Insect-specific microRNA involved in the development of the silkworm Bombyx mori

Yong Zhang,Xue Zhou,Xie Ge,Jiang-Hao Jiang,Mu-Wang Li,Shi-Hai Jia,Xiao-Nan Yang,Yun-Chao Kan,Xue-Xia Miao,Guo-Ping Zhao,Fei Li,Yong-Ping Huang 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10

MicroRNAs (miRNAs) are endogenous non-coding genes that participate in post-transcription regulation by either degrading mRNA or blocking its translation. It is considered to be very important in regulating insect development and metamorphosis. Insects are the largest group of animals and are extremely valuable in biological and agriculture research. Insects are also important pests to human health and agriculture, and efforts are necessary protect both humans and plants from disease and damage. Despite their importance, insects lag behind mammals, nematodes, and plants in miRNA research. At present, only 279 insect miRNAs have been identified from Drosophila melanogaster, Anopheles gambiae, Apis mellifera, Bombyx mori, and D. pseudoobscura in miRBase, and most of these miRNAs were computationally predicted without experimental validation. Functional analysis of insect miRNAs has only been conducted in D. melanogaster.

Laplacian-Regularized Mean Apparent Propagator-MRI in Evaluating Corticospinal Tract Injury in Patients with Brain Glioma

Jiang Rifeng,Jiang Shaofan,Song Shiwei,Wei Xiaoqiang,Deng Kaiji,Zhang Zhongshuai,Xue Yunjing 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.5

Objective: To evaluate the application of laplacian-regularized mean apparent propagator (MAPL)-MRI to brain glioma-induced corticospinal tract (CST) injury. Materials and Methods: This study included 20 patients with glioma adjacent to the CST pathway who had undergone structural and diffusion MRI. The entire CSTs of the affected and healthy sides were reconstructed, and the peritumoral CSTs were manually segmented. The morphological characteristics of the CST (track number, average length, volume, displacement of the affected CST) were examined and the diffusion parameter values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), mean squared displacement (MSD), q-space inverse variance (QIV), returnto- origin probability (RTOP), return-to-axis probabilities (RTAP), and return-to-plane probabilities (RTPP) along the entire and peritumoral CSTs, were calculated. The entire and peritumoral CST characteristics of the affected and healthy sides as well as those relative CST characteristics of the patients with motor weakness and normal motor function were compared. Results: The track number, volume, MD, RD, MSD, QIV, RTAP, RTOP, and RTPP of the entire and peritumoral CSTs changed significantly for the affected side, whereas the AD and FA changed significantly only in the peritumoral CST (p < 0.05). In patients with motor weakness, the relative MSD of the entire CST, QIV of the entire and peritumoral CSTs, and the AD, MD, RD of the peritumoral CST were significantly higher, whereas the RTPP of the entire and peritumoral CSTs and the RTOP of the peritumoral CST were significantly lower than those in patients with normal motor function (p < 0.05 for all). In contrast, no significant changes were found in the CST morphological characteristics, FA, or RTAP (p > 0.05 for all). Conclusion: MAPL-MRI is an effective approach for evaluating microstructural changes after CST injury. Its sensitivity may improve when using the peritumoral CST features.

Altered Distribution and Expression Pattern of E-cadherin in Hepatocellular Carcinomas: Correlations with Prognosis and Clinical Features

