Comparison of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios for Predicting Malignant Potential of Suspicious Ovarian Masses in Gynecology Practice

Topcu, Hasan Onur,Guzel, Ali Irfan,Ozer, Irfan,Kokanali, Mahmut Kuntay,Gokturk, Umut,Muftuoglu, Kamil Hakan,Doganay, Melike Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Purpose: To compare the diagnostic accuracy of the neutrophil/lymphocyte ratio (NLR) with the platelet/lymphocyte ratio (PLR) in predicting malignancy of pelvic masses which are pre-operatively malignant suspicious. Materials and Methods: In this retrospective study we evaluated the clinical features of patients with ovarian masses which had pre-operatively been considered suspicious for malignancy. The patients whose intraoperative frozen sections were malign were classified as the study group, while those who had benign masses were the control group. Data recorded were age of the patient, diameter of the mass, pre-operative serum Ca 125 levels, platelet count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. Results: There was statistically significantly difference between the groups in terms of age, diameter of the mass, serum Ca 125 levels, platelet number and platelet/lymphocyte ratio. Mean neutrophil/lymphocyte ratios showed no difference between the groups. ROC curve analysis showed that age, serum Ca 125 levels, platelet number and PLR were discriminative markers in predicting malignancy in adnexal masses. Conclusions: According to the current study, serum Ca 125 levels, pre-operative platelet number and PLR may be good prognostic factors, while NLR is an ineffective marker in predicting the malignant characteristics of a pelvic mass.

Risk Factors for Endometrial Hyperplasia Concomitant Endometrial Polyps in Pre- and Post-menopausal Women

Topcu, Hasan Onur,Erkaya, Salim,Guzel, Ali Irfan,Kokanali, Mahmut Kuntay,Sarıkaya, Esma,Muftuoglu, Kamil Hakan,Doganay, Melike Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Purpose: To evaluate the risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and post-menopausal women. Materials and Methods: A total of 203 patients undergoing endometrial sampling before hysterectomy were evaluated in this retrospective study. Data recorded were age, gravidity, parity, body mass index (BMI: weight(kg)/$height(m)^2$), endometrial thickness (ET), menopausal status, presence of adenomyosis and diabetes mellitus. Results: Endometrial hyperplasia and polyps were detected in 13 patients. There were statistically significant differences in terms of age, menopausal status, morbid obesity and diabetes mellitus (p<0.005). Logistic regression demonstrated that menopausal status and presence of diabetes mellitus were independent risk factors. Conclusions: According to the current study; menopause and diabetes mellitus are strong risk factors for the presence of concomitant endometrial polyps and endometrial hyperplasia.

Effects of Crushed RAP on Free and Restrained Shrinkage of Mortars

Topcu, Ilker Bekir,Isikdag, Burak Korea Concrete Institute 2009 International Journal of Concrete Structures and M Vol.3 No.2

Reclaimed asphalt pavement (RAP) is abundant substitute for natural aggregate in many areas. It is obtained by crushing of old road pavements in milling machine during rehabilitation and reconstruction process. In this study, reclaimed asphalt pavement mortars (RAPM) have been produced with different cement dosages and replacement ratios. The destructive and nondestructive tests have been conducted on specimens to determine physical and mechanical properties of RAPM. The free and restrained shrinkage tests on RAPM have been conducted to predict fractural behavior of mortars. The aim of the shrinkage tests was to delay crack formation and improve strain capacity of mortars before cracking. The results showed that RAPM exhibits lower elasticity modulus; however the tensile capacity was improved for deformation before cracking.

