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RISS 인기검색어
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- 저자 : Wahyuono, (검색결과 4 건)
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Astuti, Puji,Erden, Willy,Wahyono, Wahyono,Wahyuono, Subagus,Hertiani, Triana Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Ethyl acetate extracts obtained from culture of endophytic fungi Aspergillus sp isolated from Piper crocatum Ruiz & Pav, have been shown to possess cytotoxic activity against T47D breast cancer cells. Investigations were here conducted to determine bioactive compounds responsible for the activity. Bioassay guided fractionation was employed to obtain active compounds. Structure elucidation was performed based on analysis of LC-MS, $^1H$-NMR, $^{13}C$-NMR, COSY, DEPT, HMQC, HMBC data. Cytotoxity assays were conducted in 96 well plates against T47D and Vero cell lines. Bioassay guided isolation and chemical investigation led to the isolation of pyrophen, a 4-methoxy-6-(1'-acetamido-2'-phenylethyl)-2H-pyran-2-one. Further analysis of its activity against T47D and Vero cells showed an ability to inhibit the growth of T47D cells with IC50 values of $9.2{\mu}g/mL$ but less cytotoxicity to Vero cells with an $IC_{50}$ of $109{\mu}g/mL$. This compound at a concentration of 400 ng/mL induced S-phase arrest in T47D cells.
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Nugroho, Agung Endro,Wahyono, Wahyono,Wahyuono, Subagus,Maeyama, Kazutaka Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.3
The fruits of Piper cubeba L. are used traditionally to treat respiratory disorders in Indonesia. In order to determine the compounds responsible for this activity, the fruits were extracted with nhexane followed by ethanol to give n-hexane and ethanol extracts. Based on tracheospasmolytic assay on these two extracts, the n-hexane extract was more active to inhibit trachea contraction than that of ethanol extract. Upon bioassay guided isolation of the n-hexane extract, a tracheospasmolytic active compound was isolated and identified as dihydrocubebin [(3,4),(3',4')-bis-methylenedioxy-9,9'dihydroxylignan] $(\underline{1})$. Compound $\underline{1}$ was tested further for its ability to inhibit histamine released from mast cells, using rat basophilic leukemia (RBL-2H3) cell line and rat peritoneal mast cells RPMCs) as models; and $DNP_{24}$-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine released from mast cell. The test result showed that $\underline{1}$ inhibited histamine release from RBL-2H3 cells induced by $DNP_{24}$-BSA, thapsigargin and ionomycin. In addition, $\underline{1}$ suppressed histamine release from RPMC induced by either thapsigargin or ionomycin. However, $\underline{1}$ did not inhibit histamine release from RPMC induced by either compound 48/80 or combination PMA-sub optimum dose of ionomycin. Therefore, it was concluded that the inhibitory effects of $\underline{1}$ on the histamine released from mast cells may involve mechanisms related to intracellular $Ca^{2+}$ signaling events or downstream processes of intracellular $Ca^{2+}$ signaling in mast cells.
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Agung Endro Nugroho,Wahyono,Subagus Wahyuono,Kazutaka Maeyama 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.3
The fruits of Piper cubeba L. are used traditionally to treat respiratory disorders in Indonesia. In order to determine the compounds responsible for this activity, the fruits were extracted with n-hexane followed by ethanol to give n-hexane and ethanol extracts. Based on tracheospasmolytic assay on these two extracts, the n-hexane extract was more active to inhibit trachea contraction than that of ethanol extract. Upon bioassay guided isolation of the n-hexane extract, a tracheospasmolytic active compound was isolated and identified as dihydrocubebin [(3,4),(3’,4’)-bis-methylenedioxy-9,9’dihydroxylignan] (1). Compound 1 was tested further for its ability to inhibit histamine released from mast cells, using rat basophilic leukemia (RBL-2H3) cell line and rat peritoneal mast cells RPMCs) as models; and DNP24-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine released from mast cell. The test result showed that 1 inhibited histamine release from RBL-2H3 cells induced by DNP24-BSA, thapsigargin and ionomycin. In addition, 1 suppressed histamine release from RPMC induced by either thapsigargin or ionomycin. However, 1 did not inhibit histamine release from RPMC induced by either compound 48/80 or combination PMA-sub optimum dose of ionomycin. Therefore, it was concluded that the inhibitory effects of 1 on the histamine released from mast cells may involve mechanisms related to intracellular Ca 2+signaling events or downstream processes of intracellular Ca 2+signaling in mast cells.
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DESIGN OF REGENERATIVE BRAKING SYSTEM FOR ELECTRIC MOTORCYCLE BASED ON SUPERCAPACITOR WITH FUZZY PID
Suyanto,Purwadi Agus Darwito,Ruri Agung Wahyuono,Muh. Samsul Arifin,Bambang Sudarmanta 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.1
The Hybrid Electrical Energy Storage System (HESS) with supercapacitors in “GESITS” electric motorcycle offers greater power density and cycle life as well as a wider operating temperature range compared to batteries so as to maximize the existing regenerative braking features. In this study, the Four Switch Buck Boost Converter (FSBB) with Power Transfer is used as a current regulator to connect HESS. Fuzzy PID control is used to regulate the current that passes through the power transfer so that the braking force can be controlled based on the brake pull variable, vehicle speed and SOC supercapacitor. The results of the fuzzy control test with the MATLAB Fuzzy Designer obtained an average error of 1.44 %. While the results of the ITAE PID tuning method obtained a rise time of 3.33 seconds, a settling time of 3.11 seconds, an overshoot of 9.20 % and a steady state error of 2.20 %. From the results of the regenerative mode test, when given an input of 28-4 VDC, the average output voltage is 16.34 VDC with an average current of 8 A. While in the drive mode test with 28 VDC input, the average output voltage is 23.98 VDC and average current is 3.99 A with FSBB efficiency of 90.54 %.
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