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      • KCI등재후보

        Vinca Alkaloids 투여방법에 따른 난치성 특발성 혈소판 감소성 자반증(ITP)의 치료 효과

        이재훈,김승택,이홍복,김병국,이문호,박선양,김노경,이종석 대한내과학회 1987 대한내과학회지 Vol.33 No.2

        Treatment with vinca alkaloids which consisted of infusion of vincristine-loaded platelets, or slow infusion of vinca alkaloids or both were done in 9 patients of idiopathic thrombocytopenic purpura refractory to glucocorticoids with or without splenectomy. 2 (22%) of them showed excellent response, 5 (56%), good response, 2 (22%), poor response. However one patient of excellent response and all of good response needed repeated treatment to maintain response. The toxicity of this treatment was mininal, only mild peripheral neuropathy was observed in 2 patients. It can be concluded that the treatment with vinca alkaloids is one of the useful therapeutic modalities to manage refrectory ITP.

      • KCI등재후보

        가성 장폐쇄로 발현한 부신경절종 1 예

        김용태,이기업,박건춘,송영기,이문호,유은실,이준호,진태선 대한내과학회 1991 대한내과학회지 Vol.40 No.5

        Phenochromocytoma is a catecholamine-secreting tumor, most of which grow at the adrenal gland. About 109p Of pheochromocytomas are detected at the extra-adrenal chromaffine tissues and are called paraganglioma. The main symptoms of pheochromacytoma include hypertension, headache, palpitation, and sweating. Gastrointestinal symptoms such as abdominal pain, constipation, and vomiting are found in 20∼40% of patients with pheochromocytoma, but these are usually overlooked because of the severe, prominant cardiovascular symptoms. Intestinal pseudo-obstruction without hypertension in pheochromocytoma is very rarely found. It is caused by the decreased motility of the intestine and the over-contraction of the intestinal sphincter, which are caused by the unbalanced activation of α-and β-adrenal receptors. It can be hypothesized that catecholamine receptors in the cardiovascular system are down-regulated or desensitized, but those in the intestine remain intact. We report herein a case of pheochromocytoma in which intestinal pseudo-obstruction was the main presenting clinical manifestation. Symptoms of intestinal pseudo-obstruction were completely relieved by administration of phenoxybenzamine, an α-receptor blocker, and excisional surgery.

      • KCI등재후보

        상보형 일렉트로크로믹 소자의 제조 및 특성(1)

        김영호,이석윤,서동규,조동율,천희곤 한국센서학회 1997 센서학회지 Vol.6 No.1

        In this study, two different types of complementary electrochromic devices using amorphous WO₃ films as a working electrode, V₂O_5 film and NiO film as counter electrodes respectively were investigated. For the devices using amorphous and crystalline V₂O_5 films of 100∼150nm thickness with ITO/WO₃/LiClO₄-PC/V₂O_5 /ITO structure, an optical modulation of 50∼60% were obtained at a potential range of 1 2V. It has been shown that transmittance and reflectance of light could be electrically controlled by low applied voltage. For the devices with ITO/WO₃/LiClO₄-PC/NiO/ITO structure in which NiO film was deposited by a RF reactive sputtering, the optical modulation in visible light region (λ=550nm) and in near infrared light region (λ.1=850nm) were 25% and 30%, respectively.

      • SCOPUSKCI등재

        99mTc - MDP 골스캔에서 냉소로 나타난 전이암의 분석

        이명철,이동수,고창순,손인,정준기,최창운,양형인,배상균 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1

        The present study was purposed to evaluate the incidence and the characteristics of metastatic "cold" lesions in Tc-99m-MDP bone scans of adult patients with solid malignancies. There were 29 cold lesions in 24 patients. The incidence of cold lesions was about 1% of total cases of bone scans for the patients with malignancy, or 2.5% of cases with bone metastases, The primary sites of malignancies were lung (four cases), uterine cervix (three cases), kidney, nasopharynx, thyroid, urinary bladder, prostate, lymphoma(two cases each other), liver, breast and others (one case each other). But the relative incidence of cold lesion in lung cancer and breast cancer was low. The most frequent site of cold lesion was spine and pelvis, skull and rib were followed. The incidence of cold lesion was related to the regional incidence of bone metastases. The size of the cold lesions was greater than that of the hot. There were six cases of single cold lesion without any other abnormalities and two cases of cold lesion which were initially hot. So it should be considered that bone metastases might be presented as cold lesions in bone scan.

