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A Xin,Liu Mingliang,Chen Tong,Chen Feng,Qian Geng,Zhang Ying,Chen Yundai 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.9
Objective: To investigate the predictive value of radiomics features based on cardiac magnetic resonance (CMR) cine images for left ventricular adverse remodeling (LVAR) after acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: We conducted a retrospective, single-center, cohort study involving 244 patients (random-split into 170 and 74 for training and testing, respectively) having an acute STEMI (88.5% males, 57.0 ± 10.3 years of age) who underwent CMR examination at one week and six months after percutaneous coronary intervention. LVAR was defined as a 20% increase in left ventricular end-diastolic volume 6 months after acute STEMI. Radiomics features were extracted from the oneweek CMR cine images using the least absolute shrinkage and selection operator regression (LASSO) analysis. The predictive performance of the selected features was evaluated using receiver operating characteristic curve analysis and the area under the curve (AUC). Results: Nine radiomics features with non-zero coefficients were included in the LASSO regression of the radiomics score (RAD score). Infarct size (odds ratio [OR]: 1.04 (1.00–1.07); P = 0.031) and RAD score (OR: 3.43 (2.34–5.28); P < 0.001) were independent predictors of LVAR. The RAD score predicted LVAR, with an AUC (95% confidence interval [CI]) of 0.82 (0.75–0.89) in the training set and 0.75 (0.62–0.89) in the testing set. Combining the RAD score with infarct size yielded favorable performance in predicting LVAR, with an AUC of 0.84 (0.72–0.95). Moreover, the addition of the RAD score to the left ventricular ejection fraction (LVEF) significantly increased the AUC from 0.68 (0.52–0.84) to 0.82 (0.70–0.93) (P = 0.018), which was also comparable to the prediction provided by the combined microvascular obstruction, infarct size, and LVEF with an AUC of 0.79 (0.65–0.94) (P = 0.727). Conclusion: Radiomics analysis using non-contrast cine CMR can predict LVAR after STEMI independently and incrementally to LVEF and may provide an alternative to traditional CMR parameters.
An Xin,Xing Guannan,Wang Jing,Tian Yanhong,Liu Yunfang,Wan Qiong 한국탄소학회 2021 Carbon Letters Vol.31 No.4
The carbon spheres (CSs) synthesized by an ultrasonic-spray pyrolysis method were activated for supercapacitor electrode. There are plenty of cracks on the surface of the activated carbon spheres (ACSs), which expend with increasing the activation temperature and activator dosage. The specifc capacitance of ACSs increases with the activation temperature and activator dosage and reach to maximal value at certain conditions. Importantly, the ACS sample activated at relatively low activation temperature (600 °C) and 7 of mass ratio of KOH to CSs has the highest specifc capacitance (about 209 F g−1 at 50 mA g−1 of current density) and indicates the excellent cycling stability after 1000 consecutive charge–discharge cycles. Furthermore, the graphene sheets could be found in the samples that were activated at 1000 °C. And the electrode prepared by the sample has the very low series resistance because of the excellent conductivity of the formed graphene sheets.
Xin Liu,Xin-Huai Zhao 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.3
Mucor-fermented Mao-tofu at 3–7 days was extracted using water (pH 4.5 and pH 6.5) and ethanol solutions (40 and 80%, v/v). At protein concentration of 40 lg/mL, all the extracts showed immune activities via activating macrophages, splenocytes, and natural killer cells, which enhances the secretion of interleukin (IL)-2, interferon-c, tumor necrosis factor-a, IL-1b, IL-6, inducible nitric oxide synthase, and lysozyme, but inhibits the secretion of IL-4. All the extracts exhibited higher activities than that of soybean protein, demonstrating that Mucor-mediated fermentation enhanced the immune potentials of Mao-tofu. Fermentation time of 6 days ensured the extracts the highest activities, whereas lower activities were detected. The highest and lowest activities were detected on using a solution of water (pH 6.5) and 40% ethanol, respectively. The extract obtained using water (pH 6.5) contained more Arg and Cys with immune significance, which partially contributed to its high activities. Both fermentation times and extracting solvents were thus proved to affect the immune activities of soluble Maotofu extracts.
Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Xin Liu,Yanyan He,Wen Xie,Qingjun Wu,Youjun Zhang,Yong Liu,Shaoli Wang 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.2
Encarsia formosa Gahan is a solitary endoparasitoid that is commercially reared and released for augmentative biological control of whiteflies including Bemisia tabaci (Gennadius). Bemisia tabaci biotypes B and Q are two most invasive species that greatly reduce crop yields in China by feeding on plant sap and by transmitting Tomato Yellow Leaf Curl Virus (TYLCV). The effects of TYLCV infection of tomato on E. formosa foraging on B. tabaci B and Q are unknown. In Y-tube olfactometer assays in the present study, E. formosa significantly preferred TYLCVinfected tomato plants over TYLCV-free plants. The wasp females also significantly preferred TYLCV-infected tomato plants infested with 3rd-instar nymphs of B. tabaci biotype Q over TYLCV-free plants with biotype Q nymphs. However, no significant differences were observed when B. tabaci biotype B was infested on tomato plants. The oviposition bioassays confirmed that TYLCV infection on tomato plants resulted in the recruitment of parasitoids. These results indicate that TYLCV-infection of tomato increase the foraging of E. formosa on B. tabaci, as differs on the B and Q biotypes.
Xin Liu,Jianbo Sun 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.9
Cu/Cu2O nanoparticles-reduced graphene oxide composites (CuGCs) have been successfully prepared by a facile solvothermal method. The combined characterizations indicate the successful formation of CuGCs. The ~3 nm Cu/Cu2O nanoparticles homogeneously in situ grow on reduced graphene oxide sheets. CuGCs-based gas sensors were investigated for detection of NO2 at room temperature. The CuGCs exhibited fast response behavior, relatively high response and could achieve a detection limit as low as 5 ppm. Furthermore, sensing mechanism and the reason for enhancing sensing performance have also been discussed.
Feature-preserving, Adaptive and Anisotropic Smoothing Algorithm for Triangular Mesh Models
Liu Xu-min,Yang Li-xin,Li Cai-ling 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.11
Despite the great success in smoothing of triangular mesh, the classical methods mostly require human interactions. In order to reduce the parameter settings, an adaptive and anisotropic smoothing algorithm for removing noise and preserving features of triangular mesh model was proposed. First calculate the expected normal vector of the model triangles, the expected normal vector should be an accurate representation of the desired movement direction and be similar to the original surface normal vector, and then we compute the value of the offset value. We develop an adaptive coefficient scheme which can avoid the parameter settings to obtain the coefficient value for each vertex. Finally, we updated every vertex’s position of the model by formula. Experimental results show that the algorithm can be adaptive to preserve sharp features and avoid shrinkages by comparing with classical methods.