Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors

Yilmaz, Umit,Zeybek, Umit,Kahraman, Ozlem Timirci,Kafadar, Ali Metin,Toptas, Bahar,Yamak, Nesibe,Celik, Faruk,Yaylim, Ilhan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. ${\beta}3$ integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and ${\beta}3$ integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of ${\beta}3$ integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and ${\beta}3$ integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.

Determination of the Ground Station Locations for both Dual-Site Ranging and Site-Diversity at Q/V-band Satellite Communication for an Intersatellite System Scenario

Umit C. Yilmaz,Ismail H. Cavdar 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.3

Generally, Low Earth Orbit (LEO) satellites are used to collect image or video from earth’s surface. The collected data are stored on-board and/or transmitted to the main ground station directly or via polar ground station using terrestrial line. Today, an intersatellite link between a LEO and a GEO satellite allows transmission of the collected data to the main ground station through the GEO satellite. In this study, an approach for a continuous communication starting from LEO through GEO to ground station is proposed by determining the optimum ground station locations. In doing so, diverse ground stations help to determine the GEO orbit as well. Cross-correlation of the long term daily rainfall averages are multiplied with the logarithmic correlation of the sites to calculate the joint correlation of the diverse ground station locations. The minimum values of this joint correlation yield the optimum locations of the ground stations for Q/V-band communication and satellite control operations. Results for several case studies are listed.

Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis

Umit Aydogmus,Adem Topkara,Metin Akbulut,Adem Ozkan,Figen Turk,Barbaros Sahin,Gokhan Yuncu 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.4

Objectives. Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. Methods. This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and trachea-thyroid cartilage anastomosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free palatal mucosa graft. Re-stenosis was evaluated after 42 days. Results. The percentages of stenosis were 27%±20%, 40%±20%, and 34%±23% for group 1, 2, and 3, respectively and the difference was not statistically significant (P=0.29). Intensive and tight fibrosis was observed in 2 rabbits (13%) in group 1, in 5 rabbits (33%) in group 2, and in 3 rabbits (20%) in group 3. There was not a statistically significant difference between groups (P=0.41). Excessive inflammation was observed in 3 rabbits (20%) in group 1, in 7 rabbits (47%) in group 2, and 3 rabbits (20%) in group 3. There was no a statistically significant difference between groups although inflammation rate was higher in the rabbits which underwent buccal mucosa graft (P=0.18). Conclusion. The surgical treatments applied with free mucosa graft reduced anastomosis tension through enabling anastomosis to the distal of cricoid instead of thyroid cartilage. Free palatal mucosa grafts may be used in sub-glottic field, one of the most challenging fields of trachea surgery, due to ease of application and rapid vascularization.

Diagnostic and Therapeutic Capability of Double-Balloon Enteroscopy in Clinical Practice

Umit Akyuz,Filiz Akyuz 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.2

Advances in technology have facilitated the common use of small-bowel imaging. Intraoperative enteroscopy was the gold standard method for small-bowel imaging. However, noninvasive capsule endoscopy and invasive balloon enteroscopy are currently the main endoscopic procedures that are routinely used for small-bowel pathologies, and the indications for both techniques are similar. Although obstruction is a contraindication for capsule endoscopy, it is not considered to be problematic for double-balloon enteroscopy. The most important advantage of double-balloon enteroscopy is the applicability of therapeutic interventions during the procedure; however, double-balloon enteroscopy has certain advantages as well as disadvantages.

The experimental and numerical investigation on thermal responses of passive thermal protected batteries in different packs from low to high discharge rates

Umit Nazli Temel,Ferhat Kilinc 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7

This study contains experimental and numerical investigation of the shape effect of the pack on the performances of PCM (or GNP/PCM) based passive thermally protected battery packs. Also, the performances of the PCM and thermally enhanced GNP/PCM composite for battery thermal protection are compared from low to high discharge rates. The thermal response results show that the cylindrical pack performs worse than the rectangular pack in terms of the maximum temperature and maximum temperature difference performance criteria. For the maximum temperature restriction criteria, 7 % GNP/RT44 composite, that has enhanced thermal conductivity, performs better at first, but then its performance deteriorates compared to RT44 depending on the increase of its viscosity. It was determined that 7 % GNP/RT-44 extend the effective protection times by 95.8 %, 73.3 % and 28.0 % at the discharge rates of 4.4 W, 6.6 W and 8.8 W, respectively.

