Cancer Registration in the Peoples Republic of China

Wei, Kuang-Rong,Chen, Wan-Qing,Zhang, Si-Wei,Liang, Zhi-Heng,Zheng, Rong-Shou,Ou, Zhi-Xiong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

The current situation of cancer registration in China was systematically reviewed. So far, cancer registration in China has been making a great progress in the following aspects: the number of cancer registries and covered population have increased dramatically; a registration network has been established and completed gradually; regulations and rules improved remarkably; more attention is being paid by every level of government; a lot of registration software has been created and financial support ensured. However, we are still facing some problems and challenges, such as no stable groups of registrars, shortage of training opportunities, poor data quality, insufficient utilization and lack of multidisciplinary mechanisms, so that the cancer registration system still needs to be enhanced and improved. Along with the development of economy, science and information technology, methods and patterns of cancer registration is changing. It is to be expected that cancer registration will be automatic, nationwide and integrated with community healthcare in the near future.

Controlling Mannalian Cell Metabolism in Bioreactors

( WEI SHOU HU,WEICHANG ZHOU,LILITH F . EUROPA ) 한국미생물생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.1

Analysis of Indoleamine 2-3 Dioxygenase (IDO) and EGFR Co-expression in Breast Cancer Tissue by Immunohistochemistry

Bi, Wei-Wei,Zhang, Wei-Hua,Yin, Gui-Hua,Luo, Hong,Wang, Shou-Qin,Wang, Hongran,Li, Chao,Yan, Wei-Qun,Nie, De-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: To determine the amount of co-expression of IDO and EGFR in breast cancer patients. Materials and Methods:In order to obtain the distribution of co-expression of IDO and EGFR in breast cancer, we tested 110 breast cancer paraffin tissue blocks with immunohistochemical methods. Then we investigated the relationship between the diagnostic and pathologic characteristics (tumor size, lymph node status, histologic grade, the gene expression of ER, PR, HER2, p53, Ki67 and PCNA) with the situation of co-expression of IDO and EGFR by reviewing the medical records of 32 breast cancer patients. Results: Among 110 breast cancers, 32 cases demonstrated IDO and EGFR co-expression (29.1%), IDO and EGFR synchronous co-expression being found in 19.1% and asynchronous in 10.0%. Conclusions: IDO and EGFR were co-expressed in breast cancer, including synchronous and asynchronous co-expression. The results suggest that considering IDO and EGFR as two indicators for breast cancer treatment or prognosis analysis provides a potential option of individual treatment for the portion of breast cancer patients with co-expression of IDO and EGFR.

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Wu, Bai-Shou,Hu, Yi,Sun, Jing,Wang, Jin-Liang,Wang, Peng,Dong, Wei-Wei,Tao, Hai-Tao,Gao, Wen-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Objective: To retrospectively review the clinical characteristics and analyze the prognostic factors of Chinese patients with pulmonary neuroendocrine tumors. Materials and Methods: The clinical data of 176 patients with pulmonary neuroendocrine tumors in Chinese PLA General Hospital from Mar., 2000 to Oct., 2012 were retrospectively analyzed. The parameters were evaluated by univariate and multivariate analysis, including the gender, age, smoking history, family history, TNM staging, localization (central or peripheral), tumor size, nodal status, histological subtype and treatment (operation or non-operation). Results: There were 23 patients with typical carcinoids (TC) (13.1%), 41 with atypical carcinoids (AC) (23.3%), 10 with large cell neuroendocrine carcinoma (LCNEC) (5.7%) and 102 with small cell lung cancer (SCLC) (57.9%). The median follow-up time was 64.5 months for AC, 38 months for LCNEC and 27 months for SCLC. The typical carcinoid censored data was 18 (more than 50% of the patients), so the median follow-up time was not obtained, and actuarial 5-year survivals for TC, AC, LCNEC and SCLC were 75.1%, 51.7%, 26.7% and 38.8%, respectively. COX univariate analysis revealed that the age (P=0.001), histological subtype (P=0.005), nodal status (P=0.000), treatment (P=0.000) and TNM staging (P=0.000) were the prognostic factors of the patients with pulmonary neuroendocrine tumors, whereas its multivariate analysis showed that only the age(P=0.001), TNM staging (P=0.002) and treatment (P=0.000) were independent prognostic factors. Conclusions: Radical surgery remains the treatment of choice, and is the only curative option. The age, TNM staging and treatment are confirmed to be the independent prognostic factors in multivariable models for pulmonary neuroendocrine tumors.

