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      • KCI등재

        A Study on the Bayes Estimator of θ=Pr(Y < X)

        Yeum, Joon Keun,Kim, Jae Joo The Korean Society for Quality Management 1985 품질경영학회지 Vol.13 No.2

        We study the Bayes estimation procedure of ${\theta}=P_r$=(Y < X) when the experiment is terminated before all of the items on the test have failed and the failed items are partially replaced. Comparisons with the M.L.E., M.V.U.E. and Bayes estimator are made through Monte Carlo simulation.

      • SCIESCOPUSKCI등재

        Low Temperature Suspension Polymerization of Methyl Methacrylate for the Preparation of High Molecular Weight Poly(methyl methacrylate)/Silver Nanocomposite Microspheres

        Yeum, Jeong-Hyun,Ghim, Han-Do,Deng, Yulin The Korean Fiber Society 2005 Fibers and polymers Vol.6 No.4

        In order to prepare high molecular weight poly(methyl methacrylate) (PMMA)/silver nanocomposite microspheres, methyl methacrylate was suspension-polymerized in the presence of silver nanoparticles at low temperature with 2,2'-azobis(2,4-dimethylvaleronitrile) as an initiator. The rate of conversion was increased by increasing the initiator concentration. When silver nanoparticles were added, the rate of polymerization decreased slightly. High monomer conversion (about $85\%$) was obtained in spite of low polymerization temperature of $30^{\circ}C$. Under controlled conditions, PMMA/silver microspheres with various number-average degrees of polymerization (6,000-37,000) were prepared. Morphology studies revealed that except for normal suspension microspheres with a smooth surface, a golf ball-like appearance of the microspheres was observed, due to the migration and aggregation of the hydrophilic silver nanoparticles at the sublayer beneath the microsphere's surface.

      • SCIESCOPUSKCI등재

        Effect of Naringin Pretreatment on Bioavailability of Verapamil in Rabbits

        Yeum, Cheul-Ho,Choi, Jun-Shik The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.1

        The aim of present study is to investigate the effect of naringin on the pharmacokinetics of verapamil and its major metabolite, norverapamil in rabbits. The pharmacokinetic parameters of verapamil and norverapamil were determined after administering verapamil (9 mg/kg) orally to rabbits in the pretreated with naringin (1.5, 7.5, and 15 mg/kg). Naringin pretreatment significantly altered the pharmacokinetic parameters of verapamil. Compared with the control group (given verapamil alone), the $K_a,\;C_{max}$ and AUC of verapamil were significantly (p<0.05 or p<0.01) increased in the pretreatment of naringin, However there were no significant change in $T_{max}\;and\;t_{1/2}$ of verapamil. Consequently, pretreatment of naringin significantly (p<0.05, p<0.01) increased the AB% of verapamil significantly in a dose dependent manner (p<0.05 or p<0.01 ), and elevated the RB% of verapamil by 1.26- to 1.69-fold. the MR of verapamil were significantly (p<0.05) increased in the pretreatment of naringin, implying that pretreatment of naringin may effectively inhibit the CYP3A4-mediated metabolism of verapamil. In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil. Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement.

      • On the Efficiency for Ridge Estimator

        Yeum,Joon Keun 동국대학교 자연과학연구소 1982 자연과학연구 논문집 Vol.2 No.-

        偏?推定量인 Ridge Estimator를 一般化 分散이라는 基準에서 最小自乘推定量과 비교함. Much attention has been paid to the bias of coefficients resulting from ridge regression. Looking at bias alone implies that ridge estimators are inferior. However, using the criterion of the generalized variance, ridge estimators are better than ordinary least square estimators.

      • On the Efficiency for Ridge Estimator

        Yeum, Joon Keun 동국대학교 재료과학연구소 1982 材料科學硏究所 論文集 Vol.2 No.-

        偏倚推定量인 Ridge Estimator를 一般化 分散이라는 基準에서 最小自乘推定量과 비교함. Much attention has been paid to the bias of coefficients resulting from ridge regression. Looking at bias alone implies that ridge estimators are inferior. However, using the criterion of the generalized variance, ridge estimators are better than ordinary least square estimators.

      • SCIESCOPUSKCI등재

        Role of Tyrosine Kinases in Vascular Contraction in Deoxycorticosterone Acetate-Salt Hypertensive Rats

        Yeum, Cheol-Ho,Jun, Jae-Yeoul,Choi, Hyo-Sub The Korean Society of Pharmacology 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.5

        It has been known that activation of tyrosine kinases is involved in signal transduction. Role of the tyrosine kinase in vascular smooth muscle contraction was examined in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Male Sprague-Dawley rats underwent uninephrectomy, one week after which they were subcutaneously implanted with DOCA (200 mg/kg) and supplied with 1% NaCl and 0.2% KCl drinking water for $4{\sim}6$ weeks. Control rats were treated the same except for that no DOCA was implanted. Helical strips of carotid arteries were mounted in organ baths for measurement of isometric force development. Genistein was used as a tyrosine kinase inhibitor. Concentration-response curves to 5-hydroxytryptamine (5-HT) shifted to the right by genistein in both DOCA-salt hypertensive and control rats. Although the sensitivity to genistein was similar between the two groups, the maximum force generation by 5-HT was less inhibited by genistein in arteries from DOCA-salt hypertensive rats than in those from controls. Genistein-induced relaxations were attenuated in arteries from DOCA-salt rats. Genistein affected the contraction to phorbol 12, 13-dibutyrate (PDBu) neither in DOCA-salt nor in control arteries. These observations suggest that tyrosine kinase is involved in 5-HT-induced vascular contraction, of which role is reduced in DOCA-salt hypertension.

      • Cass Kinsolving as a Tragic Hero : Set this House on Fire

        Yeum, Kyung-sook 숙명여자대학교 대학원원우회 1987 원우논총 Vol.5 No.-

        Although holding pessimistic premises about man and his environment, William Styron(1925-) attempts to deny the conventinal dark conclusions attributed to the contemporary literature of 'absurdity'. In other words, recognizing the chaotic modern condition surrounding man and his hopeless outcry in it, Styron tries hard to present the positive potential of man's experience in his fictional treatments of man's plight. Such an attitude is suggested in the interview held for The Paris Review in 1954, when Styron was asked whether he thought current American writers worked under greater disadvantages than their literary predecessors. He admitted that "this might be an age of so-called faithlessness and depair we live in." Then he added, "Every age has its terrible aches and pains, its peculiar new horrors" and finally concluded that "I don't think the writer today is any worse off than any other tiem." In brief, Styron, attempting to resist despair, endeavours to illustrate the more affirmative aspect of the "peculiar new horrors" of the present age.

      • SCOPUSKCI등재

        Carotenoids: Functions and Recent Research Progress

        Yeum, Kyung-Jin The Korean Society of Food Science and Nutrition 1996 Preventive Nutrition and Food Science Vol.1 No.2

        Carotenoids are abundant int he Korean food supply. The intake of foods rich in carotenoids appears to be associated with optimal health, and a reduction in the risk of cancer, cardiovascular disease, macular degeneration and cataract formation. Specific dietary carotenoids may be responsible for these specific protective effects. Hydrocarbon carotenoids such as $\alpha$-,$\beta$-carotenes and lycopene may reduce the risk of cancer and heart disease, whereas oxygenated carotenoids, such as lutein and zeaxanthin, may be important in protection of the eye. Dietary carotenoids, such as lutein, cryptoxanthin, $\alpha$-carotene, $\beta$-carotene and lycopene can be readily obtained from the diet, Green leafy vegetables, such as spinach and broccoli, contain both oxygenated and hydrocarbon carotenoids ; yellow or orange vegetables, such as carrots, have high levels of $\alpha$-carotene and $\beta$-carotene ; and tomatoes contain high amounts of lycopene. Besides being important vitamin A sources, provitamin A carotenoids such as $\alpha$-carotene, $\beta$-carotene and cryptoxanthin, participate in the cell defense systems that are associated with radical quenching. Non-provitamin A carotenoids, such as lutein and lycopene, major carotenoids in human plasma, have also been reported to possess strong antioxidant capability. The alteration of dietary sources of carotenoids can modify their levels in the circulation and target tissues, and thus prevent or delay the onset of these chronic diseases.

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