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CircZNF609 Aggravated Myocardial Ischemia Reperfusion Injury via Mediation of miR-214-3p/PTGS2 Axis
Wen-Qiang Tang,Feng-Rui Yang,Ke-Min Chen,Huan Yang,Yu Liu,Bo Dou 대한심장학회 2022 Korean Circulation Journal Vol.52 No.9
Background and Objectives: Circular RNAs were known to play vital role in myocardial ischemia reperfusion injury (MIRI), while the role of CircZNF609 in MIRI remains unclear. This study was aimed to investigate the function of CircZNF609 in MIRI. Methods: Hypoxia/reoxygenation (H/R) model was established to mimic MIRI in vitro. Quantitative polymerase chain reaction was performed to evaluate gene transcripts. Cellular localization of CircZNF609 and miR-214-3p were visualized by fluorescence in situ hybridization. Cell proliferation was determined by CCK-8. TUNEL assay and flow cytometry were applied to detect apoptosis. Lactate dehydrogenase was determined by commercial kit. ROS was detected by DCFH-DA probe. Direct interaction of indicated molecules was determined by RIP and dual luciferase assays. Western blot was used to quantify protein levels. In vivo model was established to further test the function of CircZNF609 in MIRI. Results: CircZNF609 was upregulated in H/R model. Inhibition of CircZNF609 alleviated H/R induced apoptosis, ROS generation, restored cell proliferation in cardiomyocytes and human umbilical vein endothelial cells. Mechanically, CircZNF609 directly sponged miR-214-3p to release PTGS2 expression. Functional rescue experiments showed that miR-214-3p/PTGS2 axis was involved in the function of circZNG609 in H/R model. Furthermore, data in mouse model revealed that knockdown of CircZNF609 significantly reduced the area of myocardial infarction and decreased myocardial cell apoptosis. Conclusions: CircZNF609 aggravated the progression of MIRI via targeting miR-214-3p/PTGS2 axis, which suggested CircZNF609 might act as a vital modulator in MIRI.
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( Wen-wen Zhang ),( Xue-fei Zhou ),( Ya-lei Zhang ),( Peng-fei Cheng ),( Rui Ma ),( Wen-long Cheng ),( Hua-qiang Chu ) 한국미생물 · 생명공학회 2018 Journal of microbiology and biotechnology Vol.28 No.12
Natural astaxanthin mainly derives from a microalgae producer, Haematococcus pluvialis. The induction of nitrogen starvation and high light intensity is particularly significant for boosting astaxanthin production. However, the different responses to light intensity and nitrogen starvation needed to be analyzed for biomass growth and astaxanthin accumulation. The results showed that the highest level of astaxanthin production was achieved in nitrogen starvation, and was 1.64 times higher than the control group at 11 days. With regard to the optimization of light intensity utilization, it was at 200 μmo/m2/s under nitrogen starvation that the highest astaxanthin productivity per light intensity was achieved. In addition, both high light intensity and a nitrogen source had significant effects on multiple indicators. For example, high light intensity had a greater significant effect than a nitrogen source on biomass dry weight, astaxanthin yield and astaxanthin productivity; in contrast, nitrogen starvation was more beneficial for enhancing astaxanthin content per dry weight biomass. The data indicate that high light intensity synergizes with nitrogen starvation to stimulate the biosynthesis of astaxanthin.
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Wen, Ying,Pan, Xiong-Fei,Huang, Wen-Zhi,Zhao, Zhi-Mei,Wei, Wen-Qiang,Chen, Feng,Lan, Hui,Huang, He,Yang, Chun-Xia,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: The current study examined health-related quality of life (QoL) for patients with esophageal/gastric cardia precursor lesions or cancer before and after treatment to facilitate improved prevention and treatment. Materials and Methods: Patients with different stages of esophageal/gastric cardia lesions completed two QoL questionnaires, EORTC QLQ-C30 and supplemental QLQ-OES 18, before primary treatment, and at 1, 6 and 12 months after treatment. Results: Fifty-nine patients with precursor lesions, 57 with early stage cancer, and 43 with advanced cancer responded to our survey. Patients with precursor lesions or early stage cancer reported better QoL overall than those with advanced cancer before treatment (p<0.01). Global QoL scores before treatment and at 1 month after treatment were $71{\pm}9$ versus $69{\pm}9$ (p>0.01), $71{\pm}8$ versus $61{\pm}11$ (p<0.01), $67{\pm}11$ versus $62{\pm}9$ (p<0.01) for three stages of lesions. At 6 months after treatment, some QoL measures recovered gradually in precursor lesion and early cancer patients, while some continuously deteriorated in advanced cancer patients. At 12 months, all QoL scores were comparable to baseline for patients with precursor lesions (p>0.01), while global QoL, social, pain, and insomnia scores for early stage and advanced cancer were inferior to corresponding baseline levels (difference between means>5, p<0.01). At this time point, compared with patients with early stage cancer, those with advanced cancer showed worse QoL with all function and most symptom measures (p<0.01). Conclusions: Patients with precursor lesions or early stage esophageal/gastric cardia cancer show better QoL than those with advanced cancer. This indicates that screening, early diagnosis and treatment may improve the QoL for esophageal/gastric cardia cancer patients. Target intervention and counseling should be given by health care providers during treatment and follow-up to facilitate QoL improvement.
