The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection

Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.

인스트루먼트 패널용 수용성 질감 도료의 물리적 성질

김억(Ok Kim),오우정(Woo-Jeong Oh),전용(Yong Chun),김영태(Young-Tae Kim),안재범(Jae-Beom Ahn),조영호(Youngho Cho) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_3

Physical properties of waterborne soft feel coatings for instrument panel were investigated. Soft feel coatings give warm and velvet touch for cold and hard plastic materials. Waterborne soft feel coating is composed with two parts. Part A contains polyester polyurethane dispersion (PE-PUD), OH-functional water dispersible polyurethane resin (PC-PUD) and OH-functional water dispersible alkyd resin (OH-PA). Part B contains hydrophilic hexamethylene diisocyanate trimer (HHDI). Soft feeling of coated panel was related with the amounts of PC-PUD and OH-PA. The physical properties of coated panel could be controlled by the NCO/OH ratio from Part A and Part B. Soft feeling was enhanced with relevant to PE-PUD content but the content of PE-PUD was limited because of weakening of coated film strength. For excellent touch and good property, the optimum composition of soft feel coat was PC-PUD(30%) and PE-PUD(20%). The results from all reliability tests satisfied soft feeling, scratch, chemical resistance and fogging.

근자외선 레이저를 위한 Ar 섬광관의 방전 특성과 BBQ의 형광 강도

吳喆漢,林春雨,朴成珍 慶北大學校 1992 論文集 Vol.52 No.-

The fluorescence characteristics of near UV dye, BBQ, pumped by Ar flashlamp have been studied for various electrical input energies applied to the flashlamp and argon fill pressures in the flash tube. The peak wevelength of fluorescence is about 380nm when the fluorescence intensity is at the peak value. The rise time of the fluorescence pluse is about 7μsec and its FWHM is about 55μ sec When the input energy is 72J. The fluorescence energy increases linearly with the input energy and the fluorescence energy in creases as Ar fill pressure in the flash tube increases, but it decreases over 170Torr of Ar pressure. Therefore, the optimum pressure of the tube for fluorescence emission is 170Torr.

골다공성 척추 압박골절에서 경피적 척추성형술 후 강화된 척추체에 의한 합병증 : Hammer Effect Preliminary Report

전은오,이상구,유찬종,김우경,박찬우,이언 The Korean Neurosurgical Society 2003 Journal of Korean neurosurgical society Vol.34 No.6

강진만에서 미생물의 년 변화

박종천,오재영,정용욱,주현수,이원교,유춘만,이우범 國立 麗水大學校 환경문제硏究所 2001 環境硏究論文集 Vol.4 No.-

The biological surveys were performed at seven sites in the Gangjin bay from February, 1998 to November, 2001. In order to analysis of environmental variation, numbers of heterotrophic bacteria, general fungus and fecal coliforms were enumerated in each sample. The result showed that variation range of heterotrophic bacteria, general fungus, and fecal coliforms were 2.9 x 10^(3)~9.6 x 10^(3) CFU/ml, 17.2~80.1 CFU/ml, and 6.3~682.5 CFU/100ml for four tears(1988~2001), respectively. Density of heterotrophic bacteria and general fungus were gradually decreased for four tours, while fecal coliforms were suddenly increased. Specially, numbers of fecal colifoms were increased the more 100 times in 2001 than that 1998. We think that it was probably caused a little rainfall in February, 2001. There result suggests that ecosystem of Gangjin bay were mainly regulated by 2~3 factors, which were inflow of fresh water, salinity and variation of water temperature.

