한반도와 남방 문화에 관한 사료 모음Ⅰ

송위지 韓國外國語大學校 外國學綜合硏究센터 歷史文化硏究所 2000 역사문화연구 Vol.11 No.-

남방 불교 지역과 북방 불교 지역간의 왕권과 승단의 위상 비교

송위지 韓國外國語大學校 歷史文化硏究所 1998 역사문화연구 Vol.8 No.-

졸-겔법으로 제조한 ZrO_2·SiO_2계 결정화 유리의 결정화 및 파괴인성에 관한 연구

신대용,한상목,강위수 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

Precursor gels with the composition of xZrO_2·(100-x)SiO_2 systems (x=10,20 and 30mol%) were prepared by the sol-gel method. Kinetic parameter, such as activation energy, Avrami's exponent, n, and dimensionality crystal growth value, m, have been simultaneously calculated from the DTA data using Kissinger and Matusita equations. The crystallite size dependence on tetragonal to monoclinic transformation of ZrO_2 was investigated using XRD, in relation to the fracture toughness. The crystallization of tetragonal ZrO_2 occurred through 3-dimensional diffusion controlled growth(n=m=2) and the activation energy for crystallization was calculated using Kissinger and Matusita equations, as about 310∼325±10kJ/mol. The growth of t-ZrO_2, in proportion to the cube of radius, increased with increasing heating temperature and heat-treatment time. It was suggested that the diffusion of Zr4+ions by Ostwald ripening was rate-limiting process for the growth of t-ZrO_2 crystallite size. The fracture toughness of xZrO_2·(100-x)SiO_2 systems glass ceramics increased with increasing crystallite size of t-ZrO_2. The fracture toughness of 30ZrO_2·70SiO_2 system glass ceramics heated at 1,100℃ for 5h was 4.84 MPam^1/2 at a critical crystaliite size of 40 nm.

Dietary Exposure to Transgenic Rice Expressing the Spider Silk Protein Fibroin Reduces Blood Glucose Levels in Diabetic Mice: The Potential Role of Insulin Receptor Substrate-1 Phosphorylation in Adipocytes

박지은,정연재,박준범,김혜영,유영현,이광식,양원태,김도훈,김종민 한국발생생물학회 2019 발생과 생식 Vol.23 No.3

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic BKS.Cg-m+/+Leprdb mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPFfed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.

A Note on the Minimization of the Expected Makespan and the Expected Flow Time in M Machine Flow Shops with Blocking

Wie Sung Hwan Military Operations Research Society of Korea 1984 한국국방경영분석학회지 Vol.10 No.2

Consider an m machine flow shop with blocking. The processing time of job j,j=1,..., n on each one of the m machines is equal to the same random variable $X_j$ and is distributed according to $F_i$. We assume that the processing times are stochastically ordered, i.e., $F_{1_{-st}}{<}F_{2_{st}}{<}cdots_{-st}{<}F_n$. We show that the sequence 1,3,5,...,n-1,n,n-2,...,6,4,2 when n is even and sequence 1,3,5,...,n-2,n,n-1 ... 6,4,2 when n is odd minimizes the expected makespan and that the sequence 1,...,n minimizes the expected flow time.

Dexamethasone activates transient receptor potential canonical 4 (TRPC4) channels via Rasd1 small GTPase pathway

Wie, J.,Kim, J.,Ha, K.,Zhang, Y. H.,Jeon, J. H.,So, I. Springer Science + Business Media 2015 Pfl ugers Arch Vol.467 No.10

