Life Science : Pinusolide Isolated from Biotu orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells

( Ye Jin ),( Hyun Ok Yang ),( Jong Keun Son ),( Hyeun Wook Chang ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

Pinusolide, an herbal medicine isolated from Biota orientalis L. (B. orientalis), inhibited 5-lipoxygenase(5-LO)-dependent leukotriene C4 (LTC4) generation in immunoglobulin E (IgE)/Ag-induced bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To clarify the action mechanism of pinusolide on the inhibition of LTC4 generation, we examined the effect of pinusolide on phosphorylation of cytosolic phospholipase A2 (cPLA2), as well as translocation phospho-cPLA2 and 5-LO to nucleus. Inhibition of LTC4 generation by pinusolide was accompanied by a decrease in cPLA2 phosphorylation which occurred via a decrease in intracellular Ca2+ influx and blocking the c-Jun N-terminal kinase (JNK) pathways. However, pinusolide had no effect on extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein (MAP) kinas phosphorylation. Taken together, the present results suggest that potent inhibition of 5-LO dependent LTC4 generation bypinusolide requires both suppression of calcium influx and JNK phosphorylation.

퍼놀로지 기반 디지털 캠페인 참여형 UI 디자인 연구

신예진 ( Sin¸ Ye-jin ),김성훈 ( Kim¸ Sung-hoon ) 커뮤니케이션디자인학회 2021 커뮤니케이션 디자인학연구 Vol.77 No.-

현대 사회는 기술의 발전으로 일상생활에서 접하는 모든 것들이 디지털화되고 이와 연대적으로 현대 사회의 사용자들은 정서적 감정에 민감하게 반응하고 있다. 이러한 시대의 퍼놀로지 기반의 디지털 캠페인은 신속하게 진보하는 기술과 펀(Fun) 아이디어의 융합으로 다양한 디지털 공간에서 감각적인 서비스를 원하는 사용자들의 니즈와 가치를 충족시키는 마케팅으로 적합하며 디지털 공간에서 사용자들의 원활한 상호작용을 위해서는 참여형 UI 디자인이 요구된다. 따라서 본 연구에서는 사용자들이 퍼놀로지 기반 디지털 캠페인에 참여할 때 디지털 공간에서 유희적 감성 유발과 적극적 참여를 위한 퍼놀로지 기반의 디지털 캠페인의 참여형 UI 디자인 발전 방안을 제시하는 것이 목적이다. 먼저 퍼놀로지의 이론적 배경과 개념에 대해 고찰하고 디지털 캠페인의 정의와 유형에 대해 살펴보았다. 또한 선행연구를 통해 참여형 UI디자인의 요소들을 정리하고 공통된 요소를 도출하였다. 이를 통해 연구에 적용할 퍼놀로지 기반 디지털 캠페인을 사용자 체험유형(수용적 체험/참여적 체험/주도적 체험)으로 나누어 참여형 UI디자인 3가지 요소로 디자인 요소(레이아웃/컬러/그래픽/텍스트), 기술 요소(일관성/가시성/단순성), 사용자 요소(흥미성/정보성/관계성)를 분석유형을 도출하였다. 도출된 내용을 통해 사용자 체험유형에 따른 국내외 실시된 퍼놀로지 기반 디지털 캠페인의 3개 사례를 선정하여 분석하였으며 그 결과는 다음과 같다. 첫 번째, 모든 체험유형에서 디자인 요소인 ‘텍스트’를 이용하여 참여 독려와 행동을 유도하였고 캠페인 체험 시 사용방법, 맥락에 있어서 일관되게 나타나는 기술 요소인 ‘일관성’, 캠페인의 의도나 아이덴티티의 구축하는 사용자 요소인 ‘정보성’이 강하게 나타났다. 두 번째, 사용자가 캠페인을 수용적 체험일수록 디자인 요소가 강하게 나타났고 반면에 사용자 요소는 약하게 나타난 것을 확인할 수 있었다. 특히 수용적 체험에서 사용자 요소인 ‘관계성’과 주도적 체험에서 ‘레이아웃’이 가장 낮게 나타났다. 세 번째, 디자인과 기술의 질(quality)과 보상(Feedback)을 나타내는 ‘가시성’이 모든 유형에서 미미하게 나타났다. 따라서 디지털 공간에서 사용자의 능동적이고 자발적인 참여와 다양한 체험을 제공하고 사용자의 유희적 감성을 유발시키고 의미 있는 경험을 창출을 위해선 퍼놀로지 기반 디지털 캠페인의 활용성 향상을 위한 참여형 UI디자인에 대한 지속적인 연구가 진행되어야 한다. With the development of technology in modern society, everything we encounter in our daily life is being digitalized, and users in modern society respond sensitively to how they feel emotionally. The funology-based digital campaign of that era is suitable as a marketing that meets the needs and values of users who want to receive a sensible service in a variety of digital spaces due to the convergence of the rapidly advancing technology and the fun idea, and the participatory UI design is required for smooth interaction of users in those digital spaces. Therefore, this study aimed to suggest a development plan for the funology-based digital campaign’s participatory UI design to induce users’ enjoyable emotions and encourage their active participation in the digital spaces when they participate in the funology-based digital campaign. First of all, it considered the theoretical background and concept of funology and examined the definitions and types of the digital campaign. In addition, it derived common elements by organizing the elements of the participatory UI design. Based on this, it divided the funology-based digital campaign to be applied in the study into some user experience types (receptive experience/ participatory experience/ proactive experience) and derived analysis types such as design elements (layout/ color/ graphic/ text), descriptive elements (consistency/ visibility/ simplicity), and user elements (interest/ informativeness/ relatedness) as three elements of the participatory UI design. Based on the derived contents, it selected and analyzed three cases of the funology-based digital campaign performed both in the country and abroad according to the user experience types, and the results were as follows. First, it encouraged participation and induced actions by using the ‘text’, one of the design elements, among all experience types, and ‘consistency’, one of the descriptive elements, that is consistent in terms of the usage and context at the time of experiencing the campaign, and ‘informativeness’, one of the user elements that builds the intention or identity of the campaign, were strongly observed. Second, the more receptive the users’ experiences with the campaign, the stronger the design elements and the weaker the user elements. In particular, ‘relatedness’, a user element in the receptive experience, and ‘layout’ in the proactive experience were found to be the lowest. Third, it was confirmed that ‘visibility’, which represents the quality and feedback of the design and technology, appeared insignificantly in all the types. Therefore, a study on the participatory UI design to improve the usability of the funology-based digital campaign should continue to be carried out in order to attract active and voluntary participation of users, provide them with various experiences, induce their enjoyable emotions, and create meaningful experiences for them in digital spaces.