한국 지방의회와 집행기관간의 대립·갈등에 관한 실증적 조사연구 : 관련자들의 인식을 중심으로

박천오,서우선 서울대학교 행정대학원 2003 行政論叢 Vol.41 No.1

지방의회와 집행기관간에 대립·갈등이 심각하고 그러한 상황이 장기화된다면 자치행정은 큰 혼란에 빠질 수 있다. 때문에 지방자치의 효율화를 위해서는 양측간의 비생산적인 대립·갈등을 예방하거나 해소시킬 수 있는 제도적 장치나 대책이 필수적으로 요구된다. 한국의 경우는 아직 이러한 장치나 대책이 마련되지 않아 지방의회와 집행기관간의 대립·갈등으로 인한 부작용이 우려되지만 이와 관련된 실태조사는 이루어지지 않고 있다. 본 논문에서는 지방의회와 집행기관간의 대립·갈등의 실태를 관련자들의 인식을 중심으로 실증적으로 조사하였다. 구체적으로 본 논문은 지방의회의원과 의회 및 집행기관 소속공무원 900여명을 대상으로 한 2차에 걸친 질문지 조사를 통해, 지방의회와 집행기관간의 대립·갈등의 발생 정도와 그로 인한 부작용, 대립·갈등의 발생원인, 대립·갈등의 전개양상과 종결 방식, 대립·갈등의 예방 또는 해소 방안 등을 규명한다. Since severe and extended conflicts between the council and the executives could cause a chaos in local governments, some mechanisms are needed to prevent or resolve unproductive conflicts. Unfortunately korean local governments do not have those mechanisms, yet therefore they could experience various dysfunctions resulting from such conflicts. This study examines the reality concerning these situations by way of conducting questionnaire surveys to the sample of about 900 local legislatives and civil servants. The results have important implications for finding solutions of the problems related to the conflicts between the two institutions.

工業敎育大學의 實驗實習施設 共同活用 및 運營에 關한 硏究

尹錫天,牟相榮,權五憲,千炳善,周赫鍾,李永臣,金健中,羅聲雄,洪錫雨,吳德成,盧泰天 충남대학교 공업교육연구소 1983 論文集 Vol.6 No.2(A)

The College of Engineering was specialized to have a sole function for supplying technical high school teachers in 1977 and referred to as the College of Industrial Education according to the Government's policy. The economic impact mainly due to the oil-crises caused a severe problem to this college, namely discrepancy of supply to demand scale. Accordingly the number of student enrollment was to be fluctuated from 479 in 1979 through 800 in 1979 and 900 in 1980 to 430 in 1981. And the engineering departments have been attached to this Engineering Education College since 1981. These circumstanses met singnificant inefficiency in facility operation. This program aims at providing an overall relocation of the college facilities and preparing the practical system to make the joint-operation possible taking into account circulation, academic stream, budget, maintenance, etc. However this study could not get optimal spacing but some trade-off, considering the current situation.

한국 지방의회와 집행기관간의 대립·갈등에 관한 실증적 조사연구 : 정책과정을 중심으로 Focused on the Policy Process

박천오,서우선 명지대학교 사회과학연구소 2002 사회과학논총 Vol.18 No.-

급성 ST 분절 상승 심근경색증의 표준진료지침 설계

권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-

The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.

지주막하출혈에 의해 발생한 Takotsubo 심근병증의 1예

김선영,김우식,박종혁,오명기,권선옥,나종천,조욱현,최석구 인제대학교 2007 仁濟醫學 Vol.28 No.-

A 64-years-old man was admitted to emergency department with symptom of chest pain. The characteristic of symptom was squeezing pain at substernal area. The patient had a history of hypertension and diabetes mellitus. His electrocardiogram(ECG) showed ST elevation in lead Ⅰ, Ⅱ, V3-6 and his laboratory results revealed mild increase in cardiac enzymes. And his echocardiogram showed apical hypokinesis. Based on the suspicious symptoms and results for acute anterior myocardial infarction, we decided to take a coronary angiogram for further evaluation. However, coronary angiogram revealed normal epicardial coronary arteries. He was admitted at Intensive Care Unit for monitoring and treatment of heart failure. After 3 days of hospitalization, his mental status was changed. His brain computed tomography revealed subarachnoid hemorrhage. After 5 days, hypokinesis of apex was improved to nearly normal on echocardiogram. This is a case of transient left ventricular apical ballooning or takotsubo cardiomyopathy associated with subarachnoid hemorrhage.