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        Optimizing a Submerged Monascus cultivation for Production of Red Pigment with Bug Damaged Wheat using Artificial Neural Networks

        Serap Duraklı-Velioğlu,İsmail Hakkı Boyacı,Osman Şimşek,Tuncay Gümüş 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.6

        The combined effect of temperature, agitationspeed, and light on red pigment production by Monascuspurpureus (M. purpureus) Went DSM 1604 using bugdamaged wheat was studied using an artificial neuralnetwork (ANN). Information retrieved from the ANN wasused to determine the optimal operating conditions forpigment production by M. purpureus using bug damagedwheat meal. The developed ANN had R2 values fortraining, validation, and testing data sets of 0.993, 0.961,and 0.944, respectively. According to the model, thehighest pigment production of 1.874 absorbance units at510 nm (A510 nm) would be achieved at 29oC and 150 rpmunder light conditions. The mean value of the experimentalresults obtained under these optimum conditions was1.787±0.072 A510 nm, corresponding to a pigment yield of35.740 A510 nm/g. The study showed that bug damagedwheat can be used as a substrate for red pigment productionby M. purpureus.

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        Lumbar Disc Herniation in a Patient With Congenital Vertebral Body Anomaly: A Case Report

        Cem Atabey,Ahmet Eroğlu,Ali Kivanc Topuz,Murat Velioğlu,Mehmet Nusret Demircan 대한척추신경외과학회 2014 Neurospine Vol.11 No.4

        Lumbar disc herniation is characterized with low back and leg pain resulting from the degenerated lumbar disc compressing the spinal nerve root. The etiology of degenerative spine is related to age, smoking, microtrauma, obesity, disorders of familial collagen structure, occupational and sports-related physical activity. However, disc herniations induced by congenital lumbar vertebral anomalies are rarely seen. Vertebral fusion defect is one of the causes of congenital anomalies. The pathogenesis of embryological corpus vertebral fusion anomaly is not fully known. In this paper, a 30- year-old patient who had the complaints of low back and right leg pain after falling from a height is presented. She had right L5-S1 disc herniation that had developed on the basis of S1 vertebra corpus fusion anomaly in Lumbar computed tomography. This case has been discussed in the light of literature based on evaluations of Lumbar Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). This case is unique in that it is the first case with development of lumbar disc herniation associated with S1 vertebral corpus fusion anomaly. Congenital malformations with unusual clinical presentation after trauma shouldbe evaluated through advanced radiological imaging techniques.

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