      • KCI등재

        자궁경부암 환자의 혈중 Interleukin - 6 (IL- 6) 의 정량분석

        이용호,김영태,김종오,이규완,이낙우,박용균,장기훈,조윤정 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9

        목적 : 혈중 IL-6의 과발현은 다발성 골수종, 악성 흑색종, 신경 교아종, 난소암, 신장암과 림프종에서의 예후와 관련이 있다고 알려져 있는데 자궁경부암 환자의 혈중 IL-6의 농도를 정량화하여 대조군과 상피내암 및 자궁경부암에서 혈중 IL-6의 상관관계를 알아 보고자 본 연구를 시행하였다. 연구방법 : 1997년 6월부터 1998년 6월까지 자궁경부 편평상피암 29명, 자궁경부 상피내암 14명, 대조군 15명을 대상으로 혈액 시료를 채취 후 분석시까지 -70℃에 보관하였으며 ELISA(BioSource International) kit를 이용하여 IL-6를 정량 분석하였다. 결과 : 혈중 IL-6의 평균농도는 대조군 4.4±1.7 pg/ml, 자궁경부 상피내암 5.3±1.7 pg/ml, 자궁경부 편평상피암 5.6±4.1 pg/ml로 자궁경부 편평상피암에서 혈중 IL-6가 증가하는 경향을 보였으나 각 군간의 통계적 의의는 없었다(p=0.478). 결론 : 정상 대조군에 비하여 자궁경부 편평상피암과 자궁경부 상피내암에서 혈중 IL-6의 농도가 증가되는 것을 확인할 수 있었으나 통계적 유의성은 관찰할 수 없었으며 더 많은 예를 중심으로 연구가 필요하리라 사료된다. Objective : To evaluate the relationship between the level of serum IL-6 and the prognosis of cervical cancer patients, because high level of IL-6 has been reported to be related with adverse prognosis in multiple myeloma, renal cancer, glioblastoma, ovarian cancer and lymphoma. Methods : From June, 1997 to June 1998, total 58 patients including 29 patients with cervical cancer, 14 Carcinoma in situ, 15 control were enrolled in this study. We examined these patients of serum IL-6 by ELISA. Result : The mean serum IL-6 was 4.35±1.68pg/ml on control, 5.29±1.72pg/ml on carcinoma in situ and 5.57±4.10pg/ml in cervical cancer patients. Conclusion : Detectable serum IL-6 levels were more often in patients with cervical cancer and carcinoma in situ than in control group, but the difference was not statistically significant because of the small number of patients.

      • 해외 부존 사료자원의 개발 및 이용성 연구 : 2 . 해외 부존 사료자원의 광물질과 항영양인자 분석 결과

        이성실,김홍대,하종규,곽병오,한인규,고영곤,감동근,전현식,박장희 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.5

        본 연구는 해외 부존자원의 개발을 위하여 동남아시아 5개국과 중국에서 수집한 시료의 광물질, 중금속 및 항영양 인자 수준을 분석하여 원료가치를 판단하는 기초 자료를 제공하고자 실시되었다. 성분 분석 결과를 요약하면, 1. 본 시험에 공시한 부존사료자원들의 광물질 함량은 현재 우리나라에서 사용중인 원료사료와 비교 하였을 때 그 수준이 비슷하거나 높았다. 2. Bio-v-pro (India)에서 크롬 함량이 높게 나타났고, 대두박 (China)에서 납 함량이 높게 나타난 것을 제외하고는 대부분의 부존 사료자원의 중금속 함량은 안정권내에 있었다. 3. Cassava waste (Thailand)에서 HCN의 함량이 높게 나타났고, mustard cake (India)에서 tannic aicd 함량이 비교적 높게 나타난 것을 제외하고는, 아플라톡신, gossypol, nitrate 등을 포함하는 항영양성 인자들의 함량이 대부분의 부존사료자원들에서 낮은 것으로 조사되었다. This study was conducted to evaluate nutritional value of non-conventional feeds of foreign-origin. Samples collected from South-Asian countries and China were analyzed for minerals, heavy metals and anti-nutritional factors. 1. Most non-conventional feed resources obtained from 6 countries was similar or higher mineral contents in some cases than conventional feeds which used in Korea. Particularly, calcium and phosphorus were high in bone meal and fish meal from Vietnam. 2. Heavy metal contents of most non-conventional feed resources in this study was below safety level. But exceptions were bio-v-pro (India) containing higher chrome and soybean meal (China) containing higher Pb than in conventional feeds. 3. HCN was high in cassava waste (Thailand), and tannic acid was high in mustard cake (India). But in most non-conventional feed resources, the level of anti- nutritional factors was low enough to be used as feed resources.