THE STUDY OF DYNAMIC CHARACTERISTICS OF A FIGHTER TYPE AIRPLANE BY USE OF THE FLIGHT SIMULATOR

Wie, Sang Kyoo 서울대학교 1967 서울대학교 論文集 Vol.17 No.-

大氣圈空間에서 航空機는 竝進運動에다 縱搖, 偏搖, 旋回 等의 回轉運動을 同時에 할 수 있는 飛行體임으로 其 運動特性의 硏究는 飛行機가 發達된 後부터 始作되었다. 特히 美國을 비롯한 航空工業이 發達한 國家에서는 航空機運動學의 硏究는 繼續되여 왔으나 現在까지도 完璧한 結實을 보지 못하고 있다. 其 原因은 飛行機의 運動自體가 複雜하고 運動을 左右하는 運動方程式이 前後, 左右, 上下, 機體軸方向에 對힌 병진운동에 對해서 3式 또 위의 三機軸周圍의 回轉運動 卽 縱搖, 偏搖, 旋回 等에 對한 方程式이 3年이 된다. 合計 6式의 非線型 運動方程式으로서 完全히 運動을 究明할 수 있다. 이와 같이 複雜한 航空機의 運動을 解釋的으로 究明한다는 것은 어려운 問題이오나 過去 航空機의 發達과 더불어 問題를 簡素化하여 縱搖運動과 橫運動의 相互干涉을 無視할 수 있는 範圍內에서 이두가지 運動을 個別的으로 考慮해 왔다. 이런 方法은 實際로 飛行機가 複雜한 運動을 할 때는 絶對로 成立될 수 없으나 縱搖 卽「핏칭」(키노리)運動을 따로 생각해서 急激한 運動을 하지 않을 때는 實際로 飛行하면서 記錄한 實驗値와 거의 合致한다는 것은 알고 있다. 그러나 위에서 말한 運動方程式은 飛行機構造의 彈性은 無視한 剛體力學的인 假定下에서 樹立한 것이다. 構造의 彈性을 考慮하면 運動方程式은 더욱 非線型化 된다. 今番의 硏究調査에서는 彈性을 無視한 基本方程式을 一般 航空機運動學의 敎科書에서 볼 수 있는 方法을 쓰지 않고 「매트릭스」方法을 應用하여 靜止하고 있다고 假定한 地區軸과 運動하는 飛行機 機軸座標間의 關係를 容易하게 求했다. 勿論 風軸과 機軸이 一致않을 때의 風軸과 機體軸과의 關係式도 求했다. 이번의 硏究調査의 主要目的은 韓國에서 生産은 되지 않더라도 最新型 의 戰鬪機들이 晝夜로 國土防衛의 任務를 띠고 飛行하고 其飛行機의 操縱士訓練에 模擬飛行機訓練(flight Simulator)를 利用하고 있는 이 때에 飛行機의 操縱을 空中飛行할 때와 同一한 環境과 條件下에 地上에서 訓練할 수 있겠끔 電子計算機와 其他 複雜한 機構로 設計된 訓鍊裝置의 設計要素가 되는 運動學的 問題의 基本調査에 있었고 將次의 航空機運動制御工學硏究室의 開發에 도움이 될 수 있는 第一步로서 航空機運動의 特性을 簡素化된 假定下에서 調査했다. 이런 趣旨와 目的下에 縱搖(키노리, 또는 핏칭) 運動方程式의 線型化에서 從來의 唯一한 方法인 小擾亂理論을 利用하여 縱搖運動方程式(3式, 두個의 加速度式, 한個의 모우멘트式)을 線型化하고 基準飛行狀態를 假定한 다음 方程式을 無次元化하여 昇降舵를 急激히 내렸거나 위로 올렸을 때의 機體의 핏칭 傳達函數를 만들었다. 이 傳達函數는 所謂 長周期(후고이드)運動과 短周期運動이 合쳐진 四次形式이나 長周期運動은 航空機運動學에서 主要한 部分이 아님으로 短周期運動에 關한 것만을 考察하기로했다. 卽 昇降舵의 運動에 對한 縱搖 핏칭運動의 傳達函數는 振動工學이나 電氣回路에서 나오는 傳達函數와 同一한 二次式이 되고 만다. 여기서 問題는 두가지 分野로 나누어 지는데 주어진 航空機의 空氣力學的 安定微係數들이 風洞實驗結果로부터 얻을 수 있다면 傳達函數의 分母와 分子의 各係數에 代入하여 「핏치」角의 時間的 變化와 같은 動的 特性 도는 周波數應答을 究明할 수 있다. 또는 實際로 飛行實驗에서 얻은 記錄을 利用하여 上記의 機體의 「핏칭」傳達函數에서 나타는 係數들을 「후우리에」變換方法을 利用하여 求한다음 周波數應答을 求하고 安定微係數를 風洞實驗結果와 比較하는 方法 卽 逆方法論이 美國에서 많이 應用되고 있고 또 많은 硏究結果가 發表되었다. 여러가지 文獻을 調査했본 結果 同型의 飛行機는 아니지만 비슷한 機種에서 飛行實驗부터 얻은 硏究結果들은 計算한 結果와 合致됨을 알았다. 今番의 調査에서는 模型飛行訓鍊機의 性能을 檢討하는 것을 兼하여 高度 20,000「피이트」, 마흐數 0.8에서 F-86 D 型의 機體固有振動數를 F-80 飛行機의 硏究結果에 依據하여 勿論 理論的 基礎下에서 推定하고 여러 가지 樣式의 昇降舵角變化에 따른 「핏칭」角速度를 訓鍊機의 「핏치」角速度計算機에서 測定한 結果와 F-86D와 비슷한 F-80型 飛行機에 對한 空氣力學的 諸係數의 數値를 文獻부터 推定하여 「핏칭」角速度의 傳統函數에 代入하고 보니 減衰比率이 20,000「피이드」高度와 「마흐」0.8에서 適合한 數値임을 發見했다. 