Jiang, Xue-Mei,Zhang, Ju-Bo,Xiong, Ju,Huang, Xiao-Xi,Ren, Zheng-Gang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Objective: E-cadherin has been identified as a tumor suppressor in many types of carcinoma. However, some studies recently suggested that the role and expression of E-cadherin might be more complex and diverse. In the present study, we evaluated the prognostic value of E-cadherin expression with reference to levels in membranes and cytoplasm, and the membrane/cytoplasm ratio, in hepatocellular carcinomas (HCCs) after curative hepatectomy. Methods: The expression of E-cadherin was assessed by immunohistochemistry in HCC tissue microarrays from 125 patients, and its prognostic values and other clinicopathlogical data were retrospectively analyzed. Patients were followed for a median period of 43.7 months (range 1 to 126 months). Results: Univariate analysis demonstrated that a high membrane/cytoplasm (M/C) ratio of E-cadherin expression was associated with poor overall survival (OS) (P =0.001) and shorter time to recurrence (TTR) (P=0.038), as well as tumor size, intrahepatic metastasis, and TNM stage. In contrast, neither membrane nor cytoplasmic expression of E-cadherin was related with OS and TTR. Furthermore, multivariate analysis confirmed the M/C ratio to be an independent predictor of OS (P=0.031). ${\chi}^2$ tests additionally showed that the M/C ratio of E-cadherin expression was related with early stage recurrence (P=0.012), rather than later stage recurrence. Conclusion: The M/C ratio of E-cadherin expression is a strong predictor of postoperative survival and is associated with early stage recurrence in patients with HCC.

Secrecy-Enhancing Scheme for Spatial Modulation

Jiang, Xue-Qin,Wen, Miaowen,Hai, Han,Li, Jun,Kim, Sooyoung IEEE 2018 IEEE COMMUNICATIONS LETTERS Vol.22 No.3

<P>In this letter, we propose a new secrecy enhancement scheme for spatial modulation systems by exploiting the knowledge of the legitimate channel state information to rotate the indices of the transmit antennas and the constellation symbols, which are mapped into spatial and constellation bits. A secrecy rate analysis shows that the eavesdropper cannot recover any information carried by spatial and constellation bits. The numerical results on the secrecy rate and the bit error rate verify the effectiveness and robustness of the proposed scheme.</P>

The Application of Metabolomics to Processed Traditional Chinese Medicine

Xue Jiang,최형균,Il-Hwan Oh,이슬기 한국응용생명화학회 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.5

Processing technologies, which are required in the production of traditional Chinese medicine (TCM), has garnered attention in recent years. To address challenges associated with processed TCM and to promote its development in academia and industries, the application of metabolomics was introduced in this review, which primarily focuses on exploring TCM theories,identification of discovered compounds, and the evaluation and quality control of TCM through metabolomics. Thus metabolomics could be a powerful method for the TCM processing industry.

Does HBV Infection Increase Risk of Endometrial Carcinoma?

Jiang, Xue-Feng,Tang, Qiong-Lan,Zou, Yuan,Xu, Ling,Zeng, Hua,Chi, Cong,Jiang, Jing-Ru,Zhang, Bin-Zhong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Objective: Connections between chronic inflammation and tumor development and progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) is included has not been reported. Methods: We analyzed HBV serum marker status in 398 patients with endometrial cancer, comparing them to 788 control women undergoing health examination. Results: The total prevalence of HBsAg tested positive in cancer group was significantly higher than the control group (12.8% vs 6.0%, P=0.001), while positive HBsAb was significantly lower (41.2% vs 68.5%, P=0.001). Hepatitis B carriers in endometrial cancer group were also more frequent than in the control group (9.3% vs 5.5%, P=0.013). Interestingly, in the endometrial cancer group, 147 cases were HBV serum marker negative, which was also higher than in the control group (36.9% vs 15.6%, P=0.001). Conclusion: There may be a correlation between HBV infection and endometrial carcinoma.

Susceptibility of Lung Cancer with Polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 Genotypes in the Population of Inner Mongolia Region

