固眞飮子가 galactosamine으로 유발한 흰쥐의 간중독에 미치는 영향

원철환,정승현,임성우,신길조,윤상협,이원철 동국대학교 한의학연구소 1997 東國韓醫學硏究所論文集 Vol.6 No.1

최근 간질환에 대한 진단과 기술의 비약적인 발전에도 불구하고 치료방법론에서는 그 해결이 모호한 상태에 있다. 실험적으로 간중독을 유발시킨 동물에 약물을 투여하여 그 약화를 입증하려는 노력이 진행되고 있다. 이에 저자는 固眞飮子가 간독성의 완화효과에 미치는 영향을 관찰하기 위하여 固眞飮子추출물을 투여한 흰쥐에 galactosamine으로 간독성을 유발하고 간조직내 glutathione과 과산화지질의 함량, 혈청중의 GOT, GPT, γ-GPT, ALT, LDH의 효소활성측정 및 혈청중의 bile acid함량을 측정하여 다음과 같은 유의한 결과를 얻었다. glutathione의 함량은 固眞飮子을 전처치한 실험군에서 유의성 있게 증가하여고, 과산화지질, 혈청중 GOT, GPT, γ-GPT, ALT, LDH, bile acid는 고진음자를 전처치한 실험군에서 유의성있게 감소하였다. The purpose of this study is to observe the protective effect of Kojinyumja on serum reaction and hepatic tissue in galactosamine treated rats. In this study, the experimental rats divided four group(Normal group, Control group, Sample A group, and Sample B group): Under the same condition, normal and contro1 group were administered water, sample A, B group were administered Kojinyumja for 8days. And then, Coth control group and Sample B group were injected to abdomen with galactosamine for 1day. The rates of glutathione, lipid peroxide, GOT, GPT, γ-GTP, ALP, LDH, and contents of bile acid level were measured. The results are as follows: The glutathione rate significantly increased in sample group, the others(lipid peroxide, G0T, GPT, γ-GTP, ALP, LDH, bile acid) significantly decreased in sample group.

Arbitrage, Equilibrium and Smooth Trades

Won, Dong-Chun,Kim, Choong-Hwan 경제경영연구소 2004 經濟經營硏究 Vol.2 No.-

알루미늄 합금과 고장력 강판 접합을 위한 헬리컬 SPR의 단조공정 설계

김원영, 김동범, 김기호, 김도훈, 이인환, 조해용 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

A self-piercing rivet(SPR) is a mechanical component for joining dissimilar materials. It is used for joining dissimilar material sheets such as aluminum alloy and steel. The self-piercing rivet directly pierces into sheets without drilling sheets beforehand unlike conventional rivets. However, the self-piercing rivet occurs buckling when piercing high strength steel. Therefore, a helical SPR which can pierce high strength steel sheet was designed. In this study, forging process was designed for manufacturing the helical SPR and simulated by using commercial FEM code DEFORM-3D. In the simulation of forging process for manufacturing rivet, process sequence, formability, forging load were investigated. The suitable forging process could be designed by comparisons of simulated results. Experimental trials have been carried out for same conditions as simulated ones. The simulated results agreed with the experimental ones. So, the analytic approach in this thesis is useful to save cost and time in the forging industry

