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Residual Multi-dilated convolution U-Net을 이용한 다중 심장 영역 분할 알고리즘 연구
임상헌 ( Sang-heon Lim ),최한승 ( H. S. Choi ),배희진 ( S. K. Jung ),정서경 ( J. K. Jung ),정진교 ( Myung-suk Lee ),이명숙 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.1
본 연구에서는 딥 러닝을 이용하여 완전 자동화된 다중 클래스 전체 심장 분할 알고리즘을 제안하였다. 제안된 방법은 recurrent convolutional block과 residual multi-dilated block을 삽입하여 기존 U-Net을 개선한 인공신경망 모델을 사용하였다. 평가는 자동화 분석 결과와 수동 평가를 비교하였다. 그 결과 96.88%의 평균 DSC, 95.60%의 정확도, 97.00%의 recall을 얻었다. 이 실험 결과는 제안된 방법이 다양한 심장 구조에서 효과적으로 구분되어 수행되었음을 알 수 있다. 본 연구에서 제안된 알고리즘이 의사와 방사선 의사가 영상을 판독하거나 임상 결정을 내리는데 보조적 역할을 할 것을 기대한다.
Hwang, S.M.,Sung, K.,Choi, J.H.,Kim, W.,Joo, J.,Lim, J.H.,Kim, C.J.,Park, Y.S.,Kim, D.H. North-Holland 2010 Physica. C, Superconductivity Vol.470 No.20
We selected polyacrylonitrile (PAN, -[C<SUB>3</SUB>H<SUB>3</SUB>N]-) as an O-free organic dopant and fabricated C-doped MgB<SUB>2</SUB> wires by in situ and powder-in-tube techniques. 0-5 wt.% PAN powders were uniformly mixed with B powder using a liquid mixing method. The precursor powders were mixed with Mg powder, filled into Fe tubes, and then drawn into wires. Sintering was performed at 900<SUP>o</SUP>C for 1h in a flowing Ar gas. The PAN doping decreased the critical temperature (T<SUB>c</SUB>) and a-axis lattice parameter, but significantly improved the critical current density (J<SUB>c</SUB>) in high fields, upper critical field (H<SUB>c2</SUB>), and irreversibility field (H<SUB>irr</SUB>) performances. These results are attributed to the replacement of B sites with C by the PAN doping. Furthermore, as expected, the MgO amount did not increase as the doping content increased. The J<SUB>c</SUB> of the PAN-doped MgB<SUB>2</SUB> wires was more than one order of magnitude higher than that of the undoped MgB<SUB>2</SUB> wire at 5K and 6.6T (1.46-3.82kA/cm<SUP>2</SUP> vs. 0.11kA/cm<SUP>2</SUP>).
Jang, J.W.,Ko, S.Y.,Byoun, M.S.,Sung, H.W.,Lim, C.S. Elsevier Science 2015 Journal of clinical virology Vol.73 No.-
Background: Rapid identification and subtype determination of influenza virus is important in managing infected patients. Rapid influenza diagnostic tests (RIDTs) are widely used in this manner, but most can only detect influenza A and B viruses without subtyping. A new RIDT, GENEDIA Multi Influenza Ag Rapid Test (GENEDIA), was developed for detection of influenza A and B viruses and also subtyping of influenza A to H1, H3, H5 which has not been possible with other RIDTs. Objectives: Assess the performance of GENEDIA. Study design: Nasopharyngeal swabs were collected from 274 clinically suspected patients (influenza A/H1N½009 (n=50), influenza A/H3 (n=50), influenza B (n=73) and influenza-negative (n=101)) and analyzed with the real-time RT-PCR, GENEDIA, SD Bioline Influenza Ag, and Alere BinaxNow Influenza A&B Card. Also, 46 fecal specimens (H5N2 (n=3), H5N3 (n=3)) of spot-billed duck were analyzed with RT-PCR and GENEDIA. Results: Compared to real-time RT-PCR, the sensitivities of GENEDIA, SD Bioline Influenza Ag, and Alere BinaxNow Influenza A&B Card were 73.0%, 57.0%, 58.0% for influenza A, respectively, and 68.5%, 65.8%, 57.5% for influenza B, respectively. Specifically, the sensitivity of GENEDIA was 70.0% for influenza A/H1N½009 and 76.0% for influenza A/H3. From the avian influenza samples, GENEDIA detected all six H5 subtype without any cross-reactions. Conclusion: The GENEDIA Multi Influenza Ag Rapid Test was sensitive in detecting influenza viruses compared with other commercial RIDTs and also useful for rapid subtype determination of influenza A.
Substrate and pretreatment dependence of Cu nucleation by metal-organic chemical vapor deposition
Sung Kwan Kwak,Kwan Soo Chung,Ikmo Park,H. Lim 한국물리학회 2002 Current Applied Physics Vol.2 No.3
The nucleation of copper (Cu) with (hfac)Cu(VTMS) organometallic precursor is investigated for Si, SiO2, TiN, and W2Nsubstrates. As the deposition temperature is increased, the dominant growth mechanism is observed to change from the nucleationof Cu particles to the clustering of Cu nuclei around 180.C independent of the employed substrates. It is also observed that the2 sub-strates. Dimethyldichlorosilane treatment is found to passivate the surface of TiN substrate, contrary to the generally acceptedbelief, when the TiN substrate is cleaned by H2O2 solution before the treatment.. 2002 Elsevier Science B.V. All rights reserved.
