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Ling‑Hong Miao,Wen‑Jing Pan,Yan Lin,Bo Liu,Ming‑Chun Ren,Qun‑Lan Zhou,Xian‑Ping Ge 한국유전학회 2017 Genes & Genomics Vol.39 No.12
The objective of this study was to analyze the target genes and regulatory function of miR-34a in Megalobrama amblycephala using second-generation highthroughput sequencing and bioinformatic tools. Functional enrichment analysis was performed by gene ontology. MiR- 34a and target gene expression levels were measured in M. amblycephala fed normal and high-carbohydrate diets. The results revealed that miR-34a was highly conserved in several species, and miR-34a of M. amblycephala has a close evolutionary relationship to that of zebrafish and common carp. miRanda, TargetScan, RNAhybrid predicted 5,185, 6,282 and 2,168 target genes, respectively, and 645 target genes were in common. According to annotation information, the target genes were enriched in phosphate metabolism, glycerophospholipid metabolism, Golgi vesicle transport, cell division, and other biological processes (P < 0.05). Pathway enrichment analysis revealed that these target genes were mainly enriched in alpha-linolenic acid and linoleic acid metabolism, ether lipid metabolism, VEGF signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, and MAPK signaling pathway (P < 0.05). The regulatory role of miR-34a was more significant in the liver than in the brain of M. amblycephala. MiR-34a regulates glucose lipid homeostasis induced by high glucose diets by upregulating hepatic PI3K/Akt, FOXO, and TOR signaling pathways.
Effect of Graphene Oxide on Carbonyl-Iron-Based Magnetorheological Fluid
Wen Ling Zhang,Sang Deuk Kim,Hyoung Jin Choi IEEE 2014 IEEE transactions on magnetics Vol.50 No.1
<P>Soft magnetic carbonyl iron (CI) particle-based magnetorheological (MR) fluids have been broadly used in mechanical systems due to their outstanding magnetic merits. However, serious sedimentation and agglomeration problems have been regarded as critical drawbacks during preparing and testing the CI-based MR fluids. In this study, we adopted plate-like particles of graphene oxide (GO) as a gap-filler for the CI-based MR fluid to improve its sedimentation problem. MR properties were evaluated using a rotational rheometer, and the improved dispersion characteristics were observed in the CI/GO mixture systems via a Turbiscan apparatus. To study the effectiveness of the GO additive more clearly, different weight ratios of GO in CI/GO mixture MR systems were compared.</P>
A study of the fresh properties of Recycled ready-mixed soil materials (RRMSM)
Wen-Ling Huang,Her-Yung Wang,Chen Jheng-Hung 사단법인 한국계산역학회 2016 Computers and Concrete, An International Journal Vol.17 No.6
Climate anomalies in recent years, numerous natural disasters caused by landslides and a large amount of entrained sands and stones in Taiwan have created significant disasters and greater difficulties in subsequent reconstruction. How to respond to these problems efficaciously is an important issue. In this study, the sands and stones were doped with recycled materials (waste LCD glass sand, slag powder), and material was mixed for recycled ready-mixed soil. The study is based on security and economic principles, using flowability test to determine the water-binder ratio (W/B=2.4, 2.6, and 2.8), a fixed soil: sand ratio of 6:4 and a soil: sand: glass ratio of 6:2:2 as fine aggregate. Slag (at concentrations of 0%, 20%, and 40%) replaced the cement. The following tests were conducted: flowability, initial setting time, unit weight, dropweight and compressive strength. The results show that the slump values are 220 -290 mm, the slump flow values are 460 -1030 mm, and the tube flow values are 240-590 mm, all conforming to the objectives of the design. The initial setting times are 945-1695 min. The unit weight deviations are 0.1-0.6%. The three groups of mixtures conform to the specification, being below 7.6 cm in the drop-weight test. In the compressive strength test, the water-binder ratios for 2.4 are optimal (13.78-17.84 kgf/cm2). The results show that Recycled ready-mixed soil materials (RRMSM) possesses excellent flowability. The other properties, applied to backfill engineering, can effectively save costs and are conducive to environmental protection.