Effects of Curcumin on Apoptosis and Oxidoinflammatory Regulation in a Rat Model of Acetic Acid–Induced Colitis: The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase

Yeter Topcu-Tarladacalisir,Meryem Akpolat,Yesim Hulya Uz,Gulnur Kizilay,Melike Sapmaz-Metin,Aysegul Cerkezkayabekir,Imran Kurt Omurlu 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.4

The present study evaluated the effects of curcumin on epithelial cell apoptosis, the immunoreactivity of the phospho–c-Jun N-terminal kinase (JNK) and phospho-p38 mitogen-activated protein kinases (MAPKs) in inflamed colon mucosa, and oxidative stress in a rat model of ulcerative colitis induced by acetic acid. Rats were randomly divided into three groups: control, acetic acid, and acetic acid+curcumin. Curcumin (100 mg/kg per day, intragastrically) was administered 10 days before the induction of colitis and was continued for two additional days. Acetic acid–induced colitis caused a significant increase in the macroscopic and microscopic tissue ranking scores as well as an elevation in colonic myeloperoxidase (MPO) activity, malondialdehyde (MDA) levels, and the number of apoptotic epithelial cells in colon tissue compared to controls. In the rat colon, immunoreactivity of phospho–p38 MAPK was increased, whereas the phospho-JNK activity was decreased following the induction of colitis. Curcumin treatment was associated with amelioration of macroscopic and microscopic colitis sores, decreased MPO activity, and decreased MDA levels in acetic acid-induced colitis. Furthermore, oral curcumin supplementation clearly prevented programmed cell death and restored immunreactivity of MAPKs in the colons of colitic rats. The results of this study suggest that oral curcumin treatment decreases colon injury and is associated with decreased inflammatory reactions, lipid peroxidation, apoptotic cell death, and modulating p38- and JNK-MAPK pathways.

Mechanical properties of PLA and ABS parts produced with fused filament fabrication method

İsmail Topcu 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.2

The use of special and specific parts that are easily produced by the additive manufacturing method is of great importancein the following process. The ease of the materials and the low cost of the open source printers increase the use of the FusedFilament Fabrication (FFF) method. Due to the differences in FFF technology, investigation of the effects of the parameterson the mechanical properties of materials is necessary to determine the usability of the functional parts. Tensile strength wasdetermined as 46.8 MPa for polylactic acid (PLA) and 34 MPa for acrylonitrile butadiene styrene (ABS). Polylactic acidspecimens have a better wear resistance than acrylonitrile butadiene styrene (12.9 g) samples with a weight loss of 5.1 g at 5000m. According to the mechanical data Polylactic acid was found to be good properties than acrylonitrile butadiene styrene . Inorder to select most durable plastic for the unique application, the results of this study, which are given as graphs, diagramsand pictures, can help to the design engineers.

Experimental investigation on mechanical properties of Multi Wall Carbon Nanotubes (MWCNT) reinforced aluminium metal matrix composites

İsmail Topcu,Muhammet Ceylan,Elif Burcu Yilmaz 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.5

The aim of this research is to obtain better micrographs and to perform the mechanical characterization of Multi Wall CarbonNanotubes (MWCNT) consolidated aluminum matrix composite (AMC). This research is focused on the mechanical behaviorand microstructure characteristics in MWCNT consolidated aluminum matrix composites. The composites of MWCNT/Alwere successfully fabricated using powder metallurgy (PM) mechanical alloying (MA) sintering. X-ray diffraction (XRD) andScanning electron microscopy (SEM) micrographs were utilized in order to determine the porosity, density and hardnesscharacteristics to observe if they are affected or not concerning the performance of composites in different reinforced %MWCNT rate conditions. Along with SEM and XRD studies, this study details the homogeneous distribution of nanotubeswhich showed no evidence of decomposition; this was supported by a successive increase in hardness and abrasion resistance. This increase in abrasion resistance and hardness can be accredited to the further activation of the slip system due to thepresence of MWCNTs. Based on the conclusions of this study, the authors determined that the mechanical alloying sinteringmethod provides promising results for the mechanical alloying fabrication of MWCNT/Al composites, especially due to thedifferent % rate reinforced up capabilities.