      • KCI등재후보

        간문부 담관암의 임상적 고찰

        이정일,김병호,이상목,장영운,동석호,김효종,장린,한민수,홍성화 대한내과학회 1996 대한내과학회지 Vol.50 No.2

        Objectives: There is no difficulty in the diagnosis of hilar cholangiocarcinoma because of early occurrence of obstructive jaundice. Though prolonged survival can be expected with surgical resection, being advanced stage at the time of diagnosis, radical resection has been impossible in most cases. Recently the significant interest has been focused on this lesion and the aggressive surgical resection increased, but the results were various. Thus, the present study was performed to evaulate the clinical characteristics of hilar cholangiocarcinoma. Methods: We evaluated retrospectively 63 cases of hilar cholangiocarcinoma which were diagnosed at Kyung Hee University Hospital from January 1988 to July 1994. Results: 1) The mean age of the patients was 58±12.0 years and the ratio of male to female was 2.9:1. 2) Jaundice was the most common symptom (85.7%) followed by abdominel pain(53.9%), weight loss (34.9%) and pruritus(30.1%). 3) Of 13 cases(20.6%) who underwent surgical resection, 7 cases(11.1%) had curative resection. PTBD was performed in 4i cases(73%), radiotherapy in 7 cases(11.1%), chemotherapy in 4 cases (6.3%) and metallic stent insertion in 7 cases (11.1%). 4) The mean survival time was 15.3±3.0 months in resection group(13 cases, 20.6%) and 4.8±0.5 months in non-resection group(50 cases, 79.4%). The survival time of resection group was longer than that of non-resection group(p$lt;0.01). Conclusion: In conclusion, the prognosis of hilar cholangiocarcinoma is extremely poor and the prolonged survival can be expected with surgical resection. Thus, to determine the resectability, early diagnosis is important and accurate preoperative staging is necessary.

      • 조사료원의 종류가 산양의 반추위 발효성상 및 미생물 조성에 미치는 영향

        이성실,김홍대,하종규,황일환,김완영,심성수,강민원,고종렬 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.5

