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Kenneth Kin Leung Kwan,Huang Yun,Tina Ting Xia Dong,Karl Wah Keung Tsim 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.4
Background: Mitochondrial dysfunction is one of the significant reasons for Alzheimer"s disease (AD). Ginsenosides, natural molecules extracted from Panax ginseng, have been demonstrated to exert essential neuroprotective functions, which can ascribe to its anti-oxidative effect, enhancing central metabolism and improving mitochondrial function. However, a comprehensive analysis of cellular mitochondrial bioenergetics after ginsenoside treatment under Aβ-oxidative stress is missing. Methods: The antioxidant activities of ginsenoside Rb₁, Rd, Re, Rg₁ were compared by measuring the cell survival and reactive oxygen species (ROS) formation. Next, the protective effects of ginsenosides of mitochondrial bioenergetics were examined by measuring oxygen consumption rate (OCR) in PC12 cells under Aβ-oxidative stress with an extracellular flux analyzer. Meanwhile, mitochondrial membrane potential (MMP) and mitochondrial dynamics were evaluated by confocal laser scanning microscopy. Results: Ginsenoside Rg₁ possessed the strongest anti-oxidative property, and which therefore provided the best protective function to PC12 cells under the Ab oxidative stress by increasing ATP production to 3 folds, spare capacity to 2 folds, maximal respiration to 2 folds and non-mitochondrial respiration to 1.5 folds, as compared to Aβ cell model. Furthermore, ginsenoside Rg1 enhanced MMP and mitochondrial interconnectivity, and simultaneously reduced mitochondrial circularity. Conclusion: In the present study, these results demonstrated that ginsenoside Rg₁ could be the best natural compound, as compared with other ginsenosides, by modulating the OCR of cultured PC12 cells during oxidative phosphorylation, in regulating MMP and in improving mitochondria dynamics under Aβ-induced oxidative stress.
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Smart Hanger Dynamic Modeling and Fuzzy Controller Design
Eric Hoi-Kwun Fung,Yiu-Kwong Wong,Yan Ma,Chun-Wah Marcus Yuen,Wai-Keung Wong 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.4
The controlled smart hanger is an indispensable component in the automatic system for garment inspection. Fuzzy logic is chosen for the smart hanger manipulator since it can describe the human behavior remarkably well. In this paper, the dynamic model of the manipulator governing the contact force with garment fabric is first developed. An adaptive fuzzy logic PID control scheme is successfully formulated for the contact force control. Simulation results indicate that the fuzzy PID controller can yield a faster response without overshoot and a smaller error performance as compared to the traditional method based on PID. The stability of the fuzzy PID controller is also demonstrated by computer simulations.
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Huang, Yun,Kwan, Kenneth Kin Leung,Leung, Ka Wing,Yao, Ping,Wang, Huaiyou,Dong, Tina Tingxia,Tsim, Karl Wah Keung The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.4
Background: The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used "Qi-invigorating" herbs, which provides tonic and preventive effects by resisting oxidative stress, influencing energy metabolism, and improving mitochondrial function. Very few reports have systematically measured cell mitochondrial bioenergetics after ginseng treatment. Methods: Here, H9C2 cell line, a rat cardiomyoblast, was treated with ginseng extracts having extracted using solvents of different polarity, i.e., water, 50% ethanol, and 90% ethanol, and subsequently, the oxygen consumption rate in healthy and tert-butyl hydroperoxideetreated live cultures was determined by Seahorse extracellular flux analyzer. Results: The 90% ethanol extracts of ginseng possessed the strongest antioxidative and tonic activities to mitochondrial respiration and therefore provided the best protective effects to H9C2 cardiomyocytes. By increasing the spare respiratory capacity of stressed H9C2 cells up to three-folds of that of healthy cells, the 90% ethanol extracts of ginseng greatly improved the tolerance of myocardial cells to oxidative damage. Conclusion: These results demonstrated that the low polarity extracts of ginseng could be the best extract, as compared with others, in regulating the oxygen consumption rate of cultured cardiomyocytes during mitochondrial respiration.
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Yun Huang,Kenneth Kin Leung Kwan,Ka Wing Leung,Ping Yao,HuaiyouWang,Tina Tingxia Dong,Karl Wah Keung Tsim 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicineand functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng isthe most widely used “Qi-invigorating” herbs, which provides tonic and preventive effects by resistingoxidative stress, influencing energy metabolism, and improving mitochondrial function. Very few reportshave systematically measured cell mitochondrial bioenergetics after ginseng treatment. Methods: Here, H9C2 cell line, a rat cardiomyoblast, was treated with ginseng extracts having extractedusing solvents of different polarity, i.e., water, 50% ethanol, and 90% ethanol, and subsequently, theoxygen consumption rate in healthy and tert-butyl hydroperoxideetreated live cultures was determinedby Seahorse extracellular flux analyzer. Results: The 90% ethanol extracts of ginseng possessed the strongest antioxidative and tonic activities tomitochondrial respiration and therefore provided the best protective effects to H9C2 cardiomyocytes. Byincreasing the spare respiratory capacity of stressed H9C2 cells up to three-folds of that of healthy cells,the 90% ethanol extracts of ginseng greatly improved the tolerance of myocardial cells to oxidativedamage. Conclusion: These results demonstrated that the low polarity extracts of ginseng could be the bestextract, as compared with others, in regulating the oxygen consumption rate of cultured cardiomyocytesduring mitochondrial respiration.
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David Jiyao Chou,Kelly Yinching Lam,Jianping Chen,Ping Yao,Tina Tingxia Dong,Aizhen Xiong,Guixin Chou,Zhengtao Wang,Karl Wah-Keung Tsim 셀메드 세포교정의약학회 2014 셀메드 (CellMed) Vol.4 No.4
Linderae Radix, the dry roots of Lindera aggregata (Sims) Kosterm, has long been used as traditional Chinese medicine for treatment of inflammatory diseases. The total alkaloids are believed to be the active components responsible for anti-inflammation of Linderae Radix. Here, the total alkaloids of Linderae Radix were extracted and isolated, including 12 isoquinoline alkaloids and 1 furan sesquiterpene. Within the alkaloids, norisoboldine, boldine, linderaline, isoboldine, reticuline, N-methyllaurotetanine, norjuziphine were found to be the major ingredients. In lipopolysaccharide-treated macrophage RAW 264.7 cells, application of Linderae Radix extract, or total alkaloids, suppressed the transcription of pro-inflammatory cytokines, interleukin-1β and interleukin-6. Out of the 12 alkaloids, norisoboldine, boldine, and isoboldine were tested in lipopolysaccharide-treated macrophages, and norisoboldine was the strongest alkaloid in suppressing the cytokine expressions. The current studies suggested that the identification of alkaloids from Linderae Radix could provide a plausible explanation for herbal therapeutic functions.
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