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      • Early Childhood Education Policy Development in China

        Xin Zhou 육아정책연구소 2011 International Journal of Child Care and Education Vol.5 No.1

        Great progress in the field of early childhood education policy in China has been made in 2010. In the light of the National Plan for Medium and the Long-term Program for Education Reform and Development, the Chinese government has made a series of efforts aimed at promoting the development of early childhood education. The new policies include an increase in the 3-year early childhood program enrollment; the clarification of the governments’ main responsibilities for the provision of early childhood education; an increase of funding for early childhood education, (especially for disadvantaged children); the strengthening of teacher capacity; and the strengthening of program quality and management amongst other changes. Each province has developed a 3-year Action Plan to implement the policy. The challenges for the implementation of the new policy are also discussed.

      • Association Between Single Nucleotide Polymorphisms in the XRCC1 Gene and Susceptibility to Prostate Cancer in Chinese Men

        Zhou, Yun-Feng,Zhang, Guang-Bo,Qu, Ping,Zhou, Jian,Pan, Hui-Xin,Hou, Jian-Quan Asian Pacific Organization for Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

        Background: Prostate cancer (Pca) is one of the most common complex and polygenic diseases in men. The X-ray repair complementing group 1 gene (XRCC1) is an important candidate in the pathogenesis of Pca. The purpose of this study was to evaluate the association between single nucleotide polymorphisms in the XRCC1 gene and susceptibility to Pca. Materials and Methods: XRCC1 gene polymorphisms and associations with susceptibility to Pca were investigated in 193 prostate patients and 188 cancer-free Chinese men. Results: The c.910A>G variant in the exon9 of XRCC1 gene could be detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Significantly increased susceptibility to prostate cancer was noted in the homozygote comparison (GG versus AA: OR=2.95, 95% CI 1.46-5.42, ${\chi}^2$=12.36, P=0.001), heterozygote comparison (AG versus AA: OR=1.76, 95% CI 1.12-2.51, ${\chi}^2$=4.04, P=0.045), dominant model (GG/AG versus AA: OR=1.93, 95% CI 1.19-2.97, ${\chi}^2$=9.12, P=0.003), recessive model (GG versus AG+AA: OR=2.17, 95% CI 1.33-4.06, ${\chi}^2$=8.86, P=0.003) and with allele contrast (G versus A: OR=1.89, 95% CI 1.56-2.42, ${\chi}^2$=14.67, P<0.000). Conclusions: These findings suggest that the c.910A>G polymorphism of the XRCC1 gene is associated with susceptibility to Pca in Chinese men, the G-allele conferring higher risk.

      • Limited Diagnostic Value of microRNAs for Detecting Colorectal Cancer: A Meta-analysis

        Zhou, Xuan-Jun,Dong, Zhao-Gang,Yang, Yong-Mei,Du, Lu-Tao,Zhang, Xin,Wang, Chuan-Xin Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

        Background: MicroRNAs have been demonstrated to play important roles in the development and progression of colorectal cancer. Several studies utilizing microRNAs as diagnostic biomarkers for colorectal cancer (CRC) have been reported. The aim of this meta-analysis was to comprehensively and quantitatively summarize the diagnostic value of microRNAs for detecting colorectal cancer. Methods: We searched PubMed, Embase and Cochrane Library for published studies that used microRNAs as biomarkers for the diagnosis of colorectal cancer. Summary estimates for sensitivity, specificity and other measures of accuracy of microRNAs in the diagnosis of colorectal cancer were calculated using the bivariate random effects model. A summary receiver operating characteristic (SROC) curve was also generated to summarize the overall effectiveness of the test. Result: Thirteen studies from twelve published articles met the inclusion criteria and were included. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odd ratio of microRNAs for the diagnosis of colorectal cancer were 0.81 (95%CI: 0.79-0.84), 0.78 (95%CI: 0.75-0.82), 4.14 (95%CI: 2.90-5.92), 0.24 (95%CI: 0.19-0.30), and 19.2 (95%CI: 11.7-31.5), respectively. The area under the SROC curve was 0.89. Conclusions: The current evidence suggests that the microRNAs test might not be used alone as a screening tool for CRC. Combining microRNAs testing with other conventional tests such as FOBT may improve the diagnostic accuracy for detecting CRC.

      • Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

        Zhou, Xin,Gu, Yang,Zhang, Shu-Lan Asian Pacific Organization for Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

        Objective: The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation of the association between p53 codon 72 polymorphism (Arg72Pro, rs1042522 G>C) and cervical cancer risk among Asians. Methods: A literature search of Pubmed, Embase, Web of Science and CBM databases from inception through June 2012 was conducted. The meta-analysis was performed using STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Twenty-eight case-control studies were included with a total of 3,580 cervical cancer cases and 3,827 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results showed that the Pro/Pro genotype was associated with increased risk of cervical cancer under the heterozygous model (Pro/Pro vs. Arg/Pro: OR = 1.25, 95%CI: 1.02-1.53, P= 0.005). However, no statistically significant associations were found under four other genetic models (Pro vs. Arg: OR = 0.97, 95%CI: 0.85-1.10, P= 0.624; Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 0.84, 95%CI: 0.70-1.01, P= 0.058; Pro/Pro vs. Arg/Arg + Arg/Pro: OR = 1.13, 95%CI: 0.92-1.39, P= 0.242; Pro/Pro vs. Arg/Arg: OR = 0.97, 95%CI: 0.76-1.22, P= 0.765; respectively). In the subgroup analysis based on country, the Pro/Pro genotype and Pro carrier showed significant associations with increased risk of cervical cancer among Indian populations, but not among Chinese, Japanese and Korean populations. Conclusion: Results from the current meta-analysis suggests that p53 codon 72 polymorphism might be associated with increased risk of cervical cancer, especially among Indians.

