuit in 1958 and since then we've came to live in the 21st Century's Information Industry Age called as the second Industrial Revolution. This direct circuit overlaps with so tiny circuit patterns within small silicon pieces that are undistinguishable seeing through human eyes as a result of bonding together with culture in discovering and inventing important all science (physics, chemistry, mathematics, optical science, electronic Engineering). This phenomenon has been set as human beings start to begin drawing such diagrams unintended' and those beautiful and intense images have been achieved as a result of technological development of Microchip diagrams' possessing exactness. Point and line's peculiar spacing characteristics, repetition, exactness and color are like a few best arts of our time that are enough to give more than artistic impression as the same power of splendid patterns that inspire and induce zest to us. This study discusses with the aesthetic beauties found in the electronic products' unseen precise functions aiming at logically and intuitionally planned in small high-tech chips' diagrams.
Yi, Hyeon-Gyu,Lee, Jung-Nam,Ryu, Seung-Duk,Kang, Ju-Hee,Cha, Young-Nam,Park, Chang-Shin The Korean Society of Pharmacology 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.4
Primary fish-odor syndrome (FOS) is a genetic disorder caused by defective flavin-containing mono-oxygenase 3 gene (FMO3) with deficient N-oxidation of trimethylamine (TMA), causing trimethylaminuria (TMAU). By contrast, secondary FOS can be acquired by decreased FMO activities in patients with chronic liver diseases, but the underlying mechanisms are unknown. In the present study, we examined plasma NOx concentrations and viral DNA contents as well as in vivo FMO activities and their correlations in chronic viral hepatitis (CVH) patients. Plasma concentration of NOx was significantly increased by 2.1 fold $(56.2{\pm}26.5\;vs.\;26.6{\pm}5.4\;{\mu}M,\;p<0.01)$, and it was positively correlated with plasma hepatitis B virus (HBV) DNA contents $(r^2=0.2838,\;p=0.0107)$. Furthermore, the elevated plasma NOx values were inversely and significantly correlated with in vivo FMO activities detected by ranitidine-challenged test $(8.3%\;vs.\;20.0%,\;r^2=0.2109,\;p=\0.0315)$. TMA N-oxidation activities determined in CVH patients without challenge test were also significantly low (73.6% vs. 95.7%, p< 0.05). In conclusion, these results suggested that secondary FOS could be acquired by the endogenously elevated NO in patients with CVH.
Hyeon Gyu Yi,Seung-Ah Yahng,Inho Kim,Je-Hwan Lee,Chang-Ki Min,Jun Hyung Kim,Chul Soo Kim,Sun U. Song 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
Severe graft-versus-host disease (GVHD) is an often lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). The safety of clinicalgrade mesenchymal stem cells (MSCs) has been validated, but mixed results have been obtained due to heterogeneity of the MSCs. In this phase I study, the safety of bone marrow-derived homogeneous clonal MSCs (cMSCs) isolated by a new subfractionation culturing method was evaluated. cMSCs were produced in a GMP facility and intravenously administered to patients who had refractory GVHD to standard treatment resulting after allogeneic HSCT for hematologic malignancies. After administration of a single dose (1×10<sup>6</sup> cells/kg), 11 patients were evaluated for cMSC treatment safety and efficacy. During the trial, nine patients had 85 total adverse events and the rate of serious adverse events was 27.3% (3/11 patients). The only one adverse drug reaction related to cMSC administration was grade 2 myalgia in one patient. Treatment response was observed in four patients: one with acute GVHD (partial response) and three with chronic GVHD. The other chronic patients maintained stable disease during the observation period. This study demonstrates single cMSC infusion to have an acceptable safety profile and promising efficacy, suggesting that we can proceed with the next stage of the clinical trial.