A bio-inspired superhydrophobic electrospun Silicon nanofiber coating for Improvement of oil Purification

Yejin Liang(LIANG YEJIN),Heechul Choi(최희철),Minbeom Kim(김민범),Eunmok Yang(양은목),Soyoung Kim(김소영) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

Effect of Flow Rate on Smoke Control System for Railway Tunnel Fire

Yejin Ha(Yejin Ha),Joonho Jeon(Joonho Jeon) 한국화재소방학회 2023 International Journal of Fire Science and Engineer Vol.37 No.2

Tunnel is a semi-closed structure with a high risk of fire becuse of difficulty of smoke exhaust and restricted evacuation route in fire. No specific guidelines on smoke control systems have been developed for railway tunnels. Therefore, in the railway tunnel design, an average airflow velocity of 2.5 m/s inside a tunnel for the entry and exit of workers has been used as a reference. In this study, a fire simulation conducted to examine whether the average flow velocity can sufficiently apply on smoke control system in railway tunnel design. An 870-m-long railway tunnel with a single track and double track was modeled, and fire scenarios for light rail cars were simulated. It was found that the reference flow velocity showed sufficient smoke control performance, even at a maximum fire source of 60 MW. However, evacuees might be exposed to smoke due to the backlayer formed immediately. Furthermore, the smoke control performance for the reference velocity does not reflect the influence of the tunnel length. It is necessary to conduct a study on standard for appropriate smoke control performance to reduce fire risk in a railway tunnel fire.

A Model: Prediction of Small for Gestational Age Status and of the Diagnosis to Delivery Interval in Preeclampsia with Standard Parameters

( Yejin Park ),( Ja Young Kwon ),( Joon Ho Lee ),( Young Han Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

