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- 저자 : Thavamani, Aravind (검색결과 17 건)
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Thavamani, Aravind,Umapathi, Krishna Kishore,Khatana, Jasmine,Gulati, Reema The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Purpose: There is increasing prevalence of psychiatric disorders among inflammatory bowel Disease (IBD) population. Further, presence of psychiatric disorders has been shown as an independent predictor of quality of life among patients with IBD. We intended to explore the prevalence of various psychiatric disorders among pediatric and young adult population with IBD as a population-based analysis. Methods: We did a retrospective case control analysis using a deidentified cloud-based database including health care data across 26 health care networks comprising of more than 360 hospitals across USA. Data collected across different hospitals were classified and stored according to Systematized Nomenclature of Medicine-Clinical Terms. We preidentified 10 psychiatric disorders and the queried the database for the presence of at least one of the ten psychiatric disorders among IBD patients between 5 and 24 years of age and compared with controls. Results: Total of 11,316,450 patients in the age group between 5 and 24 years and the number of patients with a diagnosis of IBD, Crohn's disease or ulcerative colitis were 58,020. The prevalence of psychiatric disorders was 21.6% among IBD mainly comprising of depression and anxiety disorder. Multiple logistic regression analysis showed, IBD is 5 times more likely associated with psychiatric disorders than controls, p<0.001). We showed a steady increasing trend in the incidence of psychiatric disorders among IBD patients (2% in 2006 to 15% in 2017). Conclusion: Largest population-based analysis demonstrated an increased prevalence of psychiatric disorders among IBD patients. Our study emphasizes the need for psychological and mental health services to be incorporated as a part of the routine IBD clinic.
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Aravind Thavamani,Jasmine Khatana,Krishna Kishore Umapathi,Senthilkumar Sankararaman 대한소아소화기영양학회 2023 Pediatric gastroenterology, hepatology & nutrition Vol.26 No.1
Purpose: The incidence and prevalence of inflammatory bowel disease (IBD) are increasing along with an increasing number of patients with comorbid conditions like psychiatric and behavioral disorders, which are independent predictors of quality of life. Methods: Non-overlapping years (2003-2016) of National Inpatient Sample and Kids Inpatient Database were analyzed to include all IBD-related hospitalizations of patients less than 21 years of age. Patients were analyzed for a concomitant diagnosis of psychiatric/ behavioral disorders and were compared with IBD patients without psychiatric/behavioral disorder diagnoses for outcome variables: IBD severity, length of stay and inflation-adjusted hospitalization charges. Results: Total of 161,294 IBD-related hospitalizations were analyzed and the overall prevalence rate of any psychiatric and behavioral disorders was 15.7%. Prevalence rate increased from 11.3% (2003) to 20.6% (2016), p<0.001. Depression, substance use, and anxiety were the predominant psychiatric disorders. Regression analysis showed patients with severe IBD (odds ratio [OR], 1.57; confidence interval [CI], 1.47-1.67; p<0.001) and intermediate IBD (OR, 1.14; CI, 1.10-1.28, p<0.001) had increased risk of associated psychiatric and behavioral disorders than patients with a low severity IBD. Multivariate analysis showed that psychiatric and behavioral disorders had 1.17 (CI, 1.07-1.28; p<0.001) mean additional days of hospitalization and incurred additional $8473 (CI, 7,520-9,425; p<0.001) of mean hospitalization charges, independent of IBD severity. Conclusion: Prevalence of psychiatric and behavioral disorders in hospitalized pediatric IBD patients has been significantly increasing over the last two decades, and these disorders were independently associated with prolonged hospital stay, and higher total hospitalization charges.
