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Yu Xi Terence Law,Wei Jing Kelven Chen,Liang Shen,Wei Jin Chua 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.5
Purpose: Transurethral needle ablation (TUNA) is a minimally invasive procedure for the treatment of symptomatic benign prostatic hyperplasia (BPH). Compared to transurethral resection of the prostate (TURP), office-based TUNA is an attractive alternative as it is minimally invasive and avoids general anaesthesia. The aim of this study is to evaluate the efficacy of single session office-based TUNA. Materials and Methods: Data of 121 patients who had undergone TUNA was retrieved from June 2008 to March 2017. Patients were followed-up with visits at 1, 3, 6, and 12-months with the International Prostate Symptom Score (IPSS), quality of life (QoL) scoring and uroflowmetry. Results: Patients were 39 to 85 years old. The prostate volumes were 20.00 to 96.90 mL with a median of 26.95 mL. The median IPSS score pre-TUNA was 19, median QOL score pre-TUNA was 4 and median maximum urinary flow (Qmax) pre-TUNA was 10.3 mL/s. There is 65% improvement of IPSS post-TUNA (p<0.001). There is 75% improvement of QOL post-TUNA QOL (p<0.001). There is 35% improvement of Qmax post-TUNA Qmax (p<0.001). The mean relapse-free survival for TUNA is 6.123 years. The 1st, 3rd, and 5th year relapse-free survival rate were 91.7%, 76.6% and 63.7% respectively. Conclusions: Our study is the first to investigate the use of a single-setting office-based TUNA requiring minimal sedation in the Asian community. Complication rates were low in our series, with no associated mortality. When applied to selected patients, TUNA is an effective and reasonably safe alternative for the treatment of symptomatic BPH.
Deterministic Secure Quantum Communication Without Maximally Entangled States
Xi-Han Li,Fu-Guo Deng,Chun-Yan Li,Hong-Yu Zhou,Ping Zhou,Yu-Jie Liang 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.4
Two deterministic secure quantum communication schemes are proposed, one based on pure entangled states and the other on d-dimensional single-photon states. In these two schemes, only single-photon measurements are required for the two authorized users, which makes the schemes more convenient than others in practical applications. Although each qubit can be read out after a transmission of additional classical bit, it is unnecessary for the users to transmit qubits double the distance between the sender and the receiver, which will increase their bit rate and their security. The parties use decoy photons to check eavesdropping efficiently. The obvious advantage in the first scheme is that the pure entangled source is feasible with present techniques.
Yu, Min,Men, Hai-Tao,Niu, Zhi-Min,Zhu, Yu-Xi,Tan, Ben-Xu,Li, Long-Hao,Jiang, Juan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: The aim of this study was to analyze the prognostic implications of pretreatment circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) for the survival of patients with lung cancer. Materials and Methods: Relevant literature was identified using Medline and EMBASE. Patient clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with CEC and CEPC positive rates before treatment were extracted. STATA 12.0 was used for our analysis and assessment of publication bias. Results: A total of 13 articles (8 for CEC and 5 for CEPC, n=595 and n=244) were pooled for the global meta-analysis. The odds ratio (OR) for OS predicted by pretreatment CECs was 1.641 [0.967, 2.786], while the OR for PFS was 1.168 [0.649, 2.100]. The OR for OS predicted by pretreatment CEPCs was 12.673 [5.274, 30.450], while the OR for PFS was 4.930 [0.931, 26.096]. Subgroup analyses were conducted according to clinical staging. Odds ratio (OR) showed the high level of pretreatment CECs only correlated with the OS of patients with advanced lung cancer (stage III-IV). Conclusions: High counts of CECs seem to be associated only with worse 1-year OS in patients with lung cancer, while high level of pretreatment CEPCs correlate with both worse PFS and OS.
Characteristics of Pre-alloyed Powders for Diamond Tools
Luo Xi-Yu,Ma Hong-Qiu,Kuang Xing,Huang Man,Tang Ming-Qiang 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
In this paper, the fundamental attributes, phase composition of three pre-alloyed powders for diamond tools by water atomization were investigated. The density, hardness, bend strength and bending modulus of their hot pressing samples were examined. The results showed that the three pre-alloyed powders have excellent low temperature sintering characteristics. The physical and mechanical properties of the samples were found to be nearly the same as those of fine cobalt powders.
