고립성 폐결절의 조직학적 진단에 있어서 경기관지폐생검의 진단적 가치

김치훈,김정주,왕준호,연규민,김형수,리원연,용석중,신계철 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Transbronchial lung biopsy(TBLB) is a relatively simple and convenient diagnostic tool in solitary pulmonary nodule(SPN) on chest radiograph, which is cannot be diagnosed through routine tests. To investigate the diagnostic value and diagnostic rate of TBLB according to the variable factor, we analyzed 69 patients with radiologically SPN lesion on chest radiograph which was confirmed histologically. A histologic diagnosis of TBLB was made in 47 of 69 patients(68.1%), in which 26 of 37(70.3%) with malignancy and 21 of 32(65.6%) with benign lesion. There were no significant differences in diagnostic yield according to age, sex and location of the lesion. The diagnostic rate tended to increase with the more than 5 pieces to acquired by TBLB. When the size of SPN was less than 3 ㎝, it cannot be diagnosed. In conclusion, TBLB is a diagnostic procedure with good yield and safety, but percutaneous needle aspiration, transbronchial needle aspiration, and bronchial washing fluid cytology may be a complementary procedure to overcome the limitation of TBLB and get higher diagnostic yield for SPN.

AR기법을 이용한 SLAM 영상 개선

김현,송대건,황기환,연규헌,전계석 慶熙大學校 大學院 1998 高凰論集 Vol.22 No.-

In this paper, we have been studied the enhancement of SLAM image using average response methos. AR methos has been used to reduce the random noise in signal processing. In this the experiment, we have constructed the SLAM system of 10㎒ operating frequency and experienced for holed Al sample. In this experimental result, we have been found that SLAM using AR method was able to get the high-speed and enhanced image compared with SAM.

A rare case of extensive papillary muscle calcification in senile cardiac calcification syndrome

김은진;송봉근;강민호;손형래;홍수민;박동원;허승혜;김계연;최석구 인제대학교 2011 仁濟醫學 Vol.32 No.-

광범위 유두근 석회화는 흔하지 앉으며, 원인과 임상적 중요성에 관한 문헌만 드물게 찾아볼 수 있다. 반면에 작은 석회 침착은 노인에서 흔하며 심장 첨부에 주로 나타난다. 유두근 석회화는 관상동맥질환, 확장성 심근병증, 승모관 질환, 고칼슘혈증, 그리고 말기신부전에서 인산칼슘의 중가와 연관성이 있다. 저자는 심장초옴파와 MDCT를 통해 진단된 전외측 유두근의 광범위 석회화의 드문 사례가 있어 보고한다.

生澱粉 加水分解酵素 生産菌의 分離와 遺傳子의 클로닝

金然桂,鄭東孝 中央大學校 食糧資源硏究所 1990 食糧資源硏究所 論文集 Vol.2 No.1

토양 시료로부터 선별과정을 거쳐 생전분을 분해시킬 수 있는 amylase를 생산하는 균주를 분리 하였고, 이 균주(K-1)에 대한 행태적·생리적 성질과 클로닝 가능성 그리고 생전분 가수분해 효소제의 특성을 측정한 결과 분리균주(K-1)는 Bacillus brevis K-1으로 동정되었다. 배양일수에 따른 균의 효소 생산을 측정하였을 때 2∼3일간의 배양에서 최대의 효소활성을 나타내었고 조효소의 최적온도는 35℃, 최적 pH 7.0∼7.5, 온도 안정성은 35℃이하 그리고 pH 안정성은 pH 7.5 이상임을 알 수 있었다. 한편, 효소액의 반응산물에 대한 paper chromatography는 glucose와 maltose가 주 반응 산물인 것으로 보아 본 효소는 당화형 amylase계의 효소임을 알 수 있었다. 그리고 균주의 생육조건은 pH 7.0이고 온도는 35℃로 나타났으며 탄소원에 대한 효소생산은 호화전분 또는 glucose나 maltose를 기질로 하였을 때보다 생전분(CLP)을 기질로 하였을 때 효소 생산력이 2∼5배 이상 높았다. 생전분 가수분해 효소 gene의 HindⅢ 단편과 EcoRV 단편은 pHY300 PLK에 클로닝되었 고 E. coli와 B. subtilis(amy-)에서 발현됨을 알 수 있었다. A bacterium which can utilize raw starch as a sole carbon source was isolated and identified as Bacillus brevis K-1 from its physiological, morphological and cultural properties. Optimal conditions to produce raw starch digesting enzyme were 2∼3 days at pH 7.0 and at 35℃. The crude enzyme had an optimum pH of 7.0∼7.5 and an optimum temperature of 35℃. The enzyme was stable at pH range between 7.0 and 12.0 and at temperature below 40℃. The paper chromatography showed that the crude enzyme was saccharifying amylase. HindⅢ and EcoRV fragments of raw starch digesting amylase gene were cloned in the plasmid pHY300PLK which are E. coli-B. subtilis shuttle vector using E. coli and B. subtilis as a host.

