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Tsutsumi, Takashi,Iwashita, Hiroshi,Miyahara, Kagenobu Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.38 No.3
This paper shows the solution for an orthotropic disk under the plane strain condition obtained with complex stress functions. These stress functions were induced by Lekhnitskii and expanded by one of the authors. Regarding diametrical compression test, the finite element method poses difficulties in representing the concentrated force because the specimens must be divided into finite elements during calculation. On the other hand, the method shown in this study can exactly represent this force. Some numerical results are shown and compared with those obtained under the plane stress condition for both stress and displacement. This comparison shows that the differences between the tensile stresses occurred under the plane strain condition and also that the differences under a plane stress condition increase as the orthotropy ratio increases for some cases.
Design of launch pad for mitigating acoustic loads on launch vehicle at liftoff
Tsutsumi, Seiji The Acoustical Society of Korea 2020 韓國音響學會誌 Vol.39 No.4
우주발사체는 발사 시 추진장치에서 발생하는 고강도 소음에 의한 음향하중의 영향을 받는다. 로켓소음은 발사체와 페이로드 내 전자 및 기계 부품의 손상 및 오작동을 유발할 수 있기 때문에 음향하중의 예측 및 저감은 설계에 있어 중요한 고려사항이다. 본 논문에서는 로켓 소음의 생성 및 발사대의 음향설계 기법에 대한 최신 연구동향을 논하였다. 특히, 새로운 발사대 설계 방법론의 예로서 일본 Epsilon 로켓 발사대의 개발과정을 기술하였다. 전산유체역학 모사 및 1/42 축소모형 실험을 통하여 설계된 발사대의 음향하중 저감 효과를 Epsilon 로켓의 실제 비행 데이터 분석을 통하여 검증하였다.
Analysis of orthotropic circular disks and rings under diametrical loadings
Tsutsumi, Takashi,Hirashima, Ken-Ichi Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.9 No.1
Very few studies on orthotropic circular disks or rings under diametrical loadings are conducted because of difficulties in treatment. This paper shows analytical solutions and gives the distributions of stresses and displacements by using Lekhnitskii's complex variable method. Several numerical results are shown by graphical representation.
Tsutsumi, Atsushi,Chen, Wei,Kim, Yong Han 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.6
According to axial profile of solid concentration, the cocurrent upward three-phase reactors with liquid as continuous phase can be classified into three types: (a) gas-sparged slurry reactors, (b) three-phase bubble columns, and (c) three-phase fluidized beds. Comparative study shows that the gas hold up, bubble characteristics and mass transfer are significantly dependent on the type of three-phase reactors. Three types of reactors exhibit the different hydrodynamic and transport behaviors with particle size, solid concentration and gas holdup. The structural analysis of the axial solid distribution indicates the bubble and bubble wake dynamics are the key factors to the hydrodynamic and transport behaviors of three-phase reactors.
Hepcidin Levels and Pathological Characteristics in Children with Fatty Liver Disease
Tsutsumi, Norito,Nishimata, Shigeo,Shimura, Masaru,Kashiwagi, Yasuyo,Kawashima, Hisashi The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.3
Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels. Methods: This retrospective case series included 12 boys aged 6-17 years who were diagnosed with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) at the Tokyo Medical University Hospital. Sixteen liver biopsy samples from 12 subjects were analyzed. Serum hepcidin levels were assayed using enzyme-linked immunosorbent assay. Immunostaining for hepcidin was performed, and the samples were stratified by staining intensity. Results: Serum hepcidin levels were higher in pediatric NAFLD/NASH patients than in controls. Conversely, a significant inverse correlation was observed between hepcidin immunostaining and Brunt grade scores and between hepcidin scores and gamma-glutamyltranspeptidase, hyaluronic acid, and leukocyte levels. We observed inverse correlations with a high correlation coefficient of >0.4 between hepcidin immunostaining and aspartate aminotransferase, alanine aminotransferase, total bile acid, and platelet count. Conclusion: There was a significant inverse correlation between hepcidin immunoreactivity and fibrosis in pediatric NAFLD patients; however, serum hepcidin levels were significantly higher, suggesting that these patients experienced a reduction in the hepcidin-producing ability of the liver in response to iron levels, leading to subsequent fibrosis. Therefore, hepcidin levels can be used as markers to identify the progression of fibrosis in patients with NAFLD.
Atsushi Tsutsumi,Tetsufumi Kanazawa,Hiroki Kikuyama,Gaku Okugawa,Hiroyuki Uenishi,Toshio Miyamoto,Naoki Matsumoto,Jun Koh,Kazuhiro Shinosaki,Toshifumi Kishimoto,Hiroshi Yoneda,Toshihiko Kinoshita 대한신경정신의학회 2009 PSYCHIATRY INVESTIGATION Vol.6 No.3
We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients. We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients.
Investigation of EFL Teachers" Career and Motivation at Universities in Japan
( Rie Tsutsumi ) 범태평양응용언어학회 2013 범태평양응용언어학회지 Vol.17 No.2
Motivation is one of the most popular topics on language teaching and learning. Many studies on language learning focus on students`` motivation; however, teachers`` motivation is easily overlooked in the area of the applied linguistics field. In this paper, the researcher presents a study to investigate how satisfied English teachers at private universities in Japan are with their work as English instructors. In this study, the researcher created questionnaires and conducted a survey of thirty English teachers at private universities in Japan. This study shows the perception and the degree of satisfaction in their jobs. The study vividly shows what the most significant obstacles are as well as approaches to solve the problems. The researcher asked participants what significant aspect of teaching is included in their personal teaching philosophy. The major question the researcher was looking for was the following: what the reward was, what obstacles existed, and what possible solutions were for the problematic aspects in the field. Overall, this study clearly provides the reader a clearer idea of what motivates teachers and how closely it is related to their productivity in their daily teaching.
Takashi Tsutsumi,Hiroshi Iwashita,Kagenobu Miyahara 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.38 No.3
This paper shows the solution for an orthotropic disk under the plane strain condition obtained with complex stress functions. These stress functions were induced by Lekhnitskii and expanded by one of the authors. Regarding diametrical compression test, the finite element method poses difficulties in representing the concentrated force because the specimens must be divided into finite elements during calculation. On the other hand, the method shown in this study can exactly represent this force. Some numerical results are shown and compared with those obtained under the plane stress condition for both stress and displacement. This comparison shows that the differences between the tensile stresses occurred under the plane strain condition and also that the differences under a plane stress condition increase as the orthotropy ratio increases for some cases.