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The First Probable Case of Hereditary Angioedema in Vietnam
Khanh Bui Van,Doan Nguyen Van 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.3
Hereditary angioedema (HAE) is rare disorder due to C1-inhibitor deficiency (C1-INH) that are debilitating and may be life-threatening. HAE is a lack of consensus concerning diagnosis, therapy, and management, particularly in Vietnam. In this case report, we report a 40-year-old male patient with typical clinical symptoms and family history but he showed normal C4 level, and we could not measure C1q and C1-INH level. However, the diagnosis of HAE can be made based on typical clinical symptoms and the favorable prophylactic response to danazol treatment. Based on these findings,we suggest that he has type I HAE, although he showed normal C4 level.
Van Khanh Nguyen,이무현,박형준,이종운 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Microbial removal of heavy metals in mine tailings from a Cu–Ag mine in the Philippines wasinvestigated. Effect of bacterial strains on bioleaching and fractionation of heavy metals were alsostudied. Single and mixed cultures of Acidithiobacillus thiooxidans and Acidithiobacillus ferrooxidans wereused separately to compare efficiency of metal solubilization. The results showed that mixed cultureswere more efficient than each bacterium for Cu and As, while A. ferrooxidans demonstrated fasterextraction efficiency for Mn and Zn. The results of sequential extraction for residues indicated that purebacteria and mixed cultures mediated occurrence mode of heavy metals in different ways.
Van Khanh Nguyen,최원영,하연주,구여진,이찬희,박재현,장건우,신차정,조순자 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.78 No.-
Two highly tellurite-resistant bacteria were isolated from wastewater. Both bacteria could performtellurite reduction under an initial pH of 5–9, temperature of 20–37 C, and salinity conditions lower than5%. The maximum reduction rate of strain WYA (Vmax = 20.45 mMh 1) was much higher than that of strainWYS (Vmax = 11.49 mMh 1). Both bacteria produced tellurium nanorods that were accumulatedintracellularly or extracellularly. Strain WYA is a new strain belonging to the Raoultella genus, whereasstrain WYS belongs to the Escherichia genus. This study indicated that both these bacteria are potentialmicroorganisms for green synthesis of tellurium nanorods, which have a wide application inenvironmental remediation and the nanotechnology industry.
Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability
Van Nguyen Khanh,Dang Thu Kim,Vu Linh Thi Dieu,Ha Nhan Thi,Truong Hieu Duy,Tran Tuan Hiep 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.3
Purpose Loratadine (LOR), a commonly prescribed antihistamine, has low water solubility but high permeability. In this study, an orodispersible film incorporating the nanoparticulate loratadine was prepared to enhance the oral bioavailability of a poorly water-soluble drug. Methods Nanoparticulate loratadine was formulated using the antisolvent precipitation method and optimized by a singlefactor design based on the particle size and polydispersity index. The optimal formulation was spray-dried and characterized by powder X-ray diffraction and differential scanning calorimetry. Nanoparticulate loratadine was loaded into an orodispersible film using a solvent casting method. Results In the dissolution tests, the nanoparticulate loratadine-loaded orodispersible film exhibited a 6.5-fold higher dissolution rate than the pure loratadine-loaded film and a similar dissolution rate compared to the commercialized orodispersible tablet, Loratadine SPM. In pharmacokinetic studies conducted on rats, the maximum concentration (Cmax) and area under the curve of the plasma concentration–time profile from 0 to 24 h (AUC 0-24 h) of the nanoparticulate loratadine-loaded orodispersible film significantly increased 1.8-fold and 5.8-fold, respectively. The elimination half-life (t1//2) increased 5.1-fold compared to the loratadine-loaded counterpart. Conclusion These results suggest the potential of orodispersible films to improve the oral bioavailability of poorly watersoluble drugs and promote compliance in pediatric and geriatric patients.
Van Khanh Nguyen,Jong Un Lee 한국지질과학협의회 2014 Geosciences Journal Vol.18 No.3
The catalytic effect of activated charcoal on the microbialextraction of As and heavy metals from mine tailings collectedfrom a floatation plant in the Philippines was investigated using amixed culture of Acidithiobacillus ferrooxidans and A. thiooxidans. The addition of activated charcoal enhanced the extraction of Cu,Zn and As significantly. The optimal concentration of activatedcharcoal for enhancing Cu, Zn and As extraction was found to be4 g/L, 1 g/L, and 2 g/L, respectively. However, the presence of activatedcharcoal was observed to depress the dissolution of Mn andFe. The highest extraction efficiencies for Mn, Cu, Zn, As, and Fewere 98%, 86%, 84%, 83%, and 46%, respectively. The resultsindicated that the addition of activated charcoal to conventionalbioleaching technique may provide more effective and less costlymethod for extraction of heavy metals from mine tailings.
Nguyen, Van Khanh,Park, Younghyun,Yu, Jaecheul,Lee, Taeho Elsevier 2016 Bioresource technology Vol.212 No.-
<P><B>Abstract</B></P> <P>Selenium is said to be multifaceted element because it is essential at a low concentration but very toxic at an elevated level. For the purpose of screening a potential microorganism for selenite bioremediation, we isolated a bacterium, named strain THL1, which could perform both heterotrophic selenite reduction, using organic carbons such as acetate, lactate, propionate, and butyrate as electron donors under microaerobic condition, and electrotrophic selenite reduction, using an electrode polarized at −0.3V (vs. standard hydrogen electrode) as the sole electron donor under anaerobic condition. This bacterium determined to be a new strain of the genus <I>Cronobacter</I>, could remove selenite with an efficiency of up to 100%. This study is the first demonstration on a pure culture could take up electrons from an electrode to perform selenite reduction. The selenium nanoparticles produced by microbial selenite reduction might be considered for recovery and use in the nanotechnology industry.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Strain THL1 can use organic or electrode as electron donor for Se(IV) reduction. </LI> <LI> Strain THL1 can remove 1mM of Se(IV) within 3d under heterotrophic condition. </LI> <LI> The Se(IV) reduction rate by electrotrophy was lower than that by heterotrophy. </LI> <LI> Strain THL1 was found to be affiliated with <I>Cronobacter</I> spp. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>