      • A dual FRET based fluorescent probe as a multiple logic system

        Zhou, Xin,Wu, Xue,Yoon, Juyoung The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.1

        <P>A new fluorescent probe with a unique sequential dual FRET process was designed and constructed. This probe showed distinguished responses towards Fe<SUP>3+</SUP> and Hg<SUP>2+</SUP>, making it an ideal candidate for multiple logic operations at the molecular level.</P> <P>Graphic Abstract</P><P>The dual FRET based fluorescent probe showed distinguished responses towards Fe<SUP>3+</SUP> and Hg<SUP>2+</SUP>, making it an ideal candidate for multiple logic operations at the molecular level. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc08245a'> </P>

      • KCI등재

        AR Interaction Design Mode of Multi-user and Multi-character in Theme Parks

        Zhou Xin,반영환 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.6

        Objective: This paper expounds the influencing factors of interactive experience combining users and character images, and clarifies the relationship between them, to create the multi-user and multi-character interactive design method and framework of the theme park based on augmented reality technology, which used to improve the satisfaction of the interaction between the user and the character. Background: In theme parks, the design mode of the user and character interaction based on augmented reality is usually digital display through head-mounted display or handheld device. The disadvantage of the AR platform is that the experience of individual users and conditions are limited, and the lack of multiple users and multiple characters to participate in the interactive process of the real environment. Method: Through the interactive experience survey and role image scene recognition survey and analysis of specific users of theme parks, combined with the interactive design development needs of theme parks, the analysis and information architecture of multi-user interaction requirements based on the combination of real-world environment and characteristic role image based on AR technology Combing, build multimodal interaction design structure and dynamic behavior patterns. Results: Interaction Design model of multi-user and multi-character based on AR technology interaction, helps meet user expectations and interaction needs. It creates a solution for multi-user and multi-character interaction in the theme park, so that users don't have to worry about any equipment, thus creating the walk-in game experience, and the expertise of multimodal is also more accessible for users to high engage in the theme park with character interaction. Conclusion: AR based multi-user and multi-character interaction design model can give full play to the effects of AR technology and provide a general solution to the limitations of theme parks' character interaction design that can emulate in specific interaction scenarios. And complements the academic research on multi-user and multi-role in theme parks in theory filed. Application: In this situation, one thing is predictable: the interactive design model developed in this study can apply to user and character interaction in various theme parks, which is helpful for brand identification and character communication of different theme parks.

      • KCI등재

        Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model

        Xin Zhou,Kim Sung Won,Oak Chulho,Kwon Daa Young,Choi Jin Hyuk,Ko Taek Yong,Kim Jun Hyeong,Tang Shuo,Ahn Yeh-Chan 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.1

        BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord cause changes in the voice. Polarization-sensitive optical coherence tomography (PS-OCT) enables phase retardation measurement to evaluate birefringence of tissue with varied organization of collagen fibers in different tissue layers. Therefore, PS-OCT can visualize structural changes between normal and abnormal vocal cord tissue. METHOD: A rabbit laryngeal tumor model with different stages of tumor progression was investigated ex-vivo by PS-OCT. A phase retardation slope-based analysis, which quantifies the birefringence in different layers, was conducted to distinguish the epithelium, lamina propria, and muscle layers. RESULTS: The PS-OCT images showed a gradual decrease in birefringence from normal tissue to advanced tumor tissue. The quantitative analysis provided a more detailed comparison among different stages of the rabbit laryngeal tumor model, which was validated by the corresponding histological findings. CONCLUSION: Differences in tissue birefringence was evaluated by PS-OCT phase retardation measurement. It is also possible to indirectly infer the dysplastic changes based on the mucosal and submucosal alterations. BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord cause changes in the voice. Polarization-sensitive optical coherence tomography (PS-OCT) enables phase retardation measurement to evaluate birefringence of tissue with varied organization of collagen fibers in different tissue layers. Therefore, PS-OCT can visualize structural changes between normal and abnormal vocal cord tissue. METHOD: A rabbit laryngeal tumor model with different stages of tumor progression was investigated ex-vivo by PS-OCT. A phase retardation slope-based analysis, which quantifies the birefringence in different layers, was conducted to distinguish the epithelium, lamina propria, and muscle layers. RESULTS: The PS-OCT images showed a gradual decrease in birefringence from normal tissue to advanced tumor tissue. The quantitative analysis provided a more detailed comparison among different stages of the rabbit laryngeal tumor model, which was validated by the corresponding histological findings. CONCLUSION: Differences in tissue birefringence was evaluated by PS-OCT phase retardation measurement. It is also possible to indirectly infer the dysplastic changes based on the mucosal and submucosal alterations.

      • KCI등재

        A Longitunal Study on Young Children's Development of the Representation of Written Number Symbols

        Xin Zhou,Jianhong Wang 한국유아교육학회 2006 INTERNATIONAL JOURNAL OF EARLY CHILDHOOD EDUCATION Vol.12 No.1

        Young children’s representation of written number symbols was examined at 4 time points during two years (mean age=55, 64, 70 & 76 months). Measurements were Number Symbol Representation Task; Cardinal Concept Task; Written Addition and Subtraction Task and Written Arithmetic Formula Representation Task. The results indicated children’s rapid development in the ability to represent written number symbols. Scores on Written Number Symbolic Tasks, Cardinal Concept and Written Addition and Subtraction Task were significantly correlated. Performance of children in university affiliated childcare center surpassed that of the center serving working families at Time 1, but the advantage of the center faded at Time 3 and Time 4. A multiple regression analysis identified 2 significant predictors for children’s representation of written number symbols at the end of kindergarten: written number symbol representation score at Time 1 and the type of kindergarten.

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