Objective: To build a practical model that predicts the prognosis of preeclampsia based on information acquired at the time of diagnosis. Methods: We enrolled 401 patients who were diagnosed with preeclampsia and had delivered babies between January 2007 and March 2015. Preeclampsia progression was measured according to small for gestational age (SGA) status and the diagnosis to delivery interval (DDI). Prediction models were constructed by multiple logistic regression analyses using factors related to preeclampsia severity. Furthermore, we performed internal validation (n=200) with respect to discrimination. Results: SGA was independently associated with maternal pre-pregnancy body mass index (BMI) (odds ratio [OR]: 0.916, 95% confidence interval [CI]: 0.857-0.978), maternal hemoglobin at diagnosis (OR: 1.308, 95% CI: 1.135-1.508), and uterine artery notching on Doppler ultrasonography (OR: 3.186, 95% CI: 2.015-5.037). A prediction model derived from these variables showed an area under the curve (AUC) of 0.722 for SGA in the training cohort. When applied to the validation cohort, this model showed good discrimination (AUC: 0.717). DDI of more than one week was affected by maternal systolic blood pressure (OR: 0.984, 95% CI: 0.966-1.003), platelet counts (OR: 1.004, 95% CI: 1-1.008), aspartate transaminase (OR: 0.233, 95% CI: 0.054-1.003), and proteinuria (2+ OR: 0.648, 95% CI: 0.354-1.185; 3+ OR: 0.494, 95% CI: 0.245-0.997; 4+ OR: 0.176, 95% CI: 0.059- 0.529). The prediction model of a DDI of more than one week constructed using these variables produced an AUC of 0.694, and the validation cohort also demonstrated good discrimination (AUC: 0.669). Conclusion: Our prediction models that are derived from the factors measured at the time of diagnosis of preeclampsia can be used to estimate the sequelae of preeclamptic women and their fetuses.

A comparison study of extraction methods for bio-liquid via hydrothermal carbonization of food waste

YeJin Bang,Minseon Choi,Sunyoung Bae(편집자) 한국분석과학회 2018 분석과학 Vol.31 No.3

3차원 유도결합형 플라즈마 방전에서 전자 에너지 분포 함수 및 유체의 흐름을 고려한 시뮬레이션

Yejin Shon,Dong-Gil Kim,Eunhee Choi,Sora Lee,Deuk-Chul Kwon,HeeHwan Choe 한국진공학회 2019 한국진공학회 학술발표회초록집 Vol.2019 No.2

Antidepressant Effects of Ethanol and Ethyl Acetate Extracts from Cannabis sativa L. (Hemp) Seeds in Invertebrate and Vertebrate Models

Yejin Ahn(안예진),Hyung Joo Suh,Sung Hee Han 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.5

Comparative analysis of yeast cell viability at exponential and stationary growth phases

Yejin An,Nayoon Jo,Hyeji Kim,Dahye Nam,Woorim Son,Jinkyu Park 한국분석과학회 2022 분석과학 Vol.35 No.4

This paper describes a comparative analysis of yeast cell viability at exponential and stationary growth phases using multiple conventional techniques and statistical tools. Overall, cellular responses to various viability assays were asynchronous. Results of optical density measurement and direct cell counting were asynchronous both at exponential and stationary phases. Proliferative capacity measurement using SP-SDS indicated that cells at the end of the stationary phase were proliferative as much as exponentially growing cells. Metabolic activity assays using two different dyes concluded that the inside of cells at stationary phase is slightly less reducing compared to that of exponentially growing cells, implying that the metabolic activity imperceptibly declined as cells were aged. These results will be helpful to understand the details of yeast cell viability at exponential and stationary growth phases.

Parental intention to vaccinate daughters with the human papillomavirus vaccine in Korea: a nationwide cross-sectional survey

Yejin Ha,Kyeongmin Lee,Bomi Park,Mina Suh,Jae Kwan Jun,Kui Son Choi 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: We aimed to identify and compare the characteristics and factors associated with parental intention to vaccinate daughters under 12 years old against human papillomavirus (HPV), examining data from 2016 and 2020. METHODS: Data were obtained from the Korean National Cancer Screening Survey conducted in 2016 and 2020. The present study included 3,510 parents with daughters under 12 years old. Changes in parental intention-to-vaccinate rates were calculated. To identify factors associated with parental intention to vaccinate their daughters, the chi-square test and logistic regression analysis were used. RESULTS: The percentage of respondents intending to vaccinate their daughters increased from 33.4% in 2016 to 58.9% in 2020, constituting a 25.5 percentage point (%p) increase. Since 2016, the proportion of men expressing positive intention towards HPV vaccination increased by 31.5%p, while that of women demonstrated a 20.9%p increase. Logistic regression analysis indicated that parents with a strong intention to vaccinate their daughters tended to be younger, more educated, and aware of the free vaccination program available, as well as to have a history of HPV vaccination and to have undergone cervical cancer screening within 2 years, compared to those who did not intend to vaccinate. Being a mother with a history of HPV vaccination was the strongest predictor of positive intention to vaccinate a daughter. CONCLUSIONS: The intention among parents to vaccinate daughters remains relatively low, although it is rising. To increase the HPV vaccination rate, strong recommendations and education should be provided to parents and the younger generation.