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Pham, Tung Thanh,Nguyen, Hanh Thuy,Phung, Cao Dai,Pathak, Shiva,Regmi, Shobha,Ha, Dong-Ho,Kim, Jong Oh,Yong, Chul Soon,Kim, Sang Kyoon,Choi, Ji-Eun,Yook, Simmyung,Park, Jun-Beom,Jeong, Jee-Heon Elsevier 2019 Journal of industrial and engineering chemistry Vol.76 No.-
<P><B>Abstract</B></P> <P>Selective delivery of anti-cancer drugs to bone tumors remains an on-going developmental issue due to problems of drug availability and the physiological nature of bone. This study was undertaken to enhance accumulation of doxorubicin (DOX) in bone metastasis microenvironments using alendronate-functionalized graphene oxide nanosheets (NGO-ALs). In vivo biodistribution study showed NGO-ALs were retained for longer and at higher concentrations in bone tumor areas than non-functionalized NGOs. Our findings suggest that NGO-ALs could be used as a promising carrier to enhance antitumor effects and diminish the off-target effects of DOX for the treatment of bone metastasis.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Selective delivery of anti-cancer drugs to bone tumors remains an on-going developmental issue due toproblems of drug availability and the physiological nature of bone. This study was undertaken to enhanceaccumulation of doxorubicin (DOX) in bone metastasis microenvironments using alendronate-functionalized graphene oxide nanosheets (NGO-ALs). In vivo biodistribution study showed NGO-ALswere retained for longer and at higher concentrations in bone tumor areas than non-functionalizedNGOs. Ourfindings suggest that NGO-ALs could be used as a promising carrier to enhance antitumoreffects and diminish the off-target effects of DOX for the treatment of bone metastasis.
Pham, Tung Thanh,Nguyen, Tiep Tien,Pathak, Shiva,Regmi, Shobha,Nguyen, Hanh Thuy,Tran, Tuan Hiep,Yong, Chul Soon,Kim, Jong Oh,Park, Pil–,Hoon,Park, Min Hui,Bae, Young Kyung,Choi, Jeong Uk,Byun, IPC Science and Technology Press 2018 Biomaterials Vol.154 No.-
<P><B>Abstract</B></P> <P>This study aims to develop a novel surface modification technology to prolong the survival time of pancreatic islets in a xenogenic transplantation model, using 3,4–dihydroxyphenethylamine (DOPA) conjugated poly(lactide–co–glycolide)–poly(ethylene glycol) (PLGA–PEG) nanoparticles (DOPA–NPs) carrying immunosuppressant FK506 (FK506/DOPA–NPs). The functionalized DOPA–NPs formed a versatile coating layer for antigen camouflage without interfering the viability and functionality of islets. The coating layer effectively preserved the morphology and viability of islets in a co–culture condition with xenogenic lymphocytes for 7 days. Interestingly, the mean survival time of islets coated with FK506/DOPA–NPs was significantly higher as compared with that of islets coated with DOPA–NPs (without FK506) and control. This study demonstrated that the combination of surface camouflage and localized low dose of immunosuppressant could be an effective approach in prolonging the survival of transplanted islets. This newly developed platform might be useful for immobilizing various types of small molecules on therapeutic cells and biomaterial surface to improve the therapeutic efficacy in cell therapy and regenerative medicine.</P>
<P>As part of ongoing research to find new antidiabetic agents from medicinal plants, the chemical composition of <I>Gynostemma longipes</I>, an ethnomedicinal plant used to treat type 2 diabetes mellitus by local communities in Vietnam, was investigated. Ten new dammarane triterpenes, including two 3,4-<I>seco</I>-dammarane analogues, secolongipegenins S1 and S2 (<B>1</B> and <B>2</B>), a 3,4-<I>seco-</I>hexanordammarane, secolongipegenin S3 (<B>3</B>), two hexanordammarane glycosides, longipenosides ND1 and ND2 (<B>4</B> and <B>5</B>), and five other dammarane glycosides, longipenosides GL1-GL5 (<B>6</B>-<B>10</B>), were isolated from a 70% EtOH extract of the whole <I>G. longipes</I> plant. The structures of the new compounds were elucidated using diverse spectroscopic methods. All of the isolates were evaluated for their stimulatory activities on glucose uptake in differentiated 3T3-L1 adipocyte cells using 2-[<I>N</I>-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-<SMALL>D</SMALL>-glucose as a fluorescent-tagged glucose probe. The stimulant activities on glucose uptake by the test compounds were mediated via the activation of the AMPK pathway using differentiated mouse C2C12 skeletal myoblasts. Consequently, compounds <B>1</B>, <B>2</B>, and <B>4</B> enhanced glucose uptake and GLUT4 translocation significantly by regulating the AMPK signaling pathway.</P> [FIG OMISSION]</BR>
