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Zhou Xin Ting,Liu Jin Yan 한국고분자학회 2022 Macromolecular Research Vol.30 No.5
Acetylation of bacterial cellulose whisker (BCW) with acetic anhydride can effectively improve the thermal stability of BCW and the dispersion of interface compatibility with PHBV. The influence of the modified cellulose whiskers on the crystallization and mechanical properties of the PHBV matrix was studied using differential scanning calorimetry (DSC), polarization optical microscopy (POM), and XRD. The results show that ABCW has heterogeneous nucleation and hindrance effect on the PHBV matrix simultaneously. With the increase of ABCW content, PHBV gradually decreases from large spherulite and then increases, and the crystallinity decreases. When the content of ABCs is 1.2%, ABCW has the best strengthening effect on PHBV, and the bending strength and bending modulus are 44.7% and 34.5% higher than PHBV.
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Xin Zhou,Kim Sung Won,Oak Chulho,Kwon Daa Young,Choi Jin Hyuk,Ko Taek Yong,Kim Jun Hyeong,Tang Shuo,Ahn Yeh-Chan 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.1
BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord cause changes in the voice. Polarization-sensitive optical coherence tomography (PS-OCT) enables phase retardation measurement to evaluate birefringence of tissue with varied organization of collagen fibers in different tissue layers. Therefore, PS-OCT can visualize structural changes between normal and abnormal vocal cord tissue. METHOD: A rabbit laryngeal tumor model with different stages of tumor progression was investigated ex-vivo by PS-OCT. A phase retardation slope-based analysis, which quantifies the birefringence in different layers, was conducted to distinguish the epithelium, lamina propria, and muscle layers. RESULTS: The PS-OCT images showed a gradual decrease in birefringence from normal tissue to advanced tumor tissue. The quantitative analysis provided a more detailed comparison among different stages of the rabbit laryngeal tumor model, which was validated by the corresponding histological findings. CONCLUSION: Differences in tissue birefringence was evaluated by PS-OCT phase retardation measurement. It is also possible to indirectly infer the dysplastic changes based on the mucosal and submucosal alterations. BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord cause changes in the voice. Polarization-sensitive optical coherence tomography (PS-OCT) enables phase retardation measurement to evaluate birefringence of tissue with varied organization of collagen fibers in different tissue layers. Therefore, PS-OCT can visualize structural changes between normal and abnormal vocal cord tissue. METHOD: A rabbit laryngeal tumor model with different stages of tumor progression was investigated ex-vivo by PS-OCT. A phase retardation slope-based analysis, which quantifies the birefringence in different layers, was conducted to distinguish the epithelium, lamina propria, and muscle layers. RESULTS: The PS-OCT images showed a gradual decrease in birefringence from normal tissue to advanced tumor tissue. The quantitative analysis provided a more detailed comparison among different stages of the rabbit laryngeal tumor model, which was validated by the corresponding histological findings. CONCLUSION: Differences in tissue birefringence was evaluated by PS-OCT phase retardation measurement. It is also possible to indirectly infer the dysplastic changes based on the mucosal and submucosal alterations.
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Xin Zhou,Jie Liu 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.4
Efficient elimination of algal cells with simultaneous inhibition of algal organic matters release is vital forthe safety of drinking water. TiCl3 as a coagulant was first applied for Microcystis aeruginosa removal in the presentstudy. At the same dosage of 130 M, higher removal efficiency of 98.1% for algae cells was obtained in TiCl3 coagulationthan 64.5% for TiCl4, and the same trend was observed in turbidity and dissolved organic compound removal. Owing to the low reduction capacity of TiCl3, a low damage cell ratio was achieved. While charge neutralization plays acrucial role in the TiCl3 coagulation, the reduction capacity of TiCl3 appears to be decisive for improving the algaeremoval efficiency. This study suggests that TiCl3 could be a promising coagulant for efficient removal of algae andinhibition of algal organic matter release.
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Limited Diagnostic Value of microRNAs for Detecting Colorectal Cancer: A Meta-analysis
Zhou, Xuan-Jun,Dong, Zhao-Gang,Yang, Yong-Mei,Du, Lu-Tao,Zhang, Xin,Wang, Chuan-Xin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Background: MicroRNAs have been demonstrated to play important roles in the development and progression of colorectal cancer. Several studies utilizing microRNAs as diagnostic biomarkers for colorectal cancer (CRC) have been reported. The aim of this meta-analysis was to comprehensively and quantitatively summarize the diagnostic value of microRNAs for detecting colorectal cancer. Methods: We searched PubMed, Embase and Cochrane Library for published studies that used microRNAs as biomarkers for the diagnosis of colorectal cancer. Summary estimates for sensitivity, specificity and other measures of accuracy of microRNAs in the diagnosis of colorectal cancer were calculated using the bivariate random effects model. A summary receiver operating characteristic (SROC) curve was also generated to summarize the overall effectiveness of the test. Result: Thirteen studies from twelve published articles met the inclusion criteria and were included. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odd ratio of microRNAs for the diagnosis of colorectal cancer were 0.81 (95%CI: 0.79-0.84), 0.78 (95%CI: 0.75-0.82), 4.14 (95%CI: 2.90-5.92), 0.24 (95%CI: 0.19-0.30), and 19.2 (95%CI: 11.7-31.5), respectively. The area under the SROC curve was 0.89. Conclusions: The current evidence suggests that the microRNAs test might not be used alone as a screening tool for CRC. Combining microRNAs testing with other conventional tests such as FOBT may improve the diagnostic accuracy for detecting CRC.
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