정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

우관상정맥동에서 기시하는 단일 관상동맥 1예

정현광,김태우,조윤성,김강민,장재훈,이재우,정준훈 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Coronary artery anomalies are found incidentally in approximately 1% of all patients undergoing routine coronary angiography. Of these, an isolated single coronary artery anomaly is the rarest one. Patients with an isolated single coronary anomaly may present with symptoms such as angina pectoris, myocardial infarction, arrhythmias, syncope, sudden death, and congestive heart failure. We report a case of single coronary artery anomaly with the left anterior descending and left circumflex coronary artery originating from the right coronary artery.

Salmonella 및 Shigella의 各種 環境에서의 生存

丁泰勳,全燾基 慶北大學校 醫科大學 1979 慶北醫大誌 Vol.20 No.2

Salmonella typhi와 shigella의 食鹽加 phosphate buffer (pH7.2), 蒸溜水(pH6.2), 水道水 및 샘물에서의 生存 및 溫度가 이에 미치는 影響을 보았다. Buffer에서는 S. typhi는 20℃에서 60日까지 菌數에 큰 變動이 없이 生存하였으며 4℃에서는 時日의 經過과 따라 次次 減少되거나 60日後에도 많은 菌이 生存하였다. 그러나 -18℃에서는 生菌數가 急速히 減少되어 30日後에는 生菌을 檢出하지 못하였다. 蒸溜水에도 같은 傾向을 보였으나 다만 20℃에서는 buffer에서 보다 菌의 減少가 현저하였다. Shigella는 buffer 및 蒸溜水에서 다같이 20℃ 및 4℃에서 時日의 經過에 따라 次次 減少 하였으나 60日後에도 生菌을 檢出할 수 있었고 -18℃에서는 30日 後에는 生菌이 檢出되지 않았다. E. coli는 buffer에서 20℃에서는 時日의 經過에 따라 菌數가 增加하였고 4℃ 및 -18℃에서는 次次 減少되었으나 그 減少는 S. typhi 및 Shigella보다 緩慢하였다. S. typhi와 Shigella는 E. coli와의 共存下에서도 單獨存在時와 같은 生存曲線을 나타내는 것으로 생각되었다. 水道水와 샘물에서는 S. typhi와 shigella가 大體로 20日以內에서 滅菌되었다. 藥劑耐性菌과 感受性菌사이에 生存期間의 差異는 볼 수 없었다. The survival of Salmonella typhi and Shigella flexneri in various environments, such as phosphate buffered saline (pH 7.2), distilled water, city water, and well water, was studied at various tempereaturs. S. typhi survived in buffer at 20℃ without marked decrease in number of cells for more than 60 days. The number decreased gradually at 4℃, but a considerably large number of cells survived at 60 days. However, the cells were rapidly sterilized at -18℃ within 30 days. The survival of S. typhi in distilled water showed the similar patterns of in buffer, except 20℃ at which the decrease of viable cells was more rapid than in buffer. The number of Shigella in buffer and distilled water decreased gradually with almost the similar patterns between two media at 4℃ and 20℃, but viable cells were found even after 60 days. Shigella showed the similar pattern of survival with S. typhi at -18℃. The number of E. coli at 20℃ increased in buffer at the beginning of incubation and maintained the same level for more than 110 days, but decreased gradually at 4℃ and -18℃ at more slowly than S. typhi and Shigella. Mixed incubation of S. typhi or Shigella with E. coli did not influence the survival of these organisms alone in media. The survival of the organisms was not influenced by the resistance to drugs. S. typhi and Shigella were rapidly sterilized within 20 days in city water and well water.

자동차 배출가스 정화용 Pd/γ-AI_(2)O_(3) 촉매의 인 피독에 있어서 La_(2)O_(3)의 첨가효과에 대한 연구

정태훈,정석진 慶熙大學校 材料科學技術硏究所 1990 材料科學技術硏究論集 Vol.3 No.-

In order to suggest an efficient catalyst system for automotive emission control, Pd-La_(2)O_(3) catalyst was characterized before and after phosphorus contact. By H_(2) chemisorption experiment, it was found that the particle size of Pd was decreased and dispersion of it was increased by promotion of La_(2)O_(3) After phosphorus poisoning, it was found that amounts of H_(2) chemisorbed were decreased largely up to certain value (ca. 5wt%). However, there was small changes in the amount of H_(2) chemisorbed between 5wt% and 10wt% phosphorus poisoned catalysts. That is to say, phosphorus of high loading doesn't affect the loss of H_(2) chemisorption site by formation of multilayers on the catalyst. By engine exhaust gas test, it was observed that Pd-La_(2)O_(3) catalyst was pretty sensitive against the phosphorus poisoning.

Excel VBA를 이용한 정보시스템 구축에 관한 연구 : 소규모 부품 제조업 사례

정현석,김태훈 동의대학교 경제경영전략연구소 2010 經濟經營硏究 Vol.5 No.1

With the development of Information Technology, many companies are investing much efforts and resources in introducing an information system in order to increase their productivity and to achieve a competitiveness in the market. However, small size companies(less then 50 employees) which share 99% of whole domestic business are suffering many difficulties in constructing an information system. It comes from the development cost and the difficulty of maintenance. This research is concerned about the methodology for building information system for small size organization by using Excel VBA(Visual Basic for Application). By using the methodology proposed in this research, a company may construct a proper information system for its own organization. It was observed that much time to construct and maintain the information system could be saved. And it is believed that the proposed methodology may contribute in achieving high efficiency in management for small size company that lacks human resources and suffers the shortage of fund.