Wang, Xi,Wang, Shu-Sen,Peng, Rou-Jun,Qin, Tao,Shi, Yan-Xia,Teng, Xiao-Yu,Liu, Dong-Gen,Chen, Wei-Qing,Yuan, Zhong-Yu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Purpose: This study aimed to assess possible interactive effects of coping styles and psychological stress on depression and anxiety symptoms in Chinese women shortly after diagnosis of breast cancer. Methods: Four hundred and one patients with breast cancer were face-to-face interviewed by trained research staff according to a standardized questionnaire including information on socio-demographic characteristics, psychological stress, coping styles, and anxiety and depressive symptoms. Interactive effects were assessed by hierarchical multiple regression analyses. Results: There were significant associations of the four domains of psychological stress with anxiety and depressive symptoms except for the relationship between "worrying about health being harmed" and depressive symptoms. "Abreaction coping behavior" and "escaping coping behavior" significantly increased the level of both anxiety and depressive symptoms; whereas an "active coping style" reswulted in significant decrease. The interaction of "active coping behavior" with "worrying about health being harmed" significantly increased the risk of the anxiety symptoms, while adopting "self-relaxing coping behavior" was associated with significant decrease. The interaction of "worry about daily life and social relationship being restricted" with "escaping coping behavior" significantly increased the risk of the depressive symptoms. Conclusions: The results of this study suggest that certain coping styles might moderate the association of psychological stress with anxiety and depressive symptoms in Chinese women with breast cancer.
An Emerging Role for Circular RNAs in Osteoarthritis
Chen-Xi Yu,Shui Sun 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.3
Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form acovalently closed continuous loop without 5’ or 3’ polarities. With the development of high throughput sequencing technology, alarge number of circRNAs have been discovered in many species. More importantly, growing evidence suggests that circRNAs areabundant, evolutionally conserved, and relatively stable in cells and tissues. Strikingly, recent studies have discovered that circRNAscan serve as microRNA sponges, interact with RNA-binding protein, and regulate gene transcription, as well as proteintranslation. Osteoarthritis (OA) is the most common chronic degenerative joint disease. CircRNAs are differentially expressed inOA cartilage. Moreover, some circRNAs are involved in multiple pathological processes during OA, mainly extracellular matrixdegradation, inflammation, and apoptosis. In this review, we briefly delineate the biogenesis, characteristics, and biofunctions ofcircRNAs, and then, focus on the role of circRNAs in the occurrence and progression OA.
Wei-Xi Shen,Guang-Hua Li,Yu-Jia Li,Peng-Fei Zhang,Jia-Xing Yu,Di Shang,Qiu-Shi Wang 대한암예방학회 2023 Journal of cancer prevention Vol.28 No.4
This study aimed to investigate the prognostic significance of tumor mutation burden (TMB) among patients with non-small cell lung cancer (NSCLC) who received platinum-based adjuvant chemotherapy. Tumor tissue specimens after surgical resection were collected for DNA extraction. Somatic mutation detection and TMB analysis were conducted using next-generation sequencing (NGS). Recurrence status of the patients was assessed in the hospital during the adjuvant chemotherapy period, and long-term survival data of patients were obtained by telephone follow-up. Univariate analysis between TMB status and prognosis was carried out by survival analysis. A retrospective review of 78 patients with non-squamous NSCLC who received platinum-based adjuvant chemotherapy showed a median disease-free survival of 3.6 years and median overall survival (OS) of 5.3 years. NGS analysis exhibited that the most common mutated somatic genes among the 78 patients were tumor suppressor protein p53 (TP53), epidermal growth factor receptor, low-density lipoprotein receptor related protein 1B, DNA methyltransferase 3 alpha and FAT atypical cadherin 3, and their prevalence was 56.4%, 48.7%, 37.2%, 30.7%, and 25.6%, respectively. TMB status was divided into TMB-L (≤ 4.5/Mb) and TMB-H (> 4.5/Mb) based on the median TMB threshold. Relevance of TMB to prognosis suggested that the median OS of patients with TMB-L was significantly longer than that of patients with TMB-H (NR vs. 4.6, P = 0.014). Higher TMB status conferred a worse implication on OS among patients with non-squamous NSCLC who received platinum-based adjuvant chemotherapy.