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FTIR을 이용한 브라질 Itabira 지역 에메랄드의 분광학적 특성 연구
임예원 ( Ye Won Lim ),장윤득 ( Yun Deuk Jang ),김종랑 ( Jong Rang Kim ),김형수 ( Hyeong Soo Kim ),김종근 ( Jong Gun Kim ),김정진 ( Jeong Jin Kim ) 한국광물학회 2008 광물과 암석 (J.Miner.Soc.Korea) Vol.21 No.4
현재 에메랄드의 중요한 산지로 자리 잡아가고 있는 Itabira 지역 에메랄드의 분광학적 특성을 연구하기 위하여 에메랄드를 C-축에 수직, 수평인 방향으로 각각 절단하였으며, H2O 관련 범위의 좀 더 세부적인 피크 관찰을 위하여 KBr로 압축한 pellet시료를 만들어 적외선 분광분석(FTIR) 실험을 수행 하였다. H2O 관련 범위에서 5,271cm-1, 1,638cm-1 피크가 나타나는 것으로 보아 본 시료는 Type-Ⅱ에 해당함을 관찰할 수 있었으며, H2O-Na-H2O 배열 형태를 가지는 Type-Ⅱa에 해당하는 피크가 아주 강하게 나타나고 있다. H2O 관련 범위를 제외한 특정 범위에서는 CO2, Cl 피크 등이 관찰 되었으며, 적외선 분광분석법을 이용하여 타입의 분류뿐만 아니라 상대적인 피크 강도 비교를 통하여 Na2O 함량 또한 예측 가능한 것으로 사료된다. Emerald deposit located on Itabira, Brazil is one of the major one in the world. We applied three different analytical approaches on Itabira emerald samples, (1) perpendicular to the c-axis, (2) parallel to the c-axis, (3) emerald pallet mixed with KBr, using Fourier Transform Infrared (FTIR) spectroscopy, to understand and compare spectroscopic characteristics of three Itabira emerald samples. Occurrence of 5,271 cm-1 and 1,638 cm-1 absorption peaks within H2O-related range indicates that the samples belong to Type-II emerald. These emerald samples also display strong absorption peak generated from Type-IIa emerald preserving H2O-Na-H2O sequence. CO2- and Cl-related absorption peaks observed within specific range except for H2O-related range. These observations and results suggest that FTIR analysis can be used for not only classification of emerald types, but also prediction of Na2O content within the emerald through comparison of relative peak intensity.
Bile duct invasion can be an independent prognostic factor in early stage hepatocellular carcinoma
Ye-Rang Jang,Kwang-Woong Lee,Hyeyoung Kim,Jeong-Moo Lee,Nam-Joon Yi,Kyung-Suk Suh 한국간담췌외과학회 2015 한국간담췌외과학회지 Vol.19 No.4
Backgrounds/Aims: In hepatocellular carcinoma (HCC), bile duct invasion occurs far more rarely than vascular invasionand is not well characterized. In addition, the pathologic finding of bile duct invasion is not considered an independent prognostic factor for HCC following surgery. In this study, we determined the characteristics of HCC with bile duct invasion, and assessed the clinical significance of bile duct invasion. Methods: We retrospectively reviewed the medical records of 363 patients who underwent hepatic resection for HCC at Seoul National University Hospital (SNUH) from January 2009 to December 2011. Preoperative, operative, and pathological data were collected. The risk factors for recurrence and survival were analyzed. Subsequently, the patients were divided into 2 groups according to disease stage (American Joint Committee on Cancer/International Union Against Cancer 7<SUP>th</SUP> edition): early stage (T1 and 2) and advanced stage (T3 and 4) group; and risk factors in the sub-groups were analyzed. Results: Among 363 patients, 13 showed bile duct invasion on pathology. Patients with bile duct invasion had higher preoperative total bilirubin levels, greater microvascular invasion, and a higher death rate than those without bile duct invasion. In multivariate analysis, bile duct invasion was not an independent prognostic factor for survival for the entire cohort, but, was an independent prognostic factor for early stage. Conclusions: Bile duct invasion accompanied microvascular invasion in most cases, and could be used as an independent prognostic factor for survival especially in early stage HCC (T1 and T2).
Administration of growth factors for bone regeneration.