實驗結果와 推定한 機體「칭핏」傳達函數에서 얻은 電子計算機의 結果가 大端히 잘 一致됨을 確認하고 動力學이나 制御工學에서 運動特性을 論할 때 必要한 周波數應答을 求해 보니 其 結果 역시 여러 가지 飛行機의 實驗과 大略 같은 것을 알았다. 勿論「핏칭」角速度의 時間的 變化를 直接「후우리에」變換하여 周波數應答을 求했드라면 더 좋은 結論을 얻을 수도 있었을 터인데 施設不足과 經驗不足으로 이루지 못했음을 不幸으로 생각한다. 今番의 硏究를 基礎로 하여 韓國에서 將次 航空機運動學의 開拓할 수 있는 分野를 發見할 수 있고 制御工學을 硏究하는 實務者나 模型飛行機訓練敎育을 擔當하는 將兵들에게 도움이 될 수 있다면 이번의 硏究調査의 意義가 있다고 본다. In this paper the equations of motion for aircraft are obtained by conventional methods to understand the dynamic equations which are used in analog computations in the flight simulator to train the combat crews on the ground. Ordinarily, the aerodynamic and inertial elements appear in the equations of motion are replaced by a 'simulator", an electrical network whose constants are adjusted so that it obeys the same differential equations as the airplane on a one-to-one time basis. Since the simulator solves six non-linear equations of motion simultaneously, the main purpose of this paper is to summarize the fundamental principles governing the dynamic behavior of the airplane so that the future research and simulator engineering training problems would find great help in this country. In the remaining parts of the paper, the linearized longitudinal dynamic questions and the transfer function of the pitching response to the elevator deflection are obtained from the complete non-dimensional operational from of the equations and discared the higher-order aerodynamic and inertial terms and compared with the result of simplified method. Finally, the survey of frequency response methods of dynamic characteristics of airplane are discussed to find the acrodynamic and intertial transfer coefficients appearing in the transfer function. The last part of the paper is devoted to show the relationship between the pitching rate computer of flight simulator and longitudinal equations of motion. then the results of experiment on the flight simulator are compared with the analog computations from the transfer function for the pitching motion by the assumed values of the aerodynamic stability derivatives of a similar transonic turbojet fighter type airplane. The frequency response characteristics are found from the transfer function and this shows good agreements with other similar type of an airplane.