Ultra-high-performance concrete (UHPC) is recognized as a promising material in future civil engineering projects due to its outstanding mechanical and durability properties. However, the lack of local UHPC materials and official standards, especially for prestressed UHPC structures, has limited the application of UHPC. In this research, a large-scale prestressed bridge girder composed of nonproprietary UHPC is produced and investigated. This work has two objectives to develop the mixing procedure required to create UHPC in large batches and to study the flexural behavior of the prestressed girder. The results demonstrate that a sizeable batch of UHPC can be produced by using a conventional concrete mixing system at any precast factory. In addition, incorporating local aggregates and using conventional mixing systems enables regional widespread use. The flexural behavior of a girder made by this UHPC is investigated including flexural strength, cracking pattern and development, load-deflection curve, and strain and neutral axis behaviors through a comprehensive bending test. The experimental data is similar to the theoretical results from analytical methods based on several standards and recommendations of UHPC design.
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The paper aims to investigate the impact of foreign direct investment (FDI) on private investment with a sample having 49 developing countries in Asia (17 countries) and Africa (32 countries) during the period of 1990-2017. Unlike previous studies, we split the data into three groups for further analysis, including the Asian, African and the full-panel samples. The results confirm a crowding-in effect which shows that foreign direct investment promotes private investment on all three research samples. Besides, the lagged private investment has a positive and significant effect on itself in the next period which reflects the inertia in the trend of private investment in recipient countries. In the full-panel sample, there are some macro factors such as GDP per capita, trade openness, and electricity that also have a positive and statistically significant impact on private investment. Besides, when more deeply estimate with smaller samples, we find that trade openness and labour force have a positive and significant in Africa, on the other hand, not in Asia. However, the domestic credit variable has a negative and significant effect on private investment only in Asian developing countries. Furthermore, there is only a positive and significant impact of the electricity variable on private investment in Asia.
A method for detecting glypican 3 (GPC3) liver cancer cells by coupling of anti-glypican 3 antibody (anti-GPC3) and magnetite nanoparticles (NPs) was investigated to detect GPC3 by enzyme-linked immunosorbent assay (ELISA) in this study. Magnetite NPs with the average size of 11 nm were synthesized by using co-precipitation method of Fe2+ and Fe3+ in NH3·H2O solution. First, silica was coated on the magnetite NPs using Stöber method to obtain Fe3O4/SiO2 core-shell structures and then 3-aminopropyltriethoxysilane (APTES) was treated on the Fe3O4/SiO2 by silanization reaction to achieve Fe3O4/SiO2/APTES nanostructures. After modified by APTES, the nanostructures were activated by glutaraldehyde (GA) to obtain functional groups on the nanostructures surface to bind with anti-GPC3 by covalent immobilization. The UV–vis spectroscopy was carried out to investigate the binding of anti-GPC3 to the NPs and binding efficiency (88.35%) was estimated by the Bradford method. The NPs bound anti-GPC3 (NPs/anti-GPC3) can detect GPC3 by using ELISA at low concentration (0.16 ng/ml).
