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Wang, Xiaojing,Wang, Yanfeng,Zheng, Xu,Hao, Xiyan,Liang, Yan,Wu, Manlin,Wang, Xiao,Wang, Zhigang Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.12
Ras homolog enriched in brain (Rheb) and FK506 binding protein 38 (FKBP38) are two important regulatory proteins in the mammalian target of rapamycin (mTOR) pathway. There are contradictory data on the interaction between Rheb and FKBP38 in human cells, but this association has not been examined in cashmere goat cells. To investigate the interaction between Rheb and FKBP38, we overexpressed goat Rheb and FKBP38 in goat fetal fibroblasts, extracted whole proteins, and performed coimmunoprecipitation to detect them by western blot. We found Rheb binds directly to FKBP38. Then, we constructed bait vectors (pGBKT7-Rheb/FKBP38) and prey vectors (pGADT7-Rheb/FKBP38), and examined their interaction by yeast two-hybrid assay. Their direct interaction was observed, regardless of which plasmid served as the prey or bait vector. These results indicate that the 2 proteins interact directly in vivo. Novel evidence is presented on the mTOR signal pathway in Cashmere goat cells.
Once-weekly Subcutaneous Administration of Bortezomib in Patients with Multiple Myeloma
Wang, Liang,Wang, Ke-Feng,Chang, Bo-Yang,Chen, Xiao-Qin,Xia, Zhong-Jun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.
Optimal LQG Control for Networked Control Systems with Remote and Local Controllers
Xiao Liang,Juanjuan Xu,Xiao Lu,Qingyuan Qi,Haixia Wang,Rong Gao 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.1
We consider the finite horizon optimal LQG control problem for networked control systems with a remote controller, a local controller and communication channels with packet dropouts and transmission delays. The local controller can directly observe state signals and send them to the remote controller via a packet-dropout channel. Then the remote controller sends the received measurement signals to the local controller. Afterwards, the two controllers operate the plant through a delayed channel. The contributions of this paper are as follows: Firstly, at the side of the remote controller, we develop an optimal estimator to show that the separation principle holds. Secondly, we derive a non- homogeneous relationship between the state and the costate of systems in virtue of the maximum principle. Finally, a necessary and sufficient condition for the optimal control problem is derived in terms of the two coupled Riccati equations. Numerical examples are employed to illustrate the theoretical results.
Xiao Lu,Yuanyu Cai,Guilin Zhang,Hongxia Wang,Haixia Wang,Xiao Liang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5
This paper considers optimal control problem for networked control systems (NCSs) with Markovian packet dropouts. Since previous literatures generally consider the one-way Markovian packet dropouts, i.e., from the sensor to the estimator or from the controller to the actuator. To make a further study of this issue, we aim to give the complete solution to the control problem of the two-way Markovian packet dropouts, i.e., from the sensor to the estimator and from the controller to the actuator. Firstly, by applying the Pontryagin’s maximum principle and mathematical induction method, a solution to the forward and backward stochastic difference equations (FBSDEs) is derived. Secondly, in virtue of the solution to the FBSDEs, we obtain the necessary and sufficient condition for the optimal control problem. Thirdly, the optimal controller is given based on the complete square method. Finally, numerical examples are proposed to illustrate the effectiveness of the theoretical results.
Further Study on Networked Control Systems with Unreliable Communication Channels
Xiao Lu,Na Wang,Qingyuan Qi,Xiao Liang,Haixia Wang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1
This paper focuses on the fundamental problems of linear quadratic gaussian (LQG) control and stabilization problems for networked control systems (NCSs) with unreliable communication channels (UCCs) wherepacket dropout, input delay and observation delay occur. These basic issues have attracted extensive attentions dueto broad applications. Our contributions are as follows. For the finite horizon case, without time-stamping technique, the optimal estimator is derived by using the novelty method of innovation sequences based on the delayedintermittent observations; A necessary and sufficient condition for the optimal control problem is presented on thebasis of the solution to the forward and backward difference equations (FBDEs) and two coupled Riccati equations. For the infinite horizon case, it is shown that under certain assumption, the system can stay bounded in the meansquare sense if and only if the algebraic Riccati equation admits the unique positive solution.
Xiao-Min Wang,Liao-Liang Ke,Yue-Sheng Wang 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.87 No.1
This paper investigates the dynamic response of a functionally graded material (FGM) coated half-plane excited by distributed time harmonic loading. Three types of typical distributed surface loads, including uniform load, Hertz load, and square-root singular load, are considered. The mass density and elastic modulus of the FGM coating are supposed to be described by the exponential function. The material damping is modelled by a linearly hysteretic damping which is expressed by a complex modulus in the time harmonic motion. Using Fourier integral transform technique and numerical integral method, the effects of the excitation frequency, gradient index, damping, and load type on the dynamic stresses and displacements are discussed.
Prevalence and Genotype Distribution of Human Papillomavirus among Women from Henan, China
Wang, Xiao-Chuan,Sun, Liang-Qi,Ma, Li,Li, Hua-Xin,Wang, Xiu-Li,Wang, Xin,Yun, Tian,Meng, Nian-Long,Lv, Da-Le Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Human papillomavirus (HPV) infection has been implicated as a causative of cervical cancer. In the present study, a total of 578 samples from females attending the gynecological outpatient clinic in Henan province, China, were collected and the HPV genotypes were detected by gene chip and flow-through hybridization. Overall, 44.5% (257/578) females were found to be HPV DNA positive, and the high risk HPV (HR-HPV) rate was 35.1% (203/578). The first peak of HR-HPV infection appeared in the >60 year-old group (55.0%), and the second was within the 51-55 year-old group (50.0%) (${\chi}^2$=19.497, p<0.05). HPV 16 was the most prevalent genotype (9.2%), followed by HPV 52 (7.8%), HPV 6 (6.9%), HPV 11 (5.9%) and HPV 42 (5.0%). The single type HPV infection was 30.4%, with the five majority prevalent genotype HPV 16 (16.5%), HPV 52 (14.3%), HPV 6 (12.6%), HPV 42 (8.6%), HPV 31 (5.1%). The multiple-type HPV infections were 14.0%, and HPV 16 was the most prevalent type (29.6%), followed by HPV 52 (24.7%), HPV 6 (22.2%), HPV 11 (22.2%), HPV 42 (17.3%) and HPV 39 (17.3%).
A novel method for the synthesis of nano-sized MgAl2O4 spinel ceramic powde
Xiao-ping Liang,Rong-tao Wang,Ying Peng,Xiao-wei Fan,Jian-xin Li 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.2
This study describes the preparation and characterization of MgAl2O4 spinel ceramic powders by a polyacrylamide gel method with Al(NO3)3·9H2O and Mg(NO3)3·6H2O as the raw materials, acrylamide as the monomer, N,N-mehtylenebisacrylamide as the cross-linking agent, and deionized water as the solvent. The nanopowders were studied by X-ray diffraction (XRD) and a transmission electron microscope (TEM). The results showed that the nanopowders having a typical spinel structure are ultrapure and nano-sized. Due to the hindering effect of the polyacrylamide network, the average grain size of the MgAl2O4spinel is approximately 20 nm. Moreover, it is confirmed that the optimal sintering temperature for synthesizing the MgAl2O4spinel ceramic nanopowders is 900 oC, which is about 600-1000 oC lower than that of the traditional solid-state method.