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The Efficacy of Pharmacological Treatment in Pediatric Nonalcoholic Fatty Liver Disease
Taeshik Cho,김용주,백승삼 대한소아소화기영양학회 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.4
Purpose: With growing number of obese children, the prevalence of nonalcoholic fatty liver disease (NAFLD) in pediatric population is increasing. Nonalcoholic steatohepatitis (NASH) is a severe form of NAFLD, and can cause morbid complications. It is important to identify patients in order to grade pathologic severities and treat those children who possibly have NASH. This study was performed to evaluate whether the pharmacological therapy is also effective as well as the body weight reduction in pediatric NAFLD. Methods: Among the 52 children presenting with obesity and hepatopathy, NAFLD was diagnosed through liver biopsy in 29 children, who were 7 to 14 years of age, from January 2006 to December 2011. The patients were advised to reduce their body weight through diverse methods. Medication with Ursodeoxycholic acid (UDCA) and vitamin E was performed in children whose liver functions did not improve or their weight reductions were not successful. The therapeutic effects were monitored and assessed via the biochemical profiles and the physical measurements. Results: The therapy of vitamin E and UDCA combined with body mass index (BMI) reduction showed significantly higher rate of improvement in clinical profiles, which could be seen in data of aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT ratio, alkaline phosphatase, total bilirubin and γ-glutamyl transpeptidase. Children whose BMI were successfully reduced showed favorable clinical improvements without any medication, but those without BMI reduction did not show any improvement despite medications. Conclusion: This study showed that the first line of therapy should be the BMI reduction in NAFLD and drug therapy combined with BMI reduction could have additive therapeutic effect in children with NAFLD.
A Hybrid Adaptive Security Framework for IEEE 802.15.4-based Wireless Sensor Networks
( Taeshik Shon ),( Yongsuk Park ) 한국인터넷정보학회 2009 KSII Transactions on Internet and Information Syst Vol.3 No.6
With the advent of ubiquitous computing society, many advanced technologies have enabled wireless sensor networks which consist of small sensor nodes. However, the sensor nodes have limited computing resources such as small size memory, low battery life, short transmission range, and low computational capabilities. Thus, decreasing energy consumption is one of the most significant issues in wireless sensor networks. In addition, numerous applications for wireless sensor networks are recently spreading to various fields (health-care, surveillance, location tracking, unmanned monitoring, nuclear reactor control, crop harvesting control, u-city, building automation etc.). For many of them, supporting security functionalities is an indispensable feature. Especially in case wireless sensor networks should provide a sufficient variety of security functions, sensor nodes are required to have more powerful performance and more energy demanding features. In other words, simultaneously providing security features and saving energy faces a trade-off problem. This paper presents a novel energy-efficient security architecture in an IEEE 802.15.4-based wireless sensor network called the Hybrid Adaptive Security (HAS) framework in order to resolve the trade off issue between security and energy. Moreover, we present a performance analysis based on the experimental results and a real implementation model in order to verify the proposed approach.
Computer use at work is associated with self-reported depressive and anxiety disorder
Taeshik Kim,Mo-Yeol Kang,Min-sang Yoo,Dongwook Lee,Yun-Chul Hong 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Background: With the development of technology, extensive use of computers in the workplace is prevalent and increases efficiency. However, computer users are facing new harmful working conditions with high workloads and longer hours. This study aimed to investigate the association between computer use at work and self-reported depressive and anxiety disorder (DAD) in a nationally representative sample of South Korean workers. Methods: This cross-sectional study was based on the third Korean Working Conditions Survey (2011), and 48,850 workers were analyzed. Information about computer use and DAD was obtained from a self-administered questionnaire. We investigated the relation between computer use at work and DAD using logistic regression. Results: The 12-month prevalence of DAD in computer-using workers was 1.46 %. After adjustment for sociodemographic factors, the odds ratio for DAD was higher in workers using computers more than 75 % of their workday (OR 1.69, 95 % CI 1.30−2.20) than in workers using computers less than 50 % of their shift. After stratifying by working hours, computer use for over 75 % of the work time was significantly associated with increased odds of DAD in 20–39, 41–50, 51–60, and over 60 working hours per week. After stratifying by occupation, education, and job status, computer use for more than 75 % of the work time was related with higher odds of DAD in sales and service workers, those with high school and college education, and those who were self-employed and employers. Conclusions: A high proportion of computer use at work may be associated with depressive and anxiety disorder. This finding suggests the necessity of a work guideline to help the workers suffering from high computer use at work.
센서 네트워크에서 이동성이 있는 센서 노드의 효율적인 인증 방안
손태식(Taeshik Shon),한규석(Kyusuk Han) 한국통신학회 2010 韓國通信學會論文誌 Vol.26 No.9
최근 무선 센서 네트워크 (Wireless Sensor Network)에서 Actor Network 등의 이동성이 있는 센서에 대한 연구가 매우 활발하게 진행되고 있다. 그러나 기존의 대부분의 센서 간의 인증 및 키 교환 기술에 대한 연구는 고정된 센서만 있는 환경만을 고려하고 있으며, 이동성이 있는 센서 노드가 있는 환경에 적용하는 경우 통신 및 연산 부하가 급증하기 떄문에, 자원 제약이 있는 센서 네트워크 환경에서 적용하기 부적합하다. 따라서 본 논문을 통해 최초 인증 이후 재인증 시 자원 이용을 최소화 할 수 있는 이동성이 있는 센서 환경에 적합한 효율적인 센서 인증 및 키 교환 기술을 제안한다. Mobility of sensor node is one of the rising issues in Wireless Sensor Networks (WSN). However, current security researches on WSN only consider static environments. Thus they are not sufficient to be deployed in the dynamic environment where the resource is limited. In this paper, we propose the efficient node authentication and key exchange protocol that reduces the overhead in node re-authentication.
High-Yield Etching-Free Transfer of Graphene: A Fracture Mechanics Approach
Yoon, Taeshik,Jo, Woo Sung,Kim, Taek-Soo The Korean Microelectronics and Packaging Society 2014 마이크로전자 및 패키징학회지 Vol.21 No.2
Transfer is the critical issue of producing high-quality and scalable graphene electronic devices. However, conventional transfer processes require the removal of an underlying metal layer by wet etching process, which induces significant economic and environmental problems. We propose the etching-free mechanical releasing of graphene using polymer adhesives. A fracture mechanics approach was introduced to understand the releasing mechanism and ensure highyield process. It is shown that the thickness of adhesive and target substrate affect the transferability of graphene. Based on experimental and fracture mechanics simulation results, we further observed that compliant adhesives can reduce the adhesive stress during the transfer, which also enhances the success probability of graphene transfer.