답손(Dapsone)중독환자의 예후와 특성 분석

장석준,정성필,김승환,구홍두,심호식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

We reviewed 26 dapsone intoxication patients who had visited Severance Hospital Emergency Care Center from January 1991 to January 1995 : 13 of them ingested intentionally, but the other ingested accidentally. Among the admitted patients the highest and lowtheest initial value of methemoglobin level is 59.6% & 10.1%. The frequency of symptoms at presentation was following 16 patients complained cyanosis of lip area, 10 patients complained dyspnea, 4 patients complained mental change, 4 patients complained vomiting, 2 patients complained nausea. The inital level of methemoglobin was less than 50% except in one patient. In the view points of total doses of methylene blue used, less than 100mg was used in 9 patients(34.6%) but in one case, amount of 6400mg was loaded. There were 5 patients(19.2%) in September & 4 patients (15.4%) in January. In respect of result, there were 13 discharged cases (50%) for symptom improvement, and 5 mortality cases(19.2%). The transferred cases from Gangwondo account 19 patients(73.1%). All of them is not directly emergency care center visiting patients but transferred patients from remotely located hospitals. Dapsone intoxication results in severe tissue hypoxic symptoms from malfunction of normal hemoglobin thus only with appropriate available doses of methylene blue & activated charcoal, good outcomes will be expected. If aggressive therapy such as hemodialysis is introduced in treatment of severe dapsone intoxication, the outcomes may be slightly improved better than in other supportive care cases.

국내 콘크리트 기준의 발전 방향에 대한 고찰

심종성,최장환,문도영,박성재 漢陽大學校 工學技術硏究所 2002 工學技術論文集 Vol.11 No.-

유럽 각국의 규준을 통합한 유로 Code의 등장과 북미지역을 중심으로 한 기술통합의 흐름과 같은 Global Network화의 추세에 적극적으로 대처하고자 Asia Concrete Model Code(ACMC)의 제정이 제안되었다. 현재까지 ACMC 위원회는 LevelⅠ과 Level Ⅱ의 draft를 완성하였으며, Level Ⅲ에서는 국가/지역조건을 고려한 실제적인 지침을 준비하고 있는 단계이다. 따라서 본 연구에서는 각 시방들을 비교·분석하고 현재 제안된 ACMC Level Ⅲ Document 및 Perforomance Based Design과 관련된 문헌들을 고찰함으로써 국내현황에 적합한 ACMC Level Ⅲ Document의 작성방안을 제안하고자한다. Asian Concrete Model Code (ACMC) was proposed to cope with appearance of Euro-Code and a trend of Global Network such as a flow of the technique unification of North America. ACMC Committee has completed two drafts of LevelⅠ and LevelⅡ. Also, prectial specification considering national/regional condition is being prepared in draft of Level Ⅲ Document. On the study, each specification was analyzed and compared and a number of references were studied in order to propose ACMC Level Ⅲ Document considering domestic conditions.

磁氣천칭에 의한 Gd2 (M_(0)O₄)₃ 단결정의 유전성 Curie점 측정

김장환,서상율,장민수 부산대학교 1986 자연과학논문집 Vol.41 No.-

Magnetic susceptibilities of single crystal Gd_(2)(M_(0)O_(4))_(3) were measured in the temperature range of 340 K-510 K. The results show that the magnetic susceptibility curves obtained from the data are in agreement with the Curie's law. Near the dielectric Curie point, however, a little kink was found on the these magnetic susceptibility curves.

만성 호중구성 백혈병 1례

기장도,박치영,류보열,김태종,모성환,곽재정,문철호,박근홍,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood (PB), hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid. serun viatmin B 12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or underlying infection or disease sufficient to mimic a leukemoid reaction. We have experienced a 34-years-old male patient with atypical chronic neutrophilic leukemia. On admission, the leukocyte count was 56,860/uL. severe neutrophic leukocytosis with 76% neutrophils and rare immature forms on PB smear. Many neutrophils had toxic granules, and vacuoloes. Leukocyte alkaline phosphatase score was decreased. The cytogenetic study showed Philadelphia chromosome negative with normal karyotype.