        본 실험은 조사료의 종류 (볏짚, 알팔파 건초, 옥수수 사일리지)가 한국재래산양의 반추위내 발효성상 및 미생물 군집에 미치는 영향을 구명하기 위하여 반추위에 cannula가 장착된 3두의 재래산양을 이용하여, 3 × 3 latin square법으로 수행하였다. 사료는 체중의 1.8%, 수준으로 1일 2회로 나누어 급여하였고, 농후사료와 조사료는 30:70의 비율로 급여하였다. 본 연구에서 얻어진 실험결과를 요약하면 다음과 같다. 1. pH 변화는 옥수수 사일리지를 급여하고 4시간 경과 후에 측정한 위액의 pH가 가장 낮게 나타났으며, 볏짚과 알팔파 급여구에서의 pH는 유의적인 차이를 나타내지 않았다. 2. 암모니아 농도는 알팔파 건초 급여구에서 사료급여 시간과 관계없이 고르게 높은 수치를 나타냈으며, 볏짚 급여구에서 가장 낮게 측정됐다. 3. 총 휘발성지방산의 농도는 알팔파 건초 급여구에서 가장 높은 수치를 나타내었고 볏짚 급여구에서 가장 낮은 수치를 나타내었다. Acetate/propionate의 비율은 옥수수 사일리지 급여구에서 변화가 가장 작았으며, 사료 급여 후 4시간대의 비율이 사료의 종류와 관계없이 가장 낮았다. 4. 섬유소 분해효소인 CMCase와 xylanase의 활력은 볏짚을 급여한 구에서 다소 높은 것으로 나타났다. 5. 총 박테리아의 숫자는 조사료의 종류와 급여시간에 관계없이 일정한 경향을 보였으나 옥수수 사일리지 급여 후 4시간대에 큰 증가를 보였다. 섬유소 분해 박테리아는 볏짚 급여구에서만 8시간 후까지 계속해서 증가하였다. 곰팡이의 경우 옥수수 사일리지를 급여한 구에서 그 수가 증가하였고, 프로토조아의 경우에는 알팔파 건초 급여구에서 가장 높은 수치를 나타내었다. 6. 반추위에 서식하는 박테리아는 조사료의 종류에 관계없이 Streptococcus bocvis가 우점하는 것으로 나타났고, 곰팡이는 Piromyces communis, Neocallimastix frontalis 및 Orpinomyces joyonii 등 3종이 분리되었으며, 조사료의 종류에 관계없이 Neocallimastix frontalis가 우점하는 것으로 나타났다. This study was conducted to investigate the effects of forage sources(rice straw, alfalfa hay, and corn silage) on ruminal fermentation characteristics and the changes of microbial population in ruminants. Three ruminally cannulated Korean native goats which weighed 35㎏ in average were allocation 3 × 3 latin square design. Goats were fed the diet of 1.8% of body weight (as dry basis) and the ratio of forage to concentrate was 70 : 30. At 0, 4, and 8 hour time after feeding, rumen fluid was collected to estimate the fermentation products, microbial number and predominant microbes. Ruminal pH of goats fed corn silage was the lowest at 4 hour after feeding, but that was not affected by forage sources. Ammonia concentration was the highest in the group of goat fed alfalfa hay regardless of time after feeding and was the lowest in the group of goat fed rice straw. Total volatile fatty acid concentration was the highest in the goat fed alfalfa hay except at 0 hour time after feeding. And the ratio of acetate/propionate was the highest in the group of goat fed alfalfa hay before feeding, but the highest in the group of goat fed rice straw at 8 hour time after feeding. CMCase and xylanase activity was higher in the group of goat fed rice straw than other groups. While forage sources did not affect the total bacteria and fungi number, but cellulolytic bacteria number was increased continuously after 8 hour postfeeding. Total protozoa number was the highest in the group of goat fed alfalfa hay. Among bacteria isolated from the rumen fluid, Streptococcus bovis was the most dominant regardless of forage sources. Regardless of forage sources, Neocallimastix frontalis was the most dominant fungi in the rumen of goat.

      • KCI등재후보
      • KCI등재후보

        신기능장애 및 혈액투석환자에서의 Pyrazinamide 의 약력학적 연구

        이선희,이정상,김성권,이문호,한용철,김대중,신상구,박찬웅 대한내과학회 1986 대한내과학회지 Vol.31 No.1

        The pharmacokinetics of single oral dose(lgm) of pyrazinamide was studied in 20 patients with various degrees of renal insufficiency including 6 patients on long-term hemodialysis. The average 24 hr urinary recovery of pyrazinamide in patients with creatinine clearance 10 to 30 ml/hr/kg, and patients with creatinine clearance lesser than 10 ml/hr/kg were 7.5 and 0.9% of administered dose respectively. Serum half-life of the drug was slightly, but significantly(p$lt;0.05), prolonged in patients with creatinine clearance lesser than 10 ml/hr/kg(half-life; 11.25±2.55 hr) compared with normal subjects(half-life; 8.21±1.38 hr) previously reported. The mean serm half-life of pyrazinamide in patients on longterm hemodialysis was 12.26±2.92 hr. The half-life fell to 3.52±1.17 hr during hemodialysis. It was estimated that approximately 41% of drug in the body was removed into dialysate during 4 hr dialysis.The mean dialysance of pyrazinamide was 91.40±2.83 ml/min. From the observed pharmacokinetics of pyrazinamide in patients with impaired renal function, it is suggested that adjustment of dosage regimen may not be required for patients just with impaired renal function. However, replacement of dialysed fraction of pyrazinamide would be required for the maintenance of adequate serum level.

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