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Wen Yan,Nan Li,Zheng Miao,Guangping Liu,Yuanyuan Li 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.3
Three refractory castables containing corundum aggregates with different porosities, average pore size and strength and the same matrices were fabricated. The effects of the properties of corundum aggregates on the strength and slag resistance of refractory castables were investigated through an X-ray diffractometer (XRD), scanning electron microscopy (SEM), mercury porosimetry measurements, etc. It was found that the properties of corundum aggregates have an important effect on the bulk density, porosity, compressive strength and slag resistance of refractory castables, but have little effect on the flexural strength of refractory castables. Compared with a castable containing white fused corundum aggregate (with a porosity of 4.2% and a bulk density of 3.62 g/cm3), the castable containing a porous corundum aggregate (with a porosity of 42.0% and a bulk density of 2.29 g/cm3) has a higher porosity of 35.7%, a lower bulk density of 2.44 g/cm3, a lower but sufficient compressive strength (80.4 MPa) and a lower slag resistance, but has a similar flexural strength (20.3 MPa), and then has a potential application for a non-slag working lining of a ladle to decrease the consumption of energy and Al2O3 material.
Roles of Immunohistochemical Staining in Diagnosing Pulmonary Squamous Cell Carcinoma
Yan, Yue,Zhang, Ya-Xiong,Fang, Wen-Feng,Kang, Shi-Yang,Zhan, Jian-Hua,Chen, Nan,Hong, Shao-Dong,Liang, Wen-Hua,Tang, Yan-Na,He, Da-Cheng,Wu, Xuan,Zhang, Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: Differentiating morphologic features based on hematoxylin-eosin (HE) staining is the most common method to classify pathological subtypes of non-small-cell lung cancer (NSCLC). However, its accuracy and inter-observer reproducibility in pathological diagnosis of poorly differentiated NSCLC remained to be improved. Materials and Methods: We attempted to explore the role of immunohistochemistry (IHC) staining in diagnosing pulmonary squamous cell carcinoma (SQCC) with poorly differentiated features by HE staining or with elevated serum adenocarcinoma-specific tumor markers (AD-TMs). We also compared the difference of epidermal growth factor receptor (EGFR) mutation rate between patients with confirmed SQCC and those with revised pathological subtype. Logistic regression analyses were used to test the association between different factors and diagnostic accuracy. Results: A total of 132 patients who met the eligible criteria and had adequate specimens for IHC confirmation were included. Pathological revised cases in poor differentiated subgroup, biopsy samples and high-level AD-TMs cases were more than those with high/moderate differentiation, surgical specimens and normal-level AD-TMs. Moreover, biopsy sample was a significant factor decreasing diagnostic accuracy of pathological subtype (OR, 4.037; 95% CI 1.446-11.267, p=0.008). Additionally, EGFR mutation rate was higher in patients with pathological diagnostic changes than those with confirmed SQCC (16.7% vs 4.4%, p=0.157). Conclusions: Diagnosis based on HE staining only might cause pathological misinterpretation in NSCLC patients with poor differentiation or high-level AD-TMs, especially those with biopsy samples. HE staining and IHC should be combined as pathological diagnostic standard. The occurrence of EGFR mutations in pulmonary SQCC might be overestimated.
Research on the Method of Fault Diagnosis Based on Multiple Classifiers Fusion
Yan Wen,Jiwen Tan,Hong Zhan,Hao Wang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.2
In traditional fault diagnosis method, a large number of experiments are needed to get the optimal performance classifier which diagnoses type of fault. Because of classifier algorithm limit, there is no one classifier can be applied to all kinds of fault diagnosis. In order to avoid the disadvantages caused by single classifier approach, decision level fusion method based on multiple classifiers fusion is introduced in the field of fault diagnosis. The fusion method with fuzzy comprehensive evaluation is put forward and the basic evaluation model is set up. The reasonable distribution of classifiers weight that affects diagnosis result directly is vital. Firstly, the evaluation function which measures member classifier’s diagnostic accuracy and correctness is constructed based on the theory of information entropy. Then, weights are distributed to each classifier with entropy coefficient according to the value of evaluation function. Experiments are carried out to demonstrate the effectiveness of the proposed method and results show that fault recognition rate after fusion is higher compared with the single classifier method.