냉수 가글링과 젖은 거즈를 이용한 구강간호가 비강수술 환자의 갈증 및 구강상태에 미치는 효과 비교

이인선,심명숙,나은희,강재연,김지혜,황민영,윤계숙,성영희 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study researched the comparison of oral care methods between the wet gauze and the water gargling for nasal surgery patients. It executed to find out more effective method to relieve thirst. Method: We divided two groups; the wet gauze and the cold water garaling. We assessed patient's oral cavity state and sebjective oral dryness for three times; firstly before the intervention, secondly 15 minutes after 1st intervention and thirdly 15 minutes afrer 2nd intervention. Result: As the intervention, there was no difference on oral condition subhectvely, but there was a difference on thirsty reduction objectively. As the aral dryness has relieved through both methods. It showed the repeated gargling helps more to relieve oral dryness effectively than the wet gauge. At PACU, post nasal surgery patient's oral dryness was decreased with gauze more than two times, patient's oral dryness was relieved. Whereas the dryness was relieved after applying the cold water gargling for just one time. Conclusion: The water gargling is more effective intervention than the wet gauze. Especially, oral dryness was improved in the section of objetive oral assessment index.

일 요양병원에 입원한 만성질환자들의 건강증진 프로그램 적용후 임상검사치 변화

임기동,이영선,박계남,류소연,김기순 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Objectives and Method : To find the change of clinical laboratory value change of some chronic degenerative disease patients who were admitted to E sanatorium hospital in Y city from January 2001 to June 2002 after a health promotion program, a quasi-experimental study was done. Results : 1. The characteristics of study subjects showed 47.5% of male, 52.5% of female, 50% under 50 years in age Their common disease was cancer and cardiovascular disease, endocrine disease, liver disease followed in frequency. Before admission 74.2% smoked, 67.5% enjoyed drinking alcohol and 92.5% preferred to take meat 2. After health promotion program mean systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglyceride, fasting blood sugar and serum total protein were decreased statistically significantly, compared to the value at the beginning of admission 3. By the group of patients characteristics like sex, age, smoking status, drinking status, meat intake preference and kind of diseases suffering from, mean systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglyceride showed consistent decrease after health promotion program compared to the beginning of admission Mean levels of fasting blood sugar, serum total protein, white blood cell (WBC) counts, red blood cell (RBC) counts, GPT showed irregular change in some patients characteristics group Conclusion : Keen and consistent change was shown at blood pressure and lipid parameter after a health promotion program toward chronic degenerative disease patients. To confirm that the cause of change was due to life style change or accidental reason, further systematic studies are required.

Recent Trends in Hospice Utilization according to Service Type and Region in South Korea

Kim Woorim,Kim Kyuwoong,Nam Eun Jeong,Kye Su Yeon,Kim Minju,Choi Jin Young 건강보험심사평가원 2025 HIRA RESEARCH Vol.5 No.2

Background: This study assessed the trends in the use of hospice services and the average length of service utilization among patients with end-stage cancer in South Korea. Methods: Data from the National Hospice and Palliative Care registry and cause-of-death statistics from 2019 to 2023 were analyzed. The study population included patients with end-stage cancer as these individuals represent the vast majority of hospice users. The key variables were annual hospice utilization rates and the mean length of utilization. Trends were analyzed based on annual percentage changes using a log-linear regression model. Results: A total of 22,314 cancer patients received hospice care in 2023, primarily in an inpatient setting. Overall, hospice care utilization increased from 24.3% in 2019 to 26.2% in 2023, although no statistical significance was found for the overall trend. The number of patients receiving inpatient hospice services tended to decrease while those receiving home and consultation-based care tended to increase. The mean length of hospice care use was 28.1 days in 2023 and did not show significant differences during the study period. The age distribution shifted toward older aged patients, and regional patterns generally showed no substantial differences. Conclusion: This study comprehensively analyzed hospice utilization rates and lengths of stay across various characteristics, including service type and region. The hospice utilization rate increased slightly between 2019 and 2023; however, no significant differences emerged. Similar tendencies were found for length of stay.