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기혈소통환(氣血疏通丸)이 Monosodium iodoacetate로 골관절염(骨關節炎)을 유도(誘導)한 랫드에 미치는 영향(影響)
허문강 ( Wen-qiang Xu ),김순근 ( Soon-keun Kim ),최학주 ( Hak-joo Choi ),김동희 ( Dong-hee Kim ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.3
Objectives : In cases of osteoarthritis, the hypofunction of the cartilage and joint leads to a limited range of joint motion, swelling, and pain, which is generally treated using pharmaceutical drugs (e.g., anti-inflammatory agents, cartilage protectants, and nonsteroidal anti-inflammatory drugs) or replacement arthroplasty. However, long-term drug treatment is associated with adverse effects on the gastrointestinal systems. The present study aimed to evaluate the ability of Giheolsotong-hwan to treat of osteoarthritis symptoms in the MIA-induced rat model based on histological analysis, and factors that are associated with inflammation and bone mineral metabolism. Methods : Giheolsotong-hwan was administered orally at doses of 200 ㎎/㎏/day or 400 ㎎/㎏/day for 2 weeks before direct injection of monosodium iodoacetate (3 ㎎/50㎕ of 0.9% saline) into the intra-articular space of the rats’ right knee. The rats subsequently received the same doses of oral Giheolsotong-hwan for another 4 weeks. We evaluated the treatment effects based on serum biomarkers and histopathological analysis of the knee joints. Results : Compared to those in control rats, the Giheolsotong-hwan treatments significantly decreased the serum concentration of inflammation factors (i.e., IL-1β, IL-6, TNF-α, PGE<sub>2</sub>, and LTB<sub>4</sub>), and bone degrade factors (i.e., MMP-9, CTX-Ⅱ, and COMP). In addition, the Giheolsotong-hwan treatments significantly increased the concentration of glycosaminoglycans of bone defence factors, but no chage the TIMP-1. Furthermore, the Giheolsotong-hwan treatments effectively preserved the knee cartilage and proteoglycan. Conclusion : The results indicate that Giheolsotong-hwan treated osteoarthritis symptoms. Thus, Giheolsotonghwan may be a novel oriental therapeutic option for the management of osteoarthritis.
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Bing-qiang Zhang,Qi-wen Chen,Feng-wen Lai,Fu-Quan Chen,Bin-bin Qi 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1
A gap formation underneath pipelines could be observed during tunneling beneath existing buried pipelines, thus altering the pipeline-soil interaction behavior. However, the most existing analytical approaches typically do a full contact assumption for brevity. For such purpose, we aim to present an analytical approach coupling the effect of gap formation underneath pipelines by considering the buried pipeline as an Euler-Bernoulli beam on tensionless foundation. The pipeline can be divided into three segments according to pipeline-soil interaction behavior, and then the bending behaviors of each segment are formulated. The deflection and bending moment of the pipeline caused by tunnelling underneath from the proposed approach are compared and validated with centrifuge testing data and existing analytical solutions. The effects of pipeline-soil stiffness ratio, pipeline buried depth, tunnel buried depth, tunneling induced volume loss, and tunnel-pipeline intersection angle on the pipeline responses are further discussed. The results indicate that gap formation underneath pipeline can be observed indeed for shallowly buried pipeline and/or larger pipeline-soil stiffness ratio. The proposed analytical approach provides a theoretical guideline to predict the responses of existing pipelines to tunnelling underneath.
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高文强(Gao Wen-Qiang) 동아인문학회 2009 동아인문학 Vol.15 No.-
The class conflict between gentry and plebs was a acute society contradiction that was brought by the politics of a family of power and influence in Wei and jin Dynasties. It was more extrusive after Jin Dynasty. However, this conflict began to get de-escalatory after Song Dynasty. The cause of this phenomena were many and various and Buddhist dissemination was a all important causation. Buddhism is a foreign culture and had prevailed among gentry groups since East Jin Dynasty. Therefore, Buddhist dissemination influenced on culture mentality of gentry profoundly after Jin Dynasty and stroked effectively the class contradiction between gentry and plebs from Jin and Song Dynasties. The impact and elimination of Buddhist dissemination on the class conflict between gentry and plebs in Song and Qi Dynasties involves two aspects. The one is Buddhism take in believers coequally. Then the believers were coequal and gentry and plebes coexist in many believer communities. The other one is many hierarchs were plebes. Just about these hierarchs were made after by gentry. This culture environment played a important role in eliminating the class conflict so as to get along between gentry and plebes in Yongming period.
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