Bilateral elongated mandibular coronoid process in an Anatolian skull

Ufuk Ç,orumlu,Cem Kopuz,Mehmet Tevfik Demir,Mennan Ece Pirzirenli 대한해부학회 2016 Anatomy & Cell Biology Vol.49 No.3

Elongation or hyperplasia of coronoid process of mandible is rare condition characterized by abnormal bone development which cause malocclusion and the limited mouth opening. In this study, in an Anatolian skull, a case of bilateral elongation of mandibular coronoid process was presented. Levandoski panographic analysis was performed on the panoramic radiographie to determine the hyperplasia of the coronoid process. The right condylar process was exactly hyperplastic. The measurements of Kr-Go/Cd-Go were 95.10 mm/79.03 mm on right side and 97.53 mm/87.80 mm on left side. The ratio of Kr-Go/Cd-Go on the right side was 1.20. Elongated coronoid process is one of the factors cause mandibular hypomobility, it as reported here might lead to limited mouth opening. The knowledge of this variation or abnormality can be useful for the radiologist and surgeons and prevent misdiagnosis.

Wound Repair Potential of Olea europaea L. Leaf Extracts Revealed by In Vivo Experimental Models and Comparative Evaluation of the Extracts' Antioxidant Activity

Ufuk Koca,Ipek Süntar,Esra Küpeli Akkol,Demet Yılmazer,Murat Alper 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

Leaves and fruits of Olea europaea L. (olive) have been used externally as an emollient for skin ulcers and for healing of inflammatory wounds. n-Hexane and aqueous extracts, prepared from the dried leaves of olive, were evaluated for their wound healing activity by using in vivo wound models of linear incision and circular excision in comparison with the reference ointment Madecassol^dⓡ(Bayer, Istanbul, Turkey). The group of animals treated with the aqueous extract demonstrated increased contraction (87.1%) on excision and a significant increase in wound tensile strength (34.8%) on incision models compared to the other groups. Moreover, the antioxidant activity assay showed that aqueous extract has higher scavenging ability than the n-hexane extract. According to the experimental data, the aqueous extract of O. europaea leaves displayed wound healing activity. Secoiridoid oleuropein (4.6059%) was identified as the major active compound according to high-performance liquid chromatography analysis of the aqueous extract.

A survey evaluating hematology physicians' perspectives on central nervous system prophylaxis

Ufuk Demirci,Meltem Kurt Yüksel,Hakkı Onur Kırkızlar,Elif Birtaş Ateşoğlu,Özgür Mehtap,Ozan Salim,Ahmet Muzaffer Demir,Olga Meltem Akay 대한혈액학회 2023 Blood Research Vol.58 No.2

Background Central nervous system (CNS) prophylactic options for diffuse large B-cell lymphoma (DLBCL) are administered differently in most centers. Unfortunately, there is still not a consensus on which patients, which regimen, for how many cycles, and when prophylaxis should be administered. Thus, this remains an unmet clinical need. Methods We administered a survey study under the Lymphoma Scientific Subcommittee of the Turkish Society of Haematology. The questions were directed to hematologists through the monkey survey system. Results The CNS International Prognostic Index score is a factor that clinicians frequently use when deciding on prophylaxis and is considered reliable. Although the perspective on anatomical risk factors is similar to that reported in the literature, breast involvement is still considered a critical risk factor in Turkey. Participants considered double or triple hit and double/triple expressor lymphoma as significant risk factors. Various methods have been used to demonstrate CNS relapses. Intrathecal prophylaxis is the preferred method. Conclusion There are diverse methodological and technical ideas. The controversial results reported in the literature on the effectiveness of CNS prophylaxis may explain this finding. Although CNS prophylactic methods for patients with DLBCL are still controversial, the effect of secondary CNS involvement on survival is inevitable. Standard practices followed by national guidelines may be effective in reducing the variety of application methods and creating homogeneous results for efficacy and survival follow-up studies.

Permeation properties of concretes incorporating fly ash and silica fume

Ufuk Kandil,Şakir Erdoğdu,Şirin Kurbetci 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.4

This paper conveys the effects of fly ash and silica fume incorporated in concrete at various replacement ratios on the durability properties of concretes. It is quite well known that concrete durability is as much important as strength and permeability is the key to durability. Permeability is closely associated with the voids system of concrete. Concrete, with less and disconnected voids, is assumed to be impermeable. The void system in concrete is straightly related to the mix proportions, placing, compaction, and curing procedures of concrete. Reinforced concrete structures, particularly those of subjected to water, are at the risk of various harmful agents such as chlorides and sulfate since the ingress of such agents through concrete becomes easy and accelerates as the permeability of concrete increases. Eventually, both strength and durability of concrete reduce as the time moves on, in turn; the service life of the concrete structures shortens. Mineral additives have been proven to be very effective in reducing permeability. The tests performed to accomplish the aim of the study are the rapid chloride permeability test, pressurized water depth test, capillarity test and compressive strength test. The results derived from these tests indicated that the durability properties of concretes incorporated fly ash and silica fume have improved substantially compared to that of without mineral additives regardless of the binder content used. Overall, the improvement becomes more evident as the replacement ratio of fly ash and silica fume have increased. With regard to permeability, silica fume is found to be superior to fly ash. Moreover, at least a 30% fly ash replacement and/or a replacement ratio of 5% to 10% silica fume have been found to be highly beneficial as far as sustainability is concerned, particularly for concretes subjected to chloride bearing environments.