Antimicrobial glycoalkaloids from the tubers of Stephania succifera
Yan-Bo Zeng,Dai-Jing Wei,Wen-Hua Dong,Cai-Hong Cai,De-Lan Yang,Hui-Min Zhong,Wen-Li Mei,Hao Fu Dai 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.4
Three new glycoalkaloids, N-formyl-asimilobine-2-O-b-D-glucoside (1), (-)-1-O-b-D-glucoside-8-oxotetrahydropalmatine(2), and 1-N-monomethylcarbamateargentinine-3-O-b-D-glucoside (3) were isolated fromtubers of Stephania succifera. The structures were establishedbased on spectroscopic analysis, and the antimicrobialactivities of the three glycoalkaloids are reported.
Yan Wen,Guoli Li,Qunjing Wang,Xiwen Guo 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.6
This paper presents a position tracking control method for a three degree-of-freedom permanent magnet spherical actuator (PMSA). The control method is designed based on a dynamic model of the PMSA with uncertainties including modelling errors and external disturbance. Sliding-mode surface are adopted to restrain and eliminate the efect of external disturbances. To compensate modelling errors, an adaptive law is employed to estimate unknown model parameters so that model information can be updated in real time. By the use of dynamic surface approach, three frst-order flters are introduced to avoid the explosion of derivative terms caused by traditional adaptive backstepping approach. The stability of the closed-loop system using the proposed controller is confrmed through Lyapunov theorem. The test bench consisted of the prototype of PMSA, the host computer, the current controller and the orientation detection device is established for experiments. Simulation and experimental results are provided to validate efectiveness of the proposed method.
( Wen Jing Yan ),( Ying Chun Tan ),( Ji Cheng Xu ),( Xian Ping Tang ),( Chong Zhang ),( Peng Bo Zhang ),( Ze Qiang Ren ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.3
Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having antihepatotoxic and anticancer properties. In this paper, we investigated the effects of silibinin on behavior and neuroplasticity in mice subjected to chronic unpredictable mild stress (CUMS). After 5 consecutive weeks of CUMS, the mice were treated with silibinin (100 mg/kg, 200 mg/kg and 400 mg/kg by oral gavage) for 3 consecutive weeks. The results showed that silibinin administration significantly alleviated the CUMS-induced depressive-like behavior, including the total number of squares crossed and the frequency of rearing in the open field test, the immobility time in the tail suspension test and the forced swimming test. Furthermore, silibinin treatment increased the levels of brain-derived neurotrophic factor (BDNF), serotonin (5-HT) and norepinephrine (NE) in the prefrontal cortex and hippocampus. Our study provides new insight into the protective effects of silibinin on the depressive status of CUMS mice, specifically by improving neuroplasticity and neurotransmission.
Wen Yan Huang,Inhye Jeong,Bok Kyung Han,Mi Jeong Kim,Wan Heo,Young Jun Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Airborne particulate matter (PM) causes oxidative stress and inflammation and could chronically harm the human respiratory and circulatory systems. The protective effect of Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (CZL) extract in PM10-induced lung injury model was studied herein. The mechanism of PM10-induced inflammation was also investigated using human alveolar epithelial A549 cells and BALB/c mice. Histological assessment showed that CZL administration significantly attenuated PM10-induced pathological injury, inflammatory cell infiltration and lung edema. Phosphorylation of AKT, ERK and P65 was increased by PM10 exposure was reduced by CZL treatment in both in vivo and in vitro models. In addition, CZL treatment inhibited the expression of iNOS and COX-2 levels and the secretion of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in PM10 challenged lung cells and mice. Based on the results of this study, CZL alleviated lung inflammation caused by PM10 exposure, and could be applied as a potent therapeutic candidate for the treatment measure of lung inflammatory diseases.