Jiang, Xue-Yan,Chang, Fu-Hou,Bai, Tu-Ya,Lv, Xiao-Li,Wang, Min-Jie,Wang, Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China. Materials and Methods: PCR-RFLP, allele-specific and multiplex PCR were employed to identify the genotypes of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 in a case-control study of 322 lung cancer patients diagnosed by bronchoscopy and 456 controls free of malignancy. Results: There is a significant difference in genotypic frequency of GSTT1 of healthy Mongolian and Han subjects. A statistically prominent association was found between CYP1A1 Msp1 (vt/vt) (OR=4.055, 95%CI:2.107-7.578, p=0.000), GSTM1 (-) (OR=2.290, 95%CI:1.467-3.573, p=0.000) and lung cancer in Mongolians. Similarly, in the Han population, CYP1A1 Msp1 (vt/vt) (OR=3.194, 95%CI:1.893-5.390, p=0.000) and GSTM1 (-) (OR=1.884, 95%CI:1.284-2.762, p=0.001) carriers also had an elevated risk of lung cancer. The smokers were more susceptible to lung cancer 2.144 fold and 1.631 fold than non-smokers in Mongolian and Han populations, respectively. The smokers who carried with CYP1A1 Msp1 (wt/vt+vt/vt), exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) respectively were found all to have a high risk of lung cancer. Conclusions: CYP1A1 Msp1 (vt/vt) and GSTM1 (-) are risk factors of lung cancer in Han and Mongolian population in the Inner Mongolia region. The smokers with CYP1A1 Msp1 (wt/vt+vt/vt), CYP1A1 exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) genotypes, respectively, are at elevated risk of lung cancer.

NUMERICAL SIMULATION OF SYNOPTIC CONDITION ON A SEVERE SAND DUST STORM

JIANG, XUE-GONG,SHEN, JIAN-GUO,LIU, JING-TAO,CHUNG, YONG-SEUNG 한국교원대학교 환경과학연구소 2004 환경연구논문집 Vol.- No.8

By using observational data and MM5, an observational analysis and numerical study was conducted on the synoptic condition of a severe dust storm that was caused by a Mongolian cyclone which occurred from 6 to 8 April 2001. Results illustrated that the cyclogenesis was due to the isentropic potential voiticity (IPV) advection in the upper troposphere and the terrain modified baroclinicity in the mid-lower troposphere. The Altai-Sayan complex of mountains blocked the lower level cold air and made the isentropic surface sharply sleep. When the air slid down along the isentropic surface the increasing of baroclinicity and decreasing of stability blew up the vertical voiticity development. The formation of the dust storm was a result of a cyclonic cold front passing across the area. The occurrence of this dust storm was closely related to the strong surface wind, which was accompanied by a cold front passing, rather than the cyclogenesis, itself. Hence, the reason for the pre-front dust stonn formulation was the formation of heating convection. Reasons behind the formation of a black storm (visibility lower than 50 m), which occurred in the mid-north part of Inner Mongolia, lay in several aspects. Firstly, in this area the surface wind was strong, a direct result of the downward transport in mid-lower troposphere. Secondly, the cold front passed over the effected area near sunset so the air obtained much more surface heating to form a deeper mixed layer (ML). Thirdly, cooperation between the lower level wind and the terrain made the atmosphere in this area and acquired the maximum advective contribution necessary to form a deep post-front ML. The sensitivity experiment revealed that surface heal flux was important to the frontal lifting. In addition, the forcing of surface heating was also seen as the primary forcing mechanism of frontogenesis. Meanwhile, removal of the surface heat flux made the atmospheric stratification became stable and the pre-storm ML very shallow, which weakened the strength of the dust storm.

The Application of Metabolomics to Processed Traditional Chinese Medicine

Jiang, Xue,Oh, Il-Hwan,Lee, Seul-Gi,Choi, Hyung-Kyoon The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Processing technologies, which are required in the production of traditional Chinese medicine (TCM), has garnered attention in recent years. To address challenges associated with processed TCM and to promote its development in academia and industries, the application of metabolomics was introduced in this review, which primarily focuses on exploring TCM theories, identification of discovered compounds, and the evaluation and quality control of TCM through metabolomics. Thus metabolomics could be a powerful method for the TCM processing industry.

Interference Alignment in Two-way Relay Channel with Compute-and-Forward

( Xue Jiang ),( Baoyu Zheng ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.2

This paper analyzes interference alignment in the two-way relay network with compute-and-forward in both single relay and multiple relays networks. The advantages of compute-and-forward over other relaying strategies are that it can relay only linear combinations of the useful signals and remove the noise. The algorithm proposed in this paper adopts the criterion of maximum SINR to derive the pre-coding matrix. The experimental results show that the performance of interference alignment in two-way relay channel via compute-and-forward is better than that of amplify-and-forward, and the total sum rate in the two-way multiple relay networks is larger than that in the two-way single relay networks.