임욱,강병환,유찬세,이영신,조현민,이우성,강남기 한국마이크로전자및패키징학회 2000 추계 기술심포지움 논문집 Vol.2 No.1
Non-aqueous tape casting of LTCC with PVB binder has been studied in a continuous tape casting machine. The aim of the study was to evaluate this type of system in the different Binder/Plasticizer and solid content compositions. Each four slurry compositions were used in the experiments with varied binder/plasticizer and solid content. All the slurries gave good quality tapes with smooth surfaces without blisters or pinholes. The highest mechanical properties was obtained for the B/P=3.0, powder content 70vo1% composition from 52 ㎛ green tapes, a tensile strength of 4.6 MPa and a linear extension of 29.5%.
Sung, Y. I.,Jang, J. W.,Lim, H. B. Royal Society of Chemistry 2011 The Analyst Vol.136 No.19
<P>In this work, we developed a drop-type chemiluminescence (CL) system with a partial least squares (PLS) calibration in which the coaxial optical fiber sensing head was developed for sampling and detection to determine Cu<SUP>2+</SUP> and Co<SUP>2+</SUP> on a silicon wafer directly. The use of time-resolved signal generation and PLS calibration in addition to CL allowed us to determine the metal ions simultaneously and selectively, based on the kinetic difference of Cu and Co ions in the luminol–H<SUB>2</SUB>O<SUB>2</SUB> system. Two component mixtures with a set of 15 wafer fragments were orthogonally calibrated. After prediction test, the method was applied to an intentionally contaminated silicon wafer and validated by inductively coupled plasma-mass spectrometer (ICP-MS) measurement with a HF–HNO<SUB>3</SUB> scanning solution. The average concentrations of Cu<SUP>2+</SUP> and Co<SUP>2+</SUP> of 3.45 (±0.95) × 10<SUP>13</SUP> and 2.30 (±1.18) × 10<SUP>11</SUP> atoms per cm<SUP>2</SUP>, respectively, were obtained, which were very close to the ICP-MS results of 3.70 × 10<SUP>13</SUP> for Cu<SUP>2+</SUP> and 2.46 × 10<SUP>11</SUP> atoms per cm<SUP>2</SUP> for Co<SUP>2+</SUP>. In conclusion, this drop mode CL showed almost more than 10 times better reproducibility than the typical batch mode for the profile measurement. Moreover, the adoption of PLS calibration added the function of selectivity for the simultaneous determination to this CL system, in addition to the direct mapping capability for the solid surface analysis.</P> <P>Graphic Abstract</P><P>A drop-type chemiluminescence system with a partial least squares calibration to determine Cu<SUP>2+</SUP> and Co<SUP>2+</SUP> on a silicon wafer directly. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1an15393e'> </P>
Noh, Ha Lim,Park, Young Ki,Oh, Byeong M.,Zheng, Jian,Kim, Sung-Hoon,Lee, Woosung,Kim, Jong H. Elsevier Sequoia 2019 Sensors and actuators. B Chemical Vol.301 No.-
<P><B>Abstract</B></P> <P>In this this study, we present a new colorimetric chemosensor based on the isoindoline structure (<B>ID1</B>) for the detection of volatile organic compounds (VOCs), ethylamines. Spectral changes in the UV–vis absorption spectrum of <B>ID1</B> were observed upon exposure to mono-ethylamine, resulting in significant and fast (<1.0 s) color changes detectable by the naked-eye. The reaction and kinetics of detection of different ethylamines (mono-, di-, and tri- ethylamines) by <B>ID1</B> were investigated via <SUP>1</SUP>H NMR and LC–MS characterization, binding stoichiometry, and association constant analyses, combined with density functional theory (DFT)-based quantum calculations. From these investigations, it was found that the mechanism of the detection is based on the nucleophilic attack, which was further evidenced by color change of <B>ID1</B> when exposed to H<SUB>2</SUB>S likely due to the similar nucleophilicity to ethylamine. <B>ID1</B> showed an efficient response to mono-ethylamine under versatile conditions, i.e., in the solution and solid (thin-films and dyed nylon fabric) states, which suggests applicability of <B>ID1</B> to simple, effective, and practical sensors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new isoindoline-based chemosensor (ID1) was synthesized for ethylamine detection. </LI> <LI> Ethylamine was efficiently detected based on clear color changes ID1. </LI> <LI> Sensing mechanisms and kinetics were systemically investigated. </LI> <LI> Efficient ethylamine detection under solution, thin-film, and dyed fabric was demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
이우성,조현민,임욱,유찬세,이영신,강남기 한국마이크로전자및패키징학회 2000 추계 기술심포지움 논문집 Vol.2 No.1
Brazing characteristics of the LTCC(Low Temperature Co-fired Ceramics)/Kovar(Fe-Ni-Co alloy) was investigated. Kovar is one of the typical material for the lid of MCM and packages. In case of alumina package, Brazing process is done by higher temperature profile than 800 ℃ and Ag-Cu alloy. But, LTCC has sintering temperature near 850℃. So, it is difficult to use the same process as alumina brazing. The adhesion strength of the brazed part is affected by brazing alloy and metallization properties between conductor pattern and LTCC material. We investigated brazing characteristics of the LTCC/Kovar using various Urazing alloys(Ag-Cu, Au-Sn) and process conditions. And, we examined the influence of the glass contents in conductor on the brazing characteristics of the LTCC/Kovar.