인체기생 열두조충류의 형태비교 및 진단적 소견

임신영,강성구,양용상,백승한,류장근 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1998 Journal of biomedical laboratory sciences Vol.4 No.1

최근 우리 나라는 열두조충과 (Diphyllobothridae)에 속하는 조충류의 인체 감염예가 빈번하게 보고되고 있다. 이는 본 조충류의 감염매체인 어류를 날 것으로 생식할 기회가 많으며, 또한 본 조충류의 제1중간숙주인 물벼룩이 음료수를 통한 인체 감염이 원인일 것으로 추정되고 있다. 조충류의 진단은 충체에 있어 두적과 편절의 형태학적 특징을 감별하여 種의 분류와 진단을 하는 것이 기본적 순서가 될 것이나, 1차적으로 가능한 진단은 환자의 증상 참작과 분변으로부터 충란을 발견 감별하게 된다. 특히 광절열두조충류의 충란에 의한 種鑑別은 환자로부터 편절이나 충체의 확실한 감별을 위한 사전 정보를 가늠하는 뜻에서도 중요성이 있다. 이에 저자들은 환자의 치료와 함께 수집된 Diphyllobothrium latum, D. latum parvum 그리고 Spirometra erinacei의 편절과 충란을 재료로 형태 및 진단적 결과를 분석한 바 그 성적은 다음과 같다. 1. 환자의 분변에서 수집된 충란 50개씩을 각각 선택하여 형태와 크기에 대한 계측을 실시하였다. D. latum의 충란은 난개가 있고 난원형 또는 타원형의 모양으로 관찰되었으며 D. latum parvum은 D. latum에 비하여 더 난원형이면서 작게 관찰되었다. S. erinacei의 충란은 폭이 비대칭적이며 길쭉한 모양으로 관찰되었다. 2. D. latum, D. latum parvum 그리고 S. erinacei의 충란의 크기에서 충란의 평균 길이와 폭은 각각 61.4X41.7㎛, 55.9X41.4㎛ 그리고 66.7X36.4㎛이었다. 3. 각 조충의 편절을 고정한 다음, 첫째 포매하고 microtome으로 절편을 만들어 hematoxylin-eosin 염색을 실시하였고, 둘째 고정과 함께 semicon's aceto-carmine 염색표본을 작성하여 현미경 관찰을 한 결과 D. latum과 D. latum parvum은 생식선이 편절의 중앙선상에 위치하고 개구된 자궁구가 관찰되었다. 그리고 편절의 양측에 난황이 follicle로 관찰되었으며 전형적인 rosette모양을 형성하고 있었다. 그러나 D. latum parvum은 D. latum에 비하여 아주 작은 크기로 관찰되었다. S. erinacei의 편절은 자궁이 나선형으로 5∼7회 이상으로 말려서 관찰되었고 음경낭안에서 저정낭이 이어져 연결되고 있었다. 이로써 본 연구에서는 편절의 형태특징과 함께 충란 크기에 대한 계측과 분석을 하고자 하였으며, 공학현미경에 의한 계측치로 세 종류의 조충 감별에 유의한 참고치를 제기하는 바이다. Recently there have been frequent reports on human infection caused by the Diphyllobothridae in Korea. The adequate opportunities for Koreans to eat raw fish, the primary infection medium of cestodes and the human infection through drinking water by cyclops, the first intermediate host are believed to be main reasons for the infection. The first task of this study was to classify and diagnose the species by differentiating morphological characteristic between scolex and proglottids of cestodes. However, the initially available diagnosis was done with the patient's symptoms and the eggs obtained from his stool. It is important to differentiate the species by the eggs of Diphyllobothrium latum especially in that it can help get advance information for a more reliable analysis in the near future. The morphological and diagnostic results from proglottids and eggs of Diphyllobothrium latum, Diphyllobothrium latum parvum and Spirometra erinacei are as follows; In each kind of cestodes from the patient's stool, the shape and size of 50 eggs were measured. Eggs of Diphyllobothrium latum had an operculum and were ovoidal or ellipsoid to elliptical in shape. Eggs of Diphyllobothrium latum parvum were more ovoidal in shape and smaller in size than Diphyllobothrium latum. And eggs of Spirometra erinacei were asymmetrical in width and long and slender in shape. The average lengths and widths of Diphyllobothrium latum, Diphyllobothrium latum parvum and Spirometra erinacei were 61.4X41.7㎛, 55.9X41.4㎛ and 66.7X36.4㎛, respectively. After the segments of each cestode were fixed, embedding and hematoxylin-eosin dyeing on a microtome-made specimen were done. The micrographs of the semicon's aceto-carmine dyed specimen showed that Diphyllobothrium latum and Diphyllobothrium latum parvum had a centrally-located genital gland and an opened uterine pore. The yolks were observed on both sides of proglottids and had a typical rosette pattern. Yet, Diphyllobothrium latum parvum was shown smaller than Diphyllobothrium latum in the micrograph. Proglottids of Spirometra erinacei displayed that the uterus was rolled spirally more than five to seven times, and connected successively to the seminal vesicle in the cirrus sac. Shown above, this study was performed to measure the size of eggs and analyze the morphological characteristics of proglottids and provided the measurements of three types of cestodes obtained by a light microscope.

