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      • An Embedded Software Power Consumption Model based on Software Architecture and Support Vector Machine Regression

        Xiong Wei,Xiaobin Liu,Bing Guo,Shen Yan,Wenli Zhang 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.3

        As embedded devices prevail in daily life, high energy consumption caused by embedded software caught academic attentions. Multifarious testing and predicting methods are developed accordingly. This paper proposes a model about energy consumption of embedded device based on analysis of embedded software structure and support vector machine regression. The nonlinear relationship between energy consumption and software structure is revealed. The research finds software structure is determined by features like number of components, complexity of component interface, component coupling, and path length. These features are qualified and modeled by using support vector machine regression and energy consumption is predicted based on this model. The experiments results confirm the proposed model.

      • Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells

        Xiong, Wei,Jiang, Yong-Xin,Ai, Yi-Qin,Liu, Shan,Wu, Xing-Rao,Cui, Jian-Guo,Qin, Ji-Yong,Liu, Yan,Xia, Yao-Xiong,Ju, Yun-He,He, Wen-Jie,Wang, Yong,Li, Yun-Fen,Hou, Yu,Wang, Li,Li, Wen-Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

        Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.

      • Parecoxib: an Enhancer of Radiation Therapy for Colorectal Cancer

        Xiong, Wei,Li, Wen-Hui,Jiang, Yong-Xin,Liu, Shan,Ai, Yi-Qin,Liu, Rong,Chang, Li,Zhang, Ming,Wang, Xiao-Li,Bai, Han,Wang, Hong,Zheng, Rui,Tan, Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.

      • KCI등재
      • Non-Gaussian features of dynamic wind loads on a long-span roof in boundary layer turbulences with different integral-scales

        Xiongwei Yang,Qiang Zhou,Yongfu Lei,Yang Yang,Mingshui Li 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.5

        To investigate the non-Gaussian properties of fluctuating wind pressures and the error margin of extreme wind loads on a long-span curved roof with matching and mismatching ratios of turbulence integral scales to depth ( / ), a series of synchronized pressure tests on the rigid model of the complex curved roof were conducted. The regions of Gaussian distribution and non-Gaussian distribution were identified by two criteria, which were based on the cumulative probabilities of higher-order statistical moments (skewness and kurtosis coefficients, Sk and Ku) and spatial correlation of fluctuating wind pressures, respectively. Then the characteristics of fluctuating wind-loads in the non-Gaussian region were analyzed in detail in order to understand the effects of turbulence integral-scale. Results showed that the fluctuating pressures with obvious negative-skewness appear in the area near the leading edge, which is categorized as the non-Gaussian region by both two identification criteria. Comparing with those in the wind field with matching / , the range of non-Gaussian region almost unchanged with a smaller / , while the non-Gaussian features become more evident, leading to higher values of Sk, Ku and peak factor. On contrary, the values of fluctuating pressures become lower in the wind field with a smaller / , eventually resulting in underestimation of extreme wind loads. Hence, the matching relationship of turbulence integral scale to depth should be carefully considered as estimating the extreme wind loads of long-span roof by wind tunnel tests.

      • SCIESCOPUS

        Topology optimization for the design of perfect mode-converting anisotropic elastic metamaterials

        Yang, Xiongwei,Kim, Yoon Young ELSEVIER (APPLIED SCIENCE) 2018 COMPOSITE STRUCTURES -BARKING THEN OXFORD- Vol.201 No.-

        <P><B>Abstract</B></P> <P>This work is concerned with the topology optimization of anisotropic elastic metamaterials exhibiting perfect mode conversion, a newly discovered phenomenon that an incident longitudinal (transverse) mode is solely and maximally converted to a transmitted transverse (longitudinal) mode. The wave phenomenon occurs at a series of interference frequencies due to elaborate multimodal interferences, known as the perfect transmodal Fabry-Perot interferences. Because the metamaterial must satisfy unique anisotropic relations among its effective stiffness, design of its unit cell is difficult without a systematic strategy. Here, we propose a topology optimization method based on the effective material properties to design such artificial composites. The homogenization method is employed to evaluate the effective material properties and the anisotropy requirements are treated as a special form of constraints. Because there is no natural mass constraint, we propose to maximize the effective longitudinal-transverse coupling stiffness for stable convergence. The sensitivity analysis is performed analytically within the finite element framework to update the design variables. The validity and effectiveness of the developed method are verified by considering different lattice types and interference cases. Considering the wide potential applications of anisotropic metamaterials in industrial applications, the developed numerical method can be an important and critically useful design tool.</P>

      • Intelligent computer modeling of large amplitude behavior of FG inhomogeneous nanotubes

        Wu, Xiongwei,Fang, Ting Techno-Press 2022 Advances in nano research Vol.12 No.6

        In the current study, the nonlinear impact of the Von-Kármán theory on the vibrational response of nonhomogeneous structures of functionally graded (FG) nano-scale tubes is investigated according to the nonlocal theory of strain gradient theory as well as high-order Reddy beam theory. The inhomogeneous distributions of temperature-dependent material consist of ceramic and metal phases in the radial direction of the tube structure, in which the thermal stresses are applied due to the temperature change in the thickness of the pipe structure. The general motion equations are derived based on the Hamilton principle, and eventually, the acquired equations are solved and modeled by the Meshless approach as well as a computer simulation via intelligent mathematical methodology. The attained results are helpful to dissect the stability of the MEMS and NEMS.

      • KCI등재

        Speech Denoising via Low-Rank and Sparse Matrix Decomposition

        Jianjun Huang,Xiongwei Zhang,Yafei Zhang,Xia Zou,Li Zeng 한국전자통신연구원 2014 ETRI Journal Vol.36 No.1

        In this letter, we propose an unsupervised framework forspeech noise reduction based on the recent development oflow-rank and sparse matrix decomposition. The proposedframework directly separates the speech signal from noisyspeech by decomposing the noisy speech spectrogram intothree submatrices: the noise structure matrix, the clean speechstructure matrix, and the residual noise matrix. Evaluations onthe Noisex-92 dataset show that the proposed method achievesa signal-to-distortion ratio approximately 2.48 dB and 3.23 dBhigher than that of the robust principal component analysismethod and the non-negative matrix factorization method,respectively, when the input SNR is –5 dB.

      • KCI등재

        Robust Non-negative Matrix Factorization with β-Divergence for Speech Separation

        Yinan Li,Xiongwei Zhang,Meng Sun 한국전자통신연구원 2017 ETRI Journal Vol.39 No.1

        This paper addresses the problem of unsupervised speech separation based on robust non-negative matrix factorization (RNMF) with β-divergence, when neither speech nor noise training data is available beforehand. We propose a robust version of non-negative matrix factorization, inspired by the recently developed sparse and low-rank decomposition, in which the data matrix is decomposed into the sum of a low-rank matrix and a sparse matrix. Efficient multiplicative update rules to minimize the β-divergence-based cost function are derived. A convolutional extension of the proposed algorithm is also proposed, which considers the time dependency of the non-negative noise bases. Experimental speech separation results show that the proposed convolutional RNMF successfully separates the repeating time-varying spectral structures from the magnitude spectrum of the mixture, and does so without any prior training.

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