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Ibrahim Keser,Ahter D. Toraman,Gulay Ozbilim,Kenan Guney,Guven Luleci 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.6
Purpose: A larynx squamous cell carcinoma (LSCC) is one of the most common forms of cancer and may exhibit various complex karyotypes. Materials and Methods: We used comparative genomic hybridization (CGH) to analyze DNA gains and losses in 15 squamous cell carcinomas that consisted of 4 glottic, 10 supraglottic, and 1 transglottic localization samples. Results: The majority of the chromosomal alterations detected were gains: 3 samples of LSCCs revealed high level amplification, while 6 samples displayed gains in various chromosomal regions (17p, 3p, 4p, 5p, 6q, 8p, 9p, 14q, 18p and Xq). One sample was found to have losses (chromosomes 15q and 22q) and 5 had normal CGH profiles. Conclusion: Many of these gained regions (4p, 5p, 8p, 10q, 18q and Xq) were novel sites, which may harbor oncogene(s) that potentially play an important role in squamous cell tumorigenesis and progression at supraglottic localizations.
Mirror Image Gerbode or Partial Atrioventricular Canal Defect?
Cem Ariturk, Ass.Prof.,Ahmet Umit Gullu, Ass.Prof.,Sahin Senay, Ass.Prof.,Eyup Murat Okten, M.D.,Fevzi Toraman,E. Hasan Karabulut, Prof.,Letisya Melengic, M.S.,Cem Alhan, Prof. 대한흉부외과학회 2015 Journal of Chest Surgery (J Chest Surg) Vol.48 No.6
Gebode defect, that can accurately be treated surgical repair, is defined as a true communication between left ventricle and right atrium. A 74-year-old woman with a worsening history of ortophnea and peripheral edema was hospitalised. A communication between right atrium and left ventricle was diagnosed using transeusophageal echocardiography. The defect was repaired and mitral valve was replaced with a biologic valve. It would be beter to tailor surgical strategy for each case with atrioventricular canal defect after preoperative transeusophageal echocardiography and peroperative direct sight.