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- 검색키워드
- 저자 : Tse, Eliza Ching-Yick (검색결과 44 건)
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Quality Control Mechanisms of Molecular Chaperones in the Folding and Degradation of Client Proteins
Tse, Eric ProQuest Dissertations & Theses University of Mich 2017 해외박사(DDOD)
소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
Molecular chaperones are essential proteins that assist in the folding of substrate 'client' proteins to adopt their functionally active three-dimensional structures. The process of protein folding in the cell occurs in a highly concentrated cro.
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Sequence and structure of influenza Hemagglutinin cleavage site modulate viral pathogenesis
Tse, Long Ping Victor ProQuest Dissertations & Theses Cornell University 2014 해외박사(DDOD)
소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
Viruses are obligatory intracellular pathogens requiring host machinery for survival and reproduction. Differing from living organisms, which can grow where nutrients are available, viruses absolutely require hijacking of host machineries to complete their life cycle. Enveloped viruses evolved to have dedicated strategies to passively sense environmental cues to ensure that initiation of infection occurs at the correct moment and place. One general strategy used by enveloped viruses is to precisely control activation of their envelope glycoprotein just prior entry into host cells. Influenza A virus (AIV) is the causative agent of influenza illness and causes both economical and public health problems globally and annually. As a successful pathogen infecting a wide range of animals, IAV excels in sensing the environment to ensure efficient infection by employing two sequential activating steps during viral entry: proteolytic cleavage for priming of the hemagglutinin (HA) and low-pH-triggered conformational changes allowing release of the fusion peptide. Proteolytic cleavage of influenza HA controls viral pathogenesis by influencing viral growth rate and viral tropism. The primary sequence and tertiary structure of the HA determine the overall properties of HA activation and hence, viral pathogenesis. Mutations on the primary sequence of the HA cleavage site affect viral activation in two dimensions, 1) HA activation efficiency and 2) alteration in protease repertoire for HA activation. The former modulates viral growth kinetics and the later is important for viral tropism. Mutations that modifies HA tertiary structure also play an important role in viral activation, in particular virus growth. In this thesis, I describe three interrelated studies of mutations on primary and tertiary structure of HA and their consequence on HA cleavage and viral pathogenesis. These mutations also allow influenza virus to interact with prokaryotic pathogens and open up another dimension in virus-bacteria-host interactions and synergy.
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A Comparative Study of Four American Professional Wind Bands
Tse, Mark University of Washington ProQuest Dissertations & 2020 해외박사(DDOD)
소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
This study compares the repertoire, business models, and philosophies of four American professional wind bands; Dallas Winds, Lone Star Wind Orchestra, San Diego Winds, and the Royal Hawaiian Band. For the purposes of this study, “professional” is defined as generating sufficient income to pay the performers.The Royal Hawaiian Band is an outlier of professional wind bands because of its history and function. The other three bands perform two to nine concerts per season like the first American orchestras. For these young professional bands to achieve comparable success as current professional orchestras, they should make similar revolutionary leaps (not evolutionary steps) that early American orchestras made to guarantee their performers a full season of concerts, enough to provide a livable income.
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Tse, Laam Angela Georgia Institute of Technology 2006 해외박사(DDOD)
소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
Micro-direct methanol fuel cells (mu-DMFC) can be the power supply solution for the next generation of handheld devices. The applications of the mu-DMFCs require them to have high compactness, high performance, light weight, and long life. The major goal of this research project is to enhance the volumetric power density of direct methanol fuel cells (DMFCs). A performance roadmap has been formulated and showed that patterning the planar membrane electrode assembly (MEA) to 2-D and 3-D corrugated manifolds can greatly increase the power generation with very modest overall volume increases. In this project, different manufacturing processes for patterning MEAs with corrugations have been investigated. A folding process was selected to form 2D triangular corrugations on MEAs for experimental validations of the performance prediction. The experimental results show that the volumetric power densities of the corrugated MEAs have improved by about 25% compared to the planar MEAs, which is lower than the expected performance enhancement. ABAQUS software was used to simulate the manufacturing process and identify the causes of deformations during manufacture. Experimental analysis methods like impedance analysis and 4 point-probes were used to quantify the performance loss and microstructure alteration during the forming process. A model was proposed to relate the expected performance of corrugated MEAs to manufacturing process variables. Finally, different stacking configurations and issues related to cell stacking for corrugated MEAs are also investigated.
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