Methods to prepare novel second-order nonlinear optical (2O-NLO) materials composed of all-silica zeolite (silicalite-1) and a series of 2O-NLO molecules having high second order hyperpolarizability constants (βvalues) are reviewed. These methods include the development of novel methods to incorporate a series of hemicyanine (HC) molecules into the channels of silicaite-1 films in uniform orientations. The first method is to incorporate HC molecules tethered with long alkyl chains (octadecyl or longer) into the silicalite-1 channels with the long alkyl chain side first through the hydrophobic-hydrophobic interaction between the long alky chains and the silicalite-1 channels. The second method is to incorporate the HC molecule tethered with a medium length alkyl chain (nonyl) into the silicalite-1 channels with the medium length alkyl chain side first through hydrophobic-hydrophobic interaction between the medium length alky chain in the photoexcited state and the silicalite-1 channels. The third method is to incorporate the HC molecule tethered with propionic acid into the silicalite-1 channels with the propionic acid side last mediated by a tetrabultylammonium cation ionpaired to the propionate unit. A method to prepare a novel third-order nonlinear optical (3O-NLO) material composed of zeolite-Y and PbS or PbSe quantum dots is also reviewed. This Account thus describes a promising new direction to which the search for highly sensitive 2O-NLO and 3O-NLO materials has to be conducted and a new direction to which zeolite research and applications have to be expanded.
<P><B>Abstract</B></P> <P>The adsorption of a complex mixture of 12 selected pharmaceuticals to trimethylsilylated mesoporous SBA-15 (TMS-SBA-15) has been investigated by batch adsorption experiments. The adsorption of pharmaceuticals to TMS-SBA-15 was highly dependent on the solution pH and pharmaceutical properties (i.e., hydrophobicity (log <I>K</I> <SUB>ow</SUB>) and acidity (p<I>K</I> <SUB>a</SUB>)). Good log–log linear relationships between the adsorption (<I>K</I> <SUB>d</SUB>) and pH-dependent octanol–water coefficients ( K ow pH ) were then established among the neutral, anionic, and cationic compounds, suggesting hydrophobic interaction as a primary driving force in the adsorption. In addition, the neutral species of each compound accounted for a major contribution to the overall compound adsorption onto TMS-SBA-15. The adsorption kinetics of pharmaceuticals was evaluated by the nonlinear first-order and pseudo-second-order models. The first-order model gave a better fit for five pharmaceuticals with lower adsorption capacity, whereas the pseudo-second-order model fitted better for seven pharmaceuticals having higher adsorption capacity. In the same group of properties, pharmaceuticals having higher adsorption capacity exhibited faster adsorption rates. The rate-limiting steps for adsorption of pharmaceuticals onto TMS-SBA-15 are boundary layer diffusion and intraparticle diffusion including diffusion in mesopores and micropores. In addition, the adsorption of pharmaceuticals to TMS-SBA-15 was not influenced by the change of initial pharmaceutical concentration (10–100μgL<SUP>−1</SUP>) and the presence of natural organic matter.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Trimethylsilylated SBA-15 for adsorptive removal of a mixture of 12 pharmaceuticals. </LI> <LI> Hydrophobic interaction as a primary driving force in the adsorption. </LI> <LI> The rate-limiting steps were diffusion through boundary layer, mesopores and micropores. </LI> <LI> Adsorption efficiency was not changed as pharmaceutical concentration varied. </LI> <LI> Adsorption efficiency was not influenced by the presence of natural organic matters. </LI> </UL> </P>
The detection of hepatitis B surface antigen (HBsAg) with an immunoassay using magnetite nanoparticles (NPs) that bind hepatitis B surface antibody (anti-HBs) was investigated. Magnetite NPs with an average size of 32 nm were synthesized and functionalized using tetraethyl orthosilicate, 3-aminopropyltriethoxysilane, glutaraldehyde, and streptavidin. The functionalized NPs were conjugated with biotinylated anti-HBs to capture HBsAg. HBsAgs were detected with a sensitivity, specificity and agreement of 98%, 97%, and 97.5%, respectively, when compared to the rapid test. In addition, the novel method could also enrich HBsAgs, using different tube sizes and can facilitate amplification for the detection of microorganisms.