인간중심주의 교육에 관한 연구

원경렬,이환기 춘천교대 인문사회연구소 1998 人文社會敎育硏究 Vol.2 No.-

결핵 진단을 위한 검사 방법간의 효율성에 관한 비교 분석

이원재,최석철,정천환,성희경,김태운 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2

최근 다약제 내성균주의 출현과 후천성 면역결핍증으로 인한 결핵발병률의 증가는 전세계적으로 중요한 보건문제가 되었다. 따라서 보다 빠르고 신뢰할 만한 진단법은 결핵박멸을 위한 가장 중요한 필요조건 중의 하나일 것이다. 본 연구는 171명의 환자를 대상으로 폐결핵 진단의 전통적 방법들 (X-선,항산성 염색,배양)과 PCR법간의 진단적 가치와 효율성을 비교 검토하기 위해 시행하였다. 흉부 X-선 소견 및 검사 결과 그리고 다른 임상 소견들을 통해 결핵으로 확진된 예는 전체 171건의 검체 중 39예 (22.8%)였다. 이러한 확진을 근거로 할 때 각 검사별 민감도, 특이도, 효율성, 위양성률, 위음성률을 살펴 보면 흉부 X-선의 경우 각각 69.2%, 87.1%, 83.0%, 12.9%, 30.8%; 항산성 염색의 경우 79.9%, 95.5%, 91.8%, 4.6%, 20.5%; 배양의 경우 56.4%, 99.2%, 89.5%, 0.8%, 43.6%; PCR의 경우 82.1%, 96.2%, 93.0%, 3.8%, 17.9%였다. PCR의 경우 가장 높은 민감도 및 효율성과 가장 낮은 위음성률을 보였다. 배양법은 가장 높은 특이도와 가장 낮은 위양성률을 보였다. 결론적으로 PCR은 결핵 진단을 위한 신속하고 효율적인 우수한 검사 방법이므로 일상적 임상 검사로의 활용가치가 매우 높다고 하겠다. 그러나 전통적인 여러 방법들 역시 임상상황에 따라 그 나름대로의 특별한 가치를 지니고 있으므로 철저한 정도관리를 통해 PCR과 병행한다면 결핵균 검출율을 보다 높일 수 있으리라 판단된다. In recent years continuously increasing number of tuberculosis (TB) cases due to the emergence of strains with multidrug resistance and AIDS is a significant global health problem. Therefore, more rapid and reliable diagnosis of TB may be one of the most urgent needs in efforts to eradicate the disease. The present study was designed to compare and assess the diagnostic values and efficiencies between the conventional methods (X-ray, AFB stain and culture) and PCR for pulmonary TB on 171 cases. Chest X-ray finding and clinical features revealed that 39 (22.8%) of 171 sputum specimens were pulmonary TB cases. The statistical data were taken on the basis of the definitive diagnosis: In X-ray, overall sensitivity, specificity, efficiency and false positive and false negative incidence was respectively 69.2%, 87.1%, 83.0%, 12.9%, and 30.8%; 79.5%, 95.5%, 91.8%, 4.6% and 20.5% in AFB-stain; 56.4%, 99.2%, 89.5%, 0.8% and 43.6% in culture; 82.1%, 96.2%, 93.0%, 3.8% and 17.9% in PCR. PCR got a highest sensitivity and efficiency as well as a lowest false negative incidence. Culture had a highest specificity with a lowest false positive incidence. These results imply that PCR assay is fast, sensitive and efficient method for diagnosis of pulmonary TB. However, combined use of the conventional methods wish thorough quality control may offer more opportunities for detecting Mycobacterium tuberculosis and diagnosting TB although they have some limits.

水密性 포오틀랜드 시멘트의 製造方法과 最適組成에 關한 硏究

홍원표,황의환 충남대학교 공업교육연구소 1984 論文集 Vol.7 No.1

The construction works with concrete has the potential problems of water-tightness. The conventional treatments for water-tight concrete are not satisfactory in terms of strength and water-tightness. However, ACPC(asphalt coated portland cement), which was invented by Hong in 1972, was satisfactory in terms of water-tightness and compressive strength. ACPC was made by coating OPC(ordinary portland cement )with asphalt and adding with carbon black as pore filler in the rate of weight ranging from 0.1%to 0.9% respectively. The cause of permeation is the connection of crack and pore which are in the concrete. The purpose of this study was to find the optimum composition of ACPC according to the permeability test, the compressive strength test, and workability test. The major findings of this experiment are as follows; 1) The optimum composition of ACPC for water-tightness and compressive strength was found at 0.3% asphalt, 0.5% carbon black at the rate of the weight of cement in view of the economic consideration. 2) The compressive strength of the specimen of ACPC was lower than that of OPC in the case of aging of 7 days and 28 days but the compressive strength of the specimen of ACPC was higher that of OPC after aging 35 days. 3) The workability of ACPC was higher than that of OPC in through of the slump value test and fresh concrete air content test.