호흡기 감영증에서의 Tosufloxacin(Ozex^(�))의 임상 효과

정태훈,김성국 최신의학사 1994 最新醫學 Vol.37 No.4

랫드에서 미생탕의 4주 반복투여독성

김태명, 류재면, 서임권, 박동선, 조정희, 장용훈, 김윤배, 황석연 충북대학교 동물의학연구소 2009 Journal of Biomedical and Translational Research Vol.10 No.1

본문참고

On the Strengthening Effects Affecting Tensile and Low Cycle Fatigue Properties of Low-Alloyed Seismic/Fire-Resistant Structural Steels

Jung‑Ho Sim,Tae‑Yeong Kim,Jun‑Yeon Kim,Chi‑Won Kim,Jun‑Ho Chung,Joonoh Moon,Chang‑Hoon Lee,Hyun‑Uk Hong 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2

In the present study, low carbon ferritic and bainitic steels with different contents of Mo, Ti, and Nb were designed for bothseismic and fire-resistant applications. The microstructure of steels containing 0.3 wt% Mo–0.02 wt% Nb (‘A’ hereinafter)was mainly composed of bainite. By contrast, the microstructure of steels with 0.2 wt% Mo–0.13 wt% Ti (‘B’ hereinafter)consisted of ferrite with a high density of nano-sized (Ti,Mo)-rich MX precipitates. The results showed that the bainiticmicrostructure (‘A’ steel) was quite favorable to high-temperature strength and thermal stability. The yield strength of ‘A’ steelat both room and 600 °C temperatures increased consistently with increasing thermal exposure time (600 °C/200–1000 h),since the precipitation of NbC particles occurred while maintaining bainitic ferrite platelets with a high density of dislocationsduring exposure. In the ‘B’ steel, the formation of nano-sized (Ti,Mo)-rich MX particles was effective to impededislocation movement, leading to excellent plasticity (lower yield ratio) at room temperature. However, their contributionto precipitation hardening was not so much at 600 °C, as compared to the bainitic strengthening. During low cycle fatiguetests at room temperature, the main different feature between the two steels is that the ‘A’ steel showed cyclic softeningwhile cyclic hardening was evident in the ‘B’ steel. The bainitic microstructure showed a better fatigue life due to increasedductility manifested by cyclic softening, by which dislocation cell was developed.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

The Effect of Service Quality on Satisfaction, Image and Word-of-Mouth Intention of the Seoul Square Skating Rink Users

윤태훈,손석정,백우열 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.2

본 연구는 서울광장 스케이트장의 서비스품질이 이용객들의 만족, 이미지 그리고 구전의도에 미치는 영향을 규명하는데 그 목적이 있다. 이를 위해 서울시청 앞 서울광장 스케이트장을 이용하는 시민들을 모집단으로 선정하여 편의추출법을 통해 450명을 선택한 다음 자기평가기입법으로 설문에 응답하게 하였다. 450부의 설문지 가운데 409부가 회수되었고 이 가운데 신뢰성이 떨어진다고 판단되는 30부의 설문지를 제외하고 379부가 통계분석에 이용되었다. 수집된 자료는 SPSS Ver. 10.0프로그램을 이용하여 빈도분석, 요인분석, 신뢰도분석을 실시하였으며 연구가설의 검증을 위해 t검정과 일원변량분석, 회귀분석을 실시하였다. 이상의 연구방법을 통해 도출된 결과는 다음과 같다. 첫째, 이용시민들의 성별에서는 식음서비스에서 유의한 차이가 나타났으며, 연령별에서 운영서비스와 이벤트 및 프로그램 서비스가 유의한 차이가 나타났다. 학력별로 이벤트 및 프로그램 서비스에서 유의적인 차이가 나타났으며, 연령별로 운영서비스와 이벤트 및 프로그램 서비스가 유의적인 차이가 나타났다. 직업별로는 운영서비스와 식음서비스, 안전서비스, 이용서비스에 유의한 차이가 나타났으며, 총수입별로는 이용서비스에 있어 통계적으로 유의한 차이가 있는 것으로 나타났다. 둘째, 스케이트장 서비스품질이 이용 시민행동에 미치는 영향은 먼저 서비스품질 속성인 운영서비스, 이벤트 및 프로그램 서비스, 안전서비스가 이용객들의 만족도에 유의한 영향을 미치는 것으로 나타났으며 운영, 이벤트 및 프로그램 서비스도 이용객들의 이미지에 유의한 영향을 미치는 것으로 나타났다. 결과적으로 서울광장 스케이트장이 이용객들에게 사랑 받는 명소로 자리 잡기 위해서는 우선적으로 운영과 안전에 관련된 서비스를 개선하고 강화할 필요성이 요구되고 있다. 주요어: 스케이트장, 서비스품질, 만족도, 이미지, 구전의도