Apolipoprotein E Gene Polymorphism and Serum Lipids in Patients with Superficial Fungal Disease

Umit Tursen,Tamer Irfan Kaya,Gulcin Eskandari,Ebru Bocekli,Necati Muslu,Handan Camdeviren,Guliz Ikizoglu,Ugur Atik 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP

Superficial mycosis, including dermatophytic infections, tinea versicolor, and cutaneous candidiasis is mostly limited to the outer layers of the skin, nails, and mucous membranes. In this study, Apolipoprotein E (ApoE) polymorphism and lipoprotein cholesterol concentrations were compared between 42 patients with superficial fungal disease and 27 control subjects. Both the patients and controls were found to be normolipemic. The patients with superficial fungal disease had significantly higher concentrations of high-density cholesterol (HDL) compared to the control group (p=0.0462). However, there was no difference in the serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. A significantly higher incidence of heterozygosity E2/3 was found in the patients (p=0.0228), and significantly lower incidence of homozygosity E3/3 in all patients, and those with candidiasis and dermatophytosis (p=0.0139, 0.0194 and 0.0337, respectively) compared to the control group. The E3/4 genotype differences between patients and controls were not statistically significant. There were slight differences in the allele frequencies between the two groups, but these did not reach statistically significant levels. It was concluded that the presence of apoE2/3 genotype, high HDL-cholesterol levels and the absence of apoE3/3 genotype can be regarded as risk factors for superficial fungal disease, especially dermatophytosis.

Myoepithelial carcinoma in nasopharynx: an unusual localization

Umit Tuncel,Gulusan Ergul,Samet Ozlugedik,Adnan Unal 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.1

Myoepithelial carcinoma is an extremely rare, malignant epithelial tumor which is usually encountered in the parotid region. In this report, a myoepithelial carcinoma arising from a minor salivary gland in the nasopharynx is presented, along with a discussion of the clinical, histopathological and immunocytochemical characteristics of this rare disorder. Larger clinical series and longer follow-up periods are needed in order to establish the best therapy option for these patients.

Fate of abstracts presented at the Turkish Association of Oral and Maxillofacial Surgeons (TAOMS) meetings between 2007 and 2009

Umit Yolcu,Ayse Ozcan Kucuk 대한구강악안면외과학회 2018 대한구강악안면외과학회지 Vol.44 No.5

Objectives: The aim of this study was to determine the rate of peer-reviewed publication of abstracts presented at the annual meetings of the Turkish Association of Oral and Maxillofacial Surgeons (TAOMS) and to identify the time to publication, subspecialty, and study design. Materials and Methods: All abstracts accepted for presentation at a TAOMS meeting between 2007 and 2009 were identified from a book of abstracts and were searched for publication using PubMed and Google Scholar. The following variables were evaluated: publication rate, type of presentation (oral or poster), time to publication, subspecialty, study design, and name of the journal in which the article was published. Results: A total of 478 abstracts were presented at the TAOMS meetings between 2007 and 2009. Of these, 140 abstracts (29.3%) were subsequently published in peer-reviewed journals, including 38.2% of oral presentations and 26.6% of poster presentations. The mean time from presentation to publication was 22 months. Regarding publication fields, research and emerging technologies presentations had the highest publication rate (100%). With regard to study type, animal study (70.0%) and basic research (55.0%) had the highest publication rates. Conclusion: Only 29.3% of abstracts presented at the TAOMS meeting were subsequently published as full-text articles. This rate was found to be similar to the previously reported publication rates in the field of oral and maxillofacial surgery.

Letter to the Editor : A Low Serum γ-Glutamyltransferase Level Predicts a Sustained Virological Response in Patients with Chronic Hepatitis C Genotype 1

( Umit Bilge Dogan ),( Mustafa Salih Akin ),( Serkan Yalaki ) The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.1

Optimum design of parabolic and circular arches with varying cross section

Uzman, Umit,Daloglu, Ayse,Saka, M. Polat Techno-Press 1999 Structural Engineering and Mechanics, An Int'l Jou Vol.8 No.5

A structural optimization process is presented for arches with varying cross-section. The optimality criteria method is used to develop a recursive relationship for the design variables considering displacement, stresses and minimum depth constraints. The depth at the crown and at the support are taken as design variables first. Then the approach is extended by taking the depth values of each joint as design variable. The curved beam element of constant cross section is used to model the parabolic and circular arches with varying cross section. A number of design examples are presented to demonstrate the application of the method.