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Aravind Thavamani,Krishna Kishore Umapathi,Jasmine Khatana,Reema Gulati 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Purpose: There is increasing prevalence of psychiatric disorders among inflammatory bowel Disease (IBD) population. Further, presence of psychiatric disorders has been shown as an independent predictor of quality of life among patients with IBD. We intended to explore the prevalence of various psychiatric disorders among pediatric and young adult population with IBD as a population-based analysis. Methods: We did a retrospective case control analysis using a deidentified cloud-based database including health care data across 26 health care networks comprising of more than 360 hospitals across USA. Data collected across different hospitals were classified and stored according to Systematized Nomenclature of Medicine-Clinical Terms. We preidentified 10 psychiatric disorders and the queried the database for the presence of at least one of the ten psychiatric disorders among IBD patients between 5 and 24 years of age and compared with controls. Results: Total of 11,316,450 patients in the age group between 5 and 24 years and the number of patients with a diagnosis of IBD, Crohn's disease or ulcerative colitis were 58,020. The prevalence of psychiatric disorders was 21.6% among IBD mainly comprising of depression and anxiety disorder. Multiple logistic regression analysis showed, IBD is 5 times more likely associated with psychiatric disorders than controls, p<0.001). We showed a steady increasing trend in the incidence of psychiatric disorders among IBD patients (2% in 2006 to 15% in 2017). Conclusion: Largest population-based analysis demonstrated an increased prevalence of psychiatric disorders among IBD patients. Our study emphasizes the need for psychological and mental health services to be incorporated as a part of the routine IBD clinic.
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Aravind Thavamani,Krishna Kishore Umapathi,Jasmine Khatana,Senthilkumar Sankararaman 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.1
Purpose: Studies in adults have shown an increasing incidence of Clostridioides difficile infection (CDI) in patients hospitalized with acute pancreatitis (AP). There is lack of epidemiological data on CDI and its impact on hospitalized pediatric patients with AP. Methods: We analyzed the National Inpatient Sample and Kids' Inpatient Database between the years 2003 and 2016 and included all patients (age <21 years) with a primary diagnosis of AP using specific International Classification of Diseases codes. We compared clinical outcomes between children with CDI and those without CDI. Our primary outcome was severe AP and secondary outcomes included length of stay and hospital charges. Results: A total of 123,240 hospitalizations related to AP were analyzed and CDI was noted in 0.6% of the hospital. The prevalence rate of CDI doubled from 0.4% (2003) to 0.8% (2016), p=0.03. AP patients with CDI had increased comorbidities, and also underwent more invasive surgical procedures, p<0.05. AP patients with CDI had a higher in-hospital mortality rate and increased prevalence of severe AP, p<0.001. Multivariate regression models showed that CDI was associated with 2.4 times (confidence interval [CI]: 1.91 to 3.01, p<0.001) increased odds of severe AP. CDI patients had 7.24 (CI: 6.81 to 7.67, p<0.001) additional hospital days while incurring $59,032 (CI: 54,050 to 64,014, p<0.001) additional hospitalization charges. Conclusion: CDI in pediatric patients with AP is associated with adverse clinical outcomes and increased healthcare resource utilization. Further studies are needed to elucidate this association to prevent the development of CDI and to improve outcomes.
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Kuppusamy, Saranya,Thavamani, Palanisami,Venkateswarlu, Kadiyala,Lee, Yong Bok,Naidu, Ravi,Megharaj, Mallavarapu Pergamon Press 2017 Chemosphere Vol.168 No.-
<P><B>Abstract</B></P> <P>For more than a decade, the primary focus of environmental experts has been to adopt risk-based management approaches to cleanup PAH polluted sites that pose potentially destructive ecological consequences. This focus had led to the development of several physical, chemical, thermal and biological technologies that are widely implementable. Established remedial options available for treating PAH contaminated soils are incineration, thermal conduction, solvent extraction/soil washing, chemical oxidation, bioaugmentation, biostimulation, phytoremediation, composting/biopiles and bioreactors. Integrating physico-chemical and biological technologies is also widely practiced for better cleanup of PAH contaminated soils. Electrokinetic remediation, vermiremediation and biocatalyst assisted remediation are still at the development stage. Though several treatment methods to remediate PAH polluted soils currently exist, a comprehensive overview of all the available remediation technologies to date is necessary so that the right technology for field-level success is chosen. The objective of this review is to provide a critical overview in this respect, focusing only on the treatment options available for field soils and ignoring the spiked ones. The authors also propose the development of novel multifunctional green and sustainable systems like mixed cell culture system, biosurfactant flushing, transgenic approaches and nanoremediation in order to overcome the existing soil- contaminant- and microbial-associated technological limitations in tackling high molecular weight PAHs. The ultimate objective is to ensure the successful remediation of long-term PAH contaminated soils.