NaCl이 大麥의 發芽와 幼苗生育에 미치는 影響

崔元烈,朴鍾煥 全南大學校 農漁村開發硏究所 1986 農業科學技術硏究 Vol.21 No.-

Physiological responses and related metabolites in 4 cultivars of barley (Hordeum vulgare L. ) were measured in NaCl stress condition throughout germination and seedling stages. The higher concentrations and the passage of time unfavorably influenced seed germination status and seedling stage, specifically, delayed the emergence and reduced the germination rate. The variety with higher rate of germination under stress had the tendency to give higher ability to the salt tolerance in seedling. The variety which had high germination rate showed high amylase activity, but the activity was reduced by increasing NaCl concentration. Water potential was reduced by NaCl treatment bat the significant difference was not observed. Free proline of 2nd leaf was accumulated to 10 ~ 35 folds of control in treatment. This finding may indicate that it will be the parameter of the selection. of salt-tolerant variety as the varietal differences in accumulating ability were distinct. In testing salt-resistance of variety, it will be advisable that seeds should be immersed in high concentration at germination stage and seedling should be immersed for longer period of time.

Cisplatin과 Tobramycin이 白鼠 Corti器에 미치는 영향에 關한 電子 顯微鏡的 硏究 : Ultrastructural Study

김동환,신태균,김무강,김홍선,김원식 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

In order to study the morphological changes of Corti’s organ in the rat treated with cisplatin and tobramycin, thirty-three rats, weighing between 200∼250g, were used, and divided into 4 groups, i.e., 3 rats were used for control, and 30 rats were used for 3 experimental groups. Each experimental group was divided into cisplatin-treated, tobramycin-treated, and both cisplatin and tobramycin treated group with 10 rats. Rats were injected with a single dose of 7.7㎎/㎏ of cisplatin intraperitoneally and 50㎎/㎏/day of tobramycin for 2 days intramuscularly, respectively or both. Treated rats were sacrificed on the 3rd and 5th day after the first injection. Results were as follows; 1. Cisplatin-treated group: Outer hair cells of Corti’s organ were degenerated with the formation of vacuoles and appearance of lysosomes, however, inner hair cells showed mild vacuolization. 2. Tobramycin-treated group: NO pathological changes were found in Corti’s organ. 3. Combined cisplatin and tobramycin treated group: Outer and inner hair cells showed vacuolization, appearance of lysosomes, myelin figures and multivesicular body. There were also multivesicular body in the inner phalangeal cell and myelin figure in the Reissner’s membrance. 4. Degeneration of Corti’s organ in the combined treated group was more sever than those of the single cisplatin-treated or tobramycin-treated group. 5. NO pathological differences of Corti’s organ in duration of postinjection were manifested in any groups. It can be concluded that cisplatin induces toxicity to inner ear and cisplatin enhance toxicity more in continued treated with tobramycin.

유한요소법을 이용한 레일의 헤드에 존재하는 균열의 응력확대계수에 관한 연구

인경환,성기득,김종욱,조명래,양원호 成均館大學校 科學技術硏究所 1999 論文集 Vol.50 No.1

In recent years, the rolling stock is being increasingly developed. However, higher axle loads have increased the incidence of fatigue defects in railroad rails. Many of these fatigue-initiated defects develop in the head of the rail. The head defects are very important because they are generally not visible until they reach quite large size and they can lead to catastrophic rail fractures. In this paper, stress intensity factors(SIF) of a embedded crack in the head of the rail were analysed along the wheel positions relative to the crack plane and along the running condition using the finite element method.

컴퓨터 예측모델을 활용한 간헐폭기 활성슬러지 시스템의 결정

辛鎭煥,李元鎬 忠州大學校 1997 한국교통대학교 논문집 Vol.32 No.1

Reactor configuration on intermittently aerated activated sludge system was evaluated by IAWQ model NO.1. The aeration and nonaeration time and sludge retention time of 1hr/lhr and 20day on the performance of nutrient removals was evaluated in intermittently aerated multi-stags activated sludge system, As a result of model operation, COD and T-N removal of two-stage more intermittently aerated activated sludge system was nearly the same.