Yi, Hyeon Gyu,Yahng, Seung-Ah,Kim, Inho,Lee, Je-Hwan,Min, Chang-Ki,Kim, Jun Hyung,Kim, Chul Soo,Song, Sun U. The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
Severe graft-versus-host disease (GVHD) is an often lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). The safety of clinical-grade mesenchymal stem cells (MSCs) has been validated, but mixed results have been obtained due to heterogeneity of the MSCs. In this phase I study, the safety of bone marrow-derived homogeneous clonal MSCs (cMSCs) isolated by a new subfractionation culturing method was evaluated. cMSCs were produced in a GMP facility and intravenously administered to patients who had refractory GVHD to standard treatment resulting after allogeneic HSCT for hematologic malignancies. After administration of a single dose ($1{\times}10^6cells/kg$), 11 patients were evaluated for cMSC treatment safety and efficacy. During the trial, nine patients had 85 total adverse events and the rate of serious adverse events was 27.3% (3/11 patients). The only one adverse drug reaction related to cMSC administration was grade 2 myalgia in one patient. Treatment response was observed in four patients: one with acute GVHD (partial response) and three with chronic GVHD. The other chronic patients maintained stable disease during the observation period. This study demonstrates single cMSC infusion to have an acceptable safety profile and promising efficacy, suggesting that we can proceed with the next stage of the clinical trial.
Evaluation of alloying effect on the formation of Ni-Fe nanosized powders by pulsed wire discharge
Park, Gyu-Hyeon,Lee, Gwang-Yeob,Kim, Hyeon-Ah,Lee, A-Young,Oh, Hye-Ryeong,Kim, Song-Yi,Kim, Do-Hyang,Lee, Min-Ha Elsevier 2016 Materials science and engineering B. Advanced Func Vol.212 No.-
<P>This study investigates the effects of varying the explosion time and charging voltage of pulsed wire discharge (PWD) on the mean particle size, dispersibility and alloying reliability of powders produced from pure Ni and Ni-plated Fe wires. It was found that with increasing charging voltage, the mean particle size of Ni powders is reduced from 40.11 +/- 0.23 to 25.63 +/- 0.07 nm, which is attributed to a change in the extent of super heating with particle size. Nanosized powders of Ni-Fe alloy with a mean particle size between 25.91 +/- 0.24 and 26.30 +/- 0.26 nm were also successfully fabricated and found to consist of particles with a gamma-(Ni/Fe) core and FeO shell. The reliability for the optimization of processing parameters to control particle sizes is also evaluated. (C) 2016 Elsevier B.V. All rights reserved.</P>
A new audio compression algorithm based on modeling methods
Hyeon-Jin Jeon,Beob-Ki Chung,Dong-Hwan Kim,Don-Jin Yi,Jun-Gil Jeon,Tae-Gyu Chang 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
This paper proposes a new audio compression algorithm based on an inter-frame and an intra-frame modeling methods. The characteristics of a short period of time and spectrum are modeled as modeling parameters to maximize the compression ratio. Simulation results show that the proposed algorithm has feasibility of high compression and high quality.
Hyeon Gyu Seo,Han Byeol Kim,Min Jueng Kang,Joo Hwan Rym,Eugene C. Yi,Jin Won Cho 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07
Nucleocytoplasmic O-GlcNAc transferase (OGT) attaches a single GlcNAc to hydroxyl groups of serine and threonine residues. Although the cellular localisation of OGT is important to regulate a variety of cellular processes, the molecular mechanisms regulating the nuclear localisation of OGT is unclear. Here, we characterised three amino acids (DFP; residues 451–453) as the nuclear localisation signal of OGT and demonstrated that this motif mediated the nuclear import of non-diffusible β-galactosidase. OGT bound the importin α5 protein, and this association was abolished when the DFP motif of OGT was mutated or deleted. We also revealed that O-GlcNAcylation of Ser389, which resides in the tetratricopeptide repeats, plays an important role in the nuclear localisation of OGT. Our findings may explain how OGT, which possesses a NLS, exists in the nucleus and cytosol simultaneously.