Finite element analysis for longitudinal vibration of nanorods based on doublet mechanics

Ufuk Gul,Metin Aydogdu Techno-Press 2023 Advances in nano research Vol.15 No.5

In the present study, the axial vibration of the nanorods is investigated in the framework of the doublet mechanics theory. The equations of motion and boundary conditions of nanorods are derived by applying the Hamilton principle. A finite element method is developed to obtain the vibration frequencies of nanorods for different boundary conditions. A two-noded higher order rod finite element is used to solve the vibration problem. The natural frequencies of nanorods obtained with the present finite element analysis are validated by comparing the results of classical doublet mechanics and nonlocal strain gradient theories. The effects of rod length, mode number and boundary conditions on the axial vibration frequencies of nanorods are examined in detail. Mode shapes of the nanorods are presented for the different boundary conditions. It is shown that the doublet mechanics model can be used for the dynamic analysis of nanotubes, and the presented finite element formulation can be used for mechanical problems of rods with unavailable analytical solutions. These new results can also be used as references for the future studies.

miR-205 and miR-200c: Predictive Micro RNAs for Lymph Node Metastasis in Triple Negative Breast Cancer

Ufuk Berber,Ismail Yilmaz,Gizem Narli,Aptullah Haholu,Zafer Kucukodaci,Dilaver Demirel 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2

Purpose: We examined expression profiles of 16 micro RNAs(miRNAs) in triple negative breast cancers to identify their potentialas biomarkers for lymph node metastasis. Methods: The expressionprofiles of miR-9, miR-21, miR-30a, miR-30d, miR-31,miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a,miR-146b, miR-155, miR-181a, miR-200c, and miR-205 wereexamined by using real-time quantitative reverse transcriptionpolymerase chain reaction in tumor samples and correspondingbenign breast tissues. Their associations with histopathologicalfeatures and prognostic parameters were assessed. Results:When compared with the expression in benign breast tissues,seven of the miRNAs (miR-31, miR-205, miR-34a, miR-146a,miR-125b, miR-34c, and miR-181a) were downregulated morethan 1.5-fold in tumor tissues, whereas, only miR-21 was foundto be upregulated more than 1.5-fold in tumor tissues. AlthoughmiR-200c levels were decreased only 1.12-fold in tumor tissues,the reduced expressions of miR-200c and miR-205 were significantlyassociated with lymph node metastasis (p=0.021 and p=0.016, respectively). Conclusion: Our results demonstrate thatmiR-205 and miR-200c expression levels may be useful in predictinglymph node metastasis in triple negative breast cancerpatients.

Cuscuta arvensis Beyr ‘‘Dodder’’: In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats

Ufuk Koca-Caliskan,Ismet Yilmaz,Asli Taslidere,Funda N. Yalcin,Ceylan Aka,Nazim Sekeroglu 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.6

Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as “dodder” in Europe, in the United States, and “tu si zi shu” in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used as a folk medicine for the treatment particularly of liver problems, knee pains, and physiological hepatitis, which occur notably in newborns and their mothers in the southeastern part of Turkey. The purpose of this study was to investigate the hepatoprotective effects and antioxidant activities of aqueous and methanolic extracts of C. arvensis Beyr. on acetaminophen (APAP)-induced acute hepatotoxicity in rats. The results were supported by subsequent histopathological studies. The hepatoprotective activity of both the aqueous and methanolic extracts at an oral dose of 125 and 250 mg/kg was investigated by observing the reduction levels or the activity of alkaline phosphatase, alkaline transaminase, aspartate aminotransferase, blood urine nitrogen, and total bilirubin content. In vivo antioxidant activity was determined by analyzing the serum superoxide dismutase, malondialdehyde, glutathione, and catalase levels. Chromatographic methods were used to isolate biologically active compounds from the extract, and spectroscopic methods were used for structure elucidation. Both the methanolic and aqueous extracts exerted noticable hepatoprotective and antioxidant effects supporting the folkloric usage of dodder. One of the bioactive compounds was kaempferol-3-O-rhamnoside, isolated and identified from the methanolic extract.