Wen-Ling Dai,Xin-Tong Liu,Yi-Ni Bao,Bing Yan,Nan Jiang,Bo-Yang Yu,Ji-Hua Liu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Morphine tolerance remains a challenge in the management of chronic pain in the clinic. As shown in our previous study, the dopamine D2 receptor (D2DR) expressed in spinal cord neurons might be involved in morphine tolerance, but the underlying mechanisms remain to be elucidated. In the present study, selective spinal D2DR blockade attenuated morphine tolerance in mice by inhibiting phosphatidylinositol 3 kinase (PI3K)/serine–threonine kinase (Akt)-mitogen activated protein kinase (MAPK) signaling in a μ opioid receptor (MOR)-dependent manner. Levocorydalmine (l-CDL), which exhibited micromolar affinity for D2DR in D2/CHO-K1 cell lines in this report and effectively alleviated bone cancer pain in our previous study, attenuated morphine tolerance in rats with chronic bone cancer pain at nonanalgesic doses. Furthermore, the intrathecal administration of l-CDL obviously attenuated morphine tolerance, and the effect was reversed by a D2DR agonist in mice. Spinal D2DR inhibition and l-CDL also inhibited tolerance induced by the MOR agonist DAMGO. l-CDL and a D2DR small interfering RNA (siRNA) decreased the increase in levels of phosphorylated Akt and MAPK in the spinal cord; these changes were abolished by a PI3K inhibitor. In addition, the activated Akt and MAPK proteins in mice exhibiting morphine tolerance were inhibited by a MOR antagonist. Intrathecal administration of a PI3K inhibitor also attenuated DAMGO-induced tolerance. Based on these results, l-CDL antagonized spinal D2DR to attenuate morphine tolerance by inhibiting PI3K/Akt-dependent MAPK phosphorylation through MOR. These findings provide insights into a more versatile treatment for morphine tolerance.
Wen Ling Zhang,최형진 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.9
A suspension of semiconducting graphene oxide/polyaniline (GO/PANI) composite dispersed in silicone oil is considered as one of potential candidates for electrorheological (ER) fluids. The GO/PANI composite was synthesized by chemical oxidation polymerization of aniline in the presence of GO dispersion, in which the GO was prepared by a modified Hummers method. The characteristics of the composite were examined by SEM image and FT-IR spectra, indicating the coexistence of GO and PANI in the composite. The GO/PANI composite based ER fluid was prepared by dispersing the fabricated particles in silicone oil, and its dynamic viscoelastic properties were measured using a rotational rheometer under different electric field, showing that the ER fluid exhibited typical solid-like ER behaviors.
A Difference Expansion Based Reversible Data Hiding Algorithm Using Edge-Oriented Prediction
Wen-Chao Yang,Ling-Hwei Chen,Chang-Hsing Lee 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.6
In this paper, a difference expansion based reversible data hiding approach which achieves the low distortion requirement under the same embedding capacity is proposed. An edge-oriented prediction method and a modified overflow/underflow prevention method are proposed to achieve the requirement. For each pixel, the prediction method uses edge information to get a better predicted value in an attempt to reduce the image distortion. Experimental results have demonstrated that the proposed reversible data hiding method yields lower distortion than several well-known expansion-based reversible data hiding methods.
Field-responsive smart composite particle suspension: materials and rheology
Wen Ling Zhang,Ying Dan Liu,최형진 한국유변학회 2012 Korea-Australia rheology journal Vol.24 No.3
Both electrorheological (ER) and magnetorheological (MR) fluids are known to be smart materials which can be rapidly and reversibly transformed from a fluid-like to a solid-like state within milliseconds by show\-ing dramatic and tunable changes in their rheological properties under external electrical or magnetic field strength, respectively. Here, among various smart composite particles studied, recently developed core-shell structured polystyrene/graphene oxide composite based ER material as well as the dual-step functionally coated carbonyl iron composite based MR material are briefly reviewed along with their rheological char\-acteristics under external fields.
Wen Zhong-Ling,Yang Min-Kai,Fazal Aliya,Liao Yong-Hui,Cheng Lin-Run,Hua Xiao-Mei,Hu Dong-Qing,Shi Ji-Sen,Yang Rong-Wu,Lu Gui-Hua,Qi Jin-Liang,Zhi Hong,Qian Qiu-Ping,Yang Yong-Hua 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.8
In this study, two soybean genotypes, i.e., aluminum-tolerant Baxi 10 (BX10) and aluminumsensitive Bendi 2 (BD2), were used as plant materials and acidic red soil was used as growth medium. The soil layers from the inside to the outside of the root are: rhizospheric soil after washing (WRH), rhizospheric soil after brushing (BRH) and rhizospheric soil at two sides (SRH), respectively. The rhizosphere bacterial communities were analyzed by high-throughput sequencing of V4 hypervariable regions of 16S rRNA gene amplicons via Illumina MiSeq. The results of alpha diversity analysis showed that the BRH and SRH of BX10 were significantly lower in community richness than that of BD2, while the WRH exhibited no significant difference between BX10 and BD2. Among the three sampling compartments of the same soybean genotype, WRH had the lowest community richness and diversity while showing the highest coverage. Beta diversity analysis results displayed no significant difference for any compartment between the two genotypes, or among the three different sampling compartments for any same soybean genotype. However, the relative abundance of major bacterial taxa, specifically nitrogen-fixing and/or aluminum-tolerant bacteria, was significantly different in the compartments of the BRH and/or SRH at phylum and genus levels, indicating genotype-dependent variations in rhizosphere bacterial communities. Strikingly, as compared with BRH and SRH, the WRH within the same genotype (BX10 or BD2) always had an enrichment effect on rhizosphere bacteria associated with nitrogen fixation