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Song, Jimyeong,Kemp, Michael G.,Choi, Junx2010,Hyuk John Wiley and Sons Inc. 2017 Photochemistry and photobiology Vol.93 No.1
<P><B>Abstract</B></P><P>The human nucleotide excision repair system targets a wide variety of DNA adducts for removal from DNA, including photoproducts induced by UV wavelengths of sunlight. A key feature of nucleotide excision repair is its dual incision mechanism, which results in generation of a small, damage‐containing oligonucleotide approximately 24 to 32 nt in length. Detection of these excised oligonucleotides using cell‐free extracts and purified proteins with defined DNA substrates has provided a robust biochemical assay for excision repair activity in vitro. However, the relevance of a number of in vitro findings to excision repair in living cells in vivo has remained unresolved. Over the past few years, novel methods for detecting and isolating the excised oligonucleotide products of repair in vivo have therefore been developed. Here we provide a basic outline of a sensitive and versatile in vivo excision assay and discuss how the assay both confirms previous in vitro findings and offers a number of advantages over existing cell‐based DNA repair assays. Thus, the in vivo excision assay offers a powerful tool for readily monitoring the repair of DNA lesions induced by a large number of environmental carcinogens and anticancer compounds.</P>
Kim, E. H.,Seguin, P.,Lee, J. E.,Yoon, C. G.,Song, H.x2010,K.,Ahn, J.x2010,K.,Chung, I.x2010,M. Blackwell Publishing Ltd 2011 Journal of agronomy and crop science Vol.197 No.1
<P><B>Abstract</B></P><P>The gradual disruption of the ozone layer in the stratosphere has resulted in increased exposure of plants to ultraviolet‐B (UV‐B, 280–315 nm) radiation. UV‐B radiation is known to affect crop growth and quality negatively. A study was conducted to determine the impact of elevated UV‐B radiation levels on the isoflavones and phenolic compound concentrations of seven soybean varieties. UV‐B radiation significantly reduced the concentration of most isoflavones and phenolic compounds in soybean seeds. Exposure to elevated UV‐B levels overall resulted in 35 % reduction in total isoflavones and 31 % in phenolic compounds concentrations. The effect on individual isoflavones and phenolic compounds depended on the compound and variety, but UV‐B overwhelmingly reduced concentrations. This study suggests that increased UV‐B radiation negatively impacted soybean quality by reducing the concentration of compounds that have health‐beneficial properties.</P>
Materials and Fabrication Processes for Transient and Bioresorbable High‐Performance Electronics
Hwang, Sukx2010,Won,Kim, Daex2010,Hyeong,Tao, Hu,Kim, Taex2010,il,Kim, Stanley,Yu, Ki Jun,Panilaitis, Bruce,Jeong, Jaex2010,Woong,Song, Junx2010,Kyul,Omenetto, Fiorenzo G.,Rogers, John. A. WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.33
<P><B>Abstract</B></P><P>Materials and fabrication procedures are described for bioresorbable transistors and simple integrated circuits, in which the key processing steps occur on silicon wafer substrates, in schemes compatible with methods used in conventional microelectronics. The approach relies on an unusual type of silicon on insulator wafer to yield devices that exploit ultrathin sheets of monocrystalline silicon for the semiconductor, thin films of magnesium for the electrodes and interconnects, silicon dioxide and magnesium oxide for the dielectrics, and silk for the substrates. A range of component examples with detailed measurements of their electrical characteristics and dissolution properties illustrate the capabilities. In vivo toxicity tests demonstrate biocompatibility in sub‐dermal implants. The results have significance for broad classes of water‐soluble, “transient” electronic devices.</P>
Lee, Kyoung G.,Park, Tae Jung,Soo, Song Young,Wang, Kye Won,Kim, Byeong I.I.,Park, Jae Hong,Lee, Changx2010,Soo,Kim, Do Hyun,Lee, Seok Jae Wiley Subscription Services, Inc., A Wiley Company 2010 Biotechnology and bioengineering Vol.107 No.4
<P><B>Abstract</B></P><P>We report herein an effective strategy for encapsulating <I>Escherichia coli</I> in polyethylene glycol diacrylate (PEGDA) microdroplets using a microfluidic device and chemical polymerization. PEGDA was employed as a reactant due to the biocompatibility, high porosity, and hydrophilic property. The uniform size and shape of microdroplets are obtained in a single‐step process using microfluidic device. The size of microdroplets can be controlled through the changing continuous flow rate. The combination of microdroplet generation and chemical polymerization techniques provide unique environment to produce non‐toxic ways of fabricating microorganism‐encapsulated hydrogel microbeads. Due to these unique properties of micro‐sized hydrogel microbeads, the encapsulated <I>E. coli</I> can maintain viability inside of microbeads and green fluorescent protein (GFP) and red fluorescent protein (RFP) genes are efficiently expressed inside of microbeads after isopropyl‐<I>β</I>‐<SMALL>D</SMALL>‐thiogalactopyranoside induction, suggesting that there is no low‐molecular weight substrate transfer limitation inside of microbeads. Furthermore, non‐toxic, gentle, and outstanding biocompatibility of microbeads, the encapsulated <I>E. coli</I> can be used in various applications including biotransformation, biosensing, bioremediation, and engineering of artificial cells. Biotechnol. Bioeng. 2010;107:747–751. © 2010 Wiley Periodicals, Inc.</P>