Differential effects of premorbid functional dependency on mortality in patients with anterior and posterior circulation stroke

Kye Min-Surk,Kim Do Yeon,Kang Dong-Wan,Kim Baik-Kyun,Park Jung Hyun,Guk Hyung Seok,Kim Nakhoon,Choi Sang-Won,Kim Jun Yup,Kang Jihoon,Kim Beom Joon,Han Moon-Ku,Bae Hee-Joon 대한신경집중치료학회 2024 대한신경집중치료학회지 Vol.17 No.1

Background: This study investigated the impact of premorbid functional dependency on post-stroke mortality in patients with anterior circulation stroke (ACS) and posterior circulation stroke (PCS).Methods: This study enrolled 9,698 patients who experienced ischemic stroke between January 2011 and December 2022. The patients were classified into the ACS and PCS groups. Premorbid functional dependency was defined as modified Rankin Scale of ≥3. The risks of premorbid functional dependency and mortality at 3 months and 1-year post-stroke were assessed. A subgroup analysis was further performed to evaluate the risk of premorbid functional dependency in patients who underwent intravenous thrombolysis and endovascular treatment (EVT).Results: Among 6,358 patients with ACS and 3,340 with PCS, those with premorbid dependency were older, predominantly female, and had a higher proportion of vascular risk factors and stroke severity. Premorbid functional dependency was associated with increased mortality at both 3 months and 1 year in the PCS (odds ratio [OR], 1.79; 95% confidence interval [CI], 1.00–3.13; P=0.04 and OR, 2.87; 95% CI, 1.86–4.38; P<0.001, respectively), but not in the ACS (OR, 1.08; 95% CI, 0.77–1.51; P=0.639 and OR, 1.22; 95% CI, 0.93–1.59; P=0.140, respectively) group. Among patients who underwent EVT, premorbid functional dependency increased the risk of mortality at 1 year in the ACS group (OR, 1.80; 95% CI, 1.04–3.08; P=0.034), but was not associated with the risk in the PCS group (OR 2.56; 95% CI 0.64–10.15; P=0.176).Conclusion: Premorbid functional dependency increases the risk of mortality in patients with PCS.

Complex extracellular interactions of proteases and a protease inhibitor influence multicellular development of <i>Streptomyces coelicolor</i>

Kim, Dae Wi,Hesketh, Andy,Kim, Eun Sook,Song, Ju Yeon,Lee, Dae Hoon,Kim, In Seop,Chater, Keith F.,Lee, Kye Joon Blackwell Scientific Publications 2008 Molecular microbiology Vol.70 No.5

<P>Summary</P><P><I>Streptomyces coelicolor</I> produces an extracellular protease inhibitor protein, STI (<I>Streptomyces</I> trypsin inhibitor). We show that post-growth elimination of STI is needed for colonies to develop aerial mycelium efficiently. Inactivation of STI, and thus the normal progression of colony development, at least partly involves an extracellular protease specified by gene SCO5913. Two-hybrid analysis identified two possible targets of STI inhibition (the products of SCO1355 and SCO5447), both extracellular proteases containing a domain homologous with the P-domain of eukaryotic convertases, proteases that mediate the processing of many precursors with important cellular or developmental roles. At least the SCO1355 protease is needed for the normal progression of development. Two components of the proposed cascade are dependent on the tRNA for the rare UUA (leucine) codon, which is specified by the developmental gene <I>bldA.</I> A model is presented that links intracellular regulatory events with an extracellular protease cascade to facilitate normal development.</P>

Fatty acids fraction from Korean melania snail (Semisulcospira coreana) showing angiotensin-1 converting enzyme inhibitory activity

Yeon-Kye Kim,Kwang Soo Ha,Poong-Ho Kim,Tae Seek Lee 한국수산과학회 양식분과 2017 한국수산과학회 양식분과 학술대회 Vol.2017 No.5