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

응급의료센터 과밀화 해소를 위한 환자 전원

이경룡,구홍두,박인철,김승환,장석준,심호식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

To reduce the degree of overcrowding in level Ⅲ emergency care centers, authors have conducted a prospective study of patient who were transferred to level Ⅰ or Ⅲemergency center based on the non-emergent patient guideline currently used at the severance Hospital, level Ⅲ emergency center, during the period of 65 days from Jan. 1st 1995 to Mar. 6th 1995. Followings are guideline for non-emergent patient described by the Korean government low: 1) systolic blood pressure greater than 80/100 of normal. 2) respiration rate between 10 to 24 per minute. 3) pulse rate between 60 to 100 per minute. 4) body temperature between 36 to 37.5℃ by rectal. 5) relatively alert mental status. 6) patient not requiring emergency operation at the time of examination. The results were as follows: 1. Among the total 5,301 patients, 464 patients ranged from age of 1 to 82 years old were transferred to level Ⅰor Ⅱ emergency center after simple treatment. 2. Among the 464 patients, 276 patients were treated in expected hospital with medical problems in 101 (36.6%) patients, and 175 (63.4%) patients had surgical problems. 3. Among the 276 patients, 122 (44.2%) patients were admitted, 145 (52.9%) patients were discharged from the emergency room after adequate treatment. 4. Among the transferred patients, simple laceration (33.0%) were most common, acute gastroenteritis (12.0%), and simple contusion (10.5%) were followed. These results suggest that about 10% of patients visiting level Ⅲ emergency care center, can be safely transferred to nearest level Ⅰor Ⅱ emergency centers on the bases of non-emergent patient guideline described by Emergency Medical Service law. These guideline, if put into proper use, can reduce the degree of overcrowding problems in level Ⅲ emergency care center through out the country.

과도한 운동으로 발생한 횡문근융해증에 의한 급성신부전증 1예

문철호,류보열,모성환,김태종,기장도,박용관,김용환,정종훈 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Rhabdomyolysis may be defined as a clinical and laboratory syndrome which releases muscle cell contents into the plasma, such as creatine phosphokinase, due to skeletal muscle injuries. It can be the result of many diverse causes including muscle disease, ischemia, genetic disorder, metabolic disorder, infectious disease, drugs, comatose state, trauma or vigorous exercise that can lead to acute renal failure as a complication. Since first reported in 1941, rhabdomyolysis-induced acute renal failure has been documented many times, and the major causes of this disease are carbon monoxide poisoning, snake bites, and etc in Korea Reports of acute renal failure after exercise-related rhabdomyolysis with myoglobinemia are rare. We report a case of acute renal failure caused by exercise-related rhabdomyolysis in a 20 year old man.