Hwang, J.x2010,H.,Jeong, J.x2010,W.,Song, G.x2010,H.,Koo, T.x2010,S.,Seo, K.x2010,W. John Wiley and Sons Inc. 2017 Journal of veterinary internal medicine Vol.31 No.3
<P><B>Background</B></P><P>Esomeprazole is an S‐enantiomer of omeprazole that has favorable pharmacokinetics and efficacious acid suppressant properties in humans. However, the pharmacokinetics and effects on intragastric pH of esomeprazole in dogs have not been reported.</P><P><B>Objective</B></P><P>To determine the pharmacokinetics of esomeprazole administered via various routes (PK study) and to investigate the effect of esomeprazole on intragastric pH with a Bravo pH monitoring system (PD study).</P><P><B>Animals</B></P><P>Seven adult male Beagle dogs and 5 adult male Beagle dogs were used for PK and PD study, respectively.</P><P><B>Methods</B></P><P>Both studies used an open, randomized, and crossover design. In the PK study, 7 dogs received intravenous (IV), subcutaneous (SC), and oral doses (PO) of esomeprazole (1 mg/kg). Each treatment period was separated by a washout period of at least 10 days. Esomeprazole plasma concentrations were measured by HPLC/MS/MS. In the efficacy study, intragastric pH was recorded without medication (baseline pH) and following IV, SC, and PO esomeprazole dosing regimens (1 mg/kg) in 5 dogs.</P><P><B>Results</B></P><P>The bioavailability of esomeprazole administered as PO enteric‐coated granules and as SC injections was 71.4 and 106%, respectively. The half‐life was approximately 1 hour. Mean ± SD percent time intragastric pH was ≥3 and ≥4 was 58.9 ± 21.1% and 40.9 ± 17.3% for IV group, 75.8 ± 16.4% and 62.7 ± 17.7% for SC group, 88.2 ± 8.9% and 82.5 ± 7.7% for PO group, and 12.5 ± 3.6% and 3.7 ± 1.8% for baseline. The mean percent time with intragastric pH was ≥3 or ≥4 was significantly increased regardless of the dosing route (<I>P</I> < .05).</P><P><B>Conclusion</B></P><P>The PK parameters for PO and SC esomeprazole administration were favorable, and esomeprazole significantly increased intragastric pH after IV, PO, and SC administration. IV and SC administration of esomeprazole might be useful when PO administration is not possible. No significant adverse effects were observed.</P>
Han, Ji H.,Shin, Hanho,Rho, Jun G.,Kim, Jungx2010,Eun,Son, Dong H.,Yoon, Juhwan,Lee, Yong J.,Park, Jungx2010,Hyuck,Song, Byung J.,Choi, Changx2010,Sik,Yoon, Seul G.,Kim, Il Y.,Lee, Eun K.,Seong, Blackwell Publishing Ltd 2018 DIABETES OBESITY AND METABOLISM Vol.20 No.9
<P>Conclusions: These results suggest that peripheral CB1R blockade improves obesity-induced insulin resistance by suppressing adipose tissue inflammation via the NLRP3 inflammasome.</P>
A search for interstellar naphthalene and anthracene cations
Galazutdinov, G.,Lee, Byeongx2010,Cheol,Song, Inx2010,Ok,Kazmierczak, M.,Krełowski, J. Blackwell Publishing Ltd 2011 Monthly notices of the Royal Astronomical Society Vol.412 No.2
<P><B>ABSTRACT</B></P><P>The evidence for naphthalene and anthracene cations reported by Iglesias‐Groth and co‐authors in 2008 and 2010 respectively in the spectra of a rather cool object, (A3V) Cernis 52, was carefully examined with the aid of high‐resolving‐power (30 000 ≲<I>R</I>≲ 90 000) spectra. No possible bands of these molecules were found in high signal‐to‐noise ratio spectra of HD 147889, HD 204827, HD 207538 and HD 281259 – these objects represent both weaker and stronger interstellar molecular features and diffuse bands than Cernis 52. The idea that possible naphthalene and anthracene feature detection has a connection to the anomalous microwave emission reported in the direction of Cernis 52 has been examined using high‐quality spectra of HD 278942 and HD 281159 observed in the same area as Cernis 52. Despite the high microwave flux density in the direction of HD 281159 (∼four times higher at 60 μm than in the direction to Cernis 52), no expected features were detected. Accordingly, we consider these PAH discoveries as premature. Using the spectrum of HD 281159 we estimate the column density of interstellar naphthalene and anthracene normalized to <I>E</I>(<I>B</I>−<I>V</I>) = 1.0 as less than 2.16 × 10<SUP>12</SUP> and 1.4 × 10<SUP>12</SUP> respectively.</P>
R&D Status of High-current Accelerators at IFP
J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.