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Summary of the extent and status of global PAHs contamination in soil. </LI> <LI> Overview of established remediation approaches for PAHs and their costs. </LI> <LI> Indication of emerging options for the cleanup of PAHs polluted sites. </LI> <LI> Proposal of novel multifunctional green and sustainable cleanup systems for future. </LI> <LI> Focus only on the treatment of field soils and not spiked soils. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Multifarious activities of cellulose degrading bacteria from Koala (Phascolarctos cinereus) faeces
Singh, Surender,Thavamani, Palanisami,Megharaj, Mallavarapu,Naidu, Ravi Korean Society of Animal Science and Technology 2015 한국축산학회지 Vol.57 No.7
Cellulose degrading bacteria from koala faeces were isolated using caboxymethylcellulose-Congo red agar, screened in vitro for different hydrolytic enzyme activities and phylogenetically characterized using molecular tools. Bacillus sp. and Pseudomonas sp. were the most prominent bacteria from koala faeces. The isolates demonstrated good xylanase, amylase, lipase, protease, tannase and lignin peroxidase activities apart from endoglucanase activity. Furthermore many isolates grew in the presence of phenanthrene, indicating their probable application for bioremediation. Potential isolates can be exploited further for industrial enzyme production or in bioremediation of contaminated sites.
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도영주,박형진,Thavamani Gokulnath,성경민,박호열,진성호 한국고분자학회 2022 Macromolecular Research Vol.30 No.3
Side-chain properties of π-conjugated wide bandgap (WBG) polymers have been widely studied for application in all-polymer solar cells (all-PSCs), but the siloxane functionalized side-chains based polymers has been rarely reported. In this regard, we systematically explored a π-conjugated WBG polymer with a distinct side-chain of siloxane functionality for high performance all-PSCs. We found that the π-conjugated WBG polymer (Si-BDT) has good absorption spectra with polymer acceptor (P(NDI2OD-T2)), high charge carrier mobility and enhanced bulk-heterojunction morphology. When the polymer with siloxane functionalized side-chain had power conversion efficiency (PCE) of 7.54% with significantly enhanced photocurrent and fill factor. Notably, the additive-free Si-BDT:P(NDI2OD-T2) exhibits stable characteristics. These results demonstrate that siloxane functionalized side chains are a promising strategy to design new π-conjugated polymers toward the stable all-PSCs.
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Saranya Kuppusamy,Palanisami Thavamani,Mallavarapu Megharaj,Kadiyala Venkateswarlu,이용복,Ravi Naidu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
The potential of dried twigs of Melaleuca diosmifolia as a novel biosorbent for removing three cationicdyes, methylene blue (MB), acridine orange (AO) and malachite green (MG), and an anionic dye,eriochrome black T (EB) was evaluated in a batch adsorption process. Notably, the biosorbent removed77–99% of both cationic and anionic dyes in a wide ranging pH of 2–10, and the reactions wereendothermic. The dye adsorption equilibria were rapidly attained within 3 h. The monolayer adsorptioncapacity of the sorbent added at 5 g L 1 was 119.05, 126.8, 116.28 and 94.34 mg g 1 for MB, AO, MG andEB, respectively. The water extract obtained from the plant material induced fast decolourization of bothcategories of dyes followed by gradual flocculation, indicating its potential as a natural coagulant. Gaschromatographic analysis also indicated that the main electrostatic attraction between 1,8-cineole, 1-pmethene-8-thiol and furfural compounds of the biomaterial, and dye molecules resulted in theformation of initial supramolecular complexes which further progressed into strong aggregates, leadingto precipitation of dye–biomaterial complexes. Subsequently, the overall complex mechanism of dyeremoval was confirmed to be a combined process of adsorption and coagulation. Consistent with thebatch studies, using selected plant material in real environmental water samples also resulted ineffective dye removal, highlighting its potential for use in wastewater treatment.
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