Identification of major dietary patterns in Korean adults and their association with cancer risk in the Cancer Screening Examination Cohort

Wie, G-A,Cho, Y-A,Kang, H-h,Ryu, K A,Yoo, M-K,Kim, J,Shin, S,Chun, O K,Joung, H Macmillan Publishers Limited, part of Springer Nat 2017 European journal of clinical nutrition Vol.71 No.10

<P>CONCLUSIONS: The traditional dietary pattern with high consumption of rice, kimchi, soybean paste and vegetables may decrease the cancer risk among Koreans, and strategies based on the dietary pattern may effectively reduce the cancer risk.</P>

Red meat consumption is associated with an increased overall cancer risk: a prospective cohort study in Korea

Wie, Gyung-Ah,Cho, Yeong-Ah,Kang, Hyun-hee,Ryu, Kyoung-A,Yoo, Min-Kyoung,Kim, Young-A,Jung, Kyu-Won,Kim, Jeongseon,Lee, Joo-Hyuk,Joung, Hyojee Cambridge University Press 2014 The British journal of nutrition Vol.112 No.2

<P>Cancer is a leading cause of death, and the dietary pattern in Korea is changing rapidly from a traditional Korean diet to a Westernised diet. In the present study, we investigated the effects of dietary factors on cancer risk with a prospective cohort study. Among 26 815 individuals who participated in cancer screening examinations from September 2004 to December 2008, 8024 subjects who completed a self-administered questionnaire concerning demographic and lifestyle factors, and a 3 d food record were selected. As of September 2013, 387 cancer cases were identified from the National Cancer Registry System, and the remaining individuals were included in the control group. The hazard ratio (HR) of cancer for the subjects older than or equal to 50 years of age was higher (HR 1·80, 95 % CI 1·41, 2·31; <I>P</I>< 0·0001) than that for the other subjects. Red meat consumption, Na intake and obesity (BMI ≥ 25 kg/m<SUP>2</SUP>) were positively associated with overall cancer incidence in men (HR 1·41, 95 % CI 1·02, 1·94; <I>P</I>= 0·0382), gastric cancer (HR 2·34, 95 % CI 1·06, 5·19; <I>P</I>= 0·0365) and thyroid cancer (HR 1·56, 95 % CI 1·05, 2·31; <I>P</I>= 0·0270), respectively. Participants who had at least three dietary risk factors among the high intakes of red meat and Na, low intakes of vegetables and fruits, and obesity suggested by the World Cancer Research Fund/American Institute for Cancer Research at baseline tended to have a higher risk of cancer than the others (HR 1·26, 95 % CI 0·99, 1·60; <I>P</I>= 0·0653). In summary, high intakes of red meat and Na were significant risk factors of cancer among Koreans.</P>

Effective Vaccination and Education Strategies for Emerging Infectious Diseases Such as COVID-19

Wie Seong-Heon,Jung Jaehun,Kim Woo Joo 대한의학회 2023 Journal of Korean medical science Vol.38 No.44

Social isolation and control owing to coronavirus disease 2019 (COVID-19) are easing; however, concerns regarding new infectious diseases have not disappeared. Given epidemic experiences such as severe acute respiratory syndrome (SARS), the influenza pandemic, Middle East respiratory syndrome (MERS), and COVID-19, it is necessary to prepare for the outbreak of new infectious diseases and situations in which large-scale vaccinations are required. Although the development of vaccines against COVID-19 has contributed greatly to overcoming the pandemic, concerning vaccine side effects from the general public, including medical personnel, and decreased confidence in vaccine efficacy and side effects, present many challenges in promoting and educating vaccinations for new infectious diseases in the future. In addition to plans to develop vaccines for the outbreak of new infectious diseases, education and promotion plans are necessary to administer the latest developments of vaccines to the general public. Moreover, efforts are needed to secure the necessity, legitimacy, and evidence for rapid vaccination on a large scale at the national level. It is also necessary to carefully prepare scientific bases and explanatory statements so that the general public can easily understand them. This study aimed to establish vaccine strategies and vaccination education plans for new infectious diseases that may occur in the future. Many ways to promote vaccination to the general public and healthcare workers should be prepared to ensure that the latest vaccines against new infectious diseases are administered safely. Thus, education and promotion of vaccine efficacy and safety based on specific data from clinical studies are necessary.