Pharyngeal airway dimensions in skeletal class II: A cephalometric growth study

Uslu-Akcam, Ozge Korean Academy of Oral and Maxillofacial Radiology 2017 Imaging Science in Dentistry Vol.47 No.1

Purpose: This retrospective study aimed to evaluate the nasopharyngeal and oropharyngeal dimensions of individuals with skeletal class II, division 1 and division 2 patterns during the pre-peak, peak, and post-peak growth periods for comparison with a skeletal class I control group. Materials and Methods: Totally 124 lateral cephalograms (47 for skeletal class I; 45 for skeletal class II, division 1; and 32 for skeletal class II, division 2) in pre-peak, peak, and post-peak growth periods were selected from the department archives. Thirteen landmarks, 4 angular and 4 linear measurements, and 4 proportional calculations were obtained. The ANOVA and Duncan test were applied to compare the differences among the study groups during the growth periods. Results: Statistically significant differences were found between the skeletal class II, division 2 group and other groups for the gonion-gnathion/sella-nasion angle. The sella-nasion-B-point angle was different among the groups, while the A-point-nasion-B-point angle was significantly different for all 3 groups. The nasopharyngeal airway space showed a statistically significant difference among the groups throughout the growth periods. The interaction among the growth periods and study groups was statistically significant regarding the upper oropharyngeal airway space measurement. The lower oropharyngeal airway space measurement showed a statistically significant difference among the groups, with the smallest dimension observed in the skeletal class II, division 2 group. Conclusion: The naso-oropharyngeal airway dimensions showed a statistically significant difference among the class II, division 1; class II, division 2; and class I groups during different growth periods.

Advantages, risks and legal perspectives of GMOs in 2020s

Uslu Tugce 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.6

The term ‘genetically modified organisms (GMO)’ is still an under-discussion topic since it was introduced decades ago. Beside public concerns against GM products, some of the scientists claim it is a vital tool to improve plant breeding in the future, while others emphasize potential harmful effects of the technology. In this paper, advantages, risks, and some techno- logical developments of GMOs technology were discussed with old and recent studies to understand where we are at GMO technology in 2020s. GMO technology also has a great impact on global economy with a total of US$ 224.9 billion profit between 1996 and 2018. Its economic impact makes the technology inevitable in the future. Thus, this paper will also explain legal perspectives of the countries against GM crop breeding and marketing.

Effect of glide path preparation with PathFile and ProGlider on the cyclic fatigue resistance of WaveOne nickel-titanium files

Uslu, Gulsah,Inan, Ugur The Korean Academy of Conservative Dentistry 2019 Restorative Dentistry & Endodontics Vol.44 No.2

Objectives: The aim of this study was to investigate the effect of glide path preparation with PathFile and ProGlider nickel-titanium (NiTi) files on the cyclic fatigue resistance of WaveOne NiTi files. Materials and Methods: Forty-four WaveOne Primary files were used and divided into four groups (n = 11). In the first group (0 WaveOne), the WaveOne Primary files served as a control group and were not used on acrylic blocks. In the 1 WaveOne Group, acrylic blocks were prepared using only WaveOne Primary files, and in the PF+WaveOne group and PG+WaveOne groups, acrylic blocks were first prepared with PathFile or ProGlider NiTi files, respectively, followed by the use of WaveOne Primary files. All the WaveOne Primary files were then subjected to cyclic fatigue testing. The number of cycles to failure was calculated and the data were statistically analyzed using one-way analysis of variance (ANOVA) and the Tukey honest significant difference multiple-comparison test at a 5% significance level. Results: The highest number of cycles to failure was found in the control group, and the lowest numbers were found in the 1 WaveOne group and the PF+WaveOne group. Significant differences were found among the 1 WaveOne, PF+WaveOne, and control groups (p < 0.05). No statistically significant differences were found between the PG+WaveOne group and the other three groups (p > 0.05). Conclusion: Glide path preparation with NiTi rotary files did not affect the cyclic fatigue resistance of WaveOne Primary files used on acrylic blocks.