The impact of collateral status on cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage

Abdullah Topcu,Ayca Ozkul,Ali Yilmaz,Ho Jun Yi,Dong-Seong Shin,Bum-Tae Kim 대한뇌혈관외과학회 2023 Journal of Cerebrovascular and Endovascular Neuros Vol.25 No.3

Objective: Cerebral collateral circulation may affect subarachnoid hemorrhage (SAH) induced cerebral vasospasm and delayed cerebral ischemia. In this study our aim was to investigate the relationship between collateral status, vasospasm and delayed cerebral ischemia (DCI) in both aneurysmal and nonaneurysmal SAH. Methods: Patients diagnosed as SAH with and without aneurysm were included and their data investigated retrospectively. After the patients diagnosed as SAH according to cerebral computed tomography (CT)/magnetic resonance imaging (MRI), they underwent cerebral angiography to check for cerebral aneurysm. The diagnosis of DCI was made according to the neurological examination and control CT/MRI. All the patients had their control cerebral angiography on days 7 to 10 in order to assess vasospasm and also collateral circulation. The American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) Collateral Flow Grading System was modified to measure collateral circulation. Results: A total of 59 patients data were analyzed. Patients with aneurysmal SAH had higher Fisher scores and DCI was more common. Although there was no statistically significant difference between the patients with and without DCI in terms of demographics and mortality, patients with DCI had worse collateral circulation and more severe vasospasm. These patients had higher Fisher scores and more cerebral aneurysm overall. Conclusions: According to our data, patients with higher Fisher scores, more severe vasospasm, and poor cerebral collateral circulation may experience DCI more frequently. Additionally aneurysmal SAH had higher Fisher scores and DCI was seen more common. To improve the clinical results for SAH patients, we believe that physicians should be aware of the DCI risk factors.

Biomechanical investigation of maxillary implant-supported full-arch prostheses produced with different framework materials: a finite elements study

Mirac Berke Topcu Ersöz,Emre Mumcu 대한치과보철학회 2022 The Journal of Advanced Prosthodontics Vol.14 No.6

PURPOSE. Four and six implant-supported fixed full-arch prostheses with various framework materials were assessed under different loading conditions. MATERIALS AND METHODS. In the edentulous maxilla, the implants were positioned in a configuration of four to six implant modalities. CoCr, Ti, ZrO2,and PEEK materials were used to produce the prosthetic structure. Using finite element stress analysis, the first molar was subjected to a 200 N axial and 45°oblique force. Stresses were measured on the bone, implants, abutment screw, abutment, and prosthetic screw. The Von Mises, maximum, and minimum principal stress values were calculated and compared. RESULTS. The maximum and minimum principal stresses in bone were determined as CoCr < ZrO2 < Ti < PEEK. The Von Mises stresses on the implant, implant screw, abutment, and prosthetic screws were determined as CoCr < ZrO2 < Ti < PEEK. The highest VonMises stress was 9584.4 Mpa in PEEK material on the prosthetic screw under 4 implant-oblique loading. The highest maximum principal stress value in bone wasfound to be 120.89 Mpa, for PEEK in 4 implant-oblique loading. CONCLUSION. For four and six implant-supported structures, and depending on the loading condition, the system accumulated different stresses. The distribution of stress was reduced in materials with a high elastic modulus. When choosing materialsfor implant-supported fixed prostheses, it is essential to consider both the number of implants and the mechanical and physical attributes of the framework material.

Effects of Crushed RAP on Free and Restrained Shrinkage of Mortars

Ilker Bekir Topcu,Burak Isikdag 한국콘크리트학회 2009 International Journal of Concrete Structures and M Vol.3 No.2

Reclaimed asphalt pavement (RAP) is abundant substitute for natural aggregate in many areas. It is obtained by crushing of old road pavements in milling machine during rehabilitation and reconstruction process. In this study, reclaimed asphalt pavement mortars (RAPM) have been produced with different cement dosages and replacement ratios. The destructive and nondestructive tests have been conducted on specimens to determine physical and mechanical properties of RAPM. The free and restrained shrinkage tests on RAPM have been conducted to predict fractural behavior of mortars. The aim of the shrinkage tests was to delay crack formation and improve strain capacity of mortars before cracking. The results showed that RAPM exhibits lower elasticity modulus; however the tensile capacity was improved for deformation before cracking.

Age-dependent renal expression of acid-base transporters in neonatal ureter obstruction

Wang, Guixian,Topcu, Sukru Oguzkan,Ring, Troels,Wen, Jianguo,Djurhuus, Jens Christian,Kwon, Tae-Hwan,Nielsen, Søren,Frøkiær, Jørgen Springer-Verlag 2009 Pediatric nephrology Vol.24 No.8