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- 저자 : Venkatalakshmi, Nagella (검색결과 5 건)
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Long-Term Exposure of Sildenafil Citrate on Sperm Parameters in Rat
Suresh, Sekar,Prithiviraj, Elumali,Venkatalakshmi, Nagella,Ganesh, Mohanraj Karthik,Ganesh, Lakshmanan,Lee, Hyun-Jeong,Prakash, Seppan The Korean Society of Animal Reproduction 2011 Reproductive & developmental biology Vol.35 No.4
Sildenafil citrate (SIL) a phosphodiesterase 5 inhibitor (PDE5I) has been used for long time as a first line oral drug for erectile dysfunction. Though it has beneficial effects on erectile organ it also has some adverse effects in other cells and/or tissues related to reproductive system when exposed to longer duration. The objective of the present study is to evaluate the long term effect of SIL on sperm parameters in Wistar albino rat. The animals are divided into two groups, for group I - rats were treated with saline (vehicle alone) and group - II oral administration of 5 mg/kg b.w. of SIL was administrated orally once in a day for 120 days. At the end of the trial period animals were sacrificed and epididymal sperm were subjected to various analysis. Results showed significant reduction in sperm count, motility, viability and morphologically intact sperm in long term PDE5I exposed animals when compared to control. Acrosomal status and fertility test also showed significant reduction in long term PDE5I exposed animals. The present study clearly indicated that long term SIL has shown to induce alteration in sperm quality and quantity, leading to decline in fertility rate. Indicate that SIL impinge on spermatogenesis as well as epididymal function. Understanding the molecular down-stream events involved in long-term exposure to PDE5 inhibitor can be valuable to supervise on related infertility issues and to suggest corrective measures.
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Suresh, Sekar,Prithiviraj, Ealumali,Venkatalakshmi, Nagella,Ganesh, Mohanraj Karthik,Ganesh, Lakshmanan,Lee, Hyun-Jeong,Prakash, Seppan The Korean Society of Animal Reproduction 2011 Reproductive & developmental biology Vol.35 No.4
The study aim is to investigate the free radicals scavenging and spermatogenic potentials, as well as to analyze any reproductive toxicity of ethanolic extract of Mucuna prureins (M. pruriens) Linn. in spermatozoa, under different dosages in normal male rat. Normal rats were randomly selected and suspension of the extract was administered orally at the dosages of 150, 200 and 250 mg/kg body weight of the different groups of male rats (n=6) once in a day for 60 days and grouped as group II, III and IV respectively. Saline treated rats served as control -group I. On the $60^{th}$ day the animals were sacrificed and the epididymal sperm were subjected to various analyses like level of ROS production, LPO, enzymatic and non enzymatic antioxidant, morphology, morphometry, chromosomal integrity and DNA damage. Results showed significant reduction in ROS production and peroxidation and significant increase in both enzymic and non-enzymic antioxidants in all concentration treated groups when compared with control. Results from all the drug treated groups showed good sperm morphology, increased sperm count and motility. There was no DNA damage and showed normal chromosomal integrity even in 250 mg/kg dose. When compared with control all the three extract treated groups showed increased ROS scavenging activity. However, group II (200 mg/kg) showed significant changes in all the parameters. From the present study it was confirmed that the M. pruriens has potential to improve the sperm qualitatively and quantitatively through scavenging the excess ROS with any adverse side effects. These observations suggest that ethanolic seed extract of M. pruriens may serve as anti-oxidant that can exploit to treat the oxidative stress mediated male factor infertility.
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Snekha B.,Saravanan Venkatalakshmi,Thirumalaivasan R.,Thannmadhi S.,Sneha S.,Sournamaalya N. D.,Mangaiarkarasi N.,Mooventhan A. 대한침구의학회 2026 Journal of Acupuncture Research Vol.43 No.-
Background: Reflexology is a timeless healing art rooted in ancient Chinese, Egyptian, and Native American cultures. Cognition refers to the brain’s capacity to gather, interpret, retain, and recall information. Previous studies have highlighted the positive effects of reflexology on brain functions; however, little is known about its effects on cognitive function. Thus, this study evaluated foot reflexology’s effect on cognitive function in healthy individuals. Methods: In this randomized controlled trial, 50 healthy individuals aged 17–30 years were randomly allocated into two groups: a study group (n = 25) and a control group (n = 25). The study group underwent a 20-minutes foot reflexology session each day for 10 days, whereas the control group did not receive any treatment. Cognitive function was evaluated before and after the intervention using visual reaction time (VRT), auditory reaction time (ART), and critical flicker fusion frequency (CFFF). Statistical analysis was conducted using SPSS version 16.0. Results: The between-group analysis revealed a significant decrease in VRT (p = 0.003), while no significant changes were observed in ART and CFFF in the study group compared to the control group. In the within-group analysis, the study group demonstrated a significant reduction in ART (p = 0.003) and VRT (p = 0.001) along with a significant increase in CFFF (p = 0.001). No significant changes were observed in the control group. Conclusion: In this study, 20 minutes of foot reflexology improves cognitive function in healthy individuals. Further randomized controlled trials with a larger sample size and extended follow-up are recommended to substantiate the findings.
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