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- 저자 : Uchio (검색결과 3 건)
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Eiichi Uchio,Hirotoshi Inoue,Kazuaki Kadonosono 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.3
Purpose: Antimicrobial peptides have an important role in self-protection of the ocular surface. Human cationic antimicrobial protein (hCAP)-18 is a linear, α-helical peptide that consists of a conserved pro-sequence called a cathelin-like domain and a C-terminal peptide named LL-37. We investigated the in vitro anti-adenoviral activity of hCAP-18/LL-37 in several adenovirus types, inducing keratoconjunctivitis. Methods: A549 cells were used for viral cell culture, and human adenovirus (HAdV) types 3 (HAdV3,species B), 4 (species E), 8, 19a, and 37 (species D) were used. The cytotoxicity of LL-37 was evaluated by 3-(4,5-dimethylthiazol-2-yl)-5-(3- carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay to obtain 50% cytotoxic concentration. After pretreatment of A549 cells with serial dilutions of LL-37 for 24hours, adenovirus was cultured for seven days, and adenoviral DNA was quantitatively measured by real-time polymerase chain reaction (PCR). Results: The 50% effective concentration of LL-37 obtained by real-time PCR ranged between 118 and 270 μM. LL-37 showed a significant inhibitory effect on adenoviral proliferation in all adenovirus types except HAdV4 in a dose-dependent manner. Conclusions: LL-37 has significant inhibitory activity against HAdV3, 8, and 19, which induce keratoconjunctivitis. These results indicate that hCAP-18/LL-37 may be a possible candidate for the treatment of HAdV keratoconjunctivitis.
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Improving Urinary Continence after Radical Prostatectomy: Review of Surgical Modifications
Jonathan J. Hwang,Bo Young Kim,Edward M. Uchio 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.10
Purpose: Urinary incontinence remains the most feared long-term complication following radical prostatectomy with potentially devastating psychosocial consequences. In recent years, several surgical techniques have been introduced during radical prostatectomy, both open and laparoscopic/robotic, in the hope of improving urinary continence outcomes. Herein, we review the various surgical modifications that have shown a benefit in minimizing post-prostatectomy urinary incontinence (PPI). Materials and Methods: A comprehensive review of the current urologic literature was conducted to identify surgical techniques that have been correlated with improved continence following radical prostatectomy. Results: Over the years, several surgical modifications have been incorporated into radical prostatectomy in order to minimize the risk of prolonged PPI. Most techniques emphasize the importance of restoring the “normal” pelvic anatomy after removal of the prostate gland. In addition, certain patient factors such as preoperative posterior urethral length and patient age appear to have an independent prognostic value in predicting PPI. Postoperatively, bladder neck contracture remains the most consistent complication leading to PPI. Conclusions: The present findings suggest that the risk of PPI can be minimized, or even eliminated, through careful patient selection and surgical modifications during radical prostatectomy. Purpose: Urinary incontinence remains the most feared long-term complication following radical prostatectomy with potentially devastating psychosocial consequences. In recent years, several surgical techniques have been introduced during radical prostatectomy, both open and laparoscopic/robotic, in the hope of improving urinary continence outcomes. Herein, we review the various surgical modifications that have shown a benefit in minimizing post-prostatectomy urinary incontinence (PPI). Materials and Methods: A comprehensive review of the current urologic literature was conducted to identify surgical techniques that have been correlated with improved continence following radical prostatectomy. Results: Over the years, several surgical modifications have been incorporated into radical prostatectomy in order to minimize the risk of prolonged PPI. Most techniques emphasize the importance of restoring the “normal” pelvic anatomy after removal of the prostate gland. In addition, certain patient factors such as preoperative posterior urethral length and patient age appear to have an independent prognostic value in predicting PPI. Postoperatively, bladder neck contracture remains the most consistent complication leading to PPI. Conclusions: The present findings suggest that the risk of PPI can be minimized, or even eliminated, through careful patient selection and surgical modifications during radical prostatectomy.
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