Performance of F-18 Fluorocholine PET/CT for Detection of Hyperfunctioning Parathyroid Tissue in Patients with Elevated Parathyroid Hormone Levels and Negative or Discrepant Results in Conventional Imaging

Lebriz Uslu-Bes¸li,Kerim Sonmezoglu,Serkan Teksoz,Elife Akgun,Emre Karayel,Huseyin Pehlivanoglu,Baresh Razavi Khosroshahi,Meltem Ocak,Levent Kabasakal,Sait Sager,Yusuf Bukey 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.2

Objective: Our aim was to assess the diagnostic performance of F-18 fluorocholine (FCH) positron emission tomography/ computed tomography (PET/CT) in detecting hyperfunctioning parathyroid tissue (HPT) in patients with elevated parathyroid hormone levels with negative or inconclusive conventional imaging results and to compare the findings with those obtained using technetium-99m sestamibi (MIBI) scintigraphy and neck ultrasonography (US). Materials and Methods: Images of 105 patients with hyperparathyroidism who underwent FCH PET/CT, dual-phase MIBI parathyroid scintigraphy (median interval: 42 days), and neck US were retrospectively analyzed. The gold standard was histopathological findings for 81 patients who underwent parathyroidectomy and clinical follow-up findings in the remaining 24 patients. Sensitivities, positive predictive values (PPVs), and accuracies were calculated for all imaging modalities. Results: Among the 81 patients who underwent parathyroidectomy, either parathyroid adenoma (n = 64), hyperplasia (n = 9), neoplasia (n = 4), or both parathyroid adenoma and hyperplasia (n = 1) were detected, except 3 patients who did not show HPT. Of the 24 (23%) patients who were followed-up without operation, 22 (92%) showed persistent hyperparathyroidism. FCH PET/CT showed significantly higher sensitivity than MIBI scintigraphy and US in detection of HPT (p < 0.01). Sensitivity, PPV, and accuracy of FCH PET/CT were 94.1% (95/101), 97.9% (95/97), and 92.4% (97/105), respectively. The corresponding values for MIBI scintigraphy and US were 45.1% (46/102), 97.9% (46/47), and 45.7% (48/105) and 44.1% (45/102), 93.8% (45/48), and 42.9% (45/105), respectively. Among the 35 patients showing negative MIBI scintigraphy and neck US findings, 30 (86%) showed positive results on FCH PET/CT. FCH PET/CT could demonstrate ectopic locations of HPT in 11 patients whereas MIBI and US showed positive findings in only 6 and 3 patients, respectively. Conclusion: FCH PET/CT is an effective imaging modality for detection of HPT with the highest sensitivity among the available imaging techniques. Therefore, FCH PET/CT can be recommended especially for patients who show negative or inconclusive results on conventional imaging.

The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients

( Ahmet Uslu ),( Candan Ogus ),( Tulay Ozdemir ),( Turker Bilgen ),( Ozgur Tosun ),( Ibrahim Keser ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.8

Cytochrome P450 (CYP) 1A2 gene polymorphisms are thought to be involved in the metabolism of theophylline (TP). We aimed to investigate the effect of CYP1A2*1C, CYP1A2*1D, CYP1A2*1E, and CYP1A2*1F polymorphisms of the CYP1A2 on TP metabolism by PCR-RFLP in 100 Turkish patients with chronic obstructive pulmonary disease (COPD) receiving TP. One hundred and one healthy volunteers were included as control group. The genotype frequencies of the CYP1A2*1D and CYP1A2*1F were found to be significantly different in the patients compared to the controls. The “T” allele at -2467 delT and the “C” allele at -163 C > A in the CYP1A2 displayed association with a significantly increased risk for COPD. “T” allele at -2467 delT was also associated with a high risk of disease severity in COPD. In conclusion, our data suggest that genetic alterations in CYP1A2 may play a role both in the pharmacogenetics of TP and in the development of COPD. [BMB reports 2010; 43(8): 530-534]

Ochronotic Spondyloarthropathy Mimicking Diffuse İdiopathic Skeletal Hyperostosis

Sadettin Uslu 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.3

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True Collapse Mechanisms of Two Dimensional Frames Determined from True Nonlinear Yield Surfaces

Fethullah Uslu,Mehmet Tevfik Bayer,Mustafa Haluk Saraçoğlu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.1