Diagnosis of Sarcopenia in Head and Neck Computed Tomography: Cervical Muscle Mass as a Strong Indicator of Sarcopenia

Furkan Ufuk,Duygu Herek,Doğangün Yüksel 대한이비인후과학회 2019 Clinical and Experimental Otorhinolaryngology Vol.12 No.3

Objectives. Patients with head and neck cancer (HNC) have a high risk of sarcopenia, which is associated with poor prognosis. Skeletal-muscle area and index at the third lumbar (L3) vertebra level (L3MA and L3MI) are recommended for the detection of sarcopenia. However, L3 level is not included in many imaging protocols and there are no data for optimal levels and cutoffs for the diagnosis of sarcopenia in head and neck computed tomography (HNCT) scans. Our aim was to assess the relationship between cervical paravertebral muscle values and L3MI and to investigate optimal level to diagnose sarcopenia on HNCTs. Methods. Patients with HNC (n=159) who underwent positron emission tomography-CT for tumor staging were retrospectively analyzed. On CT images, paravertebral and sternocleidomastoid muscle areas at second (C2), third (C3), and fourth (C4) cervical vertebrae levels (C2MA, C3MA, C4MA, SCMA) and L3MA were measured. Cross-sectional areas were normalized for stature (muscle area/height square) and muscle index (C2MI, C3MI, C4MI, SCMI, L3MI) values were obtained. Spearman correlation and linear regression analyses were used for assessing correlations. To calculate the diagnostic performance of SCMI, C2MI, C3MI, and C4MI for the diagnosis of sarcopenia with respect to the cutoffs of L3MI, receiver operating characteristic (ROC) analysis was used. Results. Males had significantly higher muscle areas than females. Although C2MI, C3MI, C4MI, and SCMI values all showed very strong and significant correlation with L3MI (P<0.001). According to the ROC analysis, the best discriminative for sarcopenia was C3MI in males (area under curve [AUC], 0.967) and SCMI in females (AUC, 0.898). Conclusion. C2MI, C3MI, C4MI, and SCMI values can be used as alternatives for the diagnosis of sarcopenia in routine HNCT examinations

CYP1A1 (Ile⁴⁶²Val), CYP1B1 (Ala¹¹⁹Ser and Val⁴³²Leu), GSTM1 (null), and GSTT1 (null) Polymorphisms and Bladder Cancer Risk in a Turkish Population

Berber, Ufuk,Yilmaz, Ismail,Yilmaz, Omer,Haholu, Aptullah,Kucukodaci, Zafer,Ates, Ferhat,Demirel, Dilaver Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

We aimed to investigate bladder cancer risk with reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study. Polymorphisms were examined in 114 bladder cancer patients and 114 age and sex-matched cancer-free subjects. Genotypes were determined using allele specific PCR for CYP1A1 and CYP1B1 genes, and by multiplex PCR and melting curve analysis for GSTM1 and GSTT1 genes. Our results revealed a statistically significant increased bladder cancer risk for GSTT1 null genotype carriers with an odds ratio of 3.06 (95% confidence interval=1.39-6.74, p=0.006). Differences of CYP1A1, CYP1B1 and GSTM1 genotype frequencies were not statistically significant between patients and controls. However, the specific combination of GSTM1 null, GSTT1 null, and CYP1B1 codon 119 risk allele carriers and specific combination of GSTM1 present, GSTT1 null, and CYP1B1 432 risk allele carriers exhibited increased cancer risk in the combined analysis. We did not observe any association between different genotype groups and prognostic tumor characteristics of bladder cancer. Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.

Ideal Suggestions for Discharge Training and Telephone Counseling of Patients With Coronary Artery Bypass Graft Surgery: A Randomized Controlled and Experimental Study

Kaya Ufuk,Dal Yılmaz Ümran 대한의학회 2022 Journal of Korean medical science Vol.37 No.35

Background: In this context, discharge training and telephone counseling given to patients who underwent coronary artery bypass graft surgery increase the ability of patients to cope with and adapt to their self-care. Methods: This study was a randomized controlled, experimental design. Both experimental and control groups consisted of 35 individuals with G*power analysis (n = 70). Patients in the experimental group were given discharge training and telephone counseling for two months. At the end of the process, data collection forms were administered to both groups for the last time. Necessary ethical approvals were taken and consent was taken from the patients. Results: After the discharge training and telephone counseling given to the experimental group, the mean Exercise of Self-Care Agency Scale (ESCA) score of the patients increased by 13.94; the mean Coping and Adaptation Processing Scale (CAPS) increased by 13.6. The mean ESCA score of the control group increased by 7.86; the mean CAPS score increased by 9.14. The effect size that occurred for both groups was statistically significant (P < 0.05). Conclusion: Positive results were achieved in the experimental group which received given discharge training and telephone counseling.