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Gentamicin이 Mouse간장의 인산염 분해효소 활성에 미치는 영향
황세진,박순재,이규식 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2
Gentamicin isolated form Micromonospora purpurea has been used as an antibiotic against a wide range of bacteria, including Staphylococci, Streptococci, Pneumococci, Escherichia coli, Pseudomonas and Proteus species. It is well known that gentamicin inhibits the protein synthesis of bacteria by interfering in the first step of the synthesis that occurs at the ribosome (initiation). Like all other aminoglycosides, gentamicin (at high does) has toxic effects on the kidney and the inner ear. In this experiment, the author studied the effect of gentamicin on the mouse liver histochemically, observing the change in the activities of alkaline phosphatase, acid phosphatase and adenosine triphosphatase. Healty male mice (ICR strain) were used as experimental animals which were devided into two groups, the control and gentamicin threated groups. All experimental animal were given food and water ad libitum. The animals of experimental group were administrated gentamicin, in a dose of 100 mg per kg of body weight by intramuscular injection. The experimental animals were sacrificed at 6, 12, 24 and 36 hours after administration of gentamicin, respectively. The liver specimens sectioned by cryostat were stained by Gomori method for studying changes in the activities of alkaline phosphatase, acid phosphatase and by Wachstein and Meisel method for adenosine triphosphatase, respectively. The results obtained were as follows ; 1. The activity of alkaline phosphatase exhibited strong positive reaction in the hepatic lobule of normal control group. As the time passed by, the activity of alkaline phosphatase was decreased in the hepatic lobule. Moderate positive activities of the enzyme were observed in the hepatic lobule of gentamicin treated group at 6 and 12 hours after administration. Weak positive reaction was shown at 24 hours after administration. Moderate positive reaction was seen in the hepatic lobule of gentamicn treated group at 36 hours after administration. 2. The activity of acid phosphatase exhibited weak positive reactions in the hepatic lobule of normal control group and the gentamicin treated group at 6 hours afte administration. As the time passed by, the activities of enzyme were increased in the hepatic lobule. Moderate positive reaction of the enzyme was observed in the hepatic lobule of gentamicin treated group at 12 hours after administration. Strong positive reaction of the enzyme was observed in hepatic lobule of gentamicin treated group at 24 hours after administration. Weak positive reaction was shown in the hepatic lobule of gentamicin treated group at 36 hours after administration. 3. The activity of adenosine triphosphatase exhibited strong positive reaction in the hepatic lobule of normal control group. Weak positive activities of enzyme were observed in the hepatic lobules of gentamicin treated group at 6, 12 and 24 hours after administration. Moderate positive reaction was shown in the hepatic lobule of gentamicin treated group at 36 hours after administration. Consequently, it is suggested that gentamicin damages the liver cell of mouse probably by decreasing the activities of alkaline phosphatase and adenosine triphosphatase and by increasing the activity of acid phosphatase.
외경동맥 분지에 발생한 외상성 동맥류 4예 : 증례보고 Report of 4 Cases
황금,허철,홍순기,김헌주,한용표,최윤정 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.4
We report four cases of traumatic aneurysm in the branches of external carotid artery and reviewed other cases from the literature in view of their clinical feature and management.
외상성 뇌경막하 수낭종에서 병발된 만성 경막하 혈종의 임상적 고찰
황금,허철,홍순기,김헌주,한용표,변진수 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.8
The authors analyzed 9 cases of chronic subdural hematoma which had been originated from traumatic subdural hygroma patients who were admitted to our department from January, 1990 to June, 1991. The results of analysis were summarized as follows : 1) The range was from 23 to 73 years of age, and fifth and sixth decade were two-thirds of all with the sex ratio of male to female 3.5 to 1. 2) The hematoma sites were all the same as those sites of previous subdural hygroma, and all site involved fronatal area. 3) It took on average 8 weeks for the hygroma to convert into hematoma. 4) The major clinical symptoms and signs were headache, alteration of consciousness, motor weakness and dysphasia. 5) The densities of hematoma revealed on brain CT at the time of conversion were all hyperdense. 6) Closed drainage through burr holes resulted in an excellent clinical outcome in all cases at the time of discharge, although still remained subdural hygroma in 3 cases on follow-up brain CT. 7) Patients with traumatic subdural hygroma, even small amount, should be followed for at least 8 weeks and carefully monitored.
신경피부멜라닌증 환자의 두개강내에 발생한 원발성 악성 흑색종 : Case Report
노재섭,황금,한용표,김헌주,홍순기,허철,변진수 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10
An unusual case of neurocutaneous melanosis is presented. The patient had congenital dermal nevi, and displayed multicentric malignant cerebral melanoma associated with hydrocephalus and seizure in adult life. This suggests that a patient with congenital dermal nevus or marked generalized cutaneous pigmentation should be closely observed for the development of malignant melanoma of the nervous system.
웨이블렛 변환을 이용한 정전 탐침 자료 분석 알고리즘 개발
김곤호,김대경,황순모,김용현 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-
ECR 식각 플라즈마에서 정전 Langmuir 탐침으로 얻은 자료의 해석을 위하여 Dauberchies 웨이블렛과 이중 직교 웨이블렛 변환을 이용한 새로운 알고리즘을 개발하였다. 이 알고리즘을 이용한 자료해석 방식에서는 해석자의 선택적 입력 값을 최소로 하고 자료의 잡음제거시 일반적으로 사용하고 있는 평균을 기초로 하는 통계적인 방법을 사용하지 않았다. 본 알고리즘에서는 Dauberchies 웨이블렛을 이용하여 자료의 저주파 성분만을 추출함으로 포화 이온 및 전자 전류성분을 변환 자료에서 직접 구하였다. 또한, 원시 자료의 1차 미분자료에 대한 이중 직교 웨이블레서 변환을 이용하여 플라즈마 전위를 직접 구할 수 있어 웨이블렛 변환을 거치는 과정에서 플라즈마 전자온도를 구하는 영역이 일관성 있게 정의되었다. 전자분포 모델은 ECR 플라즈마의 특징인 hot과 bulk의 두 가지 온도를 가지는 bi-Maxwallian 분포로 가정하고 Martquardt 방법을 사용한 비선형 fitting 방법으로 두 가지 전자 온도를 구하였다. 포화 이온 및 전자 전류 곡선의 플라즈마 전위에 해당하는 전류 값으로부터 플라즈마 이온 및 전자 밀도를 얻었으며 임의의 자료에 대한 알고리즘의 정확성 검사 결과 90%이상의 정확도를 보였다. A new algorithm for automating the analysis of Langmuir-probe traces taken from the ECR magnetized plasma is developed through the Daubechies wavelet and the bi-orthogonal wavelet transformations. This approach minimizes the operator-specified inputs and provides de-noised data without using the statistical method based on the averaging techniques. In this algorithm, the electron and ion current lines are obtained from the low frequency information of the Daubechies wavelet processed data. From the bi-orthogonal wavelet transform for the differentiated data, the plasma potential can be clearly determined. The region for obtaining the electron temperature can be systematically chosen from these processed data without operator-specified inputs. The electrons are modeled by a bi-Maxwellian distribution with hot and cold temperatures and nonlienar fitting method (a Martquardt method) is used to determine the electron temperatures from this region. Ion and electron plasma densities are obtained from the ion and the electron current at the plasma potential, respectively. The evaluation results by using the artificially generated data shows over 90% accuracy.