In this work, collapse mechanisms and collapse load factors of two-dimensional frames which are subject to point loads and uniformly distributed loads are determined by employing new elastoplastic analysis method. In this new iterative method as the applied loads on frames are gradually increased, plastic hinges begin to develop at frame member sections and this continues until the partial or total collapse occurrence. If a plastic hinge develops at a section of a frame member, then a mechanical hinge is defined at this location and at each iteration reduced plastic moments are also applied as external loads. This is a new approach to search for the next plastic hinge where a series of linear elastoplastic analyses are executed. For each analysis the revised reduced plastic moments are used in the calculations. For elastoplastic calculations of two-dimensional frames, yield surface definitions of frame member sections are needed, and for I sections, yield surfaces are defined by two curves. In order to simplify collapse load factor calculations these yield surfaces are generally approximated by two lines. In this work the influences of the approximations on the elastoplastic behaviour of two-dimensional frames are examined by comparing the solutions of four example frames. When their solutions are compared, it is observed that almost equal collapse load factors are determined when true and approximate yield surfaces are used in the elastoplastic calculations but true collapse mechanisms are obtained only when true nonlinear yield surfaces are used.

Effect of glide path preparation with PathFile and ProGlider on the cyclic fatigue resistance of WaveOne nickel-titanium files

Gülşah Uslu,Uğur İnan 대한치과보존학회 2019 Restorative Dentistry & Endodontics Vol.44 No.2

Objectives: The aim of this study was to investigate the effect of glide path preparation with PathFile and ProGlider nickel-titanium (NiTi) files on the cyclic fatigue resistance of WaveOne NiTi files. Materials and Methods: Forty-four WaveOne Primary files were used and divided into four groups (n = 11). In the first group (0 WaveOne), the WaveOne Primary files served as a control group and were not used on acrylic blocks. In the 1 WaveOne Group, acrylic blocks were prepared using only WaveOne Primary files, and in the PF+WaveOne group and PG+WaveOne groups, acrylic blocks were first prepared with PathFile or ProGlider NiTi files, respectively, followed by the use of WaveOne Primary files. All the WaveOne Primary files were then subjected to cyclic fatigue testing. The number of cycles to failure was calculated and the data were statistically analyzed using one-way analysis of variance (ANOVA) and the Tukey honest significant difference multiple-comparison test at a 5% significance level. Results: The highest number of cycles to failure was found in the control group, and the lowest numbers were found in the 1 WaveOne group and the PF+WaveOne group. Significant differences were found among the 1 WaveOne, PF+WaveOne, and control groups (p < 0.05). No statistically significant differences were found between the PG+WaveOne group and the other three groups (p > 0.05). Conclusion: Glide path preparation with NiTi rotary files did not affect the cyclic fatigue resistance of WaveOne Primary files used on acrylic blocks.

Erratum: Ochronotic Spondyloarthropathy Mimicking Diffuse Idiopathic Skeletal Hyperostosis

( Sadettin Uslu ) 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.4

New Elastoplastic Analysis of Two-Dimensional Frames When Some Plastic Hinges Unload Elastically

Fethullah Uslu,Mehmet Tevfik Bayer,Mustafa Haluk Saraçoğlu 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.2

Two-dimensional frames are made of elastic and perfectly plastic materials. Frames are analized by using the step by step elastoplastic analysis method where the applied loads are gradually increased at each step until a plastic hinge is developed. Then an equivalent frame model is generated by placing a mechanical hinge at the location of the plastic hinge and the increased external loads and the reduced plastic moments acting at the plastic hinge sections are applied to this model and elastoplastic analysis is performed. This elastoplastic analysis is repeated by incrementally increasing the external loads and applying the new reduced plastic moments, until the next plastic hinge is developed. Then a new equivalent frame model is generated to search for the following plastic hinge. This step by step elastoplastic analysis continues until the frame partially or totally collapses. When a plastic hinge is developed, it means that the section is at a fully plastic stress state. In the following small load increment: if this fully plastic stress state moves to another fully plastic stress state then this movement is called plastic fl ow. But if this fully plastic stress state moves to an elastic–plastic stress state then this movement is called elastic unloading. During the search of the next plastic hinge if one of the plastic hinges begins to unload elastically then the current equivalent frame model must be revised. For this the frame member which contains the elastically unloading plastic hinge is replaced by the equivalent frame member carrying balancing loads.