Yun, Ye-Rang,Jang, Jun Hyeog,Jeon, Eunyi,Kang, Wonmo,Lee, Sujin,Won, Jong-Eun,Kim, Hae Won,Wall, Ivan Future Medicine 2012 Regenerative medicine Vol.7 No.3
<P>Growth factors (GFs) such as BMPs, FGFs, VEGFs and IGFs have significant impacts on osteoblast behavior, and thus have been widely utilized for bone tissue regeneration. Recently, securing biological stability for a sustainable and controllable release to the target tissue has been a challenge to practical applications. This challenge has been addressed to some degree with the development of appropriate carrier materials and delivery systems. This review highlights the importance and roles of those GFs, as well as their proper administration for targeting bone regeneration. Additionally, the in vitro and in vivo performance of those GFs with or without the use of carrier systems in the repair and regeneration of bone tissue is systematically addressed. Moreover, some recent advances in the utility of the GFs, such as using fusion technology, are also reviewed.</P>
Engineering of Self-Assembled Fibronectin Matrix Protein and Its Effects on Mesenchymal Stem Cells
Yun, Ye-Rang,Pham, Le B. Hang,Yoo, Yie-Ri,Lee, Sujin,Kim, Hae-Won,Jang, Jun-Hyeog MDPI 2015 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.16 No.8
<P>Fibronectin (FN) contributes to cell adhesion, proliferation, and differentiation in various cell types. To enhance the activity of fibronectin at the sites of focal adhesion, we engineered a novel recombinant fibronectin (FNIII10) fragment connected to the peptide amphiphile sequence (PA), LLLLLLCCCGGDS. In this study, the effects of FNIII10-PA on rat mesenchymal stem cells (rMSCs) were compared with those of FNIII10. FNIII10-PA showed the prominent protein adhesion activity. In addition, FNIII10-PA showed a significantly higher effect on adhesion, proliferation, and differentiation of rMSCs than FNIII10. Taken together, the FNIII10-containing self-assembled sequence enhanced rMSCs adhesion, proliferation, and differentiation.</P>
Fibroblast growth factor 2-functionalized collagen matrices for skeletal muscle tissue engineering.
Yun, Ye-Rang,Lee, Sujin,Jeon, Eunyi,Kang, Wonmo,Kim, Kook-Hyun,Kim, Hae-Won,Jang, Jun-Hyeog Kluwer Academic Publishers 2012 Biotechnology letters. Vol.34 No.4
<P>Fibroblast growth factor 2 (FGF2) protein plays important roles in wound healing and tissue regeneration. Collagen is clinically used for wound care applications. We investigated the potential value of FGF2-functionalized collagen matrices for skeletal muscle tissue engineering. When C2C12 cells were treated with FGF2, cell adhesion increased after 3 and 5 days compared to the control (P < 0.05). Wound healing activity of FGF2 was slightly higher than the control through cell migration. Cell proliferation activity of FGF2-functionalized collagen matrices on C2C12 cells also increased. Taken together, FGF2 stimulated C2C12 myoblast growth by promoting cell adhesion, proliferation and wound healing activity after injury. The potential effect of FGF2-functionalized collagen matrices was also observed. Thus FGF2 stimulates skeletal muscle development and regeneration, thereby leading to potential utility for skeletal muscle tissue engineering.</P>
Yun, Ye-Rang,Jeon, Eunyi,Lee, Sujin,Kang, Wonmo,Kim, Sang-Gi,Kim, Hae-Won,Suh, Chang Kook,Jang, Jun-Hyeog Kluwer Academic/Plenum 2012 The Protein Journal Vol.31 No.6
<P>To investigate the functions of recombinant human dentin phosphoprotein (rhDPP), we examined cell adhesion, viability and the odontoblastic differentiation activity of human dental pulp cells (hDPCs). Firstly, rhDPP was constructed using pBAD-HisA plasmid in Escherichia coli. Cell adhesion and viability of hDPCs by rhDPP was examined using a crystal violet assay and a MTT assay, ALP, mineralization activity and odontoblastic differentiation-related mRNA levels of hDPCs were measured to elucidate the odontoblastic differentiation effect of rhDPP on hDPCs. Initially, rhDPP significantly and dose-dependently increased hDPCs adhesion versus the untreated control (p < 0.05). Cell viability was also significantly increased by rhDPP at 5 days (p < 0.001). Furthermore, the odontoblastic differentiation effect of rhDPP was verified by measuring ALP activity, mineralization activity and the mRNA levels of odontoblastic differentiation markers. Taken together, rhDPP is expected to play an important role on hDPCs, thereby suggesting its potential use for tooth repair and regeneration.</P>