Modeling of Nonlinear Process System Using Parallel FNNs Architecture

Jang, Sung-Whan,Oh, Sung-Kwun,Park, Ho-Sung 원광대학교 2001 論文集 Vol.26 No.-

본 논문에서는, HCM클러스터링 방법과 유전자 알고리즘을 이용하여 병렬 FNNs구조를 동정하고 최적화 한다. 제안된 병렬 FNNs구조는 퍼지 추론 방법으로 간략 추론을, 학습으로는 오류 역전파 알고리즘을 사용한다. 병렬 FNNs 구조는 모델의 구조와 파라미터를 동정하기 위해 HCM 클러스터링과 유전자 알고리즘을 사용한다. 여기서, 시스템 모델링을 위해 데이터 전처리 기능을 수행하는 HCM클러스터링 방법은 입출력 공간분할에 의해 병렬 FNNs구조를 결정하기 위해 사용된다. 또한 유전자 알고리즘을 사용하여 멤버쉽함수의 정점, 학습을, 모멘텀 계수와 같은 병렬 FNNs모델의 파라미터들을 동조한다. 모델의 근사화와 일반화 능력 사이에 합리적 균형을 얻기 위해 하중계수를 가진 합성 성능지수를 사용한다. 이 합성 성능지수는 근사화 및 예측 능력사이의 상호 균형과 의존성을 고려한 하중계수를 가진 합성 목적함수를 의미한다. 제안된 모델의 성능 평가를 위하여 가스로 공정의 시계열 데이터를 사용한다. In this paper, the Parallel FNNs(Fuzzy-Neural Networks) architecture is identified and optimized using HCM(Hard C-Means) clustering method and genetic algorithms. The proposed Parallel FNNs architecture uses simplified inference as fuzzy inference method and error back propagation algorithm as learning rules. We use a HCM clustering and Genetic Algorithms(GAs) to identify both the structure and the parameters of a Parallel FNNs architecture. Here, HCM clustering method, which is carried out for the process data preprocessing of system modeling, is utilized to determine the structure of Parallel FNNs according to the divisions of input-output space using I/O process data. Also, the parameters of Parallel FNNs model such as apexes of membership function, learning rates and momentum coefficients are adjusted using genetic algorithms. An aggregate performance index with a weighting factor is used to achieve a sound balance between approximation and generalization abilities of the model. The aggregate performance index stands for an aggregate objective function with a weighting factor to consider a mutual balance and dependency between approximation and predictive abilities. To evaluate the performance of the proposed model, we use the time series data for gas furnace.

Fuzzy Web Usage Mining for User Modeling

Jang, Jae-Sung,Jun, Sung-Hae,Oh, Kyung-Whan Korean Institute of Intelligent Systems 2002 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.2 No.3

The interest of data mining in artificial intelligence with fuzzy logic has been increased. Data mining is a process of extracting desirable knowledge and interesting pattern ken large data set. Because of expansion of WWW, web data is more and more huge. Besides mining web contents and web structures, another important task for web mining is web usage mining which mines web log data to discover user access pattern. The goal of web usage mining in this paper is to find interesting user pattern in the web with user feedback. It is very important to find user's characteristic fer e-business environment. In Customer Relationship Management, recommending product and sending e-mail to user by extracted users characteristics are needed. Using our method, we extract user profile from the result of web usage mining. In this research, we concentrate on finding association rules and verify validity of them. The proposed procedure can integrate fuzzy set concept and association rule. Fuzzy association rule uses given server log file and performs several preprocessing tasks. Extracted transaction files are used to find rules by fuzzy web usage mining. To verify the validity of user's feedback, the web log data from our laboratory web server.