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        • KCI등재

          Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity

          Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2

          Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.

        • KCI등재

          Identification of Soluble Epoxide Hydrolase Inhibitors from the Seeds of Passiflora edulis Cultivated in Vietnam

          To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4

          Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.

        • SCOPUSKCI등재

          Identification of Soluble Epoxide Hydrolase Inhibitors from the Seeds of Passiflora edulis Cultivated in Vietnam

          Cuong, To Dao,Anh, Hoang Thi Ngoc,Huong, Tran Thu,Khanh, Pham Ngoc,Ha, Vu Thi,Hung, Tran Manh,Kim, Young Ho,Cuong, Nguyen Manh The Korean Society of Pharmacognosy 2019 Natural Product Sciences Vol.25 No.4

          Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC<sub>50</sub> value of 3.4 μM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.

        • A Review of Accounting Research Trends in the World

          Tran,Thi Phuong Thanh 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Trends in international accounting harmonization are extensive, so that demand on accounting research to meet international standards is more necessary and instant. The purpose of this paper is to conduct a review of accounting papers and find out the main characteristics of current accounting research trends in the world. I investigate trends by examining papers published in six top accouting journals (JCR 2015) from 2015 to 2016. I used citations made by accounting papers as a proxy for ranking and examine trends in topics and methodologies of these papers. This paper’s results suggest that financial accounting topics and archival methodologies are becoming more significantly over time during the research period. Moreover, the results also show that the movement in accounting research trends from a normative perspective to a positive perspective, especially an experimental research. From these results, I discuss the major characteristics of future accounting research trends and give some implications about accounting research to Vietnamese researchers.

        • Macroeconomic Conditions and Capital Structure Adjustment Speed - The Evidence in Vietnam

          Tran,Thi Muoi,Nguyen,Thi Uyen Uyen 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-

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          The relationship between capital structure and corporate value is a topic that has been and can continue to be studied by scientists around the world and Vietnam because of its helpful. The empirical evidences show that the capital structure has an impact on the value of the enterprise; therefore, businesses are always looking for an optimal capital structure to finance. In addition, many studies have shown that there is always an optimal capital structure in enterprises where the value of the enterprise is the highest, which has led to the tendency of enterprises to adjust the capital structure to achieve an optimal capital structure, that makes the capital structure of the enterprise is not static, it is always dynamic. Moreover, the study of the impact of factors on the capital structure of enterprises is also interested by many researchers in the world and Vietnam such as characteristic and macroeconomic factors; especially in the world there have been many studies on the impact of macroeconomic conditions on the speed of capital structure adjustment of enterprises, however, this subject in Vietnam is not mentioned. With this gap, the author determines to study the impact of macroeconomic conditions on the capital structure adjustment speed of Vietnam enterprises in the period 2006 -2015.

        • 2P-448 : An efficient oxidation of methane to methyl bisulfate using Pt-DMSO catalyst

          ( Tran ),이현주 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

          Periana catalyst (the Catalytica system-(bpym)PtCl<sub>2</sub>) is known as the best homogeneous catalyst for methane functionalization so far; methane is converted with 90% conversion and 81% selectivity into methyl bisulfate. However, until now, many arguments still remain about not only the reaction mechanism, but also the role of the ligands. Recent research, (bpym) ligand is proved not to be mandatory for high activity; even it actually seems to be detrimental for the catalytic activity under the reaction conditions. Moreover, simple platinum salts are concluded be stable, selective and unprecedented active under reaction conditions superior to Periana catalyst. In our research, we synthesized successfully a new and efficient Pt-based homogeneous catalyst system having DMSO as a ligand. The catalytic activity of the new catalyst was investigated by performing the oxidation of methane (25bar) in the presence of fuming sulfuric acid.

        • KCI등재

          Is Deep Better in Extreme Temperature Forecasting?

          Tran,Trang Thi Kieu,Lee,Taesam 한국방재학회 2019 한국방재학회논문집 Vol.19 No.7

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          최근 들어서 인공신경망을 이용한 딥러닝이 강우, 풍속, 온도 등의 높은 비선형성과 복잡성을 가진 여러 기상현상을 예측하는데 널리 이용되어지고 있다. 하지만 실제적인 딥러닝이 그만큼의 성능을 발휘하는지에 대한 중요한 연구들은 실제로 많이 이루어지지 못하고 있다. 따라서 본 연구에서는 하나의 은닉층을 바탕으로 한 얕은 층의 모형과 여러 은닉층을 가진 깊은 은닉층의 모형에 대해서 비교 평가하였다. 자료는 한국의 5개 기상관측지점을 대상으로 1975-2015년의 일최고기온을 바탕으로 수행되어졌다. 각각의 모형은 겨울, 봄, 여름, 가을 자료의 1일단위 예측하는데 적용되었다. 이와 더불어, 모델의 성능과 효율성이 RMSE를 통해 평가되었고, 유전알고리즘이 최상의 네트워크구조를 찾는데 사용되었다. 전체적으로, 한 개의 은닉층을 가진 모형이 다수의 은닉층을 가진 모델보다 더 좋은 성능을 가지는 특징을 보여 주었다. In recent years, the application of deep learning based on artificial neural networks (ANNs) to forecast highly non-linear and complex weather phenomena, such as rainfall, wind speed, and temperature, has become an attractive pursuit in the field of environmental sciences. However, the critical research addressing the question of whether or not a deep learning network can perform better has not been completed. The current study conducted a systematic comparison of a one-hidden-layer (shallow) network and a multiple-hidden-layer (deep) network in maximum temperature forecasting Datasets of daily maximum temperature at five stations in South Korea, spanning the years 1976 to 2015, were used for training and testing the different-architecture models, respectively. With each model, one-day-ahead forecasting was made for the winter, spring, summer, and autumn seasons. Moreover, the performance and effectiveness of the models were then assessed by the root mean square error (RMSE). In addition, a genetic algorithm was applied to select the optimal network architecture. Finally, the empirical results indicated that the ANN model with one hidden layer, compared with the case of multiple-hidden-layer networks, produced the most accurate forecasts.

        • Synthesis of trans-Metanicotine Analogues

          Park Haeil,Tran ThanhDao,Sin Kwanseog,Jang Jinhee 大韓藥學會 2001 大韓藥學會 總會 및 學術大會 Vol.2001 No.2

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        • SCOPUS

          Determinants of Intra-Industry Trade between Vietnam and Countries in TPP

          NGUYEN, Ha Minh,QUAN, Binh Quoc Minh,LE, Huong Van,TRAN, Thinh Van Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.1

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          Intra-industry trade (IIT) has played an important role in international trade of Vietnam as a result of rapid growth of the country. This article investigates the level of IIT between Vietnam and 11 trading partners in Trans-Pacific Partnership (TPP) over the period 2000-2014. Although there have been a large number of empirical researches contributed to the determinants of IIT, most of them only pay attention on developed countries where the trade flows are similar due to similar demand structure and production technology. Until now, there is no study on intra-industry trade between Vietnam and countries in TPP that Vietnam recently signed a trade agreement in early 2016. IIT is measured by the Grubel-Lloyd index. The index shows that the extent of intra-industry trade between Vietnam and the trading countries is not high due to the level of economic development and the market size. The determinants of IIT are examined using a panel regression model. In the empirical analysis, the results indicate that Vietnam's intra-industry trade is positively correlated with country size, while it is negatively correlated with income dissimilarity, the trade openness, and geographical distance. This study contributes to the new theoretical trade theory on the evidence of developing country's IIT.

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