Physics Parameters and Design Study for the Beijing Spallation Neutron Source

Shou-Xian Fang,C. Zhang,J. Wei,J.Y. Tang,Q. Qin,S. Wang,S.N. Fu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4

The Beijing Spallation Neutron Source (BSNS) will be the next large science facility in China. Based on an 80 MeV linac and a 1.6 GeV rapid cycling synchrotron, the BSNS has a goal to obtain a proton beam power of 100 kW with a repetition rate of 25 Hz in the first phase. An introduction to the conceptual design of the BSNS is given, and the main parameters and key technical features are summarized. The R&D plan is discussed.뒩b

Longissimus lumborum muscle transcriptome analysis of Laiwu and Yorkshire pigs differing in intramuscular fat content

Wei Chen,Guo‑feng Fang,Shou‑dong Wang,Hui Wang,Yong‑qing Zeng 한국유전학회 2017 Genes & Genomics Vol.39 No.7

The pig provides meat products for human consumption on a large scale. High-throughput sequencing technology provides a powerful approach for the characterization of the muscle transcriptome of pigs. Despite many studies using high-throughput technologies, the functional complexity of porcine muscle transcriptome is not fully elucidated. Therefore, the aim of this study was to gain insight into the longissimus lumborum muscle transcriptome between two pig breeds with distinct phenotypes, Laiwu pig, a Chinese indigenous pig breed, and Yorkshire pig, a Western breed. RNA-seq was applied to sample transcripts of the longissimus lumborum muscle between the two pig breeds to gain insights into wholegenome transcription profiles. For the Laiwu and Yorkshire libraries, we obtained a total of 40,498,476 and 59,072,892 high quality reads, respectively. Moreover, the resulting data set provided expression patterns for many annotated, predicted and novel pig genes. 178 significantly differentially expressed genes were identified between the Laiwu and Yorkshire pigs, with 98 up-regulated and 80 downregulated genes in Laiwu pig compared with Yorkshire pig. Gene expression results of the RNA-seq data were validated by qRT-PCR for twelve genes. Genes that were differentially expressed were involved in lipid metabolism and were more highly expressed in Laiwu pigs. The present study provides a comprehensive view of differences in the muscle transcriptome between two pig phenotypes. These results expand our knowledge of the genes transcribed in the skeletal muscle of two breeds and provide a basis for future research of the molecular mechanisms underlying the phenotypic differences on meat quality.

Characterization and differential expression of microRNA in skeletal muscle of Laiwu and Yorkshire pig breeds

Wei Chen,Guo-Feng Fang,Shou-Dong Wang,Hui Wang,Yong-Qing Zeng 한국유전학회 2017 Genes & Genomics Vol.39 No.2

The domestic pig is an important agricultural animal used as a source of meat worldwide. As an important resource, Laiwu pig has some special characteristics compared with Yorkshire pig. It is necessary to identify the differentially expressed microRNAs (miRNAs) in skeletal muscle between two pig breeds. Therefore, we herein performed a comprehensive investigation for miRNA transcriptome of skeletal muscle from the two pig breeds. On average, we obtained approximately 13,493,607 clean reads in Laiwu pig and 12,938,257 clean reads in Yorkshire pig in this study. Totally, 265 known miRNAs were identified, and among these, 229 miRNAs were expressed in all the six pigs. From the 265 known miRNAs, 19 of these miRNAs were found significantly differentially expressed (q\0.05). Of these significantly expressed miRNAs, seven miRNAs were significantly upregulated and 12 miRNAs were down-regulated in Laiwu pig compared with Yorkshire pig. Among the significantly expressed miRNAs, ssc-miR-194-5p has the largest foldchange (6.35-fold). Ten differentially expressed miRNAs selected from high throughput sequencing were confirmed by real-time RT-PCR (RT-qPCR), and the results indicated that the expression patterns were consistent with sequencing results. Our results not only present a comprehensive miRNA transcriptome profile of skeletal muscle between two pig breeds with distinct phenotypes, but also could be useful for investigating the functions of differentially expressed miRNAs associated with the phenotype traits.

