http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, You-Sun,Hong, Goohyeon,Kim, Doh Hyung,Kim, Young Min,Kim, Yoon-Keun,Oh, Yeon-Mok,Jee, Young-Koo Nature Publishing Group UK 2018 Experimental and molecular medicine Vol.50 No.11
<▼1><P>Although the positive effects of recombinant fibroblast growth factor-2 (rFGF-2) in chronic obstructive pulmonary disease (COPD) have been implicated in previous studies, knowledge of its role in COPD remains limited. The mechanism of FGF2 in a COPD mouse model and the therapeutic potential of rFGF-2 were investigated in COPD. The mechanism and protective effects of rFGF-2 were evaluated in cigarette smoke-exposed or elastase-induced COPD animal models. Inflammation was assessed in alveolar cells and lung tissues from mice. FGF-2 was decreased in the lungs of cigarette smoke-exposed mice. Intranasal use of rFGF-2 significantly reduced macrophage-dominant inflammation and alveolar destruction in the lungs. In the elastase-induced emphysema model, rFGF-2 improved regeneration of the lungs. In humans, plasma FGF-2 was decreased significantly in COPD compared with normal subjects (10 subjects, <I>P</I> <I>=</I> 0.037). The safety and efficacy of inhaled rFGF-2 use was examined in COPD patients, along with changes in respiratory symptoms and pulmonary function. A 2-week treatment with inhaled rFGF-2 in COPD (<I>n</I> = 6) resulted in significantly improved respiratory symptoms compared with baseline levels (<I>P</I> <I><</I> 0.05); however, the results were not significant compared with the placebo. The pulmonary function test results of COPD improved numerically compared with those in the placebo, but the difference was not statistically significant. No serious adverse events occurred during treatment with inhaled rFGF-2. The loss of FGF-2 production is an important mechanism in the development of COPD. Inhaling rFGF-2 may be a new therapeutic option for patients with COPD because rFGF-2 decreases inflammation in lungs exposed to cigarette smoke.</P></▼1><▼2><P><B>Lung disease: Inhaling a protein might help</B></P><P>Studies on the role of the protein ‘fibroblast growth factor-2’ (FGF-2) in chronic obstructive pulmonary disease (COPD) suggest that inhaled FGF-2 could help treat the emphysema linked to smoking. Researchers in South Korea led by Young-Koo Jee at Dankook University, Cheonan, and Yeon-Mok Oh at the University of Ulsan, Seoul, studied the role of the reduced FGF-2 levels found in mice with lung inflammation caused by exposure to cigarette smoke. They also uncovered details of a protective effect of inhaled FGF-2, identifying specific cellular and lung structure changes attributed to the administered FGF-2. Reduced FGF-2 levels were also found in patients with COPD. Initial trials revealed some improvement in patients treated with FGF-2, but not at a statistically significant level. Nevertheless, the authors suggest their results justify further investigation of the protein’s therapeutic potential.</P></▼2>
SCF를 이용한 시간지연 회로의 설계 및 제작기술 개발
황준원,박종연,장목순 江原大學校 産業技術硏究所 1996 産業技術硏究 Vol.16 No.-
This paper deals with the tapped time delay circuit with SCF(Swiched Capacitor Filters). This filter is composed fo lossless discrete integrator and the SCF has 2-phase clocks. Experimental results have shown that telephone signals (0~4kHz) could be delayed in the range of sampling frequency 80kHz.But above the range, operational amplifiers and analog switchs have been difficult in the normal operating condition
Yeon-Mok Oh,You-Sun Kim,Nurdan Kokturk,Ji-Young Kim,Sei Won Lee,Jaeyun Lim,Soo Jin Choi,Wonil Oh 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.10
Mesenchymal stem cells (MSCs) effectively reduce airway inflammation and regenerate the alveolus in cigarette- and elastase-induced chronic obstructive pulmonary disease (COPD) animal models. The effects of stem cells are thought to be paracrine and immune-modulatory because very few stem cells remain in the lung one day after their systemic injection, which has been demonstrated previously. In this report, we analyzed the gene expression profiles to compare mouse lungs with chronic exposure to cigarette smoke with non-exposed lungs. Gene expression profiling was also conducted in a mouse lung tissue with chronic exposure to cigarette smoke following the systemic injection of human cord blood-derived mesenchymal stem cells (hCB-MSCs). Globally, 834 genes were differentially expressed after systemic injection of hCB-MSCs. Seven and 21 genes, respectively, were up-and down-regulated on days 1, 4, and 14 after HCB-MSC injection. The Hbb and Hba, genes with oxygen transport and anti-oxidant functions, were increased on days 1 and 14. A serine protease inhibitor was also increased at a similar time point after injection of hCB-MSCs. Gene Ontology analysis indicated that the levels of genes related to immune responses, metabolic processes, and blood vessel development were altered, indicating host responses after hCB-MSC injection. These gene expression changes suggest that MSCs induce a regeneration mechanism against COPD induced by cigarette smoke. These analyses provide basic data for understanding the regeneration mechanisms promoted by hCB-MSCs in cigarette smoke-induced COPD.
성장기 심리적 부모화와 우울의 관계: 타인인정욕구와 자기침묵의 매개효과
정연목 ( Yeon Mok Jeong ),서수균 ( Su Gyun Seo ) 서강대학교 학생생활상담연구소 2021 人間理解 Vol.42 No.2
본 연구는 타인인정욕구와 자기침묵이 성장기 심리적 부모화와 우울의 관계를 매개하는지 검증하고자 하였다. 이를 위해 부산 지역에 소재한 4년제 대학교에 재학 중인 322명의 대학생을 대상으로 성장기 심리적 부모화, 타인인정욕구, 자기침묵, 우울을 측정하는 설문을 실시하였으며, 각 변인의 순수한 관계 양상을 규명하기 위해 학업 및 취업스트레스를 추가로 측정 및 통제하였다. 학업 및 취업스트레스와 성별, 형제관계, 과거 및 현재의 가정형편을 통제한 후 타인인정욕구와 자기침묵의 순차적 매개효과를 검증한 결과, 타인인정욕구와 자기침묵이 성장기 심리적 부모화와 우울의 관계를 순차적으로 부분 매개하는 것으로 나타났다. 즉, 성장기 심리적 부모화 수준이 높을수록 타인인정욕구가 높아지며, 이는 자기침묵의 수준을 높이게 되어 우울을 더 자주 경험하게 되는 것으로 나타났다. 이러한 결과는 성장기 심리적 부모화 수준이 높은 대학생의 우울을 감소시키기 위해 타인인정욕구와 자기침묵을 확인하고 이에 대한 개입이 필요함을 시사한다. 끝으로 본 연구의 의의와 제한점, 그리고 후속연구를 위한 제언을 논하였다. This study aimed to examine the mediation effect of need for approval and self-silencing on the relationship between childhood psychological parentification and depression. 322 students completed questionnaires about childhood psychological parentification, need for approval, self-silencing, and depression. And further measured and controlled the level of academic and job-seeking stress to identify the pure relationship between the major variables. The results showed that after controlling the level of academic and job-seeking stress, sex, sibling composition, and past and present family economical circumstances, the relationship between childhood psychological parentification and depression is mediated sequentially through both need for approval and self-silencing. Based on these results, the implications and limitations of this study were discussed. And the suggestions for future research were discussed.