CMAC-based compound control of hydraulically driven 6-DOF parallel manipulator

Shou-Kun Wang,Jun-Zheng Wang,Da-Wei Shi 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.6

The movement precision of the hydraulically driven 6-six degrees of freedom (6-DOF) parallel manipulator is determined mainly by the precision of the valve-controlled asymmetrical cylinder (VCAC). Unfortunately, the asymmetrical movement of the VCAC caused by its asymmetrical structure can significantly compromise control precision. Owing to this asymmetry and, more fundamentally, the inherent nonlinearity of hydraulic systems as well as complicated load variations, it is very difficult to achieve ideal control precision with traditional (PID) control. In the present study, the working principle and characteristics of VCAC were analyzed, with particular focus on the asymmetry problem. In order to improve the precision of both VCAC control and 6-DOF parallel manipulator movement,this paper presents a new, cerebellar model articulation control (CMAC)-based control method. Experiments on both the single VCAC system and the parallel manipulator were developed to verify the validity and effectiveness of the new compound control method. The theoretical analysis and testing results, compared with those for the PID control, proved that the proposed CMAC-based control method can acquire high movement precision on the 6-DOF motion simulator while eliminating the need to build a mathematical model or obtain accurate loading conditions.

Regeneration and Recycling of Waste Thermosetting Plastics based on Mechanical Thermal Coupling Fields

Zhong-Wei Wu,Shaobo Pan,Guang-Fu Liu,Shou-Xu Song 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

In view of the present situation that the recovery of waste thermosetting plastics and products is difficult and the utilization rate islow, regeneration mechanism, regeneration methods and recycling process of waste thermosetting plastics under mechanical thermalcoupling fields are proposed. Regeneration powders of Thermosetting Phenolic plastic are obtained by mechanochemical activatedregeneration methods, the molecular structure, properties and crosslink density of phenol regeneration materials are analyzed. Analysis results show that network crosslinked molecular structure was destroyed, reactive groups produced and the crosslink densitydecreased. The activity of regeneration powders was reinforced and its plasticity was also improving, so the utilization rate wasimproved. Regeneration composite plastics were manufactured by hot press molding or extrusion compression molding. Themicrostructure of regeneration composite plastics was analyzed, and its mechanical strength was tested. Results showed that thetensile strength and bending strength of samples (weight ratio ≥ 50%) respectively exceed 15.88 MPa and 33.49 MPa. At last processparameters for regeneration effects were discussed, and these parameters were optimized. When particle size was 80 mesh (size ≤ 0.18mm), quality proportion was 50~70%, pressure was 10Mpa, heating temperature was 180~190oC, the optimal effects for regeneratedcomposite were achieved.

Optimal design of hydraulic support landing platform for a four-rotor dish-shaped UUV using particle swarm optimization

Zhang, Bao-Shou,Song, Bao-Wei,Jiang, Jun,Mao, Zhao-Yong The Society of Naval Architects of Korea 2016 International Journal of Naval Architecture and Oc Vol.8 No.5

Four-rotor dish-shaped unmanned underwater vehicles (FRDS UUVs) are new type underwater vehicles. The main goal of this paper is to develop a quick method to optimize the design of hydraulic support landing platform for the new UUV. In this paper, the geometry configuration and instability type of the platform are defined. Computational investigations are carried out to study the hydrodynamic performance of the landing platform using the Computational Fluid Dynamics (CFD) method. Then, the response surface model of the optimization objective is established. The intelligent particle swarm optimization (PSO) is applied to finding the optimal solution. The result demonstrates that the stability of landing platform is significantly improved with the global objective index increasing from 1.